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Search Results: 1 - 10 of 189838 matches for " G. Pessina "
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Effects of acute cigarette smoke exposure on macrophage kinetics and release of tumour necrosis factor α in rats
G. P. Pessina,L. Paulesu,F. Corradeschi,E. Luzzi
Mediators of Inflammation , 1993, DOI: 10.1155/s0962935193000171
Chronic cigarette smoking enhances spontaneous release of tumour necrosis factor-α from alveolar macrophages of rats
G. P. Pessina,L. Paulesu,F. Corradeschi,E. Luzzi
Mediators of Inflammation , 1993, DOI: 10.1155/s0962935193000602
Visual Composition of Complex Queries on an Integrative Genomic and Proteomic Data Warehouse  [PDF]
Francesco Pessina, Marco Masseroli, Arif Canakoglu
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.510B019

Biomedical questions are usually complex and regard several different life science aspects. Numerous valuable and he- terogeneous data are increasingly available to answer such questions. Yet, they are dispersedly stored and difficult to be queried comprehensively. We created a Genomic and Proteomic Data Warehouse (GPDW) that integrates data provided by some of the main bioinformatics databases. It adopts a modular integrated data schema and several metadata to describe the integrated data, their sources and their location in the GPDW. Here, we present the Web application that we developed to enable any user to easily compose queries, although complex, on all data integrated in the GPDW. It is publicly available at http://www.bioinformatics.dei.polimi.it/GPKB/. Through a visual interface, the user is only required to select the types of data to be included in the query and the conditions on their values to be retrieved. Then, the Web application leverages the metadata and modular schema of the GPDW to automatically compose an efficient SQL query, run it on the GPDW and show the extracted requested data, enriched with links to external data sources. Performed tests demonstrated efficiency and usability of the developed Web application, and showed its and GPDW relevance in supporting answering biomedical questions, also difficult.

Importance of TNF-alpha in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment
Andrade, Sonia G;Magalh?es, Lorena dos Anjos;Pessina, Daniel Huber;
Memórias do Instituto Oswaldo Cruz , 2008, DOI: 10.1590/S0074-02762008005000006
Abstract: infection of c3h/he mice with the peruvian strain of trypanosoma cruzi (biodeme type i, z2b), a macrophagotropic strain, determined severe parasitism of macrophages, necrosis of the spleen, and high host mortality. in the present study, pentoxifylline (ptx), an inhibitor of tnf-a was investigated on its action upon splenic necrosis, parasitemia and host survival. immunohistochemical data suggested the importance of this cytokine in parasite destruction and decreasing of parasitemia, although paradoxically contributing to the high mortality of infected mice. necrotic lesions involving several organs, specially the heart, in acute chagas disease, are important aggravating factors, increasing cardiac morbidity. advantage of inhibiting tnf-a action was herein investigated. infected mice were divided into two groups: untreated (n = 24), and ptx treated mice (n = 25). ptx was administered in two daily doses of 30 mg/kg/bw, by intraperitoneal route. normal controls either treated with ptx or saline were also included. histopathology of the spleen and in situ immunolabeling of tnf-a, using anti-tnf-a monoclonal antibody, were performed. necrotic areas were evaluated by morphometry. mice treated with ptx showed a significant decrease of necrotic areas and diminution of tnf-a expression in spleen tissue, suggesting that ptx treatment could control tnf-a effects, and thus be used as an adjuvant in the treatment of acute chagas' disease.
CdWO4 bolometers for Double Beta Decay search
L. Gironi,C. Arnaboldi,S. Capelli,O. Cremonesi,M. Pavan,G. Pessina,S. Pirro
Physics , 2008,
Abstract: In the field of Double Beta Decay (DBD) searches the possibility to have high resolution detectors in which background can be discriminated is very appealing. This very interesting possibility can be largely fulfilled in the case of a scintillating bolometer containing a Double Beta Decay emitter whose transition energy exceeds the one of the natural gamma line of 208Tl. We present the latest results obtained in the development of such a kind of scintillating bolometer. For the first time an array of five CdWO4 (116Cd has a Double Beta Decay transition energy of 2805 keV) crystals is tested. The array consists of a plane of four 3x3x3 cm3 crystals and a second plane consisting of a single 3x3x6 cm3 crystal. This setup is mounted in hall C of the National Laboratory of Gran Sasso inside a lead shielding in order to reduce as far as possible the environmental background. The aim of this test is to demonstrate the technical feasibility of this technique through an array of detectors and perform a long background measurement in the best conditions in order to prove the achievable background in the Zero neutrino-DBD region.
A new approach to the front-end readout of cryogenic ionization detectors
C. Cattadori,B. Gallese,A. Giachero,C. Gotti,M. Maino,G. Pessina
Physics , 2011, DOI: 10.1088/1748-0221/6/05/P05006
Abstract: We present a novel approach to the readout of ionization detectors. The solution allows to minimize the number of components and the space occupation close to the detector. This way a minimal impact is added on the radioactive background in those experiments where very low signal rates are expected, such as GERDA and MAJORANA. The circuit consists in a JFET transistor and a remote second stage. The DC feedback path is closed using a diode. Two signal cables are only necessary for biasing and readout.
Characterization of ZnSe scintillating bolometers for Double Beta Decay
C. Arnaboldi,S. Capelli,O. Cremonesi,L. Gironi,M. Pavan,G. Pessina,S. Pirro
Physics , 2010, DOI: 10.1016/j.astropartphys.2010.09.004
Abstract: ZnSe scintillating bolometers are good candidates for future Double Beta Decay searches, because of the 82Se high Q-value and thanks to the possibility of alpha background rejection on the basis of the scintillation signal. In this paper we report the characteristics and the anomalies observed in an extensive study of these devices. Among them, an unexpected high emission from alpha particles, accompanied with an unusual pattern of the light vs. heat scatter plot. The perspectives for the application of this kind of detectors to search for the Neutrinoless Double Beta Decay of 82Se are presented.
A novel technique of particle identification with bolometric detectors
C. Arnaboldi,C. Brofferio,O. Cremonesi,L. Gironi,M. Pavan,G. Pessina,S. Pirro,E. Previtali
Physics , 2010, DOI: 10.1016/j.astropartphys.2011.02.006
Abstract: We report in this paper the proofs that the pulse shape analysis can be used in some bolometers to identify the nature of the interacting particle. Indeed, while detailed analyses of the signal time development in purely thermal detectors have not produced so far interesting results, similar analyses on bolometers built with scintillating crystals seem to show that it is possible to distinguish between an electron or gamma-ray and an alpha particle interaction. This information can be used to eliminate background events from the recorded data in many rare process studies, especially Neutrinoless Double Beta decay search. Results of pulse shape analysis of signals from a number of bolometers with absorbers of different composition (CaMoO4, ZnMoO4, MgMoO4 and ZnSe) are presented and the pulse shape discrimination capability of such detectors is discussed.
Effect of SiO2 coating in bolometric Ge light detectors for rare event searches
J. W. Beeman,A. Gentils,A. Giuliani,M. Mancuso,G. Pessina,O. Plantevin,C. Rusconi
Physics , 2012, DOI: 10.1016/j.nima.2013.01.019
Abstract: In germanium-based light detectors for scintillating bolometers, a SiO$_2$ anti-reflective coating is often applied on the side of the germanium wafer exposed to light with the aim to improve its light collection efficiency. In this paper, we report about a measurement, performed in the temperature range 25-35 mK, of the light-collection increase obtained thanks to this method, which resulted to be of the order of 20%. The procedure followed has been carefully selected in order to minimize systematic effects. The employed light sources have the same spectral features (peaking at $\sim 630$ nm wavelength) that will characterise future neutrinoless double beta decay experiments on the isotope $^{82}$Se and based on ZnSe crystals, such as LUCIFER. The coupling between source and light detector reproduces the configuration used in scintillating bolometers. The present measurement clarifies the role of SiO$_2$ coating and describes a method and a set-up that can be extended to the study of other types of coatings and luminescent materials.
GeFRO: a New Charge Sensitive Amplifier Design with a Minimal Number of Front-end Components
L. Cassina,C. Cattadori,A. Giachero,C. Gotti,M. Maino,G. Pessina
Physics , 2013,
Abstract: A new approach was developed for the design of front-end circuits for semiconductor radiation detectors. The readout scheme consists of a first stage made of only a few components located close to the detector, and of a remote second stage located far from the detector, several meters away. The second stage amplifies the signals from the first stage and closes the feedback loop to discharge the input node after each event. The circuit has two outputs: one gives a "fast" signal, with a bandwidth larger than 20 MHz, allowing to preserve the high frequency components of the detector signals, which may be useful for timing measurements, pile-up rejection or pulse shape discrimination. The second output gives a "slow" signal, whose gain depends only on the value of the feedback capacitor, as happens with a classic charge sensitive amplifier, allowing to obtain higher resolution and lower drift. The prototype was named GeFRO for Germanium front-end, and was tested with a BEGe detector from Canberra. The wide bandwidth of the "fast" signal gave a timing resolution of the order of 20 ns. The noise of the circuit at the "slow" output after a 10 us Gaussian shaping was close to 160 electrons RMS with an input capacitance of 26 pF.
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