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Search Results: 1 - 10 of 7870 matches for " Gabriel Bergevin-Estable "
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Le Corps et l’Esprit : une épistémologie contrastée au ZhuangZi
Gabriel Bergevin-Estable
Phares : Revue Philosophique étudiante de l’Université Laval , 2009,
Abstract:
In search of a function for the most frequent naturally-occurring length polymorphism (MFNLP) of the HIV-1 LTR: Retaining functional coupling, of Nef and RBF-2, at RBEIII?
Mario Clemente Estable
International Journal of Biological Sciences , 2007,
Abstract: Although the prototypical HIV-1 LTR sequences were determined 22 years ago from the initial isolate, elucidating which transcription factors are critical to replication in vivo, has been difficult. One approach has been to examine HIV-1 LTRs that have gone through the gamut of in vivo mutation and selection, in search of absolutely conserved sequences. In this vein, RBEIII sequences are virtually 100% conserved in naturally occurring HIV-1 LTRs. This is because when they are mutated, the MFNLP recreates an RBEIII site. Here, I enumerate some retroviral mutation mechanisms, which could generate the MFNLP. I then review the literature corresponding to the MFNLP, highlighting the discovery in 1999, that RBEIII and MFNLP sequences, bind USF and TFII-I cooperatively, within the context of earlier and later work that suggests a role in HIV-1 activation, through T-cell receptor engagement and the MAPK cascade. One exception to the nearly absolute conservation of RBEIII, has been a group of long term non progressors (LTNP). These patients harbor deletions to the Nef gene. However, the Nef gene overlaps with the LTR, and the LTNP deletions abrogate RBEIII, in the absence of an MFNLP. I suggest that the MFNLP retains functional coupling between the MAPK-mediated effects of Nef and the HIV-1 LTR, through RBEIII. I propose that difficult-to-revert-mutations, to either Nef or RBEIII, result in the convergent LTNP Nef/LTR deletions recently observed. The potential exploitation of this highly conserved protein-binding site, for chimeric transcription factor repression (CTFR) of HIV-1, functionally striving to emulate the LTNP deletions, is further discussed.
Towards Improving the Integration of Undergraduate Biology and Mathematics Education
Christopher Bergevin
Journal of Microbiology & Biology Education , 2010, DOI: 10.1128/jmbe.v11i1.134
Abstract: Arguments have recently asserted the need for change in undergraduate biology education, particularly with regard to the role of mathematics. The crux of these protests is that rapidly developing technology is expanding the types of measurements and subsequent data available to biologists. Thus future generations of biologists will require a set of quantitative and analytic skills that will allow them to handle these types of data in order to tackle relevant questions of interest. In this spirit, we describe here strategies (or lessons learned) for undergraduate educators with regard to better preparing undergraduate biology majors for the new types of challenges that lay ahead. The topics covered here span a broad range, from classroom approaches to the administrative level (e.g., fostering inter-departmental communication, student advising) and beyond. A key theme here is the need for an attitude shift with regard to mathematics education by both students and faculty alike. Such a shift will facilitate the development and implementation of new teaching strategies with regard to improving integration of mathematics and biology pedagogy.
MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription
Maksymilian F. Niedzielski , Robert Hopewell, Zohra Ismail, Mario C. Estable
International Journal of Biological Sciences , 2007,
Abstract: Translocations between the human Mixed Lineage Leukemia (MLL) and AF4 Family (AFF) member genes, are implicated in leukemia. Mutations to AFFs can disrupt lymphopoesis, CNS development and spermatogenesis. However, despite the growing list of pathologies linked to AFF members, their evolutionary relationship and the structure/function of individual members, remain to be elucidated. Here, we first report that database mining and phylogenetic analysis with AFF proteins from multiple species, revealed two monophyletic sister clades, suggesting a common Bilateria ancestor. We then examined the structure/function of the most recently discovered AFF member, MCEF (also known as AF5q31 or AFF4). In silico, the human MCEF gene was found to have 21 exons, and code for a protein with seven nuclear localization sequences (NLS). In HeLa cells, an MCEF-EGFP fusion protein, localized exclusively to the nucleus. Consequently, we made twenty constructs, expressing MCEF deletion mutants fused to EGFP and/or DsRed fluorescent proteins. Three distinct protein sequences, encoded by three separate MCEF exons, were found to mediate nuclear localization, only two of which were predicted in silico. Importantly, we also found that ectopic expression of MCEF, repressed HIV-1 LTR-directed RNA Polymerase II transcription, at the level of Tat-transactivation. We suggest that portions of MCEF could be exploited for chimeric transcription factor repression (CTFR) of HIV-1.
A potential sterile neutrino search utilizing spectral distortion in a two-reactor/one-detector configuration
M. Bergevin,C. Grant,R. Svoboda
Physics , 2013,
Abstract: There is an observed deficit of about 6\% in the expected rate of anti-neutrino interactions when averaging over many different reactor experiments. While the significance of the deficit is low (98.6 \% CL), there is speculation that a non-interacting "sterile" neutrino could be the cause. In this paper we explore the possibility of a two-reactor/one-detector experiment at intermediate distances (100-500 meters) to look for a sterile neutrino in the mass range implied by this deficit. A method for probing $\Delta m^2$ phase space is developed using interference patterns between two oscillated spectra at different baselines. This method is used to investigate the potential sensitivity of the Double Chooz experiment, which has a single Near Detector at distances of 351 m and 465 m from two reactors of identical design. We conclude that Double Chooz could investigate sterile neutrino in the $\Delta m^{2}$ range of 0.002 to 0.5 eV$^2$ over 5 years of near detector running.
The Mind-Body Problem Today  [PDF]
Gabriel Vacariu
Open Journal of Philosophy (OJPP) , 2011, DOI: 10.4236/ojpp.2011.11005
Abstract: An old philosophical problem, the mind-body problem, has not been yet solved by philosophers or scientists. Even if in cognitive neuroscience has been a stunning development in the last 20 years, the mind-body problem remained unsolved. Even if the majority of researchers in this domain accept the identity theory from an ontological viewpoint, many of them reject this position from an epistemological viewpoint. In this context, I consider that it is quite possible the framework of this problem to be wrong and this is the main reason the problem could not be solved. I offer an alternative, the epistemologically different worlds perspective, that replace the world or the universe. In this new context, the mind-body problem becomes a pseudo-problem.
Analysis of Dynamics Fields in Noninertial Systems  [PDF]
Gabriel Barceló
World Journal of Mechanics (WJM) , 2012, DOI: 10.4236/wjm.2012.23021
Abstract: In this paper, I present evidence that there exists an unstructured area in the present general assumptions of classical mechanics, especially in case of rigid bodies exposed to simultaneous noncoaxial rotations. To address this, I propose dynamics hypotheses that lead to interesting results and numerous noteworthy scientific and technological applications. I constructed a new mathematical model in rotational field dynamics, and through this model, results based on a rational interpretation of the superposition of motions caused by torques were obtained. For this purpose, I analyze velocity and acceleration fields that are generated in an object with intrinsic angular momentum, and assessed new criteria for coupling velocities. In this context, I will discuss reactions and inertial fields that cannot be explained by classical mechanics. The experiments have been analyzed and explained in a video accompanying this text. I am not aware of any concurrent study on the subject and conclusions evidenced in this paper, preventing us from making additional theoretical com- parisons or indicate to the reader other sources to compare criteria.
Proposal of New Criteria for Celestial Mechanics  [PDF]
Gabriel Barceló
International Journal of Astronomy and Astrophysics (IJAA) , 2013, DOI: 10.4236/ijaa.2013.34044
Abstract:

Based on a new interpretation on the behavior of rigid bodies exposed to simultaneous non-coaxial rotations, we have developed a hypothesis: the Theory of Dynamics Interactions, which can be applied to understand celestial mechanics. We have analyzed the velocity and acceleration fields generated in a rigid body with intrinsic angular momentum, when exposed to successive torques, to assess new criteria for this speeds coupling. In this context, reactions and inertial fields take place, which cannot be justified by means of classical mechanics. We believe that the results obtained after the analysis of dynamics fields systems accelerated by rotation will allow us to conceive a new perspective in celestial dynamics, astrometry, stellar dynamics and galactic astronomy, unknown up to date. After carrying out ample research, we have come to the conclusion that there still exists an unstructured scientific area under the present general assumptions and, more specifically, in the area of dynamic systems submitted to rotational accelerations. The aim of this paper is to present information of the surprising results obtained, and to attract the interest towards the investigation of this new area of knowledge in rotational non-inertial dynamics, and its multiple and remarkable scientific applications.

YintelligenceTM: The Mapping of the Pre-Heaven or FuXi Hexagrams to the Post-Heaven or King Wen Hexagrams  [PDF]
Gabriel Felley
Chinese Studies (ChnStd) , 2013, DOI: 10.4236/chnstd.2013.24032
Abstract: The Yijing易經belongs to the famous group of the five classics. In the Ming and Qing dynasties, the Four Books and Five Classics四書五經 were the subject of mandatory study by those Confucian scholars who wished to become government officials. The Yijing (Faure & Javary, 2002) consists of 64 figures called hexagrams 卦 formed by six Yin (broken) or Yang (unbroken) lines and commentaries on each of these hexagrams and their lines. The whole set of the hexagrams and their interdependencies make a dynamic model for the understanding or the anticipating of the different steps change goes through. The Yijing does not predict the future but gives a snap-shot of the actual situation and the holistic potentialities which may be deployed or not in order to better adapt to the on-going change. The different stages of a change are explained by the Yin-Yang polarity and the never-ending transformation of old-Yin 老陰in young-Yang少陽, old-Yang老陽, young-Yin少陰 and old-Yin again. The 64 hexagrams are built by pairing the 8 basic trigrams obtained by adding to each bigram a supplementary Yin or Yang line. Figure 1 depicts a 4-regions space (East/young Yang, South /old Yang, West/young Yin, North/old Yin) and a cyclic movement. A forthcoming article will explain the relation between this space organization and the whole set of 64 hexagrams as a network. The cyclic change is of major interest. Purpose: The 64 hexagrams of the Yijing are organized in 16 “first degree” nuclear families (Javary, 1997), which may be consolidated in 4 “second degree” nuclear families. There are another 16 families organizing the 64 hexagrams in a different structure. In the literature they are called the pre-heaven先天 hexagrams (Schlumberger, 1987), and in this paper they are referred to as the FuXi伏羲 hexagrams. They form 16 cyclic families, whose structure will be analyzed in this paper. This cyclicity induces a “predecessor-successor” relationship between the hexagrams belonging to the same FuXi family: H1H2H3H4H1. While the 4 members of each nuclear family are centered on a “master” hexagram that corresponds to a common inner lines’ structure, each FuXi family is cyclically structured and we call the hexagrams belonging to the
Theory of Dynamic Interactions: The Flight of the Boomerang  [PDF]
Gabriel Barceló
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.27063
Abstract:

We propose a new interpretation of the dynamic behavior of the boomerang and, in general, of the rigid bodies exposed to simultaneous non-coaxial rotations. We have developed a new rotational non-inertial dynamics hypothesis, which can be applied to understand both the flight of the boomerang as well as celestial mechanics. The boomerang is a particularly significant, intriguing and widely known case of bodies in rotation. We have analyzed the velocity and acceleration fields generated when rigid bodies are exposed to successive torques, in order to assess new criteria for this speed coupling. In this context, reactions and inertial fields that cannot be justified by means of classical mechanics take place. Accordingly, we propose a new Theory of Dynamic Interactions. We believe that the results obtained will enable us to conceive a new perspective in dynamics, unknown to date. After carrying out ample research, we have come to the conclusion that there still exists an unstructured scientific area in non-inertial dynamics systems subject to rotational accelerations. The aim of this paper is to present information of the surprising results obtained and to attract interest in research into dynamic field systems accelerated by rotation, and the multiple and remarkable scientific applications arising thereof. We further propose the boomerang as a clear example of the application of the Theory of Dynamic Interactions.

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