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Search Results: 1 - 10 of 189829 matches for " G Kahsay "
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Quality Assessment of the Commonly Prescribed Antimicrobial Drug, Ciprofloxacin Tablets, Marketed in Tigray, Ethiopia
G Kahsay, A G/Egziabher
Momona Ethiopian Journal of Science , 2010,
Abstract: An attempt was made to assess the quality and compare the physicochemical equivalence of six brands of ciprofloxacin tablets marketed in Tigray, Ethiopia. Six brands of ciprofloxacin tablets were used in the study. Identity, weight uniformity test, disintegration test, dissolution test and assay for the content of active ingredients were performed using the methods described in the British Pharmacopoeia. All the samples passed the identity, disintegration, and dissolution tests but Ciflox failed to release 80% of the drug content within 30 minutes as stipulated in the pharmacopoeia. This product therefore does not comply with the BP 2004 dissolution tolerance limits. All of the brands examined pass the assay for content of active ingredient. This work revealed that the six brands included in the study complied with the physicochemical quality parameters except Ciflox which failed to meet the pharmacopoeial specification for dissolution test. Nevertheless the six brands showed that there is significant difference in the drug release in vitro (p<0.05). To justify the specification limits of the in vitro dissolution test, an attempt should be made to establish a meaningful correlation between in vitro release characteristics and in vivo bioavailability parameters.
Coexistence of Superconductivity and Ferromagnetism in Superconducting HoMo6S8  [PDF]
Tadesse Desta, Gebregziabher Kahsay
World Journal of Condensed Matter Physics (WJCMP) , 2015, DOI: 10.4236/wjcmp.2015.51004
Abstract: This work focuses on the theoretical investigation of the coexistence of superconductivity and ferromagnetism in the superconducting HoMo6S8. By developing a model Hamiltonian for the system and using the Green’s function formalism and equation of motion method, we have obtained expressions for superconducting transition temperature (Tc), magnetic order temperature (Tm), superconductivity order parameter (D) and magnetic order parameter (η). By employing the experimental and theoretical values of the parameters in the obtained expressions, phase diagrams of energy gap parameter versus transition temperature, superconducting transition temperature versus magnetic order parameter and magnetic order temperature versus magnetic order parameter are plotted separately. By combining the phase diagrams of superconducting transition temperature versus magnetic order parameter and magnetic order temperature versus magnetic order parameter, we have demonstrated the possible coexistence of superconductivity and ferromagnetism in superconducting HoMo6S8.<
Study of Upper Critical Magnetic Field of Superconducting HoMo6Se8  [PDF]
Tadesse Desta, Pooran Singh, Gebregziabher Kahsay
World Journal of Condensed Matter Physics (WJCMP) , 2015, DOI: 10.4236/wjcmp.2015.53013
Abstract: This work focuses on the study of mathematical aspects of upper critical magnetic field of superconducting HoMo6Se8. At zero external magnetic field, HoMo6Se8 was found to undergo a transition from the normal state to the superconducting state at 5.6 K and returned to a normal but magnetically ordered state between the temperature range of 0.3 K and 0.53 K. The main objective of this work is to show the temperature dependence of the upper critical magnetic field of superconducting HoMo6Se8 by using the Ginzburg-Landau (GL) phenomenological Equation. We found the direct relationship between the GL coherence length (ξGL) and penetration depth (λGL) with temperature. From the GL Equations and the results obtained for the GL coherence length, the expression for upper critical magnetic field (Hc2) is obtained for the superconducting HoMo6Se8. The result is plotted as a function of temperature. The graph shows the linear dependence of upper critical magnetic field (Hc2) with temperature (T) and our finding is in agreement with experimental observations.
Strategies for implementing genomic selection in family-based aquaculture breeding schemes: double haploid sib test populations
Kahsay G Nirea, Anna K Sonesson, John A Woolliams, Theo HE Meuwissen
Genetics Selection Evolution , 2012, DOI: 10.1186/1297-9686-44-30
Abstract: Six alternative breeding schemes were simulated in which the design of the test population was varied: test sibs inherited maternal (Mat), paternal (Pat) or a mixture of maternal and paternal (MatPat) double haploid genomes or test sibs were obtained by maximum coancestry mating (MaxC), minimum coancestry mating (MinC), or random (RAND) mating. Three thousand test sibs and 3000 candidate sibs were genotyped. The test sibs were recorded for a trait that could not be measured on the candidates and were used to estimate SNP effects. Selection was done by truncation on genome-wide estimated breeding values and 100 individuals were selected as parents each generation, equally divided between both sexes.Results showed a 7 to 19% increase in selection accuracy and a 6 to 22% increase in genetic gain in the MatPat scheme compared to the RAND scheme. These increases were greater with lower heritabilities. Among all other scenarios, i.e. Mat, Pat, MaxC, and MinC, no substantial differences in selection accuracy and genetic gain were observed.In conclusion, a test population designed with a mixture of paternal and maternal double haploids, i.e. the MatPat scheme, increases substantially the accuracy of selection and genetic gain. This will be particularly interesting for traits that cannot be recorded on the selection candidates and require the use of sib tests, such as disease resistance and meat quality.In traditional aquaculture breeding schemes, selection for traits that cannot be measured on the selection candidates (e.g. disease resistance and fillet quality) is based on a performance test of sibs of the candidates, i.e. information on test sibs is used to calculate breeding values for the selection of parents. This is due to the fact that measuring meat quality traits requires killing of the fish and fish that have been challenge-tested for disease resistance cannot be used as breeding stock. However, with a sib test, only 50% of the total genetic variance of the candid
Effect of non-random mating on genomic and BLUP selection schemes
Kahsay G Nirea, Anna K Sonesson, John A Woolliams, Theo HE Meuwissen
Genetics Selection Evolution , 2012, DOI: 10.1186/1297-9686-44-11
Abstract: We studied the effect of mating designs, random, minimum coancestry and minimum covariance of ancestral contributions on rate of inbreeding and genetic gain for schemes with different information sources, i.e. sib test or own performance records, different genetic evaluation methods, i.e. BLUP or genomic selection, and different family structures, i.e. factorial or pair-wise.Results showed that substantial differences in rates of inbreeding due to mating design were present under schemes with a pair-wise family structure, for which minimum coancestry turned out to be more effective to generate lower rates of inbreeding. Specifically, substantial reductions in rates of inbreeding were observed in schemes using sib test records and BLUP evaluation. However, with a factorial family structure, differences in rates of inbreeding due mating designs were minor. Moreover, non-random mating had only a small effect in breeding schemes that used genomic evaluation, regardless of the information source.It was concluded that minimum coancestry remains an efficient mating design when BLUP is used for genetic evaluation or when the size of the population is small, whereas the effect of non-random mating is smaller in schemes using genomic evaluation.Selection and parent mating patterns are the two major components of a breeding program and must be optimised with respect to genetic gain (ΔG) and rate of inbreeding (ΔF). In the literature, several selection and mating designs have been reported that aim at reaching a high ΔG and/or low ΔF [1,2], since a high ΔF represents a risk for the long-term success of breeding programs. While there is a consensus on selection procedures [3,4], many mating designs have been developed, mostly aimed at avoiding the mating of parents that are more related than average [1,5-7].Factorial mating consists in producing half sibs from male and female parents at the expense of full sibs, while preserving offspring numbers per parent [8]; with minimum coa
Why People Strive to Get Rid of One’s Own Gene from the World? A Psychological Analysis upon Terrorism  [PDF]
Kahsay Weldeslasie Hailemariam
Open Access Library Journal (OALib Journal) , 2016, DOI: 10.4236/oalib.1102248
Abstract: Everybody remembers the April 19/2015 holocaust action committed by the ISIS terrorist group upon the Ethiopian Emigrants in the Libyan port. It was very immoral and devil action to behead and shoot people for the reason they do not know. In addition to that, it was the recent events to remember back about the massacre actions committed upon the France journalists and college students in Kenya who killed by the terrorist groups. For this inhuman and brutal action of the terrorist group, I initiated to make psychological analysis behind their behavior. I was also very eager to read different research findings about the true origin of human difference and why people strive to eliminate their own gene from the earth attributing human made differences. These and other questions are triggered me to make this psychological analysis. In the near future I will come up with detail investigation upon psychological view of terrorism.
Antibiotic Resistant Bacteria from Treated and Untreated Hospital Wastewater at Ayder Referral Hospital, Mekelle, North Ethiopia  [PDF]
Tsegahun Asfaw, Letemichael Negash, Amlsha Kahsay, Yemane Weldu
Advances in Microbiology (AiM) , 2017, DOI: 10.4236/aim.2017.712067
Abstract: The widespread emergence of antibiotic resistance among bacterial pathogens has become one of the most serious challenges in Ethiopia. This study determined the prevalence and drug resistance patterns of bacterial pathogens isolated from treated and untreated wastewater released from Ayder Referral Hospital in Northern Ethiopia. A cross sectional study design was conducted from September-December, 2015 in wastewater released from Ayder referral hospital. A total of 40 composite samples were aseptically collected, transported and processed for enumeration of indicator organisms, bacteriological identification and susceptibility testing following standard procedure. Data obtained were entered and analyzed using SPSS version 20. Mean heterotrophic plate count, total coliform count, fecal coliform count and E. coli count were found to be 1.6 × 106 CFU/mL, 2.2 × 106 CFU/100 mL, 2.0 × 105 CFU/100 mL and 1.1 × 104 CFU/100 mL from treated wastewater respectively. Among the total samples 134 bacterial isolates were detected and [84 (62.7%)] were from untreated wastewater and [50 (37.3%)] were from treated wastewater. The most frequently isolated bacteria from untreated wastewater samples was Klebsiella spp [14 (16.7%)] followed by S. aureus [13 (15.5%)] and P. aeruginosa [12 (14.3%)], similarly in treated wastewater samples Klebsiella spp [10 (20%)], P. aeruginosa [8 (16%)] and S. aureus [8 (16%)] were frequently detected. The overall multi-drug resistance (MDR) in this study was [79/134 (79.1%)]. MDR from untreated wastewater sample was [64/84 (76.2%)] while from treated wastewater sample was [42/50 (84%)] and shows significant difference with (COR: 1.64, 95% CI: 1.15 - 3.29, P: 0.001). It is concluded that treated hospital wastewater contains large numbers of antibiotic resistant bacteria. Therefore, there should be continuous monitoring and evaluation of the effluent quality of the ponds and chlorination of the final effluent should be developed.
Transcriptional Profiling of Mouse Uterus at Pre-Implantation Stage under VEGF Repression
Yan Ji, Xiaodan Lu, Qingping Zhong, Peng Liu, Yao An, Yuntao Zhang, Shujie Zhang, Ruirui Jia, Isaias G. Tesfamariam, Abraha G. Kahsay, Luqing Zhang, Wensheng Zhu, Yaowu Zheng
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0057287
Abstract: Uterus development during pre-implantation stage affects implantation process and embryo growth. Aberrant uterus development is associated with many human reproductive diseases. Among the factors regulating uterus development, vascular remodeling promoters are critical for uterus function and fertility. Vascular endothelial growth factor (VEGF), as one of the major members, has been found to be important in endothelial cell growth and blood vessel development, as well as in non-endothelial cells. VEGF mediation in reproduction has been broadly studied, but VEGF-induced transcriptional machinery during implantation window has not been systematically studied. In this study, a genetically repressed VEGF mouse model was used to analyze uterus transcriptome at gestation 2.5 (G2.5) by Solexa/Illumina’s digital gene expression (DGE) system. A number of 831 uterus-specific and 2398 VEGF-regulated genes were identified. Gene ontology (GO) analysis indicated that genes actively involved in uterus development were members of collagen biosynthesis, cell proliferation and cell apoptosis. Uterus-specific genes were enriched in activities of phosphatidyl inositol phosphate kinase, histone H3-K36 demethylation and protein acetylation. Among VEGF-regulated genes, up-regulated were associated with RNA polymerase III activity while down-regulated were strongly related with muscle development. Comparable numbers of antisense transcripts were identified. Expression levels of the antisense transcripts were found tightly correlated with their sense expression levels, an indication of possibly non-specific transcripts generated around the active promoters and enhancers. The antisense transcripts with exceptionally high or low expression levels and the antisense transcripts under VEGF regulation were also identified. These transcripts may be important candidates in regulation of uterus development. This study provides a global survey on genes and antisense transcripts regulated by VEGF in the pre-implantation stage. Results will contribute to further study the candidate genes and pathways in regulating implantation process and related diseases.
Immune restoration disease and changes in CD4+ T-cell count in HIV- infected patients during highly active antiretroviral therapy at Zewditu memorial hospital, Addis Ababa, Ethiopia
Kahsay Huruy, Afework Kassu, Andargachew Mulu, Yemataw Wondie
AIDS Research and Therapy , 2010, DOI: 10.1186/1742-6405-7-46
Abstract: A retrospective study of all HIV- infected patients starting HAART between September 1, 2005 and August 31, 2006 at Zewditu memorial hospital HIV clinic, Addis Ababa, Ethiopia was conducted. All laboratory and clinical data were extracted from computerized clinic records and patient charts.A total of 1166 HIV- infected patients with mean ± SD age of 36 ± 9.3 years were on HAART. IRD was identified in 170 (14.6%) patients. OIs diagnosed in the IRD patients were tuberculosis (66.5%, 113/170), toxoplasmosis (12.9%, 22/170), herpes zoster rash (12.9%, 22/170), Pneumocystis jirovecii pneumonia (4.1%, 7/170), and cryptococcosis (3.5%, 6/170). Of the 170 patients with IRD, 124 (72.9%) patients developed IRD within the first 3 months of HAART initiation. Low baseline CD4+ T-cell count (odds ratio [OR], 3.16, 95% confidence interval [CI], 2.19-4.58) and baseline extra pulmonary tuberculosis (OR, 7.7, 95% CI, 3.36-17.65) were associated with development of IRD. Twenty nine (17.1%) of the IRD patients needed to use systemic anti-inflammatory treatment where as 19(11.2%) patients required hospitalization associated to the IRD occurrence. There was a total of 8 (4.7%) deaths attributable to IRD.The proportion and risk factors of IRD and the pattern of OIs mirrored reports from other countries. Close monitoring of patients during the first three months of HAART initiation is important to minimize clinical deterioration related to IRD.Highly active antiretroviral therapy (HAART) improves the immune function and decreases morbidity, mortality and opportunistic infections (OIs) in HIV-infected patients [1,2]. However, the introduction of HAART presents new clinical problems, including adverse drug effects, and the event of diseases that are as the result of the restoration of the immune response. When clinical deterioration occurs during immune recovery and is associated with the host inflammatory response to pathogens, the clinical presentation has been described as immune restorat
Kalayou Kidanu Berhe*, Asrat Demissie , Alemayoh Bayeray Kahsay and Haftu Berhe Gebru
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: Background: Diabetes is a group of metabolic disorders that affect the body’s ability to process and use sugar (glucose) for energy. Type 2 diabetes mellitus resulting from the combination of resistance to insulin action and inadequate insulin secretion. The success of long-term maintenance therapy for diabetes depends largely on the patients’ adherence with self-care practices.Objective: The aim of this study was to assess diabetes self-care practices and associated factors among type 2 diabetic patients in Tikur Anbessa Specialized Hospital, Ethiopia. Method: institutional based cross sectional study was employed and 320 study subjects were selected using systematic random sampling technique. And the data was collected using interviewer administered structured questionnaire; data was analyzed and cleaned using SPSS version 16. Scoring method was employed to classify patients’ self-care practice level as adhered or not adhered to self-care practices.Results: Of all respondents 167(52.2%) female. Mean age of the respondents was 55.03±10.7 years with minimum age of 30 and maximum age of 85. The mean duration of diabetes was 12.3±7.6years with minimum of 6 months and maximum of 41 years. Respondents’ self-care practices were, the majority 270 (84.4%) respondents were not adhered to Self-Monitoring of blood glucose practice. A total of 311(97.2%) respondents were adhered to anti-diabetic medication. The majority 252 (78.8%) respondents were not adhered to recommended diet management practices. There was a significant association between Level of education, monthly income, Presence of glucometer at home, marital status, diabetic complication, age and gender and self-care practices. But there was no significant association between duration of diabetes, Occupation and family history of diabetic and self-care practices.Conclusion: findings of this study indicated that majority patients had poor adherence to self-care practices especially in self-monitoring of Blood Glucose and diet management practices.
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