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Investigation of Infrasound Radiated from Highway Bridge Owing to Moving Truck  [PDF]
Saiji Fukada, Hiroyuki Okada, Hirokazu Hama, Takeshi Mitsuda
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.412155

Several complaints arose from houses near an object bridge about rattling sounds caused by infrasound, a low-frequency noise in the 0 - 20 Hz frequency range. In Japan, conventional trucks with a rear leaf suspension have vibration frequencies of about 3.0 Hz; furthermore, their tire spring vibration frequency is 10 - 20 Hz. Infrasound is radiated from the bridge owing to the truck’s suspension spring vibration and/or tire spring vibration. In this study, the bridge vibrations were investigated using test trucks or conventional trucks to determine the cause of rattling sounds. It was found that the truck’s spring vibration caused excessive bending vibration in the object bridge; this in turn was transmitted to nearby houses as infrasound. Various preventive measures for infrasound were then considered, and their effectiveness was investigated through a simulation of the dynamic response using a running truck. The difference between each measure’s effectiveness as obtained by a comparison with each simulation’s result provided a clear picture about the infrasound reduction methods in consideration of both construction cost and working difficulty.

Correction: The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways
Toshiyuki Fukada , Contributed equally to this work with: Toshiyuki Fukada, Natacha Civic, Tatsuya Furuichi ?
PLOS ONE , 2008, DOI: 10.1371/annotation/a6c35a12-e8eb-43a0-9d00-5078fa6da1bb
Time-of-Day-Dependent Enhancement of Adult Neurogenesis in the Hippocampus
So-ichi Tamai, Kamon Sanada, Yoshitaka Fukada
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003835
Abstract: Background Adult neurogenesis occurs in specific regions of the mammalian brain such as the dentate gyrus of the hippocampus. In the neurogenic region, neural progenitor cells continuously divide and give birth to new neurons. Although biological properties of neurons and glia in the hippocampus have been demonstrated to fluctuate depending on specific times of the day, it is unclear if neural progenitors and neurogenesis in the adult brain are temporally controlled within the day. Methodology/Principal Findings Here we demonstrate that in the dentate gyrus of the adult mouse hippocampus, the number of M-phase cells shows a day/night variation throughout the day, with a significant increase during the nighttime. The M-phase cell number is constant throughout the day in the subventricular zone of the forebrain, another site of adult neurogenesis, indicating the daily rhythm of progenitor mitosis is region-specific. Importantly, the nighttime enhancement of hippocampal progenitor mitosis is accompanied by a nighttime increase of newborn neurons. Conclusions/Significance These results indicate that neurogenesis in the adult hippocampus occurs in a time-of-day-dependent fashion, which may dictate daily modifications of dentate gyrus physiology.
A causal relationship between right paraduodenal hernia and superior mesenteric artery syndrome: a case report
Tadaomi Fukada, Hideyasu Mukai, Fumihiko Shimamura, Takeshi Furukawa, Masaru Miyazaki
Journal of Medical Case Reports , 2010, DOI: 10.1186/1752-1947-4-159
Abstract: A 46-year-old Japanese man who had never undergone laparotomy was admitted to our hospital due to an acute abdomen. An enhanced multidetector-row computed tomography scan of our patient showed a cluster of small intestines with ischemic change in his right lateral abdominal cavity. Emergency surgery was subsequently performed, and strangulation of the distal jejunum along with incidental right paraduodenal hernia was found. His necrotic ileum was resected, and the jejunum encapsulated by the sac was repaired manually without reduction.Three days after the operation, however, our patient developed vomiting. An upper gastrointestinal series revealed a straight line cut-off sign on the third portion of his duodenum. A second enhanced multidetector-row computed tomography scan showed that he had a lower aortomesenteric angle and a shorter aortomesenteric distance compared to his condition before his right paraduodenal hernia was surgically repaired. We strongly suspected that the right paraduodenal hernia repair may have induced superior mesenteric artery syndrome. On the 21st post-operative day, duodenojejunostomy was performed because conservative management had failed.In this case, enhanced multidetector-row computed tomography, which permits reconstructed multiplanar imaging, helped us to visually identify these diseases easily. It is important to recognize that surgical repair of a right paraduodenal hernia may cause superior mesenteric artery syndrome.Paraduodenal hernia was first described in 1857, while superior mesenteric artery syndrome (SMAS) was first defined in 1861 [1]. While the occurrence of each case has been reported separately, their simultaneous occurrence and the possibility of their causal relationship have never been reported, to our knowledge. So far, there have been some reports on the use of ultrasound, upper gastrointestinal contrast studies, and computed tomography (CT) for the diagnosis of these diseases. However, the abilities of these moda
Coke, char and organic waste behaviour in the blast furnace with high injection rate
Gudenau, H. W.,Senk, D.,Fukada, K.,Babich, A.
Revista de Metalurgia , 2003,
Abstract: Blast furnace operation with low coke rate, high amount of auxiliary hydrocarbons and use of nut coke causes a change in coke quality requirements. In particular, not burned in the raceway residues of injected substances (char and ash) can influence the coke behaviour. Therefore combustion efficiency of various organic wastes with and without pulverized coal injection (PCI) and coal char has been investigated under the raceway simulation conditions. Mixing of various substances improves their combustion efficiency. Study on coke gasification by carbon dioxide in the presence of char showed that with the increase of char concentration, coke strength reduction becomes smaller. The reactivity of char with CO2 is higher than that of coke. Therefore char is consumed preferentially. In presence of injected char, total pore volume in coke and its wear resistance were increased. Coke reactivity and microstructure in the presence of various kinds of ash has been studied. Many ash spheres were observed on the surface of coke matrix and its size was dependent on ash properties. La operación del horno alto con una tasa baja de coque, una cantidad elevada de hidrocarburos auxiliares y el empleo de coque calibrado, origina un cambio en las necesidades de calidad del coque. En particular, pueden influir en el comportamiento del coque los residuos inquemados en el raceway (cavidad enfrente a las toberas del horno) de las sustancias que se inyectan (char y cenizas). El char es el residuo de carbón que se origina después que el carbón libera sus sustancias volátiles. Por tanto, se ha investigado la eficiencia de la combustión de varios residuos orgánicos con y sin inyección de carbón pulverizado (ICP) y char, bajo las condiciones de simulación del raceway. La mezcla de varias sustancias mejora la eficiencia a la combustión. El estudio de la gasificación del coque por el dióxido de carbono en la presencia de char, muestra que con el aumento de la concentración del char, la resistencia del coque después de la reducción se hace más peque a. La reactividad del char con el CO2 es más elevada que con la del coque. Por tanto, el char se consume con preferencia. En presencia del char inyectado aumentan el volumen total de poros del coque y la resistencia al desgaste. Se ha estudiado la reactividad y microestructura del coque con la presencia de distintos tipos de cenizas. Se observaron muchas esferas de ceniza sobre la superficie matriz del coque y el tama o de las esferas depende de la naturaleza de las cenizas.
Association of Obesity and Diabetes with Serum Prostate-Specific Antigen Levels in Japanese Males
Nagoya Journal of Medical Science , 2012,
Abstract: Patients with diabetes have been reported to be at an increased risk for cancers of the pancreas, liver, and colon; however, recent studies have suggested that men with diabetes are at a decreased risk for prostate cancer. Previous studies have found that obese men have lower serum prostate-specific antigen (PSA) concentrations than do non-obese men. Further understanding of how obesity and diabetes affect the PSA concentration may improve our ability to detect clinically relevant prostate tumors. This study examined the relationships among serum PSA level, obesity, and diabetes in apparently healthy Japanese males. We analyzed the baseline data from 2,172 Japanese males (age, 56.8 ± 6.1 years [mean ± SD]) who participated in the Japan Multi-Institutional Collaborative Cohort Study. Diabetes was defined as the presence of both a hemoglobin A1c (JDS) of ≥6.1% and a fasting plasma glucose level of ≥126 mg/dL, or a positive medical history. After adjusting for age, the PSA levels were elevated among males with a higher normal BMI (ranging from 23.0 to 24.9) and lowered among men with a BMI of ≥25.0. In the stratified analysis, these significant differences in BMI categories were absent among diabetics. The mean PSA levels were significantly lower in diabetics than in non-diabetics among subjects aged 60 and over. Our findings suggest that the pre-overweight men had increased PSA levels, and the diabetes was associated with a reduction of PSA levels in elderly.
Adult stem cell and mesenchymal progenitor theories of aging
So-ichiro Fukada,Yuran Ma,Akiyoshi Uezumi
Frontiers in Cell and Developmental Biology , 2014, DOI: 10.3389/fcell.2014.00010
Abstract: Advances in medical science and technology allow people live longer lives, which results in age-related problems. Humans cannot avoid the various aged-related alterations of aging; in other words, humans cannot remain young at molecular and cellular levels. In 1956, Harman proposed the “free radical theory of aging” to explain the molecular mechanisms of aging. Telomere length, and accumulation of DNA or mitochondrial damage are also considered to be mechanisms of aging. On the other hand, stem cells are essential for maintaining tissue homeostasis by replacing parenchymal cells; therefore, the stem cell theory of aging is also used to explain the progress of aging. Importantly, the stem cell theory of aging is likely related to other theories. In addition, recent studies have started to reveal the essential roles of tissue-resident mesenchymal progenitors/stem cells/stromal cells in maintaining tissue homeostasis, and some evidence of their fundamental roles in the progression of aging has been presented. In this review, we discuss how stem cell and other theories connect to explain the progress of aging. In addition, we consider the mesenchymal progenitor theory of aging to describing the process of aging.
$α$ cluster states in $^{44, 46, 52}$Ti
M. Fukada,M. K. Takimoto,K. Ogino,S. Ohkubo
Physics , 2011, DOI: 10.1103/PhysRevC.80.064613
Abstract: $\alpha$ decaying states of $^{44, 46, 52}$Ti were investigated with angular correlation functions between $t$ and $\alpha$ with the $^{40, 42, 48}$Ca($^7$Li, $t\alpha$)$^{40, 42, 48}$Ca reactions at E = 26.0 MeV. Many $\alpha$ cluster states were newly observed in the 10 - 15 MeV excitation energy of $^{44}$Ti and their spin-parities were assigned, in which $J^\pi=7^-$ state was found at 11.95 MeV as a candidate for the member of the $K=0_1^-$ negative parity band. In $^{46}$Ti many $\alpha$ cluster states were also found in the 11 - 17 MeV excitation energy with the $^{42}$Ca($^7$Li, $t\alpha$)$^{42}$Ca reaction, though its strength is weak compared to $^{44}$Ti. No $\alpha$ cluster states were detected for the $^{48}$Ca($^7$Li, $t\alpha$)$^{48}$Ca reaction, in which the number of coincidence events decaying from $^{48}$Ca was very small.
Adherent Monomer-Misfolded SOD1
Yasuhiro Watanabe, Eri Morita, Yasuyo Fukada, Koji Doi, Kenichi Yasui, Michio Kitayama, Toshiya Nakano, Kenji Nakashima
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003497
Abstract: Background Multiple cellular functions are compromised in amyotrophic lateral sclerosis (ALS). In familial ALS (FALS) with Cu/Zn superoxide dismutase (SOD1) mutations, the mechanisms by which the mutation in SOD1 leads to such a wide range of abnormalities remains elusive. Methodology/Principal Findings To investigate underlying cellular conditions caused by the SOD1 mutation, we explored mutant SOD1-interacting proteins in the spinal cord of symptomatic transgenic mice expressing a mutant SOD1, SOD1Leu126delTT with a FLAG sequence (DF mice). This gene product is structurally unable to form a functional homodimer. Tissues were obtained from both DF mice and disease-free mice expressing wild-type with FLAG SOD1 (WF mice). Both FLAG-tagged SOD1 and cross-linking proteins were enriched and subjected to a shotgun proteomic analysis. We identified 34 proteins (or protein subunits) in DF preparations, while in WF preparations, interactions were detected with only 4 proteins. Conclusions/Significance These results indicate that disease-causing mutant SOD1 likely leads to inadequate protein-protein interactions. This could be an early and crucial process in the pathogenesis of FALS.
UV-Sensitive Photoreceptor Protein OPN5 in Humans and Mice
Daisuke Kojima, Suguru Mori, Masaki Torii, Akimori Wada, Rika Morishita, Yoshitaka Fukada
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026388
Abstract: A variety of animal species utilize the ultraviolet (UV) component of sunlight as their environmental cues, whereas physiological roles of UV photoreception in mammals, especially in human beings, remain open questions. Here we report that mouse neuropsin (OPN5) encoded by the Opn5 gene exhibited an absorption maximum (λmax) at 380 nm when reconstituted with 11-cis-retinal. Upon UV-light illumination, OPN5 was converted to a blue-absorbing photoproduct (λmax 470 nm), which was stable in the dark and reverted to the UV-absorbing state by the subsequent orange light illumination, indicating its bistable nature. Human OPN5 also had an absorption maximum at 380 nm with spectral properties similar to mouse OPN5, revealing that OPN5 is the first and hitherto unknown human opsin with peak sensitivity in the UV region. OPN5 was capable of activating heterotrimeric G protein Gi in a UV-dependent manner. Immuno-blotting analyses of mouse tissue extracts identified the retina, the brain and, unexpectedly, the outer ears as the major sites of OPN5 expression. In the tissue sections of mice, OPN5 immuno-reactivities were detected in a subset of non-rod/non-cone retinal neurons as well as in the epidermal and muscle cells of the outer ears. Most of these OPN5-immuno-reactivities in mice were co-localized with positive signals for the alpha-subunit of Gi. These results demonstrate the first example of UV photoreceptor in human beings and strongly suggest that OPN5 triggers a UV-sensitive Gi-mediated signaling pathway in the mammalian tissues.
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