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Search Results: 1 - 10 of 176553 matches for " Frank E. Garcea "
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Preserved Tool Knowledge in the Context of Impaired Action Knowledge: Implications for Models of Semantic Memory
Frank E. Garcea,Bradford Z. Mahon
Frontiers in Human Neuroscience , 2013, DOI: 10.3389/fnhum.2013.00120
Abstract: A number of studies have observed that the motor system is activated when processing the semantics of manipulable objects. Such phenomena have been taken as evidence that simulation over motor representations is a necessary and intermediary step in the process of conceptual understanding. Cognitive neuropsychological evaluations of patients with impairments for action knowledge permit a direct test of the necessity of motor simulation in conceptual processing. Here, we report the performance of a 47-year-old male individual (Case AA) and six age-matched control participants on a number of tests probing action and object knowledge. Case AA had a large left-hemisphere frontal-parietal lesion and hemiplegia affecting his right arm and leg. Case AA presented with impairments for object-associated action production, and his conceptual knowledge of actions was severely impaired. In contrast, his knowledge of objects such as tools and other manipulable objects was largely preserved. The dissociation between action and object knowledge is difficult to reconcile with strong forms of the embodied cognition hypothesis. We suggest that these, and other similar findings, point to the need to develop tractable hypotheses about the dynamics of information exchange among sensory, motor and conceptual processes.
The Relationship between Occlusion and TMD  [PDF]
Frank E. Cordray
Open Journal of Stomatology (OJST) , 2017, DOI: 10.4236/ojst.2017.71003
Abstract: The purpose of this paper is to conduct an extensive review of the literature on the relationship between occlusion and occlusal factors and TM dysfunction. This paper attempts to explore why the link between occlusal factors, which have historically been implicated in producing TMD, and dysfunction has not been clearly evident from the dental literature.
Biologic Constraints on Modelling Virus Assembly
Robert L. Garcea
Computational and Mathematical Methods in Medicine , 2008, DOI: 10.1080/17486700802168007
Abstract: The mathematic modelling of icosahedral virus assembly has drawn increasing interest because of the symmetric geometry of the outer shell structures. Many models involve equilibrium expressions of subunit binding, with reversible subunit additions forming various intermediate structures. The underlying assumption is that a final lowest energy state drives the equilibrium toward assembly. In their simplest forms, these models have explained why high subunit protein concentrations and strong subunit association constants can result in kinetic traps forming off pathway partial and aberrant structures. However, the cell biology of virus assembly is exceedingly complex. The biochemistry and biology of polyoma and papillomavirus assembly described here illustrates many of these specific issues. Variables include the use of cellular ‘chaperone’ proteins as mediators of assembly fidelity, the coupling of assembly to encapsidation of a specific nucleic acid genome, the use of cellular structures as ‘workbenches’ upon which assembly occurs, and the underlying problem of making a capsid structure that is metastable and capable of rapid disassembly upon infection. Although formidable to model, incorporating these considerations could advance the relevance of mathematical models of virus assembly to the real world.
Is tumor necrosis factor - 376a promoter polymorphism associated with susceptibility to multiple sclerosis?
Kauffman,Marcelo A.; González Morón,Dolores; Sandoval,Gustavo; Sica,Roberto E.; Garcea,Orlando; Villa,Andrés M.;
Medicina (Buenos Aires) , 2007,
Abstract: a single nucleotide polymorphism (snp) at position -376 of the tumor necrosis factor á gene (tnfa) has been associated with susceptibility to multiple sclerosis (ms) in spain. however, no association was found in populations from the usa and the netherlands. here we investigate the association between the tnfa - 376a snp and ms susceptibility in argentinean patients with ms. the a/g genotype was found in 4.4% of patients (n=90) and in 4.8% of healthy individuals (n=84; p=0.92; odds ratio=0.93; confidence interval: 0.23- 3.84). thus, no significant differences in genotype and allele frequencies were found between healthy individuals and patients with ms in argentina.
Spatial Analysis, the Wisconsin Idea and the UW-System. The Use and Abuse of Dispersion Statistics (Partial Reprint)
Frank E. Barmore
Solstice : Electronic Journal of Geography and Mathematics , 1998,
Abstract: The link to the fulltext on a current website is given below. Should that link fail to work, please go to this persistent URL and download the associated file for this issue. http://deepblue.lib.umich.edu/handle/2027.42/58219While you are there, take a look around and see if there are other issues and documents that are related to your interests!
Where Are We? Comments on the Concept of Center of Population
Frank E. Barmore
Solstice : Electronic Journal of Geography and Mathematics , 1992,
Abstract: The link to the fulltext on a current website is given below. Should that link fail to work, please go to this persistent URL and download the associated file for this issue. http://deepblue.lib.umich.edu/handle/2027.42/58219While you are there, take a look around and see if there are other issues and documents that are related to your interests!
Notes on the Inheritance of Variations in the Color Pattern of Crioceris Asparagi
Frank E. Lutz
Psyche , 1908, DOI: 10.1155/1908/23659
Protesting the Independent Candidacy in Tanzania’s Elections: A Bona Fide Cause?
Frank J. Mateng'e
Journal of Politics and Law , 2012, DOI: 10.5539/jpl.v5n1p18
Abstract: Independent candidates are legally prohibited in the Tanzanian electoral system. Promoting representative democracy; preserving peace, order, and security, and the ability of political parties to advance people’s interests have often been cited as the rationale for such proscription. This paper interrogates the validity of these claims. Based on documentary analysis and primary data gathered by the author, the paper argues that the proscription of independent candidates in Tanzania under the guise of people’s interests fails the test of validity. Further, although independent candidates are prohibited in Tanzania, findings suggest that the country’s 2010 general election results presented a case for their de facto presence. The remarkable discrepancies in electoral support between the parliamentary and presidential candidates of the same political parties present indicative evidence to that effect.
Frank E Marino
Journal of Sports Science and Medicine , 2008,
Abstract: Vol 53 (Medicine & Sport Science) This collection on the latest interpretation of research data about the relationship between thermoregulation, exercise performance and fatigue is published as the 53rd volume of Medicine and Sport Science Journal. PURPOSE The book aims to explain how the advances in technology and methodology allowed studying the affects of the changing body temperature on metabolism and the role played by the nervous system in shaping human performance under challenging thermal situations. FEATURES This publication provides different interpretations of recent research for a better understanding of the limitations of thermoregulation in nine titles. The presented titles are: The Evolutionary Basis of Thermoregulation and Exercise Performance; Comparative Thermoregulation and the Quest for Athletic Supremacy; Thermoregulation, Fatigue and Exercise Modality; Neuromuscular Response to Exercise Heat Stress; Intestinal Barrier Dysfunction, Endotoxemia and Gastrointestinal Symptoms: The 'Canary in the Coal Mine' during Exercise-Heat Stress?; Effects of Peripheral Cooling on Characteristics of Local Muscle; Cooling Interventions for the Protection and Recovery of Exercise Performance from Exercise-Induced Heat Stress; Ethnicity and Temperature Regulation; Exercise Heat Stress and Metabolism. The evidence for the human's ability to adjust their performance according to the thermal limits in order to preserve cellular homeostasis is particularly noteworthy. AUDIENCE This is a fundamental book for any students and/or researchers involved in the fields of medicine, exercise physiology and human performance with special reference to thermal regulation. ASSESSMENT This publication is a must-read text for all those working in thermal medicine, exercise physiology and human performance fields
Comparison of cosmic ray flux at sqrt(s) > 14 TeV with LHC luminosity
Frank E. Taylor
Physics , 2008,
Abstract: The high energy cosmic ray flux impinging on the sun and earth for 4 Gyr is compared to the operation of the CERN Large Hadron Collider (LHC) at design energy and luminosity. It is shown by two different calculations that both the integrated luminosity and the total hadronic interaction rate from the cosmic ray flux of comparable energy are many orders of magnitude larger than that of the LHC operated for 10 years. This study indicates that it is extremely unlikely that pernicious exotic particles, such as mini-black holes, would be produced by the LHC that would destroy the earth.
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