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Search Results: 1 - 10 of 351485 matches for " G. P. Talwar "
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Vaccines and Antibodies for Therapeutic Use in Cancers  [PDF]
G. P. Talwar, Jagdish C. Gupta, M. Diwan, J. Frick, S. K. Sharma, S. N. Wadhwa, R. M. Gupta, S. K. Gupta, Shilpi Purswani, Hemant K. Vyas
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.76040
Abstract: This review describes briefly the beneficial use of two vaccines developed by us for treatment of cancers. The vaccine against Luteinizing Hormone Releasing Hormone (LHRH) is effective in carcinoma of prostate as well as in breast cancers dependent on androgens and estrogens respectively. LHRH being identical in both males and females, the same vaccine is usable in both Prostate and Breast steroid hormones-dependent-cancers. Monoclonal antibodies are finding therapeutic utility in several cancers, and many have received Drugs Regulatory approval. The monoclonals developed by us against hCG and against epitopes present on androgen-independent castration resistant prostate cancers are briefly recapitulated. Anti-hCG antibodies kill several cancers expressing hCG. An example is given of A549 lung carcinoma. MoAb730 and MoAb7B2G10 kill DU-145 and PC-3 androgen-independent castration resistant prostate cancer cells. Some cancers such as MOLT-4, a T-lymphoblastic leukemia, though expressing hCG are not killed by PiPP, the high affinity anti-hCG antibody. Linking the antibody to curcumin however works like a “Magic Bullet”. All MOLT-4 cells are killed by this conjugate, the antibody homes selectively to cancer cells expressing hCG to deliver curcumin which exercises the killing effect. A recombinant vaccine, hCGβ-LTB (human chorionic gonadotropin subunit β linked to B subunit of heat-labile enterotoxin of E. coli) has been made, which induces high titre bioeffective antibodies not only in BalbC, but also in other genetic strains of mice. The vaccine employs autoclaved Mycobacterium indicus pranii (MiP) as adjuvant. MiP invigorates both humoral and cell mediated immune responses against Human chorionic gonadotropin (hCG). Besides being a potent adjuvant, MiP used alone heals anogenital warts in humans and has the property of preventing and curing SP2/O Myelomas in mice.
Computerised tomography of the orbits
Talwar Inder,Burde G
Indian Journal of Ophthalmology , 1988,
Abstract: Computerised Tomography has revolutionised the approach to many problems, especially orbital diseases. It is a simple, safe, non-invasive diagnostic examination done on an out patient. Computerised Tomography not only shows the presence of a lesion but also shows the extent of the disease and its relationship to other intraorbital and adjacent structures. With coronal scans, relationship of orbital disease to the optic nerve and extraocular muscles can be well demonstrated. However it must be remembered that Computerised Tomography is not a microscope to give histopathological diagnosis but we can often draw a conclusion of the nature of the disease by Computerised′ Tomography appearances and clinical details. Now Computerised Tomography has become the primary investigation of choice in evaluating orbital disease.
Hybrid fixation in rotating platform mobile bearing total knee arthroplasty using low contact stress knee
Maini P,Kailey P,Talwar Naveen
Indian Journal of Orthopaedics , 2006,
Abstract: Background : Mobile bearings in total knee arthroplasty reduce wear of polyethelene and mechanical loosening of components. Method : Non-cemented Low Contact Stress (LCS) femoral implant and cemented LCS rotating platform tibial tray and polyethylene insert was used in 100 knees. Pre-operative diagnosis was osteoarthritis (OA) in 85 and rheumatoid arthritis (RA) in 15 knees. Results : Ninetyeight knees were available for follow-up at a mean interval of 38 months. Minimum of 90° flexion was achieved in all the cases. All patients were females with a mean age of 67 years. Non progressive radiolucent lines of 1-2mm were seen in 6 femoral components. Twelve tibial components also showed similar radiolucent lines in 2 or less zones. Knee Society Knee Score improved from 32 to 93 and function score from 47 to 79. Results were good to excellent in 95 knees. There was no case for bearing spin out or revision. Conclusion : Results of this study suggest that the hybrid fixation can reliably provide excellent or good results in selected patients. Key-words: Mobile bearing knee; Arthroplasty; Porocoat; Hybrid.
Ocular histoplasmosis
Dhir S,Talwar P,Jain I
Indian Journal of Ophthalmology , 1981,
Angiokeratoma circumscriptum : Some unusual features
Talwar S,Suresh M,Jha P
Indian Journal of Dermatology, Venereology and Leprology , 1992,
Abstract: A case of angiokeratoma circumscriptum in 55-year old female involving both breasts and intermammary area is reported. Late onset, unusual site, bilateral involvement and associated extensive telangiectasia are interesting features in this case.
Hirschprung’s Disease: A Rare Cause of Intestinal Obstruction in Adults
Nikhil Talwar, O. P. Pathania, Romesh Lal
JK Science : Journal of Medical Education & Research , 2005,
Abstract: Hirschprung’s disease (aganglionosis) in the adult is a rare condition but needs to be considered as adiagnosis in any case of intractable constipation.We report a case of twenty-year-old woman withadult hirschprung’s disease, presenting as intestinal obstruction. Diagnosis is discussed and operativemanagement evaluated.
First direct measurement of resonance strengths in 17O(α, γ)21Ne
A. Best,J. G?rres,M. Couder,R. deBoer,S. Falahat,A. Kontos,P. J. LeBlanc,Q. Li,S. O'Brien,K. Sonnabend,R. Talwar,E. Uberseder,M. Wiescher
Physics , 2011, DOI: 10.1103/PhysRevC.83.052802
Abstract: The reaction 17O({\alpha},{\gamma})21Ne has been measured by in-beam gamma spectroscopy for the first time in the energy range E{\alpha} = 750 keV to 1650 keV using highly enriched anodized Ta2(17O)5 targets. Resonances were found at E({\alpha}) = 1002 keV, 1386 keV and 1619 keV. Their strengths and primary gamma-ray branchings are given. The new results exclude the low reaction rate of Descouvemont and support the rate of Caughlan and Fowler. Implications for the neutron poisoning efficiency of 16O in the weak s process are discussed.
Testing the Mutually Enhanced Magicity Effect in Nuclear Incompressibility via the Giant Monopole Resonance in the $^{204,206,208}$Pb Isotopes
D. Patel,U. Garg,M. Fujiwara,T. Adachi,H. Akimune,G. P. A. Berg,M. N. Harakeh,M. Itoh,C. Iwamoto,A. Long,J. T. Matta,T. Murakami,A. Okamoto,K. Sault,R. Talwar,M. Uchida,M. Yosoi
Physics , 2013, DOI: 10.1016/j.physletb.2013.08.027
Abstract: Using inelastic $\alpha$-scattering at extremely forward angles, including $0^\circ$, the strength distributions of the isoscalar giant monopole resonance (ISGMR) have been measured in the $^{204,206,208}$Pb isotopes in order to examine the proposed mutually enhanced magicity (MEM) effect on the nuclear incompressibility. The MEM effect had been suggested as a likely explanation of the "softness" of nuclear incompressibility observed in the ISGMR measurements in the Sn and Cd isotopes. Our experimental results rule out any manifestation of the MEM effect in nuclear incompressibility and leave the question of the softness of the open-shell nuclei unresolved still.
Unravelling the Cipher of Indian Rupee’s Volatility: Testing the Forecasting Efficacy of the Rolling Symmetric and Asymmetric GARCH Models  [PDF]
Shalini Talwar, Aparna Bhat
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.86079
Abstract: Modelling exchange rate volatility is crucially important because of its diverse implications on the profitability of corporations and decisions of policy makers. This paper empirically investigates exchange rate volatility of India’s currency by applying rolling symmetric and asymmetric GARCH models to the USDINR and EURINR daily exchange rates for a period spanning April 1, 2006 through January 31, 2018, resulting in total observations of 2861. To estimate GARCH (1,1) and EGARCH (1,1) models, the data window is rolled over five years with nearly 1200 observations and one month is used as forecast period for each window. Both, in-sample criteria like the log likelihood criteria, Akaike information criterion (AIC), the Bayesian information criterion (SIC) and Hannan Quinn criterion (HQC) as well as the out-of-sample criteria like Mean Squared Error (MSE) and Mean Absolute Error (MAE) have been used to test model fit and forecast accuracy of the models. To test the robustness of the findings, Diebold-Mariano test is used to compare the predictive accuracy of both the models. Further, the forecasting accuracy of the two models has also been tested by splitting the sample period into periods of tranquility and volatility in Indian exchange rate. Results show that GARCH (1,1) model with generalized error distribution is adequate to capture the mean and volatility process of USDINR and EURINR exchange rate returns.
Integration of GDP and FDI in Economies at Different Stages of Growth  [PDF]
Shalini Talwar, Shaila Srivastava
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.811144
Abstract: The objective of this study is to analyze the relationship between FDI and GDP for countries representing developed, developing and underdeveloped economies around the world. The countries identified for the purpose are Bhutan, Ethiopia, India, Brazil, USA and UK. Johansen cointegration test reveals that long-run equilibrium relationship between the two variables exists for Ethiopia, India and UK only. The VEC model shows no related short-run causality for any of these three countries. The study has implications in terms of policy decisions. Using FDI to boost GDP growth rate in the short-run is not an effective option for any country under the study. Since the vector error correction (VEC) model suggests that the two variables have a statistically significant adjustment mechanism for India, the study concludes that India can use FDI to leverage her long-term GDP. No evidence of link between the state of development of economy and integration of FDI and GDP is found by the study.
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