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Search Results: 1 - 10 of 366958 matches for " G.; Antón Aparicio "
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Tumor primario pulmonar versus tumor secundario de origen endometrial
Gallegos,M. I.; García Campelo,R.; Quindós,M.; Dopico,D.; Alonso,G.; Antón Aparicio,L. M.;
Oncología (Barcelona) , 2006, DOI: 10.4321/S0378-48352006000400006
Abstract: purpose: to describe a case of endometrial carcinoma with an atypical outcome. material and methods: we report a typical early endometrial adenocarcinoma with a good prognosis, which after a long latent period showed an atypical outcome with the appearance of a lung tumour suspicious to be another primary tumour. however, a good response was obtained treating with carboplatin and paclitaxel, known as an active chemotherapy of endometrial neoplasms. discussion: early endometrial tumours have survival rates between 80 and 90%. it is unusual the development of progression after a long disease-free period.
The controversial early brightening in the first half of 20th century: a contribution from pyrheliometer measurements in Madrid (Spain)
M. Antón,J. M. Vaquero,A. J. P. Aparicio
Physics , 2014, DOI: 10.1016/j.gloplacha.2014.01.013
Abstract: A long-term decrease in downward surface solar radiation from the 1950s to the 1980s ("global dimming") followed by a multi-decadal increase up to the present ("brightening") have been detected in many regions worldwide. In addition, some researchers have suggested the existence of an "early brightening" period in the first half of 20th century. However, this latter phenomenon is an open issue due to the opposite results found in literature and the scarcity of solar radiation data during this period. This paper contributes to this relevant discussion analyzing, for the first time in Southern Europe, the atmospheric column transparency derived from pyrheliometer measurements in Madrid (Spain) for the period 1911-1928. This time series is one of the three longest dataset during the first quarter of the 20th century in Europe. The results showed the great effects of the Katmai eruption (June 1912, Alaska) on transparency values during 1912-1913 with maximum relative anomalies around 8%. Outside the period affected by this volcano, the atmospheric transparency exhibited a stable behavior with a slight negative trend without any statistical significance on an annual and seasonal basis. Overall, there is no evidence of a possible early brightening period in direct solar radiation in Madrid. This phenomenon is currently an open issue and further research is needed using the few sites with available experimental records during the first half of the 20th century.
State of the Art in Silico Tools for the Study of Signaling Pathways in Cancer
Vanessa Medina Villaamil,Guadalupe Aparicio Gallego,Isabel Santamarina Cainzos,Manuel Valladares-Ayerbes,Luis M. Antón Aparicio
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13066561
Abstract: In the last several years, researchers have exhibited an intense interest in the evolutionarily conserved signaling pathways that have crucial roles during embryonic development. Interestingly, the malfunctioning of these signaling pathways leads to several human diseases, including cancer. The chemical and biophysical events that occur during cellular signaling, as well as the number of interactions within a signaling pathway, make these systems complex to study. In silico resources are tools used to aid the understanding of cellular signaling pathways. Systems approaches have provided a deeper knowledge of diverse biochemical processes, including individual metabolic pathways, signaling networks and genome-scale metabolic networks. In the future, these tools will be enormously valuable, if they continue to be developed in parallel with growing biological knowledge. In this study, an overview of the bioinformatics resources that are currently available for the analysis of biological networks is provided.
Crossing Paths in Human Renal Cell Carcinoma (hRCC)
Guadalupe Aparicio Gallego,Vanessa Medina Villaamil,Enrique Grande,Isabel Santamarina Caínzos,Luís M. Antón Aparicio
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms131012710
Abstract: Historically, cell-signaling pathways have been studied as the compilation of isolated elements into a unique cascade that transmits extracellular stimuli to the tumor cell nucleus. Today, growing evidence supports the fact that intracellular drivers of tumor progression do not flow in a single linear pathway, but disseminate into multiple intracellular pathways. An improved understanding of the complexity of cancer depends on the elucidation of the underlying regulatory networks at the cellular and intercellular levels and in their temporal dimension. The high complexity of the intracellular cascades causes the complete inhibition of the growth of one tumor cell to be very unlikely, except in cases in which the so-called “oncogene addiction” is known to be a clear trigger for tumor catastrophe, such as in the case of gastrointestinal stromal tumors or chronic myeloid leukemia. In other words, the separation and isolation of the driver from the passengers is required to improve accuracy in cancer treatment. This review will summarize the signaling pathway crossroads that govern renal cell carcinoma proliferation and the emerging understanding of how these pathways facilitate tumor escape. We outline the available evidence supporting the putative links between different signaling pathways and how they may influence tumor proliferation, differentiation, apoptosis, angiogenesis, metabolism and invasiveness. The conclusion is that tumor cells may generate their own crossroads/crosstalk among signaling pathways, thereby reducing their dependence on stimulation of their physiologic pathways.
Perspectivas teóricas sobre la dinámica de la mixomatosis con aplicaciones en control biológico
Aparicio,Juan P; Solari,Hernán G; Bonino,Never A;
Ecolog?-a austral , 2006,
Abstract: myxomatosis is a lethal disease for the european rabbit (oryctolagus cuniculus) produced by the myxoma virus and transmitted by mosquitos and fleas. myxomatosis has been used for the biological control of exotic populations of the european rabbit in some countries, for example in australia. exotic rabbit populations produce an important negative impact on the economy of diverse regions of the world, including argentina. in this work we present mathematical models representing the local dynamics of myxomatosis as well as its dispersion on wild populations of o. cuniculus, the latter with the aid of an explicit spatial model. the dispersion speeds obtained are consistent with those obtained in field studies in great britain, but under-estimate observations made in australia. resorting to stochastic simulations we show that the likelihood for myxomatosis to be established depends on the viral strain used. the standard strategy, consisting in introducing highly virulent strains in wild rabbits populations, might not be the optimal according to our results.
The Two-loop Massless phi^4 Model in Non-translational Invariant Domain
M. Aparicio Alcalde,G. Flores Hidalgo,N. F. Svaiter
Mathematics , 2005, DOI: 10.1063/1.2194632
Abstract: We study the $\frac{\lambda}{4!}\phi^{4}$ massless scalar field theory in a four-dimensional Euclidean space, where all but one of the coordinates are unbounded. We are considering Dirichlet boundary conditions in two hyperplanes, breaking the translation invariance of the system. We show how to implement the perturbative renormalization up to two-loop level of the theory. First, analyzing the full two and four-point functions at the one-loop level, we shown that the bulk counterterms are sufficient to render the theory finite. Meanwhile, at the two-loop level, we have to introduce also surface counterterms in the bare lagrangian in order to make finite the full two and also four-point Schwinger functions.
Alport Syndrome: De Novo Mutation in the COL4A5 Gene Converting Glycine 1205 to Valine
Pilar Antón-Martín,Cristina Aparicio López,Soraya Ramiro-León,Sonia Santillán Garzón
Clinical Medicine Insights: Pediatrics , 2012,
Abstract:
Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy
Moisés Blanco Calvo,Angélica Figueroa,Enrique Grande Pulido,Rosario García Campelo,Luís Antón Aparicio
International Journal of Endocrinology , 2010, DOI: 10.1155/2010/205357
Abstract: Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. Cancer cells are well known to display an enhanced sugar uptake and consumption. In fact, sugar transporters are deregulated in cancer cells so they incorporate higher amounts of sugar than normal cells. In this paper, we compile the most significant data available about biochemical and biological properties of sugar transporters in normal tissues and we review the available information about sugar carrier expression in different types of cancer. Moreover, we describe the possible pharmacological interactions between drugs currently used in anticancer therapy and the expression or function of facilitative sugar transporters. Finally, we also go into the insights about the future design of drugs targeted against sugar utilization in cancer cells. 1. Introduction In animal cells, sugars are the major source of metabolic energy. However, as the plasma membrane is impermeable to polar molecules, membrane-associated carrier proteins are necessary for the introduction of sugars in cells. There are two described families of transporters: GLUT [solute carrier family 2 (facilitated glucose transporter), gene name SLC2A] and SGLT [solute carrier family 5 (sodium/glucose cotransporter); gene name: SLC5A]. GLUT transporters use existing gradients in sugar concentration, between external and internal sides of plasma membrane, to facilitate its translocation. Conversely, SGLT proteins move sugars inside of cells against gradient concentration, with the consequent energy cost. There are distinct GLUT genes encoding distinct GLUT transporters, which share an important sequence homology, although they display different affinity for sugars and present a marked tissue-specific expression pattern. Among all sugars, glucose is the most used by cells. Glucose uptake is the rate-limiting step in its use, underlining the importance of GLUT transporters in metabolism. Glycolysis is the catabolic pathway by which glucose undergoes the first transformation to obtain energy. In normal cells, after glycolysis, glucose is further metabolized through tricarboxilic acid cycle and oxidative phosphorylation in mitochondria. However, cancer cells display an increased consumption of glucose [1] which is metabolized primarily through the fermentative pathway with the consequent lactic acid production [1, 2]. Probably, the use of fermentative catabolism by cancer cells is due to a
Simple Human Gesture Detection and Recognition Using a Feature Vector and a Real-Time Histogram Based Algorithm  [PDF]
Iván Gómez-Conde, David Olivieri, Xosé Antón Vila, Stella Orozco-Ochoa
Journal of Signal and Information Processing (JSIP) , 2011, DOI: 10.4236/jsip.2011.24040
Abstract: Gesture and action recognition for video surveillance is an active field of computer vision. Nowadays, there are several techniques that attempt to address this problem by 3D mapping with a high computational cost. This paper describes software algorithms that can detect the persons in the scene and analyze different actions and gestures in real time. The motivation of this paper is to create a system for thetele-assistance of elderly, which could be used as early warning monitor for anomalous events like falls or excessively long periods of inactivity. We use a method for foreg-round-background segmentation and create a feature vectorfor discriminating and tracking several people in the scene. Finally, a simple real-time histogram based algorithm is described for discriminating gestures and body positions through a K-Means clustering.
Experience of three years of SER group in Carlos Ardilla Lulle clinical
Javier Enríquez Gómez Guarín,Norma Cecilia Serrano Díaz,Fernando Aparicio Higuera Aparicio,Carlos Hernán Becerra Mojica
MedUNAB , 1998,
Abstract:
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