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Search Results: 1 - 10 of 402044 matches for " Gamboa Márquez "
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Factores mecánicos en enfermedades osteocondrales
Gamboa Márquez,Alejandro; Garzón-Alvarado,Diego Alexander;
Revista Cubana de Investigaciones Biom??dicas , 2011,
Abstract: the osteochondroses are diseases affecting the developing skeleton and that in its advanced stages provoke deformations and changes of physical activity and movement patterns of the subjects. to achieve an effectiveness therapeutic intervention or to detect the diseases in its earliest stagers, it is necessary to know it etiology, which remains uncertain and generally it is classes as mulfifactor and idiopathic. since they are bone growth diseases, these same responsible factors influenced on the disease pathogenesis including the mechanical loads underwent by bones. in past decades computer models have been developed to represent the mechanic factors on the bone growth allowing us to improve the understanding of mechanic implications associated to growth which corresponding with the experimental observations. in present paper is shown a review of current knowledge on boner growth process, osteochondrosis etiology and some computer models which, with some modifications or improvements, could be used in the future to modeling the disease course.
Modelamiento matemático de la enfermedad de Legg-Calvé-Perthes
Gamboa Márquez,Alejandro; Garzón-Alvarado,Diego Alexander;
Revista Cubana de Investigaciones Biom??dicas , 2011,
Abstract: the legg-calvé-perthes disease is a disorder characterized by the avascular necrosis of femoral head of developing skeleton. although this disease was described a century ago still there is a significant controversy on its etiology and its treatment. between etiology and treatment there is a close relation with biological and mechanical events. the knowledge of such events and of its combined action, could give rise to a better understanding and management of this disease. present paper proposes a approach to this understanding by means of the use of a computer modeling, which must to has into account among other factors, the disease pathogenesis and the different results depending on age of appearance in the child.
Factores mecánicos en enfermedades osteocondrales Mechanical factors of osteochondral diseases
Alejandro Gamboa Márquez,Diego Alexander Garzón-Alvarado
Revista Cubana de Investigaciones Biom??dicas , 2011,
Abstract: Las osteocondrosis son enfermedades que afectan al esqueleto en crecimiento y que en sus estados avanzados producen deformaciones y cambios de los patrones de actividad física y movimiento del individuo. Para lograr una intervención terapéutica efectiva o detectar la enfermedad en sus estados iniciales, es necesario conocer su etiología, la cual sigue siendo incierta y generalmente se cataloga simplemente como multifactorial e idiopática. Como se trata de enfermedades del crecimiento óseo, los mismos factores responsables de este tienen efectos sobre la patogénesis de la enfermedad; dentro de estos se incluyen las cargas mecánicas a las que están sometidos los huesos. En las últimas décadas se han desarrollado modelos computacionales para modelar el efecto de los factores mecánicos sobre el crecimiento de los huesos, los cuales han permitido mejorar la comprensión de las implicaciones mecánicas asociadas al crecimiento y se han correspondido con las observaciones experimentales. En este artículo se muestra una revisión del conocimiento actual del proceso de crecimiento óseo, la etiología de las osteocondrosis y algunos modelos computacionales, que con ciertas modificaciones o mejoras pudieran emplearse en el futuro para modelar el transcurso de la enfermedad. The osteochondroses are diseases affecting the developing skeleton and that in its advanced stages provoke deformations and changes of physical activity and movement patterns of the subjects. To achieve an effectiveness therapeutic intervention or to detect the diseases in its earliest stagers, it is necessary to know it etiology, which remains uncertain and generally it is classes as mulfifactor and idiopathic. Since they are bone growth diseases, these same responsible factors influenced on the disease pathogenesis including the mechanical loads underwent by bones. In past decades computer models have been developed to represent the mechanic factors on the bone growth allowing us to improve the understanding of mechanic implications associated to growth which corresponding with the experimental observations. In present paper is shown a review of current knowledge on boner growth process, osteochondrosis etiology and some computer models which, with some modifications or improvements, could be used in the future to modeling the disease course.
Modelamiento matemático de la enfermedad de Legg-Calvé-Perthes Mathematical modeling of Legg-Calvé-Perthes disease
Alejandro Gamboa Márquez,Diego Alexander Garzón-Alvarado
Revista Cubana de Investigaciones Biom??dicas , 2011,
Abstract: La enfermedad de Legg-Calvé-Perthes es un desorden caracterizado por la necrosis avascular de la cabeza femoral del esqueleto en desarrollo. Aunque la enfermedad fue descrita hace un siglo, aún existe gran controversia respecto a su etiología y al tratamiento que se le debe dar. Tanto la etiología como el tratamiento tienen una fuerte relación con eventos biológicos y mecánicos. Un entendimiento de dichos eventos y de su acción combinada, podría dar lugar a una mejor comprensión y manejo de la enfermedad. Este trabajo propone un acercamiento a esta comprensión mediante el uso del modelamiento computacional, el cual debe tener en cuenta, entre otros factores, la patogénesis de la enfermedad y los diferentes resultados en dependencia de la edad a la cual esta se manifieste en el ni o. The Legg-Calvé-Perthes disease is a disorder characterized by the avascular necrosis of femoral head of developing skeleton. Although this disease was described a century ago still there is a significant controversy on its etiology and its treatment. Between etiology and treatment there is a close relation with biological and mechanical events. The knowledge of such events and of its combined action, could give rise to a better understanding and management of this disease. Present paper proposes a approach to this understanding by means of the use of a computer modeling, which must to has into account among other factors, the disease pathogenesis and the different results depending on age of appearance in the child.
Nanomaterials for Drugs Delivery  [PDF]
Francisco Márquez, Carmen Morant
Soft Nanoscience Letters (SNL) , 2014, DOI: 10.4236/snl.2014.43007
Abstract:

As expected for years, nanotechnology has revolutionized engineering, biology, chemistry, physics and medicine of today. These disciplines are evolving thanks to the ongoing development of new materials and applications. Nanomedicine, as application of nanotechnology in the field of health care, has undergone unprecedented development. Some of these changes have real applications as, for example, the use of nanoparticles in MRI imaging, in hyperthermia, in immunotherapy, or to improve the bioavailability of drugs, among others [1]-[3].

When a drug is administered to a patient, the blood distributes it throughout the body. In the case of very localized diseases (i.e. tumors), only a small fraction of the drug reaches the target. Chemotherapy is one of the most aggressive treatment options used in some types of cancer, and is usually administered intravenously. In this type of therapy, the drug circulates throughout the body, reaching and destroying healthy and cancerous tissues, producing side effects throughout the body, sometimes with serious consequences for the health of the patient (nephrotoxicity, cardiotoxicity, peripheral neuropathy, anemia, etc.). Among the many applications of nanotechnology, the fabrication of nanostructures capable of safely transporting these drugs is seen as a strategy for reducing these side effects. Nanoparticles are able to carry and release the drug in the right place and with the required dose, greatly reducing the problems associated with direct treatment with these drugs.

In recent years, there have been continuous improvements in the design and development of new tailor-made drug delivery systems [4], including hollow magnetic nanoparticles, liposomal structures, dendrimers, nanoporous silicon, etc. These structures can be obtained with different molecular weights (in the case of polymers), structures, shapes, and even with the appropriate functional groups for interaction at the desired positions. However, a great effort is still required to solve many of the current problems [5], including toxicity, aggregation, solubility and stability in the human body, physiological processes of elimination, identification of targets by highly specific receptors, controlled drug release over time, etc.

Nanomaterials for Sensor Applications  [PDF]
Francisco Márquez, Carmen Morant
Soft Nanoscience Letters (SNL) , 2015, DOI: 10.4236/snl.2015.51001
Abstract: Recently, a large part of the advances in nanotechnology have been directed towards the development of high-speed electronics, more efficient catalysts, and sensors. This latter group of applications has great relevance and unprecedented development potential for the coming years.So far, some of the main objectives for the development of sensors have focused on making more sensitive, effective and specific sensing devices.The improvement of these systems and the increase of specificity are clearly associated with a decrease in size of the components, which can lead to obtaining more rapid action, almost in real time. Nanomaterials currently used in sensor development include a long list of nanostructured systems, as for example: metal nanotubes, nanowires, nanofibers, nanocomposites, nanorods, nanoparticles, nanostructured polymers, and different allotropes of carbon as carbon nanotubes, graphene or fullerenes, among others.
CARLOS HUNEEUS. El régimen de Pinochet
ANGEL M. SOTO GAMBOA
Historia (Santiago) , 2001,
Abstract:
La encomienda y las sociedades indígenas del nuevo reino de Granada: el caso de la provincia de Pamplona (1549-1650)
Gamboa M., Jorge Augusto
Revista de Indias , 2004,
Abstract: This article is about the introduction of the encomienda system in the indigenous communities of the Pamplona Province (East-North region of the New Kingdom of Granada, actual Colombia) as a result of the Spanish Conquest. The sources used are the visits of oidores of the Santafé Real Audiencia as a basis for the reconstruction of the main lines of the changing process. It is argued that different domination strategies were enforced in this region according the the natives’ different organization systems –from ierarchical cacicazgos up to more egalitarian tribal societies. The main aim of this work is to show that far from being a monolithic instiitution, the encomienda had to adapt itself to a variety of circumstances. El artículo trata sobre la implantación del régimen de la encomienda a raíz de la conquista espa ola en las comunidades indígenas de la Provincia de Pamplona, ubicada al nororiente del Nuevo Reino de Granada (actual República de Colombia) y las transformaciones que sufrieron dichas comunidades durante el primer siglo de la Colonia (1549-1650). Las fuentes utilizadas han sido las visitas practicadas por los oidores de la Real Audiencia de Santafé durante aquellos a os, buscando a través de ellas reconstruir las líneas principales de los procesos de cambio. Se argumenta que en esta región se dise aron diferentes estrategias de dominación, dependiendo de las distintas formas de organización social de los nativos, desde los cacicazgos jerarquizados, hasta sociedades tribales más igualitarias. El objetivo principal es mostrar que la encomienda no fue una institución monolítica, sino que tuvo que adaptarse a las diversas circunstancias.
Electron Confinement Effect of Laser Dyes within Dendritic Structures  [PDF]
Francisco Márquez, María José Sabater
Journal of Encapsulation and Adsorption Sciences (JEAS) , 2011, DOI: 10.4236/jeas.2011.11001
Abstract: Dendrimers are a novel class of nanometric-size macromolecules with a regular tree-dimensional like array of branch units.1,2 Their synthetic availability in a wide range of sizes combined with their peculiar architecture makes them versatile building blocks for a wide range of potential applications.3 Some years ago, Meijer and co-workers reported that the modification of terminal amine functionalities of a fifth generation poly(propyleneimine) dendrimer (DAB-dendr-(NH2)64) with bulky substituents, (typically N-t-BOC protected phenylalanine), results in the formation of the so-called “dendritic box” (DAB-dendr-(NH-t-BOC-L-Phe)64).4 Within this macromolecular structure it is possible to encapsulate a variety of guest molecules due to the existence of internal cavities in the core. The photophysical properties of the guests can be modulated by the innovative electron confinement effect. In this respect, we wish to report that the emission frequency of organic dyes can be easily modulated by encapsulation in a dendritic box. The emission bands of dye molecules incorporated into a dendrimer can effectively be red shifted with respect to their emission in solution and contrary to other confined spaces of considerable hardness, the magnitude of this shifting can be regulated under appropriate experimental conditions. This peculiar effect could have unprecedented applications in the development of supramolecular devices relating to the frequency tuning of organic laser dyes.
PPAR and Local Renin-Angiotensin Systems in Cardiovascular and Metabolic Diseases Associated with Obesity: A Unifying Hypothesis  [PDF]
Gustavo Márquez-Salom, Javier Diez
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2013, DOI: 10.4236/ojemd.2013.35A001
Abstract:

Recent research has revealed roles for the PPAR family of transcription factors in the modulation of the RAAS. In particular, PPARα and PPARγ have been shown to control the transcription of renin in several tissues and influence the activity of local renin-angiotensin-systems coupling vascular and metabolic functions and contributing to their modulation. In this conceptual framework, PPAR and local RAS participate in the pathophysiology of blood pressure elevation, as well as in organ and tissue damage, and disturbances of glucose and lipid metabolism associated with cardiovascular diseases and obesity. The understanding of these mechanisms here discussed and their adequate pharmacological manipulation enlarge the potential to intervene pathological processes that connect the obesity with associate diseases and could alert about the adverse effects of some PPAR agonists on involved organs.

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