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Search Results: 1 - 10 of 5059 matches for " Frankwich Karen "
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Proof of Concept: Matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes
Frankwich Karen,Tibble Courtney,Torres-Gonzalez Moises,Bonner Mariah
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-35
Abstract: Background Obesity is a state of subclinical inflammation resulting in loss of function of insulin receptors and decreased insulin sensitivity. Inhibition of the inflammatory enzymes, matrix metalloproteinases (MMPs), for 6 months in rodent models restores insulin receptor function and insulin sensitivity. Methods This 12-week double-blind, randomized, placebo (PL)-controlled proof-of-concept study was performed to determine if the MMP inhibitor (MMPI), doxycycline, decreased global markers of inflammation and enhanced muscle insulin sensitivity in obese people with type 2 diabetes (DM2). The study included non-DM2 controls (n = 15), and DM2 subjects randomized to PL (n = 13) or doxycycline 100 mg twice daily (MMPI; n = 11). All participants were evaluated on Day 1; MMPI and PL groups were also evaluated after 84 days of treatment. Results There was a significant decrease in inflammatory markers C-reactive protein (P < 0.05) and myeloperoxidase (P = 0.01) in the MMPI but not PL group. The MMPI also significantly increased skeletal muscle activated/total insulin signaling mediators: 3’phosphoinositide kinase-1 (PDK1) (p < 0.03), protein kinase B (PKB/Akt) (p < 0.004), and glycogen synthase kinase 3 (GSK3 ) (p < 0.03). Conclusions This study demonstrated short term treatment of people with diabetes with an MMPI resulted in decreased inflammation and improved insulin sensitivity. Larger, longer studies are warranted to determine if doxycycline can improve glucose control in people with diabetes. Trial Registration Clinicaltrials.gov NCT01375491
Defending the Self in a Total Institution: Staff Prompting and Patient Burlesque  [PDF]
Karen Bettez Halnon
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.24060
Abstract: This paper offers an analysis of forms of social interaction between direct care staff and patient members of a state institution for the “Mentally Retarded” (MR) and dually-diagnosed (MR with a mental disorder diagnosis) located in the northeastern United States. This work’s significance is that it updates and extends Erving Goffman’s (1961) classic study of the underlife of total institutions. It does so by delineating a sub-type of secondary adjustment to total institutions, termed ancillary adjustment. Ancillary adjustment is defined as performances of patient role that undercut the institution’s official prescription for patient identity toward normalizing direct staff member identity. It is shown how ancillary adjustment arose as an unintended consequence of the institutional reforms of the 1970s, or how, under a professionally reformed and bureaucratized “New School”, direct care staff members experienced themselves as disempowered and discredited as “normal” professionals and defensively and repeatedly cued hyper-stigmatized comedic spectacles through types of staff-patient interaction termed staff prompting and patient burlesque. This paper is based on a three-year fieldwork study entitled Defending the Self in an Institution for the Mentally Retarded that utilized Glaser and Strauss’ (1967) and Strauss and Corbin’s (1990) grounded theory methods for qualitative research.
Embracing Empowerment in the Healthcare of the United States  [PDF]
Bozena Padykula, Karen Wexell
Open Journal of Leadership (OJL) , 2013, DOI: 10.4236/ojl.2013.24013
Abstract:

The United States experiences an economic and healthcare crisis that calls for change. Transformational leadership model by Kouzes and Posner (2003) defines traits that are important to embrace by today’s healthcare leaders in promoting organizational change. To promote growth, engaging and empowering all members in the organization opens the door for collaborative work intentionally establishing sustainable healthcare outcomes. Since nurses play a significant role in US and global healthcare systems, healthcare organizations demand empowered nursing leaders that have an equal voice. The significance of this review to the future is to awaken nursing leaders to step away from a dependent mode and to step forward to an empowered mode.

Plasma cell pleocytosis in HSV-2 aseptic meningitis  [PDF]
Rohit Kalia, Karen Hennessey
Open Journal of Internal Medicine (OJIM) , 2013, DOI: 10.4236/ojim.2013.34026
Abstract:

Plasma cell pleocytosis has been seen in cerebrospinal fluid (CSF) analysis of patients with multiple myeloma, multiple sclerosis, leukemia, west nile encephalitis and lymphoma. There also have been some anecdotal reports suggesting the presence of plasma cells in CSF as possible early indicator of WNV encephalitis. We describe a case of plasma cell pleocytosis in CSF due to HSV-2 meningitis, adding it to the list of possible etiologies for the same. 

The Role of Technology in the Marketing Communications Industry: An Exploratory Study of the Impact of North American Influence on Local Business in Trinidad and Tobago  [PDF]
Prahalad Sooknanan, Karen Crichlow
Advances in Journalism and Communication (AJC) , 2014, DOI: 10.4236/ajc.2014.23009
Abstract: New communication technologies such as the Internet are causing sweeping changes within the global marketing communications industry. Therefore, the implications of e-marketing for business in Trinidad and Tobago are profound as seen in a national plan to address this need. This study examines the efforts of local businesses and consumers to get on the e-marketing bandwagon already commonplace in the U.S. Two surveys were conducted among local businesses and local consumers to determine their readiness and/or success. In spite of governmental efforts to expand Internet capabilities, lethargy and lack of access still plague local businesses. This contrasts with local consumers who are more receptive to e-marketing expressing an increasing demand for online information. It is therefore imperative for the T&T government to address the deficiencies in its ICT plan so that local businesses and consumers can catch up with the rest of the world before the gap widens to a point where it becomes impossible to do so.
Development, Dependency and HIV Risk in Kiribati  [PDF]
Karen McMillan, Heather Worth
World Journal of AIDS (WJA) , 2014, DOI: 10.4236/wja.2014.42028
Abstract:

A study was undertaken in Kiribati, a small Pacific island nation, that has a low-level HIV epidemic but a high incidence of STIs among seafarers, their spouses (and children), and those involved in sex work. There are connections between development and dependency and HIV risk in Kiribati. Kiribati is a peripheral and dependent small island state underwritten by conditional aid and financial assistance and advice from donor countries, entwined in, and subject to, external globalising processes. We found two major factors related to Kiribati’s dependency engendered HIV risk. The first is Kiribati’s reliance on transnational seafaring. Long periods away from home, shipboard and port mateship cultures, and infrequent condom use in casual and paid sexual relations while in overseas ports, exacerbated by heavy alcohol use, have rendered i-Kiribati seafarers vulnerable to HIV. The second factor is related to the labour force participation of young women, which is extremely limited. In this context, some young i-Kiribati women choose to work on board, foreign fishing vessels selling sex. They stay with one client while on board a boatfor up to three monthsand sex work is not only an economic transaction, but also emotional and affective labour. It is a pattern that makes consistent condom use problematic. Having multiple sequential seafarer partners may in fact generate considerable HIV vulnerability.

But You Promised: Children’s Judgments of Broken Promises  [PDF]
Karen Hussar, Jared Horvath
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.412152
Abstract:

Current conceptions regarding children’s understanding of promises (and promise breaking) rely upon absolute distinction: namely, a promise versus a non-promise. The current study expands the understanding of children’s judgments of broken promises to include more nuanced, refined descriptions. Utilizing a four-point rating scale—ranging from “OK” to “very bad”—forty children aged 6 to 10 judged story cards depicting characters breaking commitments not to engage in specific behaviors across three different domains (moral, social-conventional, and personal). Analyses indicated that children judge broken promises in the moral domain more severely than those in the social-conventional domain and broken promises in the social-conventional domain more severely than those in the personal domain. Therefore, children appear to judge broken commitments on a sliding scale in much the same way they judge actions from the moral, social-conventional and personal domains. Results from the current study also suggest an inverse pattern of judgment with regards to broken commitments. Specifically, it appears that the more severely an initial action is judged, the less severely its concurrent commitment condition is judged; and vice versa. These findings help refine our understanding of childhood interpretations of broken promises and engender several unique ideas for future research in this field.

A Basis for Causal Scattering Waves, Relativistic Diffraction in Time Functions  [PDF]
Salvador Godoy, Karen Villa
Journal of Modern Physics (JMP) , 2016, DOI: 10.4236/jmp.2016.710107
Abstract: Relativistic diffraction in time wave functions can be used as a basis for causal scattering waves. We derive such exact wave function for a beam of Dirac and Klein-Gordon particles. The transient Dirac spinors are expressed in terms of integral defined functions which are the relativistic equivalent of the Fresnel integrals. When plotted versus time the exact relativistic densities show transient oscillations which resemble a diffraction pattern. The Dirac and Klein-Gordon time oscillations look different, hence relativistic diffraction in time depends strongly on the particle spin.
Pedagogical Innovation among University Faculty  [PDF]
Karen E. Boden
Creative Education (CE) , 2019, DOI: 10.4236/ce.2019.105063
Abstract: Faculty often emphasize research compared with teaching in their work. However, some faculty endeavor to be excellent teachers by innovating pedagogy to enhance student learning. This qualitative study focused on developing a theory to describe faculty’s innovative process. The theory defined as Reciprocal Engagement includes one category: Practice. Three sub-categories emergedCycle of Innovation, Cycle of Feedback, and Gradation of Innovation—which describe the process of innovation. Cycle of Innovation indicates an accumulation of innovation over the course of a faculty’s career. Cycle of Feedback suggests the academic and social engagement between faculty and students. Gradation of Innovation describes the three levels of pedagogical innovation.
Addressing the challenges of patient-centred design
Karen Ryan,Karen LaBat
Australasian Medical Journal , 2009,
Abstract: Patient-centred design is a relatively new term, but a longstanding concept in clinical practice. This discussion looks at patient-centred design and explores the relationships of patient-centred design to universal design, user-centred design and the newer human-centred design. It also explores why interdisciplinary approaches are needed for patient-centred design and how interdisciplinary collaboration works to address the challenges of patient centred design. Successful patient-centred solutions can grow from collaborations which include shared visions, understanding of both the nature and degree of variation in the patient,materials, and the designed solution, clear regular communication among all parties with careful definition of terms, and respect for the inherent cultures of all disciplines involved.
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