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Search Results: 1 - 10 of 974 matches for " Gabriella Pusch "
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Clinical importance of aspirin and clopidogrel resistance
Gergely Feher,Andrea Feher,Gabriella Pusch,Katalin Koltai
World Journal of Cardiology , 2010,
Abstract: Aspirin and clopidogrel are important components of medical therapy for patients with acute coronary syndromes, for those who received coronary artery stents and in the secondary prevention of ischaemic stroke. Despite their use, a significant number of patients experience recurrent adverse ischaemic events. Interindividual variability of platelet aggregation in response to these antiplatelet agents may be an explanation for some of these recurrent events, and small trials have linked “aspirin and/or clopidogrel resistance”, as measured by platelet function tests, to adverse events. We systematically reviewed all available evidence on the prevalence of aspirin/clopidogrel resistance, their possible risk factors and their association with clinical outcomes. We also identified articles showing possible treatments. After analyzing the data on different laboratory methods, we found that aspirin/clopidogrel resistance seems to be associated with poor clinical outcomes and there is currently no standardized or widely accepted definition of clopidogrel resistance. Therefore, we conclude that specific treatment recommendations are not established for patients who exhibit high platelet reactivity during aspirin/clopidogrel therapy or who have poor platelet inhibition by clopidogrel.
Flow and Ductility of Smectite Clay for Skin Treatment  [PDF]
Roland Pusch
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2014, DOI: 10.4236/jcdsa.2014.42010
Abstract:

It is important that pastes and creames for skin treatment have suitable rheological properties and ability to establish a good contact with the tissues while retaining their tightness. Thixotropy is desired for providing fluidity when agitated and a suitably degree of stiffening thereafter. This requires low shear resistance in the coating phase and microstructural reorganization when leaving the paste to rest. Following the principle of using only mineral components for skin treatment, use of expandable hydrophilic clay minerals should be considered. They sorb cations and positively charged organic molecules and are impermeable to fluids and gas under low pressure, hence providing oxygen-free micro-environment. They can balance pH and are excellent agents for cleaning skin.

Gas Permeation Models for Dilatant Deformation of Rock Salt under Deviatoric Stress Conditions
Guenter Pusch
Acta Montanistica Slovaca , 2007,
Abstract: Permeability of 30 rock salt cores were measured under various deviatoric stress conditions. A triaxial cell was designed and built to measure the hydraulic properties such as the pore volume and permeability during the compression experiments. To determine variations in the pore volume, a high precision pump was used and the pore volume changes as well as the gas permeabilities were recorded continuously as a function of time and stresses. A permeability reduction in the compression stage is not obvious although the decrease of pore volume appears to be a controlling phenomenon of the compression. Similarly to previous studies, a spontaneous increase in the permeability was observed shortly after the dilatancy boundary was exceeded, separating the compression from the dilatant deformation phase. At the end of the dilatant deformation, the permeability reaches a plateau value which afterward remains approximately a constant for low stress rates up to the fracture pressure. This allows the percolation of gas along the extended grain boundaries of the salt crystals and through the inter-crystalline flow paths and yields an increase of the permeability of 3 to 6 tens of order. Combined acoustic emission measurements performed with 8 sensors showed that the percolation begins equally throughout the core at the same time. The dilatancy and permeability are found to be controlled by many factors,most importantly by the minimal principal stresses. The end porosities of the stressed cores were correlated with the permeability in the form of a Kozeny-Carman type relationship. Semi-empirical and percolation flow models were applied to match the observed flow characteristics of cores with corresponding properties of the excavation damaged zone in the Asse salt mine.
Patientenakzeptanz und Vertr glichkeit von Risedronat zur Osteoporosetherapie - Ergebnisse einer Phase IV-Studie
Pusch HH
Journal für Mineralstoffwechsel , 2001,
Abstract: Anwendungsbeobachtungen (Phase IV-Studien) haben nach den erfolgreich absolvierten klinischen Prüfungen (Phase III) den Zweck, die Vertr glichkeit, Sicherheit, Compliance und Akzeptanz eines Pr parates in der t glichen praktischen Medizin zu erfassen und auszuwerten. Eine AWB ist prospektiv aufgebaut. Die 1121 in dieser Studie erfa ten Patienten stellen ein solides Fundament für die statistische Aufarbeitung der erhobenen Daten dar. Die Ergebnisse zu den Themen Patientendaten, Diagnosestellung, Risikofaktoren, Frakturen und Mobilit t zeigen deutlich, da hier ein spezielles Patientengut vorliegt: Der Patient mit Osteoporose mit den typischen alterskorrelierten Begleiterkrankungen. Die Osteoporose verl uft, so lange keine Frakturen eintreten, praktisch schmerzfrei - ein Grund, warum diese Erkrankung so oft und so lange ignoriert wird. Begleitende Beschwerden gehen nach der derzeitigen Lehrmeinung stets auf degenerative oder entzündlich-rheumatische Prozesse am Bewegungsapparat zurück. Aus diesem Blickwinkel bieten die Ergebnisse dieser Studie eine überraschung: Die im Bereich der Wirbels ule beobachtete und statistisch hochsignifikante Schmerzlinderung. Sie l t sich jedoch mit der Hemmung des Knochenabbaues durch Risedronat alleine nicht befriedigend erkl ren. M glicherweise liegen hier andere, bisher unbekannte pharmakologische Effekte dieser Substanz vor. Zus tzliche Hinweise ergeben sich daraus, da beim Mb. Paget hnliche Wirkungen auf die Begleitschmerzen bei Bisphosphonatbehandlung berichtet wurden. Die analgetische Wirkung von Calcitonin ist bekannt, sie beruht auf einer zentralnerv sen Wirkung, ebenso wie auf der Hemmung der Freisetzung von freien Kalzium-Ionen, die als Schmerzmediator angesehen werden, aus dem Knochen. Vielleicht liegen hier vergleichbare Effekte vor, die in den Phase II und III Studien nicht zutage treten konnten. Diese überraschenden Ergebnisse sollten Anla für weitere Forschungen sein. Die strengen Einnahmevorschriften für Bisphosphonate sind Ausdruck der Sorge um eventuelle gastrointestinale Nebenwirkungen. Dazu liefert die vorliegende Anwendungsbeobachtung den praktisch wertvollen Hinweis, da diese unerwünschten Wirkungen, wenn überhaupt, stets schon am Anfang der Therapie auftreten. Therapieabbrüche kommen in der Beobachtungsphase zwischen den Monaten 4-6 kaum mehr vor. Der Einnahmezeitpunkt war den Patienten freigestellt worden, um die besonders morgens geh ufte Medikamenteneinnahme besser verteilen zu k nnen. überraschenderweise entschieden sich über 70% der Patienten dennoch für die morgendliche Einnahme des Pr parate
Mit Tintín auf Schatzsuche: Anmerkungen zu den katalanischen Versionen von "Le trésor de Rackham le Rouge" [Hunting for treasures with Tintin: Remarks on the Catalan versions of "Le trésor de Rackham le Rouge"]
Pusch, Claus D.
Zeitschrift für Katalanistik , 2012,
Abstract: This paper is devoted to the inter- and intra-linguistic comparison of comics on the basis of the volume "Le trésor de Rackham le Rouge" (engl. "Red Rackham’s Treasure") of the Franco-Belgian Tintin series and its two Catalan versions published in 1964 and 2002, respectively. These versions are analyzed with respect to morpho-syntactic (forms of address, clitic pronoun combinations, clause-initial "que" and future-oriented temporal adverbial clauses introduced by "quan") and lexical criteria (technical vocabulary). The study reveals that the models for the reference variety applied by the translators diverge and that the translations reflect, to a certain extent, the sociolinguistic situation of Catalan at the moment of their creation.
Modeling of Multiphase with Respect to Low Interfacial Tension by Pseudo-Two-Phase Relative Permeability Functions Modélisation d'un écoulement polyphasique à faible tension interfaciale par des fonctions pseudo-biphasiques de perméabilité relative
Pusch G.,Muller T.
Oil & Gas Science and Technology , 2006, DOI: 10.2516/ogst:1990004
Abstract: A new 2-parameter desaturation function is introduced which offers a broader range of applicability to reservoir rock. Based on this function two-phase relative permeabilities are derived for oil phase and microemulsion flow. These functions are used to match a laboratory experiment by using surfactant flooding for a single surfactant system. Les auteurs présentent une nouvelle fonction de désaturation à deux paramètres qui offre une plus large gamme de possibilités d'application aux roches réservoir. On tire de cette fonction des perméabilités relatives biphasiques pour l'écoulement de la phase pétrole et d'une microémulsion. Ces fonctions sont utilisées pour reproduire une expérience de laboratoire avec injection de surfactant pour un seul système surfactant.
Molecular Pharmacology of Kidney and Inner Ear CLC-K Chloride Channels
Antonella Gradogna,Michael Pusch
Frontiers in Pharmacology , 2010, DOI: 10.3389/fphar.2010.00130
Abstract: CLC-K channels belong to the CLC gene family, which comprises both Cl? channels and Cl?/H+ antiporters. They form homodimers which additionally co-assemble with the small protein barttin. In the kidney, they are involved in NaCl reabsorption; in the inner ear they are important for endolymph production. Mutations in CLC-Kb lead to renal salt loss (Bartter’s syndrome); mutations in barttin lead additionally to deafness. CLC-K channels are interesting potential drug targets. CLC-K channel blockers have potential as alternative diuretics, whereas CLC-K activators could be used for the treatment of patients with Bartter’s syndrome. Several small organic acids inhibit CLC-K channels from the outside by binding to a site in the external vestibule of the ion conducting pore. Benzofuran derivatives with affinities better than 10 μM have been discovered. Niflumic acid (NFA) exhibits a complex interaction with CLC-K channels. Below ~1 mM, NFA activates CLC-Ka, whereas at higher concentrations NFA inhibits channel activity. The co-planarity of the rings of the NFA molecule is essential for its activating action. Mutagenesis has led to the identification of potential regions of the channel that interact with NFA. CLC-K channels are also modulated by pH and [Ca2+]ext. The inhibition at low pH has been shown to be mediated by a His-residue at the beginning of helix Q, the penultimate transmembrane helix. Two acidic residues from opposite subunits form two symmetrically related intersubunit Ca2+ binding sites, whose occupation increases channel activity. The relatively high affinity CLC-K blockers may already serve as leads for the development of useful drugs. On the other hand, the CLC-K potentiator NFA has a quite low affinity, and, being a non-steroidal anti-inflammatory drug, can be expected to exert significant side effects. More specific and more potent activators will be needed and it will be important to understand the molecular mechanisms that underlie NFA activation.
Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke
George Füst, Lea Munthe-Fog, Zsolt Illes, Gábor Széplaki, Tihamér Molnar, Gabriella Pusch, Kristóf Hirschberg, Robert Szegedi, Zoltán Széplaki, Zoltán Prohászka, Mikkel-Ole Skjoedt, Peter Garred
Journal of Neuroinflammation , 2011, DOI: 10.1186/1742-2094-8-185
Abstract: Sera were obtained within 12 hours after the onset of ischemic stroke (admission samples) and 3-4 days later (follow-up samples) from 65 patients. The control group comprised 100 healthy individuals and 135 patients with significant carotid stenosis (patient controls). The concentrations of ficolin-2 and ficolin-3, initiator molecules of the lectin complement pathway, were measured by ELISA methods. Concentration of C-reactive protein (CRP) was also determined by a particle-enhanced immunturbidimetric assay.Concentrations of both ficolin-2 and ficolin-3 were significantly (p < 0.001) decreased in both the admission and in the follow-up samples of patients with definite ischemic stroke as compared to healthy subjects. Concentrations of ficolin-2 and ficolin-3 were even higher in patient controls than in healthy subjects, indicating that the decreased levels in sera during the acute phase of stroke are related to the acute ischemic event. Ficolin-3 levels in the follow-up samples inversely correlated with the severity of stroke indicated by NIH scale on admission. In follow-up samples an inverse correlation was observed between ficolin-3 levels and concentration of S100β, an indicator of the size of cerebral infarct. Patients with low ficolin-3 levels and high CRP levels in the follow up samples had a significantly worse outcome (adjusted ORs 5.6 and 3.9, respectively) as measured by the modified Rankin scale compared to patients with higher ficolin-3 and lower CRP concentrations. High CRP concentrations were similarly predictive for worse outcome, and the effects of low ficolin-3 and high CRP were independent.Our findings indicate that ficolin-mediated lectin pathways of complement activation contribute to the pathogenesis of ischemic stroke and may be additive to complement-independent inflammatory processes.Neuroinflammation is a key element in the ischemic cascade after cerebral ischemia that results in cell damage and death in the subacute phase.[1]Complement act
Suggested landfill sites for hazardous waste in Iraq  [PDF]
Nadhir Al-Ansari, Roland Pusch, Sven Knutsson
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.54060
Abstract:

Iraq experienced two devastating wars in 1991 and 2003, during which massive amounts of new weapons and sophisticated manufactured nuclear weapons were used called Depleted Uranium (DU). As a consequence of the radioactive contamination; the humans are suffering from various disease like cancer and the environment is polluted. In practice, there is no strategy and/ or national program, not even well thought out plans and scientific personnel and technical equipment required to clean Iraq of these wastes. Reviewing the geological, topographical and hydrological data, it had been noticed that Umm Chaimin depression is a good candidate site to dump all contaminated radioactive scrap and soil. The suggested design of the landfill will ensure safe containment of the waste for hundreds of thousands of years even if significant climatic changes will take place.

Rheological Properties of Cement-Based Grouts Determined by Different Techniques  [PDF]
Mohammed Hatem Mohammed, Roland Pusch, Sven Knutsson, Gunnar Hellstr?m
Engineering (ENG) , 2014, DOI: 10.4236/eng.2014.65026
Abstract:

The rheological properties of cement-based grouts containing talc or palygorskite were investigated for optimizing fluidity and quick strengthening at injection. The fluidity controls the ability of grout to penetrate fractures and can be determined by pipe flow tests, Marsh funnel tests, mini-slump cone tests and rheometer tests. The grouts were 1) Talc for fluidity and strength by reacting with cement, 2) Palygorskite (attapulgite) for early gelation by being thixotropic, and 3) Powdered quartz for chemical integrity. The freshly prepared grouts behaved as Bingham fluids with viscosities from 0.151 to 0.464 Pas and yield stresses 5.2 Pa to 36.7 Pa. Statistical analysis of the flow test data converted Marsh flow time into viscosity. The pipe flow tests gave 26.5% higher values than the viscometer for grout with Portland cement and talc, and about 13.7% lower than the viscometer data for the grout with low-pH cement and talc. The big Marsh funnel gave values differing by 5.2% - 5.3% from those of the viscometer for grout with talc and Portland, and Merit 5000 cements. For grout with palygorskite the viscosity was at least twice that of the other grouts. Grout fluidity was positively affected by talc and negatively by palygorskite and early cement hydration.

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