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Search Results: 1 - 10 of 940 matches for " GABRIELLA POCSFALVI "
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Synthesis of a steroidal dendrimer core
Journal of the Serbian Chemical Society , 2004,
Abstract: Synthesis of a steroidal dendrimer core possessing various functional termini, such as ester, carboxy and hydroxy, is presented. The approach described enables further simple manipulations for the introduction of more complex functionalities.
Antimalarial peroxides: the first intramolecular 1,2,4,5-tetraoxane
Journal of the Serbian Chemical Society , 2002,
Abstract: An intramolecular steroidal 1,2,4,5-tetraoxane has been synthesised in six steps starting from methyl 3-oxo-7a,12a-diacetoxy-5b-cholan-24-oate. The synthesised 1,2,4,5-tetraoxane has moderate in vitro antimalarial activity against P. falciparum strains (IC50 (D6) = 0.35 mg/mL; IC50 (W2) = 0.29 mg/mL).
Human Hsp60 with Its Mitochondrial Import Signal Occurs in Solution as Heptamers and Tetradecamers Remarkably Stable over a Wide Range of Concentrations
Silvia Vilasi, Rita Carrotta, Maria Rosalia Mangione, Claudia Campanella, Fabio Librizzi, Loredana Randazzo, Vincenzo Martorana, Antonella Marino Gammazza, Maria Grazia Ortore, Annalisa Vilasi, Gabriella Pocsfalvi, Giosalba Burgio, Davide Corona, Antonio Palumbo Piccionello, Giovanni Zummo, Donatella Bulone, Everly Conway de Macario, Alberto J. L. Macario, Pier Luigi San Biagio, Francesco Cappello
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097657
Abstract: It has been established that Hsp60 can accumulate in the cytosol in various pathological conditions, including cancer and chronic inflammatory diseases. Part or all of the cytosolic Hsp60 could be na?ve, namely, bear the mitochondrial import signal (MIS), but neither the structure nor the in solution oligomeric organization of this cytosolic molecule has still been elucidated. Here we present a detailed study of the structure and self-organization of na?ve cytosolic Hsp60 in solution. Results were obtained by different biophysical methods (light and X ray scattering, single molecule spectroscopy and hydrodynamics) that all together allowed us to assay a wide range of concentrations of Hsp60. We found that Na?ve Hsp60 in aqueous solution is assembled in very stable heptamers and tetradecamers at all concentrations assayed, without any trace of monomer presence.
Leucine Aminopeptidase, β-Glucosidase and Alkaline Phosphatase Activity Rates and Their Significance in Nutrient Cycles in Some Coastal Mediterranean Sites
Gabriella Caruso
Marine Drugs , 2010, DOI: 10.3390/md8040916
Abstract: In aquatic microbial ecology, knowledge of the processes involved in the turnover of organic matter is of utmost importance to understand ecosystem functioning. Microorganisms are major players in the cycling of nutrients (nitrogen, phosphorus) and carbon, thanks to their enzymatic activities (leucine aminopeptidase, LAP, alkaline phosphatase, AP, and β-glucosidase, β-GLU) on organic polymers (proteins, organic phosphates and polysaccharides, respectively). Estimates of the decomposition rates of organic polymers are performed using fluorogenic compounds, whose hydrolysis rate allow us to obtain information on the “potential” metabolic activity of the prokaryotic community. This paper refers the enzyme patterns measured during recent oceanographic cruises performed in some coastal Mediterranean sites, not yet fully investigated in terms of microbial biogeochemical processes. Mean enzyme activity rates ranged from 5.24 to 5558.1 nM/h, from 12.68 to 244.73 nM/h and from 0.006 to 9.51 nM/h for LAP, AP and β-GLU, respectively. The highest LAP and AP activity rates were measured in the Gulf of Milazzo (Tyrrhenian Sea) and in the Straits of Messina, in association with the lowest bacterioplankton abundance; in contrast, the lowest ones were found in the northern Adriatic Sea. β-GLU was more active in the Straits of Messina. Activity rates were analysed in relation to the main environmental variables. Along the northern Adriatic coastal side affected by the Po river, significant inverse relationships linked LAP and AP with salinity, pointing out that fluvial inputs provided organic substrates for microbial metabolism. Both in the Gulf of Manfredonia and in the Straits of Messina, LAP and AP levels were inversely related with the concentration of nitrate and inorganic phosphorus, respectively. In the Gulf of Milazzo, high cell-specific AP measured in spite of phosphorus availability suggested the role of this enzyme not only in phosphorus, but also in carbon release.
Schools and Communities of Norm-awareness
Gabriella Pusztai
Religions , 2011, DOI: 10.3390/rel2030372
Abstract: The relationship between religiosity and educational attainment is an important question in the sociology of religion literature. It is widely contested whether the natural outgrowth of the spreading rational worldview and the increase of educated people can account for the decline of religious adherence. Is there any other explanation for the different opportunities of religious and non-religious societal groups to obtaining the highest educational level? After the political transformation in Central and Eastern Europe, one of the most important challenges of restructuring the educational system was how different cultural groups would be able to infuse their own spirituality into their children's education after the domination of the totalitarian ideology. The Hungarian case is unique because of the mixed confessional landscape, the populous Hungarian minority outside the border, the alternating hard and soft periods of religious harassment. Recently, more than half of the Hungarian population can be described as religious in their own way, one sixth strongly affiliated with churches, and another sixth are atheists. However, several studies showed that basic indicators of social status were very strongly and negatively interrelated with religiosity. It turned out that preferred educational views, values, approaches and priorities regarding the norms at schools differ very sharply according to the religious views, and belonging to a religious network significantly supports educational careers. This paper is a comprehensive review of research on the educational functions of denominational schools and religious communities in contemporary Hungary.
Historia (Santiago) , 2009, DOI: 10.4067/S0717-71942009000200001
Abstract: the article analyzes the reasons that motivated the decision to guarantee voting rights to literate people only in peru and the change towards a direct suffrage. this brought consequences such as the restriction of the electoral body, the introduction of changes in the citizen profile, the political geography of the country and the selection criteria for members of the parliament. behind these measures taken by government elites was the attempt to propose the construction of a modernizing political project and the idea of a new kind of state and nation. indigenous people were considered useless and inappropriate for these projects. different primary sources were used to explore these topics, including legislative and constitutional documents, parliamentary debates as well as electoral registers and minutes.
Evolutionary approach to communication between humans and dogs
Annali dell'Istituto Superiore di Sanità , 2011, DOI: 10.4415/ANN_11_04_08
Abstract: dog-human communication has been widely investigated recently for different theoretical reasons, in most cases through dogs' comprehension of human gestural cues. dogs have been reported to be very skilful in comprehending a variety of human pointing gestures in many independent studies. this paper provides a short overview of the possible explanations behind the dogs' exceptional communicational abilities towards humans from an evolutionary perspective, concluding that the different and seemingly contradictory hypotheses are not exclusive but they might have a synergic effect.
An activity-based system of models for student mobility simulation
Gabriella Mazzulla
European Transport Research Review , 2009, DOI: 10.1007/s12544-009-0017-2
Abstract: The proposed system of models adopt the activity-based travel approach combined with the conjoint use of the RP and SP methodologies, allowing a better understanding and prediction of users responses to travel demand management measures. The model structure is very realistic for student mobility simulation, helping the analyst in evaluating the effects of park pricing policies and the introduction of a new transport system in the travel users choices.
Technology architecture: the discipline for the future definition of a manifesto
Gabriella Peretti
Techne : Journal of Technology for Architecture and Environment , 2011,
Abstract: The author proposes a reflection on the evolution and possible future developments of Architectural Technology as an academic discipline, in light of its historical roots, through a path that sees it divided into different areas of specialized knowledge, all heavily characterized by attention to the methodological aspects in the project. Faced with potential developments, the author identifies two alternatives: one aimed at consolidating specialized aspects according to a plural vision of technologies, the other aimed at reconstructing a uni- que integrated discipline. The author takes the second direction, proposing to guide Archi- tectural Technology, in research and training, towards the construction of generalized skills, albeit with controlled specificities, that support the project’s capacity to direct.
La Ninfa: permanenza e mobilità di un’immagine nella cultura occidentale The Nymph: an Icon and Symbol of western Culture
Gabriella Brugnara
Between , 2011,
Abstract: La Nascita di Venere di Botticelli e la Bagnante di Mirò. Quasi quattrocentocinquant’anni di storia dividono questi due quadri che, anche dal punto di vista stilistico, non presentano punti di contatto. Il semplice accostarli, però, suggerisce un legame intuitivo, come se la Venere botticelliana fosse stata il riferimento di Mirò nel momento in cui ha tracciato le linee stilizzate della sua Bagnante. Guardando la tela del pittore catalano si potrebbe ipotizzare che la Venere del Rinascimento abbia ripreso il suo fluttuare sull’acqua e, dopo un lungo viaggio, sia approdata ad altre acque: quelle della Bagnante narranti la storia di un tempo distante. Complice di questo viaggio il concetto warburghiano di Nachleben per il quale può accadere che condensazioni significative di immagini del passato riprendano il “movimento”, assumendo, però, un significato che si sottopone a continue trasformazioni nel tempo e nello spazio. Nel movimento dei capelli e dei panneggi della Primavera e della Nascita di Venere, Warburg ravvisa una funzione iconografica, poetica e “patetica” in cui vede riflettersi l’atmosfera della Firenze rinascimentale, attratta dal movimento pieno di grazia e di passione di cui la Ninfa rappresenta l’emblema. The Nascita di Venere by Botticelli, the Bagnante by Mirò. Almost four-hundred and fifty years divide these two paintings that, also from a stylistic point of view, have no meeting points. But, simply by catching a glimpse of the two atmospheres painted, the observer feels the tight bound that lies between them: as if the Botticellian Venere had been the reference for Mirò when he was drawing the stylized lines of his Bagnante. When you observe the canvas of the Catalan artist it easily comes to you the idea that the figure you are looking at could be the Venere of Botticelli which, after a long travel along time and space, has arrived to a new land of water (the one of the Bagnante), located in a distant and different time, but where the Nymph can still dance with her striking elegance. An important role in this travel is played by the concept of Nachleben described by Warburg. According to it, it can happen that significant images from the past restart again their “movement” in the future, but with a transformed meaning.
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