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Search Results: 1 - 10 of 24109 matches for " Fusheng Jiang "
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Modulation of Anopheles stephensi Gene Expression by Nitroquine, an Antimalarial Drug against Plasmodium yoelii Infection in the Mosquito
Jian Zhang, Shuguang Zhang, Yanyan Wang, Wenyue Xu, Jingru Zhang, Haobo Jiang, Fusheng Huang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089473
Abstract: Background Antimalarial drugs may impact mosquito’s defense against Plasmodium parasites. Our previous study showed nitroquine significantly reduced infection of Anopheles stephensi by Plasmodium yoelii, but the underlying mechanism remains unclear. In order to understand how transmission capacity of An. stephensi was affected by nitroquine, we explored the transcriptome of adult females after different treatments, examined changes in gene expression profiles, and identified transcripts affected by the drug and parasite. Methodology/Principal Findings We extended massively parallel sequencing and data analysis (including gene discovery, expression profiling, and function prediction) to An. stephensi before and after Plasmodium infection with or without nitroquine treatment. Using numbers of reads assembled into specific contigs to calculate relative abundances (RAs), we categorized the assembled contigs into four groups according to the differences in RA values infection induced, infection suppressed, drug induced, and drug suppressed. We found both nitroquine in the blood meal and Plasmodium infection altered transcription of mosquito genes implicated in diverse processes, including pathogen recognition, signal transduction, prophenoloxidase activation, cytoskeleton assembling, cell adhesion, and oxidative stress. The differential gene expression may have promoted certain defense responses of An. stephensi against the parasite and decreased its infectivity. Conclusions/Significance Our study indicated that nitroquine may regulate several immune mechanisms at the level of gene transcription in the mosquito against Plasmodium infection. This highlights the need for better understanding of antimalarial drug’s impact on parasite survival and transmission. In addition, our data largely enriched the existing sequence information of An. stephensi, an epidemiologically important vector species.
Antioxidant, Antityrosinase and Antitumor Activity Comparison: The Potential Utilization of Fibrous Root Part of Bletilla striata (Thunb.) Reichb.f.
Fusheng Jiang, Weiping Li, Yanfen Huang, Yitao Chen, Bo Jin, Nipi Chen, Zhishan Ding, Xinghong Ding
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058004
Abstract: This study was carried out to evaluate the utilization probability of the fibrous root part (FRP) of Bletilla striata, which was usually discarded and harvesting pseudobulb part (PSP). The chemical composition, total phenolic content, DPPH radical scavenging activity, Ferric-reducing antioxidant power and tyrosinase inhibition activity were compared between FRP and PSP. Antioxidant and pro-oxidant effect as well as antitumor effect of the extract of FRP and PSP were analyzed by in vitro cell system as well. Thin layer chromatography and high performance liquid chromatography analysis indicated that the chemical compositions in the two parts were similar, but the content in FRP was much higher than PSP. Meanwhile, the FRP extracts showed higher phenolic content, stronger DPPH scavenging activity, Ferric-reducing antioxidant capacity and tyrosinase inhibition activity. Sub-fraction analysis revealed that the distribution characteristic of phenolic components and other active constituents in FRP and PSP were consistent, and mainly deposited in chloroform and acetoacetate fractions. Especially, the chloroform sub-fraction (sch) of FRP showed extraordinary DPPH scavenging activity and tyrosinase inhibition activity, with IC50 0.848 mg/L and 4.3 mg/L, respectively. Besides, tyrosinase inhibition activity was even stronger than the positive compound arbutin (31.8 mg/L). Moreover, In vitro cell system analysis confirmed that FRP extract exerts comparable activity with PSP, especially, the sub-fraction sch of FRP showed better antioxidant activity at low dosage and stronger per-oxidant activity at high dosage, and both sch of FRP and PSP can dose-dependent induce HepG2 cells apoptosis, which implied tumor therapeutic effect. Considering that an additional 0.3 kg FRP would be obtained when producing 1.0 kg PSP, our work demonstrated that FRP is very potential to be used together with PSP.
Preparation and Properties of Polyester Based Nanocomposites with Good Air-tightness
Fusheng Luo
International Journal of Chemistry , 2009, DOI: 10.5539/ijc.v1n1p82
Abstract: The permeability of polymer is determined by its chain configuration, phase morphology and the interaction with the penetrant. Based on these principles, the permeability of the polyester of poly (ethylene terephthalate)(PET) is enhanced through different modifiers in order to apply it to barrier packing bottle. In this paper, poly (m-xylylene adipamide-terephthalyl amide) (MXD6T) and nanometer silicon dioxide (SiO2) nanocomposite with SiO2 load from 5% to 20% (by mass) is prepared and used to improve the barrier property of polyester bottle materials. In preparing MXD6T-SiO2 (NMXD6T), silica is in-situ polymerized with hexane diacid, terephthalic acid (TPA), alkyl and aromatic diamine. The different molar ratio of hexane diacid to terephthalic acid with the same molar diamine is designed to give the composites with different viscosity, thermal performance and the barrier properties. The 3-8 times of enhanced permeability of these polyester matrix nanocomposites with this NMXD6T to pure polyester resins are reported. The relationship of NMXD6T’s configuration and the permeability properties of polyester nanocomposites are characterized by techniques of the dynamic scanning calorimeter (DSC), FT Infrared, and Transmission Electronic Microscopy (TEM). DSC shows that NMXD6T is totally amorphous. FTIR shows the existence of silicon-oxygen bond formed in the nanocomposite, and TEM indicates an average size from 30nm to 100nm of SiO2 particles being phase separated from MXD6T matrix, while well bonded to the polyester chains. It is concluded that the NMXD6T-PET nanocomposites may be one of the best way to enhance the barrier properties of polyesters for their packing application.
The impact of HBV/HCV coinfection on HBV DNA levels and the severity of liver diseases in HBV-infected patients undergoing hemodialysis
ZHU Fusheng
Journal of Clinical Hepatology , 2013,
Abstract: ObjectiveTo investigate the impact of hepatitis B virus (HBV)/hepatitis C virus (HCV) coinfection on HBV DNA levels and the severity of liver diseases in HBV-infected patients undergoing hemodialysis. MethodsA total of 178 hemodialysis patients showing positivity for HBV infection were enrolled for study and divided into two groups according to co- or monoinfection status. Eighty-six patients tested positive for both HBV and HCV (HBV+/HCV+ group), and 92 patients tested positive for HBV and negative for HCV (HBV+/HCV- group). HBV DNA levels and blood biochemical parameters were measured. The significance of inter-group differences was assessed by t-test (normally distributed data) or Mann-Whitney U test (non-normally distributed data). Multivariate logistic stepwise regression was use to evaluate the association of parameters with HCV infection. ResultsThe two groups showed similar levels of serum aminotransferase (P>0.05). In contrast, the HBV+/HCV+ patients showed significantly lower levels of serum HBV DNA than the HBV+/HCV- patients [(0.42±0.10) vs. (1.25±0.28)log scale/ml, P<0.01]. HCV infection was found to be independently associated with lower HBV DNA levels (OR=0.316, 95% CI: 0.236-0.865, P<0.01). ConclusionIn hemodialysis patients, HBV/HCV coinfection is associated with lower HBV DNA levels but not more severe liver diseases.
Influence of shelterbelts structure on snow distribution pattern in shelternets in Northeast China
东北地区农田防护林结构对林网内积雪分布格局的影响

FAN Zhiping,ZENG Dehui,CHEN Fusheng,ZHU Jiaojun,JIANG Fengqi,SHA Jianguo,
范志平
,曾德慧

应用生态学报 , 2004,
Abstract: The amount of snow that falls in farmland during winter in Northeast China is the important source of soil water in farmland, so the influence of shelterbelt structure on snow distribution pattern is the key problem in order to adjust structure of shelterbelts according to porosity in management practice. Based on snow depths in shelternets composed of shelterbelts with three levels of porosity, which were shelternet No. 1, shelternet No. 2, and shelternet No. 3, the snow distribution patterns in farmland were studied. The results showed that the structure of shelternet had great influence on snow distribution in farmland. With different levels of porosities, spatial pattern of snow distribution were obviously different in three shelternets. The more variant in porosity, the more obvious difference in snow distribution pattern, and the best uniformity of snow distribution appeared in shelternet with porosity of phi 2w = 0.579, phi 2s = 0.268, in which snow depth in farmland was relative even and the variability of snow depth was the least. Consequently, the relationship of porosity of shelterbelt with snow distribution pattern could be used to guide structure adjustment and optimization management of shelterbelts.
Micromagnetic Investigation of Microwave Permeability of Magnetic Artificial Spin Ice  [PDF]
Fusheng Ma, Yuping Wu, Baoyu Zong
Materials Sciences and Applications (MSA) , 2014, DOI: 10.4236/msa.2014.514100
Abstract: The complex permeability of the artificial spin ice array at different magnetic states is calculated using the micromagnetic simulation method. It is observed that the permeability spectra are dependent on the magnetization distributions of the array. The dependence of the permeability spectrum on the applied magnetic field strength and on the spacing gap between the neighboring elements is also investigated. Depending on the initial magnetization saturating direction, the permeability spectrum exhibits different sensitivity to the strength of the external applied magnetic field and to the spacing distance between the comprising elements of the artificial spin ice array.
Characterization on Specific Characteristics of Sericin Silkworm, and Physiological Genetics Analysis  [PDF]
Bing Li, Chongjun Ye, Fusheng Chen
Journal of Biosciences and Medicines (JBM) , 2017, DOI: 10.4236/jbm.2017.511001
Abstract:
Sericin silkworm is a kind of gene mutant silkworm that can only synthesis and secrete sericin protein instead of fibroin protein. In this study, according to the knowledge of physiology and heredity, the reasons of this special phenomenon for the sericin silkworm were analyzed in order to explore the utilization clues in the production of natural sericin and product development.
Monte Carlo Numerical Models for Nuclear Logging Applications
Fusheng Li,Xiaogang Han
Journal of Systemics, Cybernetics and Informatics , 2012,
Abstract: Nuclear logging is one of most important logging services provided by many oil service companies. The main parameters of interest are formation porosity, bulk density, and natural radiation. Other services are also provided from using complex nuclear logging tools, such as formation lithology/mineralogy, etc. Some parameters can be measured by using neutron logging tools and some can only be measured by using a gamma ray tool. To understand the response of nuclear logging tools, the neutron transport/diffusion theory and photon diffusion theory are needed. Unfortunately, for most cases there are no analytical answers if complex tool geometry is involved. For many years, Monte Carlo numerical models have been used by nuclear scientists in the well logging industry to address these challenges. The models have been widely employed in the optimization of nuclear logging tool design, and the development of interpretation methods for nuclear logs. They have also been used to predict the response of nuclear logging systems for forward simulation problems. In this case, the system parameters including geometry, materials and nuclear sources, etc., are pre-defined and the transportation and interactions of nuclear particles (such as neutrons, photons and/or electrons) in the regions of interest are simulated according to detailed nuclear physics theory and their nuclear cross-section data (probability of interacting). Then the deposited energies of particles entering the detectors are recorded and tallied and the tool responses to such a scenario are generated. A general-purpose code named Monte Carlo N– Particle (MCNP) has been the industry-standard for some time. In this paper, we briefly introduce the fundamental principles of Monte Carlo numerical modeling and review the physics of MCNP. Some of the latest developments of Monte Carlo Models are also reviewed. A variety of examples are presented to illustrate the uses of Monte Carlo numerical models for the development of major nuclear logging tools, including compensated neutron porosity, compensated density, natural gamma ray and a nuclear geo-mechanical tool.
The Game Analysis of Manufacturers’ Political Connections on Product Safety in Supply Chain: Evidence from China
Zhao Na,Wang Fusheng
Discrete Dynamics in Nature and Society , 2013, DOI: 10.1155/2013/695384
Abstract: This paper studied the political connections on product safety in supply chain. In market economy, information asymmetry exists throughout the entirety of supply chains that ought to ensure product safety. Due to the existence of game relations between the government and manufacturers in the aspects of product safety and regulation, the formation of market equilibrium depends on political connections between the government and manufacturers. Based on study and analyses of a static game model and a dynamic game model, this paper reveals that governments and manufacturers must use positive political connections to achieve product protection and supervision of safety throughout the supply chain. On the other hand, negative political connections lead to losses of both governmental credibility and social profits. This study indicates that inherent mechanism of political connections exists in the supply chain; it will help to enrich the theory of supply chain. 1. Introduction Product safety is an issue of utmost importance all around the world and it is related to the supply chain in its entirety. The situation brings some new problems to traditional supply chain [1]. As the world’s second largest economy, with frequent international business and a large population, China considers product safety a top priority. Product safety affects not only national credibility and the credibility of companies but also the important basic commitments of a nation and its enterprises for users. However, because of information asymmetry, product users require product manufacturers to be highly disciplined and require strict supervision and management of government departments. “Product” refers to everything available in the market that can meet the specific needs of people, including in-kind, service assurance, ideas, and other forms. “Security” refers to the conditions that prevent death, injury, occupational diseases, equipment damage, property damage, and environmental damage. Ensuring the safety of products first depends on sound laws and regulations. In addition, government departments must work with the law, enforce the law, properly regulate rules, and abandon favoritism or irregularities. Second, the manufacturers should develop and enforce their own techniques for ensuring production quality, sustaining the self-regulation of the industry, and maintaining the professional ethics of the employed. In order to strengthen the safety supervision of special equipment, prevent accidents, ensure the safety of people’s lives and property, and promote economic development,
On fermionic representation of the framed topological vertex
Fusheng Deng,Jian Zhou
Mathematics , 2011,
Abstract: The Gromov-Witten invariants of \mathbb{C}^3 with branes is encoded in the topological vertex which has a very complicated combinatorial expression. A simple formula for the topological vertex was proposed by Aganagic et al in the fermionic picture. We will propose a similar formula for the framed topological vertex and prove it in the case when there are one or two branes.
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