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Search Results: 1 - 10 of 11 matches for " Galizzi "
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Label, nudge or tax? A review of health policies for risky behaviours
Matteo M. Galizzi
Journal of Public Health Research , 2012, DOI: 10.4081/jphr.2012.e5
Abstract: This work proposes a critical, non systematic, review of the three main lines of health policy interventions to deal with risky behaviours, such as over-eating, smoking, sedentary lives, and excess alcohol drinking, namely: i) the release of information on health risks and consequences; ii) the use of financial incentives; and iii) direct policy intervention in markets, through regulation and taxation. First, the health and economic impact of the risky behaviours epidemics are briefly described. Then a critical review follows on the evidence existing on the effectiveness of each type of intervention. The review will also highlight the public health approach staying beyond each type of policy on risky behaviours and critically consider them within the context of more general health and social policy interventions.
Descomposición de hojas de Tessaria integrifolia (Asteraceae) y colonización por invertebrados en un cauce secundario del río Paraná Medio
Galizzi,María Celeste; Marchese,Mercedes;
Interciencia , 2007,
Abstract: the decomposition of leaf litter of tessaria integrifolia and its colonization by invertebrates were studied in the tiradero viejo river. leaves were collected at abscission and 6g dry weight and were placed in nylon bags with 5 mm mesh net. samplings were carried out between may and september 2002 and three replicates were collected after 7, 14, 28, 56 and 112 days. the decay coefficient calculated over 112 days of decomposition was 0.0143d-1. invertebrate densities increased with the progressive decomposition of the leaves, reaching the maximum at 56 days (395 individuals/g of leaves dry weight). the highest species richness (43) and shannon?s index (4.24) were obtained at 28 days of leaf decomposition. colonization of decomposing leaves was dominated by oligochaetes (pristina leidyi, p. aequiseta, dero multibranchiata), chironomids (polypedilum spp., phanopsectra sp.) and mussels (limnoperna fortunei). gatherers-collector were dominant during the first time, the filterers increasing at the end of the colonization experiment and the shredders were more constant over time but scarce.
Colonización de hojas en descomposición de Eucalyptus camaldulensis Dehnhardt por invertebrados en un cauce secundario del río Paraná medio
Galizzi, María Celeste;Marchese, Mercedes;
Hidrobiológica , 2009,
Abstract: eucalyptus camaldulensis leaves collected at abscission and 6 g dry weight were placed innylon bags of 5 mm mesh net in a secondary channel of middlle parana river (31° 40's y 60° 33' w). three replicates were collected after 7, 14, 28, 56 and 112 days during low water level (may-september 2002). the decay coefficient (k) calculated over 112 days was 0.0131 d-1. the time estimated for 95% of leaves decomposition was 36 days according to the k obtained. the highest invertebrate density (600 ind.g-1 of leaves dry weight) and taxonomic richness (39 taxa) were obtained at 112 days and 14 days of leaf decomposition, respectively. the colonization on decomposing leaves was dominated by chironomids and mussels. gatherers-collectors (naididae and chironominae) were dominant during the first time and filterers-collector (limnoperna fortunei) increasing at the end of colonization experiment. the shredders (polypedilum spp.) were more abundant in the first and media colonization phases.
Diet and functional feeding groups of Chironomidae (Diptera) in the Middle Paraná River floodplain (Argentina)
Galizzi, M. Celeste;Zilli, Florencia;Marchese, Mercedes;
Iheringia. Série Zoologia , 2012, DOI: 10.1590/S0073-47212012000200001
Abstract: the gut contents of nine genera of benthic chironominae and tanypodinae from the middle paraná river floodplain habitats (a lake and a secondary channel) were analyzed to determine their feeding patterns and functional feeding groups. amorphous detritus, animal and vegetal tissues, and mineral materials (predominantly sand) were observed in the larval guts. amorphous detritus were the main food item found for polypedilum (tripodura) sp., chironomus gr. decorus sp., endotribelos sp., phaenopsectra sp., cladopelma sp., and pelomus sp. (chironominae), while animal tissues (mainly oligochaetes) were the most important food item found for ablabesmyia (karelia) sp., coelotanypus sp., and procladius sp. (tanypodinae). dietary overlap was calculated for all pairs of genera. within predators, the highest overlap was obtained between coelotanypus sp. and ablabesmyia (karelia) sp., while within detritivores the highest niche overlap was obtained between endotribelos sp. and phaenopsectra sp.
Colonización de hojas en descomposición de Eucalyptus camaldulensis Dehnhardt por invertebrados en un cauce secundario del río Paraná medio Invertebrate colonization on Eucalyptus camaldulensis Dehnhardt leaf litter breakdown in an anabranche of the Middle Parana River
María Celeste Galizzi,Mercedes Marchese
Hidrobiológica , 2009,
Abstract: Hojas de Eucalyptus camaldulensis, fueron recolectadas después de la abscisión y se colocaron 6 g de hojas secas en bolsas de nylon de 5 mm de abertura de malla en un cauce secundario del río Paraná medio (31° 40'S y 60° 33' O). Se extrajeron 3 réplicas a los 7, 14, 28, 56 y 112 días durante un período de estiaje del agua (mayo-septiembre, 2002). El coeficiente de descomposición (k) fue de 0.0131 d-1 a los 112 días. El tiempo necesario estimado para que se descomponga el 95% del material vegetal fue de 36 días, teniendo en cuenta el coeficiente k obtenido. La mayor densidad de invertebrados (600 ind.g-1 de peso seco de hojas) y riqueza taxonómica (39 taxa) fueron obtenidas a los 112 y 14 días de exposición, respectivamente. Los quironómidos y bivalvos fueron los taxa dominantes en la colonización de hojas en descomposición. Los colectores - recolectores (principalmente Naididae y Chironominae) dominaron las primeras etapas de la sucesión y los colectores - filtradores (Limnoperna fortunei) aumentaron notablemente en las etapas finales. Mientras que los trituradores (Polypedilum spp.) fueron más abundantes durante las primeras fases de la colonización. Eucalyptus camaldulensis leaves collected at abscission and 6 g dry weight were placed innylon bags of 5 mm mesh net in a secondary channel of Middlle Parana River (31° 40'S y 60° 33' W). Three replicates were collected after 7, 14, 28, 56 and 112 days during low water level (may-september 2002). The decay coefficient (k) calculated over 112 days was 0.0131 d-1. The time estimated for 95% of leaves decomposition was 36 days according to the k obtained. The highest invertebrate density (600 ind.g-1 of leaves dry weight) and taxonomic richness (39 taxa) were obtained at 112 days and 14 days of leaf decomposition, respectively. The colonization on decomposing leaves was dominated by chironomids and mussels. Gatherers-collectors (Naididae and Chironominae) were dominant during the first time and filterers-collector (Limnoperna fortunei) increasing at the end of colonization experiment. The shredders (Polypedilum spp.) were more abundant in the first and media colonization phases.
Investigating the inter-relationships between beliefs, autonomy, and motivation in the context of foreign language learning/teaching
Maria Letícia Galizzi da Luz Moreira,Fábio Alves
Revista Brasileira de Linguística Aplicada , 2004,
Abstract: This article aims at investigating the beliefs of teachers' and students' of English as a foreign language in the public school network of the city of Belo Horizonte, Brazil. The analysis focuses on five main topics, namely, aptitude to learn languages, the degree of difficulty of a particular language, the nature of learning languages in general, the learning strategies and the degree of autonomy and motivation of the students involved in the research. The results provide evidence that teachers' and students' beliefs are relatively similar as far as the nature and the degree of difficulty of English are concerned, as well as in relation to the notion of aptitude to learn languages and even in relation to the learning strategies used in the classroom. However, they differ considerably in the vision that both groups have of the student. A pesquisa tratada no artigo tem como objetivo identificar as cren as de professores e alunos de inglês da rede escolar municipal de Belo Horizonte sobre cinco temas principais, a saber: a aptid o para a aprendizagem de línguas estrangeiras, o grau de dificuldade do idioma, a natureza da aprendizagem de línguas, as estratégias de aprendizagem e o grau de autonomia e motiva o dos alunos. Os resultados obtidos nos permitiram verificar que as cren as de alunos e professores s o relativamente semelhantes no que diz respeito à natureza e ao grau de dificuldade que a língua apresenta, à no o de aptid o para a aprendizagem de línguas e até mesmo em rela o às estratégias de aprendizagem utilizadas em sala. No entanto, diferem consideravelmente no que se refere à vis o que ambos têm do aluno.
Molecular Insights on Pathogenic Effects of Mutations Causing Phosphoglycerate Kinase Deficiency
Laurent R. Chiarelli, Simone M. Morera, Paola Bianchi, Elisa Fermo, Alberto Zanella, Alessandro Galizzi, Giovanna Valentini
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0032065
Abstract: Phosphoglycerate kinase (PGK) catalyzes an important ATP-generating step in glycolysis. PGK1 deficiency is an uncommon X-linked inherited disorder, generally characterized by various combinations of non-spherocytic hemolytic anemia, neurological dysfunctions, and myopathies. Patients rarely exhibit all three clinical features. To provide a molecular framework to the different pathological manifestations, all known mutations were reviewed and 16 mutant enzymes, obtained as recombinant forms, were functionally and structurally characterized. Most mutations heavily affect thermal stability and to a different extent catalytic efficiency, in line with the remarkably low PGK activity clinically observed in the patients. Mutations grossly impairing protein stability, but moderately affecting kinetic properties (p.I47N, p.L89P, p.C316R, p.S320N, and p.A354P) present the most homogeneous correlation with the clinical phenotype. Patients carrying these mutations display hemolytic anemia and neurological disorders, and,except for p.A354P variant, no myopaty. Variants highly perturbed in both catalytic efficiency (p.G158V, p.D164V, p.K191del, D285V, p.D315N, and p.T378P) and heat stability (all, but p.T378P) result to be mainly associated with myopathy alone. Finally, mutations faintly affecting molecular properties (p.R206P, p.E252A, p.I253T, p.V266M, and p.D268N) correlate with a wide spectrum of clinical symptoms. These are the first studies that correlate the clinical symptoms with the molecular properties of the mutant enzymes. All findings indicate that the different clinical manifestations associated with PGK1 deficiency chiefly depend on the distinctive type of perturbations caused by mutations in the PGK1 gene, highlighting the need for determination of the molecular properties of PGK variants to assist in prognosis and genetic counseling. However, the clinical symptoms can not be understood only on the bases of molecular properties of the mutant enzyme. Different (environmental, metabolic, genetic and/or epigenetic) intervening factors can contribute toward the expression of PGK deficient clinical phenotypes.
The Role of SwrA, DegU and PD3 in fla/che Expression in B. subtilis
Serena Mordini, Cecilia Osera, Simone Marini, Francesco Scavone, Riccardo Bellazzi, Alessandro Galizzi, Cinzia Calvio
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0085065
Abstract: In B. subtilis swarming and robust swimming motility require the positive trigger of SwrA on fla/che operon expression. Despite having an essential and specific activity, how SwrA executes this task has remained elusive thus far. We demonstrate here that SwrA acts at the main σA-dependent fla/che promoter PA(fla/che) through DegU. Electrophoretic mobility shift assays (EMSA) reveal that SwrA forms a complex with the phosphorylated form of DegU (DegU~P) at PA(fla/che) while it is unable to do so with either unphosphorylated DegU or the DegU32(Hy) mutant protein. Motility assays show that a highly phosphorylated DegU is not detrimental for flagellar motility provided that SwrA is present; however, DegU~P represses PA(fla/che) in the absence of SwrA. Overall, our data support a model in which DegU~P is a dual regulator, acting either as a repressor when alone or as a positive regulator of PA(fla/che) when combined with SwrA. Finally, we demonstrate that the σD-dependent PD3(fla/che) promoter plays an important role in motility, representing a contingent feedback loop necessary to maintain basal motility when swrA is switched to the non-functional swrA- status.
Calcium Uptake and Proton Transport by Acidocalcisomes of Toxoplasma gondii
Peter Rohloff,Kildare Miranda,Juliany C. F. Rodrigues,Jianmin Fang,Melina Galizzi,Helmut Plattner,Joachim Hentschel,Silvia N. J. Moreno
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018390
Abstract: Acidocalcisomes are acidic calcium stores found in diverse organisms, being conserved from bacteria to humans. They possess an acidic matrix that contains several cations bound to phosphates, which are mainly present in the form of short and long polyphosphate chains. Their matrix is acidified through the action of proton pumps such as a vacuolar proton ATPase and a vacuolar proton pyrophosphatase. Calcium uptake occurs through a Ca2+/H+ countertransporting ATPase located in the membrane of the organelle. Acidocalcisomes have been identified in a variety of microorganisms, including Apicomplexan parasites such as Plasmodium and Eimeria species, and in Toxoplasma gondii. We report the purification and characterization of an acidocalcisome fraction from T. gondii tachyzoites after subcellular fractionation and further discontinuous iodixanol gradient purification. Proton and calcium transport activities in the fraction were characterized by fluorescence microscopy and spectrophotometric methods using acridine orange and arsenazo III, respectively. This work will facilitate the understanding of the function of acidocalcisomes in Apicomplexan parasites, as we can now isolate highly purified fractions that could be used for proteomic analysis to find proteins that may clarify the biogenesis of these organelles.
Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice
Sabrina Le Bouter,Marianne Rodriguez,Nolwen Guigal-Stephan,Sophie Courtade-Ga?ani,Laura Xuereb,Catherine de Montrion,Vincent Croixmarie,Thierry Umbdenstock,Claire Boursier-Neyret,Michel Lonchampt,Manuel Brun,Catherine Dacquet,Alain Ktorza,Brian-Paul Lockhart,Jean-Pierre Galizzi
PPAR Research , 2010, DOI: 10.1155/2010/679184
Abstract: Rosiglitazone (RSG), developed for the treatment of type 2 diabetes mellitus, is known to have potent effects on carbohydrate and lipid metabolism leading to the improvement of insulin sensitivity in target tissues. To further assess the capacity of RSG to normalize gene expression in insulin-sensitive tissues, we compared groups of 18-day-treated db/db mice with increasing oral doses of RSG (10, 30, and 100?mg/kg/d) with untreated non-diabetic littermates (db/+). For this aim, transcriptional changes were measured in liver, inguinal adipose tissue (IAT) and soleus muscle using microarrays and real-time PCR. In parallel, targeted metabolomic assessment of lipids (triglycerides (TGs) and free fatty acids (FFAs)) in plasma and tissues was performed by UPLC-MS methods. Multivariate analyses revealed a relationship between the differential gene expressions in liver and liver trioleate content and between blood glucose levels and a combination of differentially expressed genes measured in liver, IAT, and muscle. In summary, we have integrated gene expression and targeted metabolomic data to present a comprehensive overview of RSG-induced changes in a diabetes mouse model and improved the molecular understanding of how RSG ameliorates diabetes through its effect on the major insulin-sensitive tissues. 1. Introduction Type 2 diabetes, also known as non-insulin-dependent diabetes mellitus, is a chronic disease that affects more than 100 million people worldwide, and its prevalence is soaring in western countries driven by high-fat diets and sedentary lifestyles. This pathology is characterized by resistance to the effects of insulin in peripheral tissues, which is manifested as reduced insulin-stimulated glucose uptake into skeletal muscle and adipose tissue, defective insulin-dependent suppression of hepatic glucose output, and reduced insulin secretion from pancreatic β-cells. Insulin-sensitising drugs, such as RSG, are widely used in clinical practice to improve diabetes alteration in glucose metabolism. Thiazolidinediones (TZDs) are already known to decrease blood glucose concentration, to improve liver and muscle insulin sensitivity [1, 2], and to have significant impact on adipose tissue by inducing adipose differentiation, lipogenesis, and TG storage [3–6]. The mechanisms of action of TZDs are mediated through binding and activation of the peroxisome proliferator-activated receptor (PPAR ), a nuclear receptor that has a regulatory role in lipid metabolism and in cell differentiation, particularly in adipocytes [7, 8]. PPAR is also expressed in several
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