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Search Results: 1 - 10 of 18690 matches for " Gao Meina "
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Long time stability of KAM tori for nonlinear wave equation
Cong Hongzi,Gao Meina,Liu Jianjun
Mathematics , 2014,
Abstract: It is proved that the KAM tori (thus quasi-periodic solutions) are long time stable for infinite dimensional Hamiltonian systems generated by nonlinear wave equation, by constructing a partial normal form of higher order around the KAM torus and showing $p$-tame property persists under KAM iterative procedure and normal form iterative procedure.
Clinical Efficacy of Crizotinib in Treatment of Patients with Advanced NSCLC
Emei GAO, Jun ZHAO, Minglei ZHUO, Zhijie WANG, Yuyan WANG, Tongtong AN, Meina WU, Xue YANG, Jia ZHONG
- , 2016, DOI: : 10.3779/j.issn.1009-3419.2016.03.07
Abstract: Background and objective Crizotinib was developed in recent years based on targets of anaplastic lymphoma kinase (ALK) fusion genes. The aim of this study is to explore the efficacy of crizotinib in treatment of non-small cell lung cancer (NSCLC) with ALK/ROS1 rearrangement. Methods Retrospective analysis of 40 patients with ALK/ROS1-positive NSCLC, who received treatment in Beijing Cancer Hospital during the period from Jun. 2013 to Dec. 2014. Results Among these cases, 39 were adenocarcinoma and adenosquamous carcinoma, with characters involving signet-ring cell carcinoma, polypoid adenocarcinoma, acini and papillary adenocarcinoma. The median age was 49.5 years old, with the overall response rate of 62.5% and disease control rate of 95.0%. Of all the cases, median follow-up was 14.6 months and median PFS 7.5 months; median OS has not been reached; the one-year survival rate was 77.4%. The median PFS and OS of patients receiving first and second-line treatment tend to be longer than those who received post-second line treatment, but with no statistical significance (PFS: 9 mo vs 6 mo, P=0.06; OS: 21.5 mo vs 14.6 mo, P=0.12). Twenty patients who experienced progression in brain metastases. After experiencing progression, the patients receiving 2nd/3rd generation ALK-TKI treatment showed efficacy of disease control and survival. The adverse events include gastrointestinal reaction, transaminase elevation, and distinctive visual abnormalities, etc. Conclusion The clinical features, efficacy, and adverse events of crizotinib in the treatment of the 40 patients with ALK/ROS1-positive NSCLC are similar to the data from the previous reports. The most common site of progression was brain metastases. The treatment of crizotinib-resistant patients using 2nd/3rd generation ALK-TKI could delay progression.
The Role of System-Specific Molecular Chaperones in the Maturation of Molybdoenzymes in Bacteria
Meina Neumann,Silke Leimkühler
Biochemistry Research International , 2011, DOI: 10.1155/2011/850924
Abstract: Biogenesis of prokaryotic molybdoenzymes is a complex process with the final step representing the insertion of a matured molybdenum cofactor (Moco) into a folded apoenzyme. Usually, specific chaperones of the XdhC family are required for the maturation of molybdoenzymes of the xanthine oxidase family in bacteria. Enzymes of the xanthine oxidase family are characterized to contain an equatorial sulfur ligand at the molybdenum center of Moco. This sulfur ligand is inserted into Moco while bound to the XdhC-like protein and before its insertion into the target enzyme. In addition, enzymes of the xanthine oxidase family bind either the molybdopterin (Mo-MPT) form of Moco or the modified molybdopterin cytosine dinucleotide cofactor (MCD). In both cases, only the matured cofactor is inserted by a proofreading process of XdhC. The roles of these specific XdhC-like chaperones during the biogenesis of enzymes of the xanthine oxidase family in bacteria are described.
The Role of System-Specific Molecular Chaperones in the Maturation of Molybdoenzymes in Bacteria
Meina Neumann,Silke Leimkühler
Biochemistry Research International , 2011, DOI: 10.1155/2011/850924
Abstract: Biogenesis of prokaryotic molybdoenzymes is a complex process with the final step representing the insertion of a matured molybdenum cofactor (Moco) into a folded apoenzyme. Usually, specific chaperones of the XdhC family are required for the maturation of molybdoenzymes of the xanthine oxidase family in bacteria. Enzymes of the xanthine oxidase family are characterized to contain an equatorial sulfur ligand at the molybdenum center of Moco. This sulfur ligand is inserted into Moco while bound to the XdhC-like protein and before its insertion into the target enzyme. In addition, enzymes of the xanthine oxidase family bind either the molybdopterin (Mo-MPT) form of Moco or the modified molybdopterin cytosine dinucleotide cofactor (MCD). In both cases, only the matured cofactor is inserted by a proofreading process of XdhC. The roles of these specific XdhC-like chaperones during the biogenesis of enzymes of the xanthine oxidase family in bacteria are described. 1. Introduction Molybdenum is a transition metal that is incorporated as a biologically active cofactor (molybdenum cofactor, Moco) in a class of widely distributed proteins collectively known as molybdoenzymes [1]. Moco is associated with a wide range of redox enzymes and is found in most organisms from bacteria to humans. The metal in Moco is coordinated to a pterin derivative called molybdopterin to form the molybdenum-containing molybdopterin (Mo-MPT) cofactor [2]. A wide variety of transformations are catalyzed by these enzymes at carbon, sulfur, and nitrogen atoms, which include the transfer of an oxygen group or two electrons to or from the substrate. The mononuclear molybdenum enzymes are categorized on the basis of the structures of their molybdenum centers, dividing them into three families, each with a distinct active site structure and a distinct type of reaction catalyzed: the xanthine oxidase family, the sulfite oxidase family, and the DMSO reductase family [1] (Figure 1). The xanthine oxidase family is characterized by an LMoVIOS(OH) core in the oxidized state, with one equivalent of the pterin cofactor (designated L) coordinated to the metal. These enzymes (including xanthine dehydrogenase [XDH] and xanthine oxidase [XO]) typically catalyze the hydroxylation of carbon centers [1]. Enzymes of the sulfite oxidase family coordinate a single equivalent of the pterin cofactor with an LMoVIO2(S-Cys) core in its oxidized state (the cysteine ligand is provided by the polypeptide) [1]. Members of this family (including sulfite oxidase and plant nitrate reductase) catalyze the transfer of an
Research on the Social Responsibility of Corporations in China
Dianwei Qi,Chunhua Feng,Meina Jin
Asian Social Science , 2012, DOI: 10.5539/ass.v8n15p184
Abstract: It is the consensus of the Chinese enterprises to focus on the sustainable development of enterprises and society and emphasize responsibility and contribution. Compared with the large and medium-sized enterprises, the small and medium enterprises (SME) have fulfilled certain social responsibility and played an irreplaceable role in promoting economic growth, increasing employment, technological innovation and social harmony and stability. However, there are some problems for corporation of China to fulfill their social responsibilities that the paper will discuss, then put forward the measures how to strengthen social responsibility fulfillment.
Analysis of Prognostic Factors in 541 Female Patients with Advanced Non-small Cell Lung Cancer
Meina WU,Yuyan WANG,Tongtong AN,Jun ZHAO
Chinese Journal of Lung Cancer , 2011,
Abstract: Background and objective As there is a sharp increase in the incidence of lung cancer in women in recent years, it has brought broad concerns with its unique clinical and epidemiological characteristics and better prognosis. The aim of this study is to analyze the clinical data of women with advanced non-small cell lung cancer (NSCLC) retrospectively to explore the prognostic factors. Methods Clinical data of 541 female patients with advanced NSCLC were collected and followed up till death. The primary endpoint is overall survival (OS). SPSS 11.0 statistical analysis software was used for univariate and multivariate analysis. Results The mean age is 59 years (20 years-86 years), adenocarcinoma account for 80.2% (434/541). The median OS was 15 months (95%CI: 13.87-16.13), and 1, 2, 5-year survival rates were 58.8%, 23.7% and 3.20% respectively. Univariate analysis showed that clinical stage, ECOG score, weight loss, clinical symptoms, liver/bone/brain metastasis and received more than one chemotherapy regimen, good response to the first-line chemotherapy, EGFR-TKI targeted therapy and radiotherapy treatment were significantly correlated with the OS and survival rate (P < 0.05). Combined with multivariate analysis, weight loss before treatment, ECOG score, received EGFR-TKI targeted therapy and response to first-line chemotherapy were independent prognostic factor for survival (P < 0.05). Conclusion There is a higher percentage of adenocarcinoma in female NSCLC. Weight loss before treatment, ECOG score, EGFR-TKI targeted therapy and response to first-line chemotherapy may become independent prognostic factors for survival of female patients with advanced NSCLC.
Intelligent Predictor of Energy Expenditure with the Use of Patch-Type Sensor Module
Meina Li,Keun-Chang Kwak,Youn-Tae Kim
Sensors , 2012, DOI: 10.3390/s121114382
Abstract: This paper is concerned with an intelligent predictor of energy expenditure (EE) using a developed patch-type sensor module for wireless monitoring of heart rate (HR) and movement index (MI). For this purpose, an intelligent predictor is designed by an advanced linguistic model (LM) with interval prediction based on fuzzy granulation that can be realized by context-based fuzzy c-means (CFCM) clustering. The system components consist of a sensor board, the rubber case, and the communication module with built-in analysis algorithm. This sensor is patched onto the user’s chest to obtain physiological data in indoor and outdoor environments. The prediction performance was demonstrated by root mean square error (RMSE). The prediction performance was obtained as the number of contexts and clusters increased from 2 to 6, respectively. Thirty participants were recruited from Chosun University to take part in this study. The data sets were recorded during normal walking, brisk walking, slow running, and jogging in an outdoor environment and treadmill running in an indoor environment, respectively. We randomly divided the data set into training (60%) and test data set (40%) in the normalized space during 10 iterations. The training data set is used for model construction, while the test set is used for model validation. The experimental results revealed that the prediction error on treadmill running simulation was improved by about 51% and 12% in comparison to conventional LM for training and checking data set, respectively.
Male and Female Adult Population Health Status in China: A Cross-Sectional National Survey
Jing Shi, Meina Liu, Qiuju Zhang, Mingshan Lu, Hude Quan
BMC Public Health , 2008, DOI: 10.1186/1471-2458-8-277
Abstract: The Chinese Third National Health Services Survey was conducted in 2003 to collect information about health status and quality of life from randomly selected residents. Of the 193,689 respondents to the survey (response rate 77.8%), 139,831 (69,748 male and 70,083 female) respondents who were 18 years of age or older were analyzed.Among the respondents, fewer males than females rated their overall wellbeing as being poor or very poor (4.8% versus 6.2%), reported illness in the last 2 weeks (14.1% versus 17.4%), presence of physician diagnosed chronic disease (15.0% versus 17.7%) and at least one functional problem in seven items of the quality of life (26.9% versus 32.8%). More males than females were currently smoking (52.4% versus 3.4%) and drank alcohol more than three times per week (16.5% versus 1.1%). Physically inactive rate was similar between males and females (85.8% versus 87.0%). Fewer rural respondents reported chronic disease than urban respondents (13.0% versus 19.9% for males and 15.5% versus 22.8% for females). In all seven items of the quality of life measured, rural respondents reported less problems than urban respondents (26.2% versus 28.7% for males and 32.0% versus 34.7% for females).Males had better health status than females in terms of self-perceived wellbeing, presence of illness, chronic disease, and quality of life. However, smoking and frequent alcohol drinking was more prevalent among males than that among females. In contrast with the social-economic gradient in health commonly found in the literature, the wealthier urban population in China was not found to be healthier than the rural population in terms of physician diagnosed chronic disease.China's population of 1.3 billion accounts for 20% of the world population, making it the most populated country in the world. With rapid economic growth and globalization, Chinese people's lifestyle has been changing dramatically towards being more physically inactive, eating more fast food, and
Survey of HBsAg-positive pregnant women and their infants regarding measures to prevent maternal-infantile transmission
Yan Guo, Jianqiong Liu, Liping Meng, Hu Meina, Yukai Du
BMC Infectious Diseases , 2010, DOI: 10.1186/1471-2334-10-26
Abstract: HBsAg-positive pregnant women were selected by a random sampling method when they accepted prenatal care in district-level Maternal and Child Health Hospitals. On a voluntary basis, these women completed questionnaires by face-to-face or phone interviews. The collected data were used to evaluate the immunization programs that pregnant women had received for preventing hepatitis B maternal-infantile transmission.Among the 158 women, 143(90.5%) received Hepatitis B immune globulin during pregnancy, and 86.0% of their children were given Hepatitis B immune globulin and Hepatitis B vaccine. The rate of cesarean section was 82.3%, and 28.5% of these were aimed at preventing HBV infection. The rate of bottle feeding was 51.9%, and 89.0% of bottle feeding cases were for the purpose of preventing HBV infection. There were 71 cases of participants who were HBeAg-positive. Compared with the HBsAg+ HBeAg- group (only HBsAg-positive), the HBsAg + HBeAg+ group (HBsAg-positive and HBeAg-positive) had significantly higher rates of the caesarean section and bottle feeding resulting from hepatitis B (P < 0.05). Five cases were HBsAg-positive by Umbilical Cord Blood detection. The intrauterine infection rate of newborns was 6.7%. The chronic HBV rate of children was 4.0%.Most HBsAg positive pregnant women have a growing awareness of maternal-infantile transmission of Hepatitis B virus and are receiving some form of preventative treatment, like combined immunization. Caesarean and bottle feeding are very common, often primarily to prevent transmission. Relatively few intrauterine infections were identified in this sample, but many infants did not appear to seroconvert after vaccination.Hepatitis B virus infection is a serious public health problem. China has a high incidence of HBV infection, with a 10% HBsAg positive rate in the general population. There are more than 130 million chronic carriers of HBV in China, 30% ~50% of which can be attributed to maternal-infantile transmission[
Engineering Escherichia coli for succinate production from hemicellulose via consolidated bioprocessing
Zongbao Zheng, Tao Chen, Meina Zhao, Zhiwen Wang, Xueming Zhao
Microbial Cell Factories , 2012, DOI: 10.1186/1475-2859-11-37
Abstract: Xylanases were extracellular environment-directed by fusing with OsmY. Subsequently, twelve variant OsmY fused endoxylanase-xylosidase combinations were characterized and tested. The combination of XynC-A from Fibrobacter succinogenes S85 and XyloA from Fusarium graminearum which appeared to have optimal enzymatic properties was identified as the best choice for xylan hydrolysis (0.18 ± 0.01 g/l protein in the broth with endoxylanase activity of 12.14 ± 0.34 U/mg protein and xylosidase activity of 92 ± 3 mU/mg protein at 8 h after induction). Further improvements of hemicellulases secretion were investigated by lpp deletion, dsbA overexpression and expression level optimization. With co-expression of α-arabinofuranosidase, the engineered E. coli could hydrolyze beechwood xylan to pentose monosaccharides. The hemicellulolytic capacity was further integrated with a succinate-producing strain to demonstrate the production of succinate directly from xylan without externally supplied hydrolases and any other organic nutrient. The resulting E. coli Z6373 was able to produce 0.37 g/g succinate from xylan anaerobically equivalent to 76% of that from xylan acid hydrolysates.This report represents a promising step towards the goal of hemicellulosic chemical production. This engineered E. coli expressing and secreting three hemicellulases demonstrated a considerable succinate production on the released monosaccharides from xylan. The ability to use lower-cost crude feedstock will make biological succinate production more economically attractive.Lignocellulosic biomass represents an abundant, low-cost and renewable source of fermentable sugars. It is an alternative candidate besides petroleum as feedstock for fuel and chemical production [1]. Generally, lignocellulosic biomass comprises of 35-50% cellulose, 20-35% hemicellulose and 10-25% lignin [2]. As the major component of hemicellulose, xylan is one of the most abundant natural polysaccharides with a β-(1, 4)-linked xylose
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