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Mecanismos del dolor neuropático: Del laboratorio a la clínica
Gómez-Barrios,Juan Vicente; Tortorici,Víctor;
Archivos Venezolanos de Farmacología y Terapéutica , 2009,
Abstract: neuropathic pain is a very complex clinical syndrome that results as a consequence of lesions or diseases affecting the somatosensory system. lesion of peripheral nerves, diabetes, herpes zoster virus, among others, are clinical entities that may cause neuropathic pain. neuropathic pain also reflects changes of the normal physiology of the nociceptive transmission neurons that may happen at peripheral and central levels. these mechanisms include the generation of ectopic discharges, genomic changes of the neurons involved, alterations of ionic channels and of the endogenous inhibition of pain, abnormal activation of the immune system as well as peripheral and central sensitization. this article review the molecular and neuroplastic mechanisms associated to neuropathic pain and discuss different experimental models for its study. the development of these models has been helpful to understand the subjacent mechanisms of this pathology, and has contributed to design new therapeutical approaches and the correct diagnose of the disease.
Mecanismos del dolor neuropático: Del laboratorio a la clínica
Juan Vicente Gómez-Barrios,Víctor Tortorici
Archivos Venezolanos de Farmacología y Terapéutica , 2009,
Abstract: El dolor neuropático es un síndrome de muy difícil manejo en la práctica clínica. Suele originarse a consecuencia de lesiones o enfermedades que afectan al sistema somatosensorial. Lesiones de nervios periféricos, la diabetes, el virus herpes zoster, entre otras, son ejemplos de entidades clínicas que causan dolor neuropático. Este tipo de dolor supone modificaciones de la fisiología normal de las neuronas que integran la vía de transmisión nociceptiva y que operan tanto a nivel periférico, como central. Entre estos mecanismos se incluye la generación de descargas ectópicas, cambios en el genoma de las neuronas involucradas, alteración de canales iónicos, pérdida de las actividades inhibitorias endógenas, activación anormal del sistema inmunitario y sensibilización tanto periférica, como central. Este artículo resume los mecanismos moleculares y neuroplásticos que ocurren en situaciones de dolor neuropático y revisa diferentes modelos experimentales para su estudio. El desarrollo de estos modelos ha permitido dilucidar los mecanismos subyacentes de esta patología, el dise o de nuevas estrategias terapéuticas y el diagnóstico acertado de la enfermedad. Neuropathic pain is a very complex clinical syndrome that results as a consequence of lesions or diseases affecting the somatosensory system. Lesion of peripheral nerves, diabetes, herpes zoster virus, among others, are clinical entities that may cause neuropathic pain. Neuropathic pain also reflects changes of the normal physiology of the nociceptive transmission neurons that may happen at peripheral and central levels. These mechanisms include the generation of ectopic discharges, genomic changes of the neurons involved, alterations of ionic channels and of the endogenous inhibition of pain, abnormal activation of the immune system as well as peripheral and central sensitization. This article review the molecular and neuroplastic mechanisms associated to neuropathic pain and discuss different experimental models for its study. The development of these models has been helpful to understand the subjacent mechanisms of this pathology, and has contributed to design new therapeutical approaches and the correct diagnose of the disease.
Reconstruyendo el objeto de la crítica: sobre las posibles confluencias entre psicología crítica y estudios sociales de la ciencia y la tecnología
JARABA-BARRIOS,BRUNO; MORA-GáMEZ,FREDY;
Revista Colombiana de Psicología , 2010,
Abstract: as methodological and conceptual resources that can support the purpose of critical psychology, this paper presents some general aspects of the social studies of science and technology (sts), which have opened promising avenues for addressing the mutual constitution of science and society. derived from the sts and related to possible research lines within critical psychology, three major methodological contributions are introduced: the principles of the so-called strong program of the sociology of scientific knowledge, the methodologies and guidelines of laboratory ethnographies, and the rhetorical analysis of scientific texts. additionally, some theoretical considerations provided by the sts are discussed in order to contribute to a creative rethinking of critical psychology.
Aspectos biométricos y dinámica reproductiva de la langosta espinosa, Panulirus argus, en áreas de pesca de la costa norte de la Península de Paria, estado Sucre, Venezuela
Gómez,Gabriel; Guzmán,Ramón; Barrios,Alexander;
Zootecnia Tropical , 2007,
Abstract: abstract the size structure of cephalothorax (lc) and the reproductive characteristics of the spiny lobster, panulirus argus, from the northern coast of paria peninsula were analyzed in order to facilitate the evaluation of the resource and to suggest management policies. in this sense, a total of 1270 animals were measured from those landed by the fleet of puerto santo, which were sampled monthly between november 2003 and april 2004. most of the animals in the sample (61%) were below the minimum legal size for lc (120 mm), being the average for females 109.4 mm and for males 121.1 mm, with significant differences between sexes (p<0.05). the general average size was 115.9 mm. a common length - weight regression equation was defined as: p = 0.0051*(lc)2.61. the proportion of sexes was significantly in favor of males (1:1.29) (p<0.001). the largest frequency of mature females was observed in november (40%) and december (27%), being the spermatophore plate the main reproductive indicator, since 71% of the mature females showed this property. the size at which 50% of females were mature was estimated in the interval 100-109.9 mm lc, and is still considered overestimated
RECONSTRUYENDO EL OBJETO DE LA CRíTICA: SOBRE LAS POSIBLES CONFLUENCIAS ENTRE PSICOLOGíA CRíTICA Y ESTUDIOS SOCIALES DE LA CIENCIA Y LA TECNOLOGíA
Bruno Jaraba-Barrios,Fredy Mora-Gámez
Revista Colombiana de Psicología , 2010,
Abstract: En su calidad de recursos metodológicos y conceptuales quepueden apoyar el propósito de la psicología crítica, se presentanalgunos aspectos generales de los estudios sociales dela ciencia y la tecnología (esct), los cuales han abierto promisoriassendas para el abordaje de la recíproca constituciónentre ciencia y sociedad. Las directrices del llamado programafuerte de sociología del conocimiento científico, los métodosy líneas de acción de las etnografías del laboratorio, y el abordajede análisis retórico a los textos científicos, son los tresprincipales modelos metodológicos derivados de los esct,expuestos y relacionados con las posibles líneas de investigacióndentro de la psicología crítica. Además de tales metodologías,los esct aportan ciertas consideraciones teóricasque son sometidas aquí a discusión con el fin de contribuir areplanteamientos creativos al interior de la psicología crítica
Vitamina B12: metabolismo y aspectos clínicos de su deficiencia
Forrellat Barrios,Mariela; Gómis Hernández,Irma; Gautier du Défaix Gómez,Hortensia;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 1999,
Abstract: a review is made on the metabolism of vitamin b12, its chemical structure, dietetic spurces and requirements in the different age groups, as well as on its absorption and distribution in the body. the metabolic function of cobalamins, their role in the etiology of megaloblastic anemias, the causes of the deficiency of this vitamin and its treatment are also explained in this paper
Vitamina B12: metabolismo y aspectos clínicos de su deficiencia Vitamin B12: metabolism and clinical aspects of its deficiency
Mariela Forrellat Barrios,Irma Gómis Hernández,Hortensia Gautier du Défaix Gómez
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 1999,
Abstract: Se hace una revisión sobre el metabolismo de la vitamina B12, su estructura química, fuentes dietéticas y requerimientos en los diferentes grupos de edades, así como su absorción y distribución en el organismo. Se explica además la función metabólica de las cobalaminas y su papel en la etiología de las anemias megaloblásticas, así como las causas de deficiencia de esta vitamina y su tratamiento A review is made on the metabolism of vitamin B12, its chemical structure, dietetic spurces and requirements in the different age groups, as well as on its absorption and distribution in the body. The metabolic function of cobalamins, their role in the etiology of megaloblastic anemias, the causes of the deficiency of this vitamin and its treatment are also explained in this paper
Quantum mechanical description of Stern-Gerlach experiments
G. Potel,F. Barranco,S. Cruz-Barrios,J. Gómez-Camacho
Physics , 2004, DOI: 10.1103/PhysRevA.71.052106
Abstract: The motion of neutral particles with magnetic moments in an inhomogeneous magnetic field is described in a quantum mechanical framework. The validity of the semi-classical approximations which are generally used to describe these phenomena is discussed. Approximate expressions for the evolution operator are derived and compared to the exact calculations. Focusing and spin-flip phenomena are predicted. The reliability of Stern-Gerlach experiments to measure spin projections is assessed in this framework.
Temperatura base y tasa de extensión foliar en frijol
Barrios-Gómez, Edwin J.;López-Casta?eda, Cándido;
Agrociencia , 2009,
Abstract: temperature is one of the most important abiotic factors that influence physiological and biochemical processes in the growth and development of plants. for bean (phaseolus vulgaris l.), it is postulated that the minimal temperature for growth is 10 °c. with this purpose, a foliar extension rate was calculated (fer, μm d-1) by measuring the central leaflet (mm) from the first trifoliated leaf at 18:00 and 06:00 h; in addition, the base temperature (tb , temperature at which growing stops) was calculated with the fer, in seedlings of commercial and creole bean varieties. therefore, two experiments were carried out in the open at the colegio de postgraduados, montecillo, méxico. experiment i (e-i) was from january 19th to february 8th and experiment ii (e-ii) from february 8th to the 27th in 2005. the seedlings were exposed to nocturnal environmental temperature (e-i, average maximum of 15.8 °c and average minimum of 3.9 °c; e-ii, average maximum of 16.0 °c and average minimum of 3.9 °c) from 18:00 to 06:00 h, with artificial light (800 μe m-2 s-1). the fer in e-i was 58.7 μm d-1 and 61.5 μm d-1 in e-ii, and the tb in e-i was 8.2 and 8.4 °c in e-ii, with an average value of 8.3 °c in both experiments. this value of the tb is useful for calculating the degree-day or development units of heat in mexican genotypes of bean.
El valor de la marca desde la perspectiva del consumidor. Estudio empírico sobre preferencia, lealtad y experiencia de marca en procesos de alto y bajo involucramiento de compra
González Hernández, Eva M.;Orozco Gómez, Ma. Margarita;Barrios, Alejandra de la Paz;
Contaduría y administración , 2011,
Abstract: the main objective of this study is to understand the relationships among a set of dimensions proposed in the customer-based brand equity model (cbbe): knowledge, attitudinal and brand relationship and brand preference under different involvement purchase process. specifically, the main purpose of this study is to understand the principal relationships between: a) brand preference and customer attributes evaluations; b) brand preference and brand loyalty; and finally, c) brand preference and brand experience. in order to understand the different involvement process three product categories were selected: laptops (high-involvement), cellular phones (medium-involvement) and soft drinks (low-involvement). a survey was applied to 341 undergraduate business school students. the study compared the top five brands in each category. the results provide evidence that the level of involvement purchase process is a relevant factor in understanding consumer evaluations, brand preference, brand attitude, attitudinal loyalty and brand experience.
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