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Search Results: 1 - 10 of 189878 matches for " G. G. Nicklin "
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Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis
Sindhu T Mohanty, Lucksy Kottam, Alessandra Gambardella, Martin J Nicklin, Les Coulton, David Hughes, Anthony G Wilson, Peter I Croucher, Ilaria Bellantuono
Arthritis Research & Therapy , 2010, DOI: 10.1186/ar3098
Abstract: We have used Balb/C Interleukin-1 receptor antagonist knock-out mice, which spontaneously develop RA-like disease in 100% of mice by 20 weeks of age to determine the number of mesenchymal progenitors and their differentiated progeny before, at the start and with progression of the disease.We showed a decrease in the number of mesenchymal progenitors with adipogenic potential and decreased bone marrow adipogenesis before disease onset. This is associated with a decrease in osteoclastogenesis. Moreover, at the onset of disease a significant increase in all mesenchymal progenitors is observed together with a block in their differentiation to osteoblasts. This is associated with accelerated bone loss.Significant changes occur in the BM niche with the establishment and progression of RA-like disease. Those changes may be responsible for aspects of the disease, including the advance of osteoporosis. An understanding of the molecular mechanisms leading to those changes may lead to new strategies for therapeutic intervention.Rheumatoid arthritis (RA) is a systemic autoimmune disease characterised by chronic disruptive polyarthritis. There is no cure for RA and today's treatments aim at achieving the lowest possible level of arthritis disease activity. In the UK alone RA costs the health system around £560 million a year, and £1.8 billion a year in absence from work. The events preceding the disease and leading to its initiation and progression are unknown. Thus, an understanding of these processes is crucial for the identification of new and more cost-effective treatments and for the move from a manageable to a curable disease.Although the main disease site is the synovium, there is growing evidence that the bone marrow (BM) is actively involved and may even be the primary initiating site of the disease [1]. Abnormalities in both the haemopoietic progenitor cells and the BM stroma have been described [2]. Patients with active RA have been seen to exhibit low frequency and a
Track Reconstruction and Performance of DRIFT Directional Dark Matter Detectors using Alpha Particles
S. Burgos,J. Forbes,C. Ghag,M. Gold,V. A. Kudryavtsev,T. B. Lawson,D. Loomba,P. Majewski,J. E. McMillan,D. Muna,A. StJ. Murphy,G. G. Nicklin,S. M. Paling,A. Petkov,S. J. S. Plank,M. Robinson,N. Sanghi,N. J. T. Smith,D. P. Snowden-Ifft,N. J. C. Spooner,T. J. Sumner,J. Turk,T. Tziaferi
Physics , 2007, DOI: 10.1016/j.nima.2007.10.013
Abstract: First results are presented from an analysis of data from the DRIFT-IIa and DRIFT-IIb directional dark matter detectors at Boulby Mine in which alpha particle tracks were reconstructed and used to characterise detector performance--an important step towards optimising directional technology. The drift velocity in DRIFT-IIa was [59.3 +/- 0.2 (stat) +/- 7.5 (sys)] m/s based on an analysis of naturally-occurring alpha-emitting background. The drift velocity in DRIFT-IIb was [57 +/- 1 (stat) +/- 3 (sys)] m/s determined by the analysis of alpha particle tracks from a Po-210 source. 3D range reconstruction and energy spectra were used to identify alpha particles from the decay of Rn-222, Po-218, Rn-220 and Po-216. This study found that (22 +/- 2)% of Po-218 progeny (from Rn-222 decay) are produced with no net charge in 40 Torr CS2. For Po-216 progeny (from Rn-220 decay) the uncharged fraction is (100 +0 -35)%.
Measurement of the Range Component Directional Signature in a DRIFT-II Detector using 252Cf Neutrons
S. Burgos,E. Daw,J. Forbes,C. Ghag,M. Gold,C. Hagemann,V. A. Kudryavtsev,T. B. Lawson,D. Loomba,P. Majewski,D. Muna,A. St. J. Murphy,G. G. Nicklin,S. M. Paling,A. Petkov,S. J. S. Plank,M. Robinson,N. Sanghi,D. P. Snowden-Ifft,N. J. C. Spooner,J. Turk,E. Tziaferi
Physics , 2008, DOI: 10.1016/j.nima.2008.11.147
Abstract: The DRIFT collaboration utilizes low pressure gaseous detectors to search for WIMP dark matter with directional signatures. A 252Cf neutron source was placed on each of the principal axes of a DRIFT detector in order to test its ability to measure directional signatures from the three components of very low energy (~keV/amu) recoil ranges. A high trigger threshold and the event selection procedure ensured that only sulfur recoils were analyzed. Sulfur recoils produced in the CS2 target gas by the 252Cf source closely match those expected from massive WIMP induced sulfur recoils. For each orientation of the source a directional signal from the range components was observed, indicating that the detector is directional along all 3 axes. An analysis of these results yields an optimal orientation for DRIFT detectors when searching for a directional signature from WIMPs. Additional energy dependent information is provided to aid in understanding this effect.
First Results from the DRIFT-IIa Dark Matter Detector
S. Burgos,J. Forbes,C. Ghag,M. Gold,V. A. Kudryavtsev,T. B. Lawson,D. Loomba,P. Majewski,D. Muna,A. StJ. Murphy,G. G. Nicklin,S. M. Paling,A. Petkov,S. J. S. Plank,M. Robinson,N. Sanghi,N. J. T. Smith,D. P. Snowden-Ifft,N. J. C. Spooner,T. J. Sumner,J. Turk,E. Tziaferi
Statistics , 2007, DOI: 10.1016/j.astropartphys.2007.08.007
Abstract: Data from the DRIFT-IIa directional dark matter experiment are presented, collected during a near continuous 6 month running period. A detailed calibration analysis comparing data from gamma-ray, x-ray and neutron sources to a GEANT4 Monte Carlo simulations reveals an efficiency for detection of neutron induced recoils of 94+/-2(stat.)+/-5(sys.)%. Software-based cuts, designed to remove non-nuclear recoil events, are shown to reject 60Co gamma-rays with a rejection factor of better than 8x10-6 for all energies above threshold. An unexpected event population has been discovered and is shown here to be due to the alpha-decay of 222Rn daughter nuclei that have attached to the central cathode. A limit on the flux of neutrons in the Boulby Underground Laboratory is derived from analysis of unshielded and shielded data.
Self-Regulation of Goals and Performance: Effects of Discrepancy Feedback, Regulatory Focus, and Self-Efficacy  [PDF]
Jessica M. Nicklin, Kevin J. Williams
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.23030
Abstract: We adopted a social cognitive approach of motivation (Bandura, 1986, 1989, 2002) to examine the influence of normative feedback and self-set goals on positive discrepancy creation and goal revision in the face of a novel task. The moderating effects of self-efficacy and regulatory focus were also examined. A laboratory study in-cluding 297 undergraduate students demonstrated that feedback, whether based on normative standards of performance or goal-performance discrepancies was a strong predictor of positive discrepancy creation and goal revision. Self-efficacy was also an independent predictor of goal revision, but regulatory focus was not. These findings have important practical implications for a variety of performance contexts (e.g., work, school, sports). Individuals will modify their goals based largely on feedback received (goal-performance discrepancies and normative standards); however, self-efficacy independently influences goal revision beyond the effects of feed-back. Other implications for research and practice are discussed.
The NAIAD experiment for WIMP searches at Boulby mine and recent results
B. Ahmed,G. J. Alner,H. Araujo,J. C. Barton,A. Bewick,M. J. Carson,D. Davidge,J. V. Dawson,T. Gamble,S. P. Hart,R. Hollingworth,A. S. Howard,W. G. Jones,M. K. Joshi,V. A. Kudryavtsev,T. B. Lawson,V. Lebedenko,M. J. Lehner,J. D. Lewin,P. K. Lightfoot,I. Liubarsky,R. Luscher,J. E. McMillan,B. Morgan,G. Nicklin,S. M. Paling,R. M. Preece,J. J. Quenby,J. W. Roberts,M. Robinson,N. J. T. Smith,P. F. Smith,N. J. C. Spooner,T. J. Sumner,D. R. Tovey
Physics , 2003, DOI: 10.1016/S0927-6505(03)00115-4
Abstract: The NAIAD experiment (NaI Advanced Detector) for WIMP dark matter searches at Boulby mine (UK) is described. The detector consists of an array of encapsulated and unencapsulated NaI(Tl) crystals with high light yield. Six crystals are collecting data at present. Data accumulated by four of them (10.6 kg x year exposure) have been used to set upper limits on the WIMP-nucleon spin-independent and WIMP-proton spin-dependent cross-sections. Pulse shape analysis has been applied to discriminate between nuclear recoils, as may be caused by WIMP interactions, and electron recoils due to gamma background. Various calibrations of crystals are presented.
The case for a directional dark matter detector and the status of current experimental efforts
S. Ahlen,N. Afshordi,J. B. R. Battat,J. Billard,N. Bozorgnia,S. Burgos,T. Caldwell,J. M. Carmona,S. Cebrian,P. Colas,T. Dafni,E. Daw,D. Dujmic,A. Dushkin,W. Fedus,E. Ferrer,D. Finkbeiner,P. H. Fisher,J. Forbes,T. Fusayasu,J. Galan,T. Gamble,C. Ghag,I. Giomataris,M. Gold,H. Gomez,M. E. Gomez,P. Gondolo,A. Green,C. Grignon,O. Guillaudin,C. Hagemann,K. Hattori,S. Henderson,N. Higashi,C. Ida,F. J. Iguaz,A. Inglis,I. G. Irastorza,S. Iwaki,A. Kaboth,S. Kabuki,J. Kadyk,N. Kallivayalil,H. Kubo,S. Kurosawa,V. A. Kudryavtsev,T. Lamy,R. Lanza,T. B. Lawson,A. Lee,E. R. Lee,T. Lin,D. Loomba,J. Lopez,G. Luzon,T. Manobu,J. Martoff,F. Mayet,B. Mccluskey,E. Miller,K. Miuchi,J. Monroe,B. Morgan,D. Muna,A. St. J. Murphy,T. Naka,K. Nakamura,M. Nakamura,T. Nakano,G. G. Nicklin,H. Nishimura,K. Niwa,S. M. Paling,J. Parker,A. Petkov,M. Pipe,K. Pushkin,M. Robinson,A. Rodriguez,J. Rodriguez-Quintero,T. Sahin,R. Sanderson,N. Sanghi,D. Santos,O. Sato,T. Sawano,G. Sciolla,H. Sekiya,T. R. Slatyer,D. P. Snowden-Ifft,N. J. C. Spooner,A. Sugiyama,A. Takada,M. Takahashi,A. Takeda,T. Tanimori,K. Taniue,A. Tomas,H. Tomita,K. Tsuchiya,J. Turk,E. Tziaferi,K. Ueno,S. Vahsen,R. Vanderspek,J. Vergados,J. A. Villar,H. Wellenstein,I. Wolfe,R. K. Yamamoto,H. Yegoryan
Physics , 2009, DOI: 10.1142/S0217751X10048172
Abstract: We present the case for a dark matter detector with directional sensitivity. This document was developed at the 2009 CYGNUS workshop on directional dark matter detection, and contains contributions from theorists and experimental groups in the field. We describe the need for a dark matter detector with directional sensitivity; each directional dark matter experiment presents their project's status; and we close with a feasibility study for scaling up to a one ton directional detector, which would cost around $150M.
A Characterization of the Members of a Subfamily of Power Series Distributions  [PDF]
G. Nanjundan
Applied Mathematics (AM) , 2011, DOI: 10.4236/am.2011.26099
Abstract: This paper discusses a characterization of the members of a subfamily of power series distributions when their probability generating functions satisfy the functional equation where a, b and c are constants and is the derivative of f.
Double Negative Left-Handed Metamaterials for Miniaturization of Rectangular Microstrip Antenna  [PDF]
G. Singh
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2010, DOI: 10.4236/jemaa.2010.26044
Abstract: In this paper, I have explored a significant concept for the miniaturization of microstrip patch antenna configuration by using the double negative (DNG) left-handed Metamaterials, which have dielectric permittivity and magnetic permeability both negative, simultaneously. It is achieved through the concept of phase-compensation by thin slab consist of the double positive (DPS) material, which have dielectric permittivity and magnetic permeability both positive, simultaneously and DNG metamaterials as a substrate of the microstrip patch antenna. By combining the DNG metamaterial slab with the slab made of DPS materials form a cavity resonator whose dispersion relation is independent of the sum of thickness of the slabs filling this cavity but it depends on the ratio of their thicknesses. This cavity constitutes by DPS and DNG material is used as substrate of the microstrip antennas and the DNG material slab is behave as phase compensator.
Dynamic and Configurational Approach to the Glass Transition by Nanoscale Cooperativity  [PDF]
G. Romeo
Open Journal of Biophysics (OJBIPHY) , 2012, DOI: 10.4236/ojbiphy.2012.23012
Abstract: Here we examine the findings obtained for disaccharide/water mixtures near glass transition that involves cooperative relaxation features on kinetic by viscosity and on thermodynamic behaviour by neutron scattering. Then to address cooperative phenomena that mitigate the Debye-Waller behaviour we invoke Adam-Gibbs’ idea of a cooperative rearranging region. Neutron results suggest that the excess mean square displacement behaves as free volume and is closely connected to an elementary step of the structural relaxation. Then viscosity data evidence a breakdown of the Einstein-Debye relation, decoupling attributed to the intermolecular cooperativity.
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