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INHIBITION OF SPLEEN TYROSINE KINASE (SYK) IN SILICO BY THIAZOLE DERIVATIVES
S. J. Takate,S. S. Jadhav,Gaikar Rajendra Babasaheb,A. S. Burungale
International Research Journal of Pharmacy , 2013,
Abstract: Variously substituted thiazoles derivatives showed wide range of biological activity. The computational evaluation of the substituted thiazole containing derivatives as SYK inhibitor was performed. By using online servers applying different approaches the Tyrosine protein kinase (SYK) was identified as target for variously substituted thiazole containing derivatives. The molecular descriptor analysis was performed to identify drug likeness of the thiazole derivatives by Lipinski’s rule of five. Then docking analysis was performed by PyRx software using AutoDock vina 4. Derivatives showed comparatively significant binding energy value followed Lipinski’s rule. The study provides the base for further in vitro and in vivo study of substituted azoles containing compounds as SYK inhibitor and proposed drug to be used for allergic diseases.
COMPUTATIONAL EVALUATION OF SPIROISOXAZOLINES AS INHIBITOR OF AChe
Gaikar Rajendra Babasaheb,Vikhe Pratik Prakash,Gadhave Anil Gorakshanath,Karale Bhausaheb Kisan
International Research Journal of Pharmacy , 2012,
Abstract: Spiroisoxazolines are structurally diverse group of compounds that show wide range of biological activity. The computational evaluation of the spiroisoxazolines derivatives as the acetylcholinesterase inhibitor was performed. By using online servers applying different approaches the acetylcholinesterase was identified as the target for the synthesized derivative. The docking analysis was performed by PyRx software using AutoDock 4. Further the molecular descriptor analysis was performed to identify drug likeness of the derivatives by Lipinski’s rule of five. Derivatives showed comparatively significant binding energy values and followed the Lipinski’s rule. The study provides the base for further in vitro and in vivo study of the spiroisoxazolines derivatives as acetylcholinesterase inhibitor and proposed drug to be used for Alzheimer disease.
Synergistic Antioxidant Action of Oregano, Ajowan and Borage Extracts  [PDF]
Hafeeza Khanum, Kulathooran Ramalakshmi, Pullabhatla Srinivas, Babasaheb Bhaskarrao Borse
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.25054
Abstract: Radical scavenging activity (RSA), antioxidant activity (AA), reducing power, total polyphenol (TP) and flavonoid contents (TFC) of oregano (Oreganum vulgare spp), ajowan (Trachyspermum ammi) and Indian borage (Plectranthus amboinicus) extracts were evaluated. Oregano exhibited maximum radical scavenging activity (88.2%, 82.3%) for aqueous and ethanolic extracts at 50 ppm concentration respectively, followed by ajowan (86.9%, 68.4%) and Indian borage (30.5%, 30.4%). Extracts of oregano and ajowan showed better antioxidant activity and reducing power than that of Indian borage. Aqueous extracts of oregano had highest TP (Gallic acid equivalents) and TFC (Catechin equivalents) of 27.7% and 50.6 % respectively compared to ajowan (6.7%, 24.4%) and Indian borage (4.2%, 5.5%). Synergistic studies showed that the addition of oregano extract appreciably enhanced the RSA of ajowan and Indian borage extracts even at 50 ppm concentration.
Microwave Assisted and Al2O3/K2CO3 Catalyzed Synthesis of Azetidin-2-One Derivatives Containing Aryl Sulfonate Moiety with Anti-Inflammatory and Anti-Microbial Activity  [PDF]
Babasaheb V. Kendre, Mahadev G. Landge, Sudhakar R. Bhusare
Open Journal of Medicinal Chemistry (OJMC) , 2012, DOI: 10.4236/ojmc.2012.23012
Abstract: We report the novel synthesis of azetidin-2-one derivatives containing aryl sulfonate moiety from the reaction of 2-hydroxy benzaldehyde with p-toluene sulfonyl chloride afforded firstly 2-formylphenyl 4-methylbenzene sulfonate (2). The compound (2) on reaction with p-aminobenzoic acid or 2-aminopyridine gave the corresponding aldimines (3). Furthermore, the aldimines are on reaction with chloroacetyl chloride gives corresponding azetidin-2-ones in good to moderate yield. Among the eight synthesized azetidin-2-ones, five selected compounds have been screened for the an-ti-inflammatory activity, few of them showed good anti-inflammatory activity compared with standard drugs. Anti- microbial activity of all synthesized compounds has been tested and most of the compounds showed good anti-bacterial and anti-fungal activities.
Synthesis and Characterization of Cr Doped ZnO Nanocrystals  [PDF]
Vishwanath Dattu Mote, Vishnu Ramrao Huse, Babasaheb Nivrutti Dole
World Journal of Condensed Matter Physics (WJCMP) , 2012, DOI: 10.4236/wjcmp.2012.24035
Abstract: Samples of chromium doped ZnO were synthesized using co-precipitation technique at room temperature. Structural and optical properties of Cr doped ZnO samples were investigated by X-ray diffraction technique (XRD and UV-Visible spectroscopy (UV-Vis) respectively. X-ray diffraction (XRD) patterns confirm that the samples have hexagonal (wurtzite) structure with no additional peak which suggests that Cr ions go to the regular Zn sites in the ZnO crystal structure. The lattice constants were calculated using X-ray diffraction data and it is found that lattice parameters decrease with increasing Cr content. The average grain size was calculated using Scherrer’s formula for pure and Cr doped ZnO samples and it is observed that grain size is in the range 11 to17 nm. Band gap of Zn1–xCrxO samples has been evaluated using UV-Vis spectrometer. It is found that the band gap decreases as Cr increases; it is attributed to the s-d and p interactions and the smaller average grain size. It indicates that incorporation of Cr ions into the ZnO matrix. The chemical species of the grown crystals were identified by Fourier transform infrared spectroscopy (FTIR). From FTIR spectra it is observed that IR peaks corresponding to the Zn-O bands. Such results are presented in this paper quantitatively and qualitatively.
The Crystallographic and Optical Studies on Cobalt Doped CdS Nanoparticles  [PDF]
Vishnu R. Huse, Vishwanath D. Mote, Babasaheb N. Dole
World Journal of Condensed Matter Physics (WJCMP) , 2013, DOI: 10.4236/wjcmp.2013.31008
Abstract:

The samples of Cd1 - xCoxS with compositions x = 0.0 & 0.6 were prepared by Co-precipitation route at room temperature. XRD analysis confirms that the samples have cubic structure with no impurity phases. The lattice parameter, volume cell, X-ray density and grain size were calculated using XRD data. It is found that lattice parameter, volume of unit cell and X-ray density decrease with enhancing Co content. It is due to the smaller ionic radius of Co than the Cd. It is well noticed that the grain size increases with increasing Co content, it may be owing to the good synthesis technique. The functional groups and chemical interaction were determined by FTIR spectra. From FTIR spectra, it is investigated that absorption bands show the presence of resonance interaction between vibrational modes of oxide ions in the crystal. The energy band gap of Co doped CdS samples was calculated using UV-Vis analysis. It is observed that energy band gap decreases with increasing Co content owing to the sp-d exchange interaction between Co and CdS atoms.

Architectural History and Painting Art at Ajanta: Some Salient Features
Manager Singh,Babasaheb Ramrao Arbad
Arts , 2013, DOI: 10.3390/arts2030134
Abstract: The present paper deals with the period of India’s greatest cultural fluorescence, The Golden Age. A lively intellectual debate has been going on among historians and archaeologists on the subject of the chronology of the caves at Ajanta. The study shows addition of many iconographic styles from Ajanta to Bagh caves and vice-versa due to movement of skilled workers and craftsmen between these two Buddhist sites. Many iconographic figures were added / deleted depending on the local condition of rock at both the sites. The art and architecture of these sites reflects India’s great materials culture. The Ajanta paintings are not just a milestone in the history of development of world art but they also convey unique insights about the life of ancient Indians and their culture. This paper outlines some of the architectural features introduced from Ajanta into the other cultures. Furthermore, structural conservation measures and scientific methodology adopted for the preservation of Ajanta murals have also been highlighted.
SVD-EBP Algorithm for Iris Pattern Recognition
Babasaheb G. Patil,Shaila Subbaraman
Computer Science , 2012,
Abstract: This paper proposes a neural network approach based on Error Back Propagation (EBP) for classification of different eye images. To reduce the complexity of layered neural network the dimensions of input vectors are optimized using Singular Value Decomposition (SVD). The main of this work is to provide for best method for feature extraction and classification. The details of this combined system named as SVD-EBP system, and results thereof are presented in this paper. Keywords- Singular value decomposition(SVD), Error back Propagation(EBP).
The Determinants of Trade Credit: Evidence from Indian Manufacturing Firms  [PDF]
Rajendra R. Vaidya
Modern Economy (ME) , 2011, DOI: 10.4236/me.2011.25079
Abstract: Trade credit (accounts receivable and accounts payable) is both an important source and use of funds for manufacturing firms in India. This paper empirically investigates the determinants of trade credit in the Indian context. The empirical evidence presented suggests that strong evidence exists in support of an inventory management motive for the existence of trade credit. Highly profitable firms both give and receive less trade credit. Firms with greater access to bank credit offer less trade credit to their customers. On the other hand, firms with higher bank loans receive more trade credit. Holdings of liquid assets have a positive influence on both accounts receivable and accounts payable.
Nonconscious processing and a novel target for schizophrenia research  [PDF]
Rajendra D. Badgaiyan
Open Journal of Psychiatry (OJPsych) , 2012, DOI: 10.4236/ojpsych.2012.224047
Abstract: Analysis of the pattern of altered cognition observed in schizophrenia provides better insight into neurocognitive deficits. It reveals a potential novel target for schizophrenia research. To understand this target we reviewed the findings of neuroimaging studies on implicit [nonconscious] memory. These studies have consistently reported attenuated activity in the area V3A of the extrastriate cortex during retrieval of studied items. It was suggested that the attenuation limits the pool of information available for further cognitive processing. Therefore, if V3A is functionally damaged, individuals will have access to a larger pool of information for cognitive processing. Since cognitive tasks that are not dependent on attention [attention independent] process a larger pool of information more efficiently, performance in these tasks is likely to improve after V3A is damaged. Conversely, tasks that are dependent on attentional resources are more efficient in processing smaller pool of information. Performance in these tasks therefore is expected to deteriorate if a large pool of information is made available following V3A damage. A review of cognitive performance in schizophrenia suggests that patients perform at above normal level in attention independent priming tasks and perform at subnormal level in attention dependent episodic and working memory tasks. These findings indicate possible impairment of V3A activity. It could therefore be a potentially important unstudied target for schizophrenia research, particularly because a number of investigators have reported that the activity in this area is altered in schizophrenia.
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