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IL-17 receptor signaling is required to control polymicrobial sepsis
A Freitas
Critical Care , 2009, DOI: 10.1186/cc7810
Abstract: Adult C57BL/6 WT and IL-17 receptor KO mice were subjected to nonsevere (NS-CLP) sepsis. Intraperitoneal neutrophil migration, bacteremia, cytokines and liver injury were evaluated 6 hours after surgery. The ability of IL-17 to mediate the neutrophil microbicidal activity in vitro, as well the neutrophil migration in vivo and in vitro, were also evaluated. It was observed that IL-17R-deficient mice, subjected to CLP-induced nonsevere sepsis, show reduced neutrophil recruitment into the peritoneal cavity, spread of infection, and increased systemic inflammatory response as compared with BL6 littermates. As a consequence, the mice showed an increased mortality rate. Moreover, IL-17 induced intraperitoneal neutrophil migration in vivo and in vitro. Besides, we demonstrated that neutrophils harvested from IL-17R-defective mice already show reduced microbicidal activity, compared with WT neutrophils, suggesting a physiological role of IL-17R signaling in the microbicidal activity of neutrophils. Furthermore, WT neutrophils treated with IL-17 showed strong enhancement of microbicidal activity by a mechanism dependent on nitric oxide.Taken together, our results demonstrate that IL-17 receptor signalization plays a critical role in host protection during polymicrobial sepsis.Supported by FAPESP/CNPq/FAEPA.
Indústria cultural: o empobrecimento narcísico da subjetividade
Freitas, Verlaine;
Kriterion: Revista de Filosofia , 2005, DOI: 10.1590/S0100-512X2005000200016
Abstract: the goal of the text is to analyze the critical dimension of the cultural industry concept as proposed by adorno and horkheimer, starting from the psychoanalytical notion of narcissism such as adorno has interpreted it. the mass culture is to be seen as offering the radically illusory pleasure of satisfying the anxiety of magnification of the ego, exactly in the moment when it keeps the individual within the inertial tendencies of the social unity.
Constru??o e Desconstru??o da Rela??o entre Migra??es For?adas e Desafios de Seguran?a em áfrica
Freitas,Raquel;
Cadernos de Estudos Africanos , 2011,
Abstract: the debate on transnational challenges to security is framed within the context of the blurring of the traditional concept of state, centred on a territory delimited by borders and with a monopoly of legitimate physical violence. in the african context the debate is guided by two important dimensions: political will and the capacity of the state to protect its citizens. this article suggests that at least the political will dimension is largely constrained by the interpretation of the state on issues of citizenship, in a context where ethnicity is a structuring element of relations and belongings much more powerful than that of citizenship and encompasses the transnational dimension of such relations. therefore, it is argued that forced migrations should be framed within a societal context, focusing on the role of local populations and local contexts of violence and peace as well as the regional dynamics of integration or rejection of those who flee. in this process it is important to understand the way in which forced migrations are framed as a cause or consequence of insecurity.
A tor??o mimética do real: sobre a concep??o freudiana da literatura
Freitas, Verlaine;
Pandaemonium Germanicum , 2012, DOI: 10.1590/S1982-88372012000200007
Abstract: the objective of this paper is to make a reading of conceptual elements present in the freudian view on poetry and literature, pointing out its problematic aspects, but also the relevant ones to the analysis of the aesthetic phenomenon. initially, we review briefly the significant points in the tradition of critical comments on freudian aesthetic reflections, then comment on the text "creative writers and day-dreaming" (1908), in which we employ the comparison with themes and concepts in the poetics of aristotle and in the critique of judgment of kant. in the last part we opposed some of the concepts presented in this first text to the article "the uncanny" (1919), where we propose a reading that makes a contrast of the role and importance given to the aesthetic dimension in both texts. the entire trajectory is oriented to demonstrate the need to conceive of the aesthetic from the intertwining, from identity and difference, between the unconscious psychic field and its ways of actualization refracted by the imagistic-imaginary dimension.
Arte e movimento estudantil: análise de uma obra de Antonio Manuel
Freitas, Artur;
Revista Brasileira de História , 2005, DOI: 10.1590/S0102-01882005000100005
Abstract: can the visual manifestations participate critic and reflexively of the great debates of the public space? usually, during the first years of military regime, the plastic arts believed in this participation, and this faith sustained the public, oppositional and collective activity of the brazilian vanguards. in this historical context, therefore, this article will analyze some aesthetic and ideological implications presents in the work movimento estudantil 68, engraving of antonio manuel rewarded in the sal?o paranaense of 1968. movimento estudantil 68 was produced in the political effervescence peak of student movement, but it was exhibited for the public in the first days ofact institutional number 5.thus, this art work will be understood here as a discursive plot, a crossing between history and visuality.
Desenvolvimento e mudan?a paradigmática na Madeira: Atitudes sociais sobre ambiente
Freitas,André;
Sociologia, Problemas e Práticas , 2007,
Abstract: tendo como pano de fundo o processo de exponencial crescimento económico que tem pautado a madeira e as suas decorrentes implica??es nas complexas rela??es ambiente-sociedade, este artigo procura cogitar a modernidade madeirense sob o signo de uma interpreta??o qualitativa, ou n?o convencional, do desenvolvimento que coloque a tónica nas suas dimens?es humanas e ecológicas, garante da própria sustentabilidade dos investimentos realizados.
Radiative corrections to co-annihilation processes
Freitas, A.
High Energy Physics - Phenomenology , 2007, DOI: 10.1016/j.physletb.2007.07.019
Abstract: In co-annihilation scenarios, the weakly interacting dark matter particle (WIMP) is close in mass to another particle that can decay into the WIMP. As a result, both particles freeze out at roughly the same time in the early universe, and both contribute to the effective dark matter annihilation cross-section. Since the heavier particle does not need to be weakly interacting, the co-annihilation processes are in general subject to sizeable radiative corrections. Here this is analyzed for the example of neutralino-stop co-annihilation in supersymmetry. The leading QCD corrections are calculated and it is found that they have a large effect on the effective annihilation cross-section, reaching more than 50% in some regions of parameter space.
Status of Constraints on Supersymmetry
Freitas, A.
High Energy Physics - Phenomenology , 2008,
Abstract: A short summary of constraints on the parameter space of supersymmetric models is given. Experimental limits from high energy colliders, electroweak precision data, flavor and Higgs physics, and cosmology are considered. The main focus is on the MSSM with conserved R- and CP-parity and minimal flavor violation, but more general scenarios and extended models will also be discussed briefly.
Novas tendências no estudo do conhecimento, economia & sociedade
Christiana Freitas
Sociedade e Estado , 2002, DOI: 10.1590/s0102-69922002000100010
Abstract:
A arte moderna como historicamente-sublime um comentário sobre o conceito de sublime na teoria estética de TH. Adorno
Verlaine Freitas
Kriterion: Revista de Filosofia , 2013,
Abstract: O objetivo do texto é propor uma interpreta o do conceito de sublime na Teoria estética de Theodor Adorno, partindo do confronto com leituras significativas de outros comentadores, de modo a fornecer uma concep o que associe o movimento de transcendência e alteridade da forma estética à dinamica histórico-processual das obras. The objective of this paper is to propose an interpretation of the concept of sublime in the Aesthetic Theory of Theodor Adorno, starting with the confrontation with meaningful readings of other commentators, in order to provide a conception that links the movement of transcendence and otherness of the aesthetic form to the process-historical dynamics of the works.
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