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Search Results: 1 - 10 of 461747 matches for " García Alcina "
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La serie de normas ISO 30300 y otros productos ISO de gestión de documentos
García Alcina, Montserrat
Revista Espa?ola de Documentación Científica , 2013,
Rese as críticas
Gil, Juan,Navarro García, Luis,Santamaría García, Antonio,Alcina Franch, José
Anuario de Estudios Americanos , 1995,
Rese as críticas
García, Marcela A.,Alcina Franch, José,Casta?eda, Carmen,Von Wobeser, Gisela
Anuario de Estudios Americanos , 1996,
El espa ol como lengua de la ciencia y de la medicina
María Amparo Alcina Caudet
Panace@ : Revista de Medicina, Lenguaje y Traducción , 2001,
Fotovaporización prostática (FVP) mediante láser verde: Ventajas quirúrgicas en pacientes de riesgo
López Alcina,E.; Juan Escudero,J. U.; Fabuel Deltoro,M.; Serrano de la Cruz Torríjos,F.; Montoliu García,A.; Sánchez Ballester,F.; Ramada Benlloch,F.; Marques Vidal,E.;
Archivos Espa?oles de Urología (Ed. impresa) , 2008, DOI: 10.4321/S0004-06142008000900012
Abstract: it is more and more common to have patients in our clinics with the diagnosis of bph and indication for surgery who present limitations due to their medications, age, associated morbidity or psychosocial conditions. transurethral resection of the prostate, though it is the surgical standard of reference, is not free from complications such as reabsorption syndrome, bleeding, or even blood transfusion in a percentage of cases. laser pvp may be a valid alternative in this subgroup of patients. we review our experience with this procedure, as well as the published articles on this topic, and describe technical recommendations we consider useful to avoid complications when possible during surgery or the immediate postoperative period.
Detección sérica de PSA mediante un test rápido (SD Bioline PSA)
Serrano de la Cruz Torrijos,Francisco; López Alcina,Emilio; Juan Escudero,Joaquín Ulises; Fabuel Deltoro,Milagros; Montoliu García,Ana; Real Romaguera,Arcadio; Ramos de Campos,Macarena; Marqués Vidal,Emilio;
Archivos Espa?oles de Urología (Ed. impresa) , 2008, DOI: 10.4321/S0004-06142008000600003
Abstract: objectives: over the last years numerous semiquantitative psa tests have appeared , based on serum or plasma immunochromatography. we present our experience using the sd bioline psa test, which is performed with plasma or serum for fast qualitative determination of psa; the cutpoint is 3 ng/ml. methods: we analized 54 patients who were admitted in our hospital ward. two blood samples were obtained from every patient, one for cuantitative psa determination at the hospital laboratory and the other one for qualitative determination with the sd bioline psa test, and the results were compared. two urologists independently interpreted the test without knowing the psa values from the lab. to calculate the effect of test reading time, readings were performed at 15, 20 and 25 minutes. results were classified in a classic contingency table, which enabled us to calculate sensitivity and specificity of the test, as well as positive and negative predictive values. results: mean age was 71.1 years (range 43-96 yr). from 54 patients in the study 26 (48.14%) had a psa > 3 ng/ml (mean 18.5 ng/ml, range 3.9-66.9 ng/ml) and 28(51.86%) psa < 3 ng/ml (mean 0.8 ng/ml, range 0-2.9 ng/ml), in the conventional test. results for each interval and observer were: 15 min: observer 1: sensitivity (s) 76,92%, specificity (e) 100%, positive predictive value (ppv) 100% , negative predictive value (npv) 82.35%; observer 2: s 76.92%, e 100% , ppv 100%, npv 82.35%. 20 minutes: observer 1: s 100%, e 93.33%, ppv 92.30%, npv 100%; observer 2: s 100%, e 93.33%, ppv 92.30% ,npv 100%. 25 minutes: observer 1: s 100%, e 85.71%, ppv86.66%, npv 100%; observer 2: s 92.30%, e 92.85%, ppv 92.30%, npv 92.85%. conclusions: the sd bioline psa test complies with the characteristics required to be used as a test for prostate cancer detection, it is simple, fast, cheap, not much invasive, and has a good efficacy.
Litiasis medicamentosa en pacientes VIH + en tratamiento con Indinavir
Juan Escudero,Joaquín Ulises; López Alcina,Emilio; Ordo?o Domínguez,Felipe; Fabuel Deltoro,Milagros; Serrano de la Cruz Torrijos,Francisco; Montoliu García,Ana; Ramada Benlloch,Francisco; Marqués Vidal,Emilio;
Archivos Espa?oles de Urología (Ed. impresa) , 2008, DOI: 10.4321/S0004-06142008000100005
Abstract: objectives: therapy with protease inhibitors is commonly used in patients infected by human inmunodeficency virus (hiv). 20% of the administered dose is excreted by the kidney, and when alkaline urine is present , indinavir may crystallize forming stones and patients may experience renal colic due to this fact. methods: between january 1998 and june 2005, 26 patients receiving antiretroviral treatment with protease inhibitors received care at our hospital because of renal colic or flank pain. all of them underwent physical examination, echography and urography as well as blood and urine analysis. patients were treated ambulatory excepting those in whom oral analgesics were insufficient to control the pain. results: all patients had been treated with indinavir for longer than 12 months. they represented 4% of all patients treated with the recommended dose of crivixan ?. most of them presented flank pain, associated in most cases to microhaematuria. five of them required hospitalization because of persistent pain in spite of endovenous analgesia. imaging tests (echography and urography) showed functional delay of the kidney (2 cases), ureteral stasis (4 cases) and little lithiasic concretions of mild radiologic density (5 cases). urinalysis revealed suggestive christaluria and alkaline ph. all patients required hidratation and analgesic treatment. in 3 patients indinavir dose was reduced, it was retired in another one, and 100mg of rito-navir were added in another one. unsuccesfuly ureteral cateterization was tried in one patient. all of them presen-ted symptomatic improvement. conclusions: we ought to know the capability of indinavir to form urolithiasis in hiv patients treated with protease inhibitors, although its use is decreasing along time. prevalence of urolithiasis in these patients seems to be higher as length of treatment becomes longer. metabolic alterations in urine have been proved in these patients, contributing to a higher incidence of lithiasis than in
Foto vaporización prostática con Láser Verde-KTP: Experiencia inicial en un hospital público
Juan Escudero,Joaquín Ulises; López Alcina,Emilio; Ordo?o Domínguez,Felipe; Fabuel Deltoro,Milagros; Serrano de la Cruz Torrijos,Francisco; Montoliu García,Ana; Marques Vidal,Emilio; Navalón Verdejo,Pedro;
Archivos Espa?oles de Urología (Ed. impresa) , 2007, DOI: 10.4321/S0004-06142007000900008
Abstract: objectives: despite the fact that transurethral resection of the prostate (turp) continues being the gold standard for the surgical treatment of benign prostatic hyperplasia (bph), the good results obtained with the use of new energy sources have led to their use in daily practice. methods: between september 2005 and january 2007, we have treated 63 patients with ktp laser photoselective vaporization of the prostate (pvp) in our service. preoperatively we asked for ipss, performed physical exam, digital rectal exam, abdominal , renal, bladder and prostatic ultrasound measuring postvoid residual volume, as well as flowmetry and psa determination. patients were revised after 1, 3, 6 and 12 months, undergoing uroflowmetry, ipss, ultrasound and psa; a satisfaction survey was also fulfilled at this interviews. results: mean age was 67 years (range 58-85) and mean preoperative prostatic volume was 48cc (range 34-67 ), mean preoperative ipss was 17.7 and mean maximum flow 8.1 ml/s. 12 patients presented post void residual volume larger than 100ml. most patients presented medium or high anaesthetic risk. mean operative time was 64 minutes (range 45-95). in most cases we used just one fibre, and mean energy released was 175.000 joules (range 85.000-24.000). mean hospital stay was 32.2 hours (range 19-55). in postoperative revisions we could state a significant decrease of ipss , improvement in maximum flow, and also good or very good satisfaction degree in about 80% of the patients. only 3 of them presented hematuria that needed to be attended by the urologist, none of them needed transfusion. one patient was admitted for severe urinary infection and eight patients referred irritative low urinary tract symptoms in their first postoperative checkup. conclusions: ktp laser pvp is a safe, reproducible technique with optimal short and middle term outcomes, which should be considered as the first choice surgical treatment in elderly patients, patients with chronic anaemic disease
CD40: Novel Association with Crohn's Disease and Replication in Multiple Sclerosis Susceptibility
Fiona Blanco-Kelly,Fuencisla Matesanz,Antonio Alcina,María Teruel,Lina M. Díaz-Gallo,María Gómez-García,Miguel A. López-Nevot,Luis Rodrigo,Antonio Nieto,Carlos Carde?a,Guillermo Alcain,Manuel Díaz-Rubio,Emilio G. de la Concha,Oscar Fernandez,Rafael Arroyo,Javier Martín,Elena Urcelay
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011520
Abstract: A functional polymorphism located at ?1 from the start codon of the CD40 gene, rs1883832, was previously reported to disrupt a Kozak sequence essential for translation. It has been consistently associated with Graves' disease risk in populations of different ethnicity and genetic proxies of this variant evaluated in genome-wide association studies have shown evidence of an effect in rheumatoid arthritis and multiple sclerosis (MS) susceptibility. However, the protective allele associated with Graves' disease or rheumatoid arthritis has shown a risk role in MS, an effect that we aimed to replicate in the present work. We hypothesized that this functional polymorphism might also show an association with other complex autoimmune condition such as inflammatory bowel disease, given the CD40 overexpression previously observed in Crohn's disease (CD) lesions.
Fine Mapping and Functional Analysis of the Multiple Sclerosis Risk Gene CD6
Bhairavi Swaminathan, Angélica Cuapio, Iraide Alloza, Fuencisla Matesanz, Antonio Alcina, Maria García-Barcina, Maria Fedetz, óscar Fernández, Miguel Lucas, Teresa órpez, Ma Jesus Pinto-Medel, David Otaegui, Javier Olascoaga, Elena Urcelay, Miguel A. Ortiz, Rafael Arroyo, Jorge R. Oksenberg, Alfredo Antigüedad, Eva Tolosa, Koen Vandenbroeck
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062376
Abstract: CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface scavenger receptor involved in T-cell activation and proliferation, as well as in thymocyte differentiation. In this study, we performed a haptag SNP screen of the CD6 gene locus using a total of thirteen tagging SNPs, of which three were non-synonymous SNPs, and replicated the recently reported GWAS SNP rs650258 in a Spanish-Basque collection of 814 controls and 823 cases. Validation of the six most strongly associated SNPs was performed in an independent collection of 2265 MS patients and 2600 healthy controls. We identified association of haplotypes composed of two non-synonymous SNPs [rs11230563 (R225W) and rs2074225 (A257V)] in the 2nd SRCR domain with susceptibility to MS (Pmax(T) permutation = 1×10?4). The effect of these haplotypes on CD6 surface expression and cytokine secretion was also tested. The analysis showed significantly different CD6 expression patterns in the distinct cell subsets, i.e. – CD4+ na?ve cells, P = 0.0001; CD8+ na?ve cells, P<0.0001; CD4+ and CD8+ central memory cells, P = 0.01 and 0.05, respectively; and natural killer T (NKT) cells, P = 0.02; with the protective haplotype (RA) showing higher expression of CD6. However, no significant changes were observed in natural killer (NK) cells, effector memory and terminally differentiated effector memory T cells. Our findings reveal that this new MS-associated CD6 risk haplotype significantly modifies expression of CD6 on CD4+ and CD8+ T cells.
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