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Search Results: 1 - 10 of 191399 matches for " G. Garrido-Garrido "
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Introducción de la suplementación con formulaciones Vimang en el síndrome doloroso regional complejo: experiencia en 15 pacientes Introduction of supplementation with Vimang formulations in complex regional pain syndrome: Experience in 15 patients
B. Garrido-Suárez,M.C. Rabí,F. Bosch,G. Garrido-Garrido
Revista de la Sociedad Espa?ola del Dolor , 2009,
Abstract: Introducción: En la actualidad el estrés oxidativo, la neuroinflamación y la activación glial han adquirido relevancia en la fisiopatología del síndrome doloroso regional complejo (SDRC), de ahí que la terapia con agentes antioxidantes e inhibidores de la producción de citocinas proinflamatorias ha comenzado a ensayarse. El Vimang es una marca comercial registrada que cubre varios tipos de formulaciones a partir del extracto de la corteza del árbol de mango con efecto inhibidor de la activación del factor de transcripción nuclear kB (NFkB), promotor de la expresión de mediadores y sistemas enzimáticos involucrados en la inflamación y el dolor, el estrés oxidativo y la plasticidad sináptica. Objetivo: El propósito del presente estudio fue determinar la actividad analgésica de la suplementación con formulaciones Vimang en 15 pacientes con SDRC y la posible mejoría de la capacidad funcional postratamiento. Material y métodos: Los pacientes recibieron Vimang tabletas 1.800 mg/día/8 h, crema 1,2% en el miembro afectado 3 veces/día y un bloqueo simpático semanal durante 4 meses. Se introdujo la fisioterapia al mes. Las variables evaluadas fueron las puntuaciones diarias medias de dolor (PDMD) mediante una escala de Likert, el área e intensidad de la alodinia mecánica dinámica, la alodinia al frío, somática profunda y la frecuencia del dolor paroxístico. Se aplicó la escala de Enneking et al. modificada para evaluar la funcionabilidad articular. Resultados: Las PDMD y el resto de las alteraciones sensoriales se redujeron significativamente desde la semana 2 a 3 de iniciado el tratamiento respecto a los valores iniciales. La funcionabilidad del miembro afectado aumentó de un promedio de 22,7 a 78,7%. Estas formulaciones pudieran introducirse en el tratamiento del SDRC, pero es necesario sistematizar los estudios. Introduction: Currently, oxidative stress, neuroinflammation and glial activation are accepted as playing a pathophysiological role in complex regional pain syndrome (CRPS) and consequently antioxidant agents and proinfl ammatory cytokine inhibitors have begun to be assessed in the treatment of this disorder. Vimang is a new phytodrug prepared from the stem bark of Mangifera indica L., registered in Cuba with inhibitory effect on nuclear transcription factor kB (NFkB), which induces expression of some mediators and enzymes involved in inflammation, oxidative stress, pain, and synaptic plasticity. Objective: To determine the analgesic effects of Vimang tablets and 1.2% cream as a topical agent in 15 patients with CRPS, as well as possible improvemen
Utilidad del Extracto de Mangifera Indica L (VIMANG) en el Síndrome Doloroso Regional Complejo: A propósito de un caso Usefulness of Mangifera Indica L (Vimang ) in the treatment of Complex Regional Pain Syndrome (CRPS): A case report
B. Garrido-Suárez,F. Bosch,G. Garrido-Garrido,R. Delgado-Hernández
Revista de la Sociedad Espa?ola del Dolor , 2007,
Abstract: Los avances en el conocimiento actual de la fisiopatología del Síndrome Doloroso Regional Complejo (SDRC), conducen a la búsqueda de nuevos fármacos dirigidos a los blancos moleculares que se involucran en sus complejos mecanismos. En la actualidad se considera el papel activo de la neuroinflamación en el fenómeno de hiperexcitabilidad del cuerno dorsal espinal y el establecimiento de la sensibilización central dentro de sus procesos subyacentes. El Extracto obtenido de la corteza de variedades seleccionadas de la especie Mangifera indica L. y que se comercializa en Cuba bajo la Marca Registrada VIMANG , posee actividad antioxidante, antiinflamatoria y antihiperalgésica in vivo. Por otra parte estudios in vitro demostraron su efecto inhibidor sobre múltiples moléculas que participan en la cascada de la sensibilización central y en un modelo de isquemia-reperfusión sus cualidades neuroprotectoras. Presentamos el caso de una paciente con diagnóstico de SDRC tipo II, secundario a una lesión del plexo braquial, con sección del nervio radial a nivel humeral que fue provocada por el desplazamiento de la fractura del húmero izquierdo. La paciente llega a nuestro servicio a los 4 meses de evolución, con síntomas sensoriales, dolor persistente quemante y paroxístico, alodinia mecánica, edema, cambios vasomotores hacia la hiperhemia y mano en flexión por pérdida de la función motora de los músculos extensores del antebrazo. Con compromiso de la articulación del carpo y hombro de limitación severa y dolor de valor 5 en una escala numérica de Likert. El estudio de conducción nerviosa mostró alteraciones mielínico-axonales discretas del nervio mediano y mielínico-axonales severas del nervio radial. Se instauró el tratamiento con Vimang (300mg) 2 tabletas cada 8 horas por 4 meses y la aplicación local de la crema Vimang 3 veces al día, asociado a los bloqueos simpáticos y somáticos para miembro superior y a la fisioterapia. La evolución clínica y electrofisiológica fue muy favorable. Este caso constituye el primero descrito en la literatura, en el cual se introduce este producto a la terapia múltiple del síndrome, se deben dirigir los estudios básicos y clínicos en este sentido, dadas las posibilidades terapéuticas del Vimang en el SDRC. Advances in our understanding of Complex Regional Pain Syndrome (CRPS) physiopathology have led to new drugs targeted toward molecular mediators involved in the complex mechanisms of pain. Neuroinflammation is thought to have an active role in phenomena underlying spinal cord dorsal horn hyperexcitability and the establishment of cen
Introducción de la suplementación con formulaciones Vimang? en el síndrome doloroso regional complejo: experiencia en 15 pacientes
Garrido-Suárez,B.; Rabí,M.C.; Bosch,F.; Garrido-Garrido,G.; Delgado-Hernández,R.;
Revista de la Sociedad Espa?ola del Dolor , 2009,
Abstract: introduction: currently, oxidative stress, neuroinflammation and glial activation are accepted as playing a pathophysiological role in complex regional pain syndrome (crps) and consequently antioxidant agents and proinfl ammatory cytokine inhibitors have begun to be assessed in the treatment of this disorder. vimang? is a new phytodrug prepared from the stem bark of mangifera indica l., registered in cuba with inhibitory effect on nuclear transcription factor kb (nfkb), which induces expression of some mediators and enzymes involved in inflammation, oxidative stress, pain, and synaptic plasticity. objective: to determine the analgesic effects of vimang? tablets and 1.2% cream as a topical agent in 15 patients with crps, as well as possible improvement in post-treatment functional capacity. material and methods: the patients received a daily dose of 1800 mg of vimang? tablets for 120 days, 1.2% cream in the affected limb 3 times/day, and sympathetic blocks once a week for 4 months. physiotherapy was introduced after 30 days. the variables evaluated were changes in average daily pain score through a likert scale, the area and rate of dynamic mechanical allodynia, rate of cold allodynia, deep somatic allodynia and frequency of burning spontaneous pain. a modified scale of enneking et al. was applied to evaluate functional capacity. results: the average daily pain score and sensory abnormalities significantly improved from week 2-3. on average, the functional capacity of the affected limb increased from 22.7 % to 78.7%. our results suggest that vimang? formulations might be useful in crps treatment. however, further studies are required.
Utilidad del Extracto de Mangifera Indica L (VIMANG) en el Síndrome Doloroso Regional Complejo: A propósito de un caso
Garrido-Suárez,B.; Bosch,F.; Garrido-Garrido,G.; Delgado-Hernández,R.; Porro,J. N.; Manero,J. M.;
Revista de la Sociedad Espa?ola del Dolor , 2007,
Abstract: advances in our understanding of complex regional pain syndrome (crps) physiopathology have led to new drugs targeted toward molecular mediators involved in the complex mechanisms of pain. neuroinflammation is thought to have an active role in phenomena underlying spinal cord dorsal horn hyperexcitability and the establishment of central sensitivity. an extract from the bark of selected mangifera indica l species, registered under the vimang? trade mark in cuba, has antioxidant, anti-inflammatory and antihyperanalgesic activity in vivo. in vitro studies have demonstrated that it has an inhibitory effect on several molecules mediating the central sensitization cascade and an ischemic-reperfusion model has proved its cerebral neuroprotective qualities. we present a patient with type ii crps secondary to a brachial plexus lesión following a displaced left humerus fracture that sectioned the radius nerve. the patient presented in our pain clinic four months after the accident with sensorial symptoms, persistent burning pain mechanical allodynia, oedema, vasomotor alterations tending to hyperhaemia and a flexed hand due to loss of the motor function in the fore arm extensors. carpal and shoulder joint movement was severely limited and she scored 5 on the likert pain scale. electrophysiological study revealed mild myelin-axonal alterations in the median nerve and severe alterations in the radial nerve. treatment with vimang (300 mg; 2 tablets/8 hours/4 months) with topical administration of vimang cream 3 times per day combined with sympathetic and somatic nerve blocks in the upper limb and physiotherapy were begun. the patient's clinical and electrophysiological evolution was very favourable. this is the first description of the use of this product in combined crps therapy. our results indicate that further basic and clinical research into the use of vimang? for crps is justified.
Pólipos de colon Colorectal polyps
A. Garrido Botella,E. Garrido Gómez
Revista Espa?ola de Enfermedades Digestivas , 2007,
Abstract:
Pendulum Integration and Elliptic Functions
P. L. Garrido,G. Gallavotti
Physics , 2008, DOI: 10.1063/1.3316076
Abstract: Revisiting canonical integration of the classical pendulum around its unstable equilibrium, normal hyperbolic canonical coordinates are constructed
Boundary Dissipation in a Driven Hard Disk System
P. L. Garrido,G. Gallavotti
Physics , 2006, DOI: 10.1007/s10955-006-9244-2
Abstract: A simulation is performed aiming at checking the existence of a well defined stationary state for a two dimensional system of driven hard disks when energy dissipation takes place at the system boundaries and no bulk impurities are present
Antecedentes y nuevos retos en la formación de técnicos de la salud en Cuba
Pernas Gómez,Marta; Garrido Riquenes,Carmen;
Educaci?3n M??dica Superior , 2004,
Abstract: the historical stages of the training of health technicians and assistants in cuba are analyzed. it is exposed a new stage in the training of health technology professionals that came into effect in the academic course 2002-2003 with the introduction of a new traininig curriculum that meets the needs of the national health system of increasing the number and quality of the human resources devoted to develop these services and whose most significant characteristics are: admission with 12th grade finished, although it also serves as a way to continue the studies of the technicians working in the national health system; a design created to guarantee an early incorporation to work for being structured with 2 intermediate outlets and whose milestone is working education as a synthesis of theory and practice, of the basic and the professional; the structure consisting of 2 basic components, which are the meetings at the university seat and the intermeetings at work under the guidance and control of a tutor, as well as its flexibility on giving the opportunity to fit the duration of the career to the individual possibilities of concluding each curricular unit. the selection and accreditation of the teaching-assistance settings and the selection and training of the professors are key factors for the success of the new curriculum.
La complementariedad entre la igualdad y la diferencia
Garrido Gómez,María Isabel;
Frónesis , 2008,
Abstract: abstract this study analyses the question of difference related to the general rule of equality; its objective is to find a method for inclusion and integration which lays down the rules of the game to be followed between the majority group and the other groups. from this viewpoint, the study begins with the premise that equality should always be postulated, while no factual inequality offers a reason to permit or impose a differentiated regulation, demonstrating, thus, that formal equal treatment acts as a differentiating instrument to bring about the connection with material equality. finally, the study makes a particular reference to cultural minorities and concludes that big problems and solutions for the deficit in defense and demand techniques should be resolved in the political arena. this article uses open and dynamic analytical methodology.
LA PREDECIBILIDAD DE LAS DECISIONES JUDICIALES
Garrido Gómez,María Isabel;
Ius et Praxis , 2009, DOI: 10.4067/S0718-00122009000100003
Abstract: the issue addressed in this study is the predictability of judicial decisions, linked to the values of liberty, the feeling of security it affords people, and equality. the jurisdictional principal guiding judges is to exercise the guarantee of closure of the system by correcting the margins of legal deviation and illegitimacy that might have occurred. from this perspective, i am addressing the framework in which the theory and practice of the predictability of said decisions within a democratic state must be built, and of the concatenate play of the values outlined. in order to analyse the play, i examine the issue of the reasoning informing rulings, legal discretionality, the meanings and elements of legal security and precedents. the treatment given to the predictability of the law by american legal realism, especially by frank and llewellyn, is gone into in greater depth. lastly, i must point out that the changes undergone by the applicative law model break with the concept of strict formalism, and spaces related to non-legal purposes and strategies are created. consequently, it may be understood that american legal realism was right in regarding the law as a reality that undergoes unceasing changes, owing to creative legal activity. in this regard, it is made clear that legislators and judges alike play a part in this process. its creation goes back to the interpretation of the regulation in force and to the fact that the specific regulation on the basis of which the decision is made is not a consequence of logic.
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