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Shelke PV,Dumbare AS,Gadhave MV,Jadhav SL
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups. Fast dissolving oral films (FDOFs) are the most advanced form of oral solid dosage form due to more flexibility and comfort. It improve the efficacy of APIs by dissolving within minute in oral cavity after the contact with less saliva as compared to fast dissolving tablets, without chewing and no need of water for administration. The FDOFs place as an alternative in the market due to the consumer’s preference for a fast dissolving product over conventional tablets / capsules. The oral thin-film technology is still in the beginning stages and has bright future ahead because it fulfils all the need of patients. Eventually, film formulations having drug/s will be commercially launched using the oral film technology. In the present study fast dissolving film of Amlodipine Besylate was prepared using sodium alginate as film forming polymer. To decrease the disintegration time of formulationssodium starch glycolate was used as disintegrating agent. A full 32factorial design was applied using concentration of polymer and disintegrant as independent variable and disintegration time and % cumulative drug release as dependent variable. Response surface curves were plotted. Batch F6 was found to be the optimized batch as its disintegration was completed within the minimum time as compared to all other batches. The formulation (F6) was also showing sufficient drug release after 6 min. All the nine formulation was showing approximately 70-85% drug release after 6 min
*Pawar SD,Gadhave MV,Jadhav SL,Gaikwad DD
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: The field of Ocular drug delivery is one of the interesting and challenging endeavors facing the pharmaceutical scientist. The most frequently used dosage forms i.e. ophthalmic solutions and suspensions are compromised in their effectiveness by several limitations, leading poor ocular bioavailability. Ocuserts (or) Ophthalmic inserts are sterile preparations containing drug as dispersion or as solution in the polymeric support. Ocusert helps to improve ocular bioavailability by increasing the duration of contact with corneal tissue, thereby reducing the frequency of administration. Ciprofloxacin is a fluoroquinolone antibacterial drug effective in the treatment of bacterial conjunctivitis. The ciprofloxacin hydrochloride ocuserts were then evaluated for their physicochemical parameters like uniformity of thickness, weight, drug content and in vitro release pattern. It can be concluded that this ocular inserts formulation can be a promising for controlled release formulation.
Pawar RG,Pawar SD,Gadhave MV,Jadhav SL
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: Excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivering drug molecules to the systemic circulation by this route. Various formulation approaches used to systemically deliver drug molecules include use of prodrugs/lipophilic analogs, permeation enhancers, sub saturated systems and entrapment into vesicular systems. Further, the adhesive mixture, physical system of the delivery system and release liner influence drug release and its permeation across the skin. The novel microneedle dual-delivery method combines the advantages of hypodermic syringes and transdermal patches. Composed of dozens to hundreds of hollow microneedles, a (1–2) cm2 transdermal patch is applied to the skin to increase its permeability. Arrays of microneedles that are 100–1000 μm in length poke through the top layers of skin and allow micron-scale drugs to pass into the body. The needles are too small to stimulate nerve endings; patients wouldn’t feel any pain when a microneedle injection is performed. This review gives an overview of microneedles for drug delivery applications. The concept of miniaturized needles is presented and defined. Specific requirements for microneedles aimed for transdermal drug delivery are discussed and the scope is delimited. Some of the basic microfabrication methods used to fabricate microneedles is introduced and microneedles for drug delivery presented so far are reviewed and commented.
Gadhave S. V.
International Journal of Pharmaceutical Research and Development , 2011,
Abstract: The carpal tunnel is an anatomical compartment located at the base of the wrist. Carpal Tunnel Syndrome (CTS) is a common problem which interferes with the normal use of the hand. About three in 100 men and five in 100 women develop carpal tunnel syndrome at some point in their life. CTS is a condition in which one the median nerve becomes compressed inside a "tunnel" in the wrist. CTS may be job related or associated with other diseases. It can cause various symptoms including pain, numbness, tingling, or a "funny feeling" in the fingers, hand, or wrist. The reference standard for the diagnosis of CTS is electrophysiological testing, other test includes Phalens test, Tinel test and Durkans test. Various non surgical and surgical treatments are present now a day to treat the CTS.
Study of Cross-Linking between Boric Acid and Different Types of Polyvinyl Alcohol Adhesive  [PDF]
Ravindra V. Gadhave, Prakash A. Mahanwar, Pradeep T. Gadekar
Open Journal of Polymer Chemistry (OJPChem) , 2019, DOI: 10.4236/ojpchem.2019.91002
Abstract: Polyvinyl alcohol (PVA) is water-soluble polymer manufactured by the saponification of polyvinyl acetate. The physical properties and its specific application depend on the degree of hydrolysis. To enhance the properties of different hydrolyzed PVA grades, it is generally chemically modified with various cross-linkers. Here, different degree hydrolyzed PVA grades with enhanced properties were achieved by cross-linking with boric acid. These samples were then characterized by Differential Scanning Calorimetry (DSC) and Gel permeation chromatography (GPC). For further analysis a film of samples were prepared by casting on glass plate. The effects of amount of boric acid and degree of hydrolysis of PVA on performance properties like tensile strength, pencil hardness and thermal properties like glass transition temperature were studied. The results showed that by cross-linking there was an increase in mechanical strength and thermal property.
Some of the problems in first year students’ academic writing in some SADC Universities
MV Mpepo
Inkanyiso: Journal of Humanities and Social Sciences , 2009,
Abstract: There are many problems that confront English as a Second Language (ESL) learners in academic writing in some Southern African Development Community (SADC) universities. Some observers and commentators have noted that most graduates from Historically Black Universities (HBUs) exhibit poor performance in English when compared to neighbouring countries like Lesotho and Swaziland. One of these problems is the low proficiency which manifests itself in numerous syntactic errors and inappropriate lexical selection in their use of the target language. The forms or varieties are simply mistakes or errors which can be eradicated by teaching. The learners need to learn and understand the structure and nature of the English language. The deviations and innovations arise owing to a number of processes which are sketched out in the paper. This article also argues that the problem stems from the fact that the burden has been placed on departments of English which seem not to want to abandon the literary tradition. It presents some of the problems that African learners of English in HBUs seem to exhibit in academic writing when they enter university education. It discusses what is done and what needs to be done for first-year students when they enter university in HBUs. In HBUs English language programmes are not mandatory or do not exist, as is the case with most SADC universities and some Historically White Universities (HWUs). The conclusion suggests that it becomes necessary to mount similar English language programmes at first year level in institutions which do not have these programmes. It is hoped that this would improve learners’ language proficiency and hopefully competence as well as the way students acquire their education.
Grigoruta MV
Scientific Annals of the Alexandru Ioan Cuza University of Iasi : Economic Sciences Series , 2005,
Ultrasonication-Induced Synthesis and Antimicrobial Evaluation of Some Multifluorinated Pyrazolone Derivatives
Anil Gadhave,Shashikant Kuchekar,Bhausaheb Karale
Journal of Chemistry , 2013, DOI: 10.1155/2013/741953
Study of Magnetic Vibration Absorber with Permanent Magnets along Vibrating Beam Structure
F. B. Sayyad,N. D. Gadhave
Journal of Structures , 2013, DOI: 10.1155/2013/658053
Abstract: The vibration absorbers are frequently used to control and minimize excess vibration in structural system. Dynamic vibration absorbers are used to reduce the undesirable vibration in many applications such as pumps, gas turbines, engine, bridge, and electrical generator. To reduce the vibration of the system, the frequency of absorber should be equal to the excitation frequency. The aim of this study is to investigate the effect of magnetic vibration absorber along vibrating cantilever beam. This study will aim to develop a position of magnetic vibration absorber along the cantilever beam to adopt the change in vibratory system. The absorber system is mounted on a cantilever beam acting as the primary system. The objective is to suppress the vibration of the primary system subjected to a harmonic excitation whose frequencies are varying. It can be achieved by varying the position of magnetic vibration absorber along the length of beam. The advantage of magnetic vibration absorber is that it can be easily tuned to the excitation frequency, so it can be used to reduce the vibration of system subjected to variable excitation frequency. 1. Introduction Dynamic vibration absorbers are used to reduce undesirable vibrations in many applications such as electrical transmission lines, helicopters gas turbines, engines, and bridges. Traditional treatment methods of vibration control that involve structural modifications are often time consuming and expensive. Some of them can be used as tunable vibration absorbers to control vibrations. Tunable dynamic vibration absorber which is simple to construct can be easily tuned to excitation frequency to minimize the vibrations and can be effectively used to minimize vibrations of structure. Absorber with variable frequencies can be used to minimize vibrations of structures having variable frequency drive. Dynamic vibration absorbers (DVAs) were first invented in 1909 by Hermann Frahm, and since then it has been successfully used to suppress wind-induced vibration and seismic response in buildings. In recent studies, interest has also been focused on the use of feedback and feedforward control systems and the synthesis of DVAs for multiple-degree-of-freedom systems. Igarasi et al. [1] have developed a magnetic dynamic vibration absorber with adjustable natural frequency, in these three permanent magnets arranged with opposite pole to each other. Repelling force between two magnets was used as spring constant. In 1993 they developed a dynamic vibration absorber using permanent magnets to suppress the vibrations of beam
Starch Based Bio-Plastics: The Future of Sustainable Packaging  [PDF]
Ravindra V. Gadhave, Abhijit Das, Prakash A. Mahanwar, Pradeep T. Gadekar
Open Journal of Polymer Chemistry (OJPChem) , 2018, DOI: 10.4236/ojpchem.2018.82003
Abstract: Petroleum derived plastics dominate the food packaging industry even today. These materials have brought a lot of convenience and attraction to agro, food and packaging industry. These materials also have brought along with them problems relating to the safe-disposal and renewability of these materials. Due to the growing concern over environmental problems of these materials, interest has shifted towards the development and promoting the use of “bio-plastics”. Bio-plastic is a term used for sustainable packaging materials derived from renewable resources i.e. produced from agro/food sources, materials such as starch, cellulose, etc. and which are considered safe to be used in food applications. To enhance the mechanical properties, and water barrier properties, it can be blended easily with other polymer as well as nano fillers. The current paper is a review of the progress of research in starch based sustainable packaging materials.
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