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Search Results: 1 - 10 of 470258 matches for " Frank A. Treiber "
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Impact of Transcendental Meditation on Left Ventricular Mass in African American Adolescents
Vernon A. Barnes,Gaston K. Kapuku,Frank A. Treiber
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/923153
Abstract: Background. An early sign of ventricular remodeling is increased left ventricular mass (LVM) which over time may lead to left ventricular hypertrophy, the strongest predictor of cardiovascular morbidity and mortality, other than advancing age. Methods. 62 (30 TM; 32 CTL) African American adolescents (age 16.2±1.3 years) with high normal systolic BP were randomly assigned to either 4-month Transcendental Meditation (TM) or health education control groups. The echocardiographic-derived measure of LVM index (LVMI = LVM/ht2.7) was measured before and after the 4-month TM study and at 4-month followup. 2D-guided M-mode echocardiography using a Hewlett Packard 5500 echosonograph was used to determine LVMI. Results. The TM group exhibited a greater decrease in LVMI at 4-month followup compared to the CTL group (−2.6 versus
Impact of stress reduction on negative school behavior in adolescents
Vernon A Barnes, Lynnette B Bauza, Frank A Treiber
Health and Quality of Life Outcomes , 2003, DOI: 10.1186/1477-7525-1-10
Abstract: Forty-five African American adolescents (ages 15–18 years) with high normal systolic blood pressure were randomly assigned to either Transcendental Meditation (n = 25) or health education control (n = 20) groups. The meditation group engaged in 15-min sessions at home and at school each day for 4 months. The control group was presented 15-min sessions of health education at school each day for 4 months. Primary outcome measures were changes in absenteeism, school rule infractions and suspension days during the four-month pretest period prior to randomization compared with the four-month intervention period.Comparing the pretest and intervention periods, the meditation group exhibited a mean decrease of 6.4 absentee periods compared to an increase of 4.8 in the control group (p < .05). The meditation group exhibited a mean decrease of 0.1 infractions over the four months compared to an increase of 0.3 in the control group (p < .03). There was a mean reduction of 0.3 suspension days due to behavior-related problems in the meditation group compared to an increase of 1.2 in the control group (p < .04).These findings demonstrate that the Transcendental Meditation program conducted in the school setting has a beneficial impact upon absenteeism, rule infractions, and suspension rates in African American adolescents.The prevalence of negative school behaviors remains a significant health problem in the U.S [1]. For example, with respect to behaviors that contribute to intentional injuries, according to the Youth Risk Behavior Surveillance Survey, 36.6% of high school students reported having been in a physical fight in the past month, with 14.8% of the fights occurring on school property, 3.5% were injured in a physical fight and five percent of students missed school because of feeling unsafe [1]. Results of studies attempting to reduce such aggressive behaviors in schools have been mixed. A school-based violence prevention curriculum reportedly reduced self-reported aggre
Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure
Mathew J. Gregoski,Vernon A. Barnes,Martha S. Tingen,Yanbin Dong,Haidong Zhu,Frank A. Treiber
International Journal of Hypertension , 2012, DOI: 10.1155/2012/510291
Abstract: Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine.
Differential Impact of Stress Reduction Programs upon Ambulatory Blood Pressure among African American Adolescents: Influences of Endothelin-1 Gene and Chronic Stress Exposure
Mathew J. Gregoski,Vernon A. Barnes,Martha S. Tingen,Yanbin Dong,Haidong Zhu,Frank A. Treiber
International Journal of Hypertension , 2012, DOI: 10.1155/2012/510291
Abstract: Stress-activated gene × environment interactions may contribute to individual variability in blood pressure reductions from behavioral interventions. We investigated effects of endothelin-1 (ET-1) LYS198ASN SNP and discriminatory stress exposure upon impact of 12-week behavioral interventions upon ambulatory BP (ABP) among 162 prehypertensive African American adolescents. Following genotyping, completion of questionnaire battery, and 24-hour ABP monitoring, participants were randomized to health education control (HEC), life skills training (LST), or breathing awareness meditation (BAM). Postintervention ABP was obtained. Significant three-way interactions on ABP changes indicated that among ET-1 SNP carriers, the only group to show reductions was BAM from low chronic stress environments. Among ET-1 SNP noncarriers, under low chronic stress exposure, all approaches worked, especially BAM. Among high stress exposure noncarriers, only BAM resulted in reductions. If these preliminary findings are replicated via ancillary analyses of archival databases and then via efficacy trials, selection of behavioral prescriptions for prehypertensives will be edging closer to being guided by individual's underlying genetic and environmental factors incorporating the healthcare model of personalized preventive medicine. 1. Introduction Essential hypertension (EH) is a major risk factor for cardiovascular disease (CVD), and EH incidence among youth is increasing [1]. African Americans (AAs) experience a higher prevalence, earlier onset, and greater severity of EH-related complications than other ethnic groups [2]. From late childhood onward, AAs display increased levels of resting and ambulatory blood pressure (ABP) compared to other ethnic groups [3–5]. BP levels are monotonically associated with future CVD morbidity and mortality [6]. Stage I prehypertensive adults (i.e., SBP/DBP 121–129/81–84?mmHg) have a 40% increased risk and adults with stage II prehypertension (i.e., SBP/DBP 130–139/85–89?mmHg) are twice as likely to develop CVD compared to those with optimal BP (<120/<80?mmHg) [6–8]. BP percentile ranking tracks from late childhood into adulthood [9–11] placing AA adolescents with BP between the 50th and 95th percentiles for age and sex at an increased risk of future EH and CVD development [9]. EH, like other multifactorial chronic diseases, results from a complex interplay between an individual’s genetic underpinnings, lifestyle behaviors, psychosocial factors, and exposures to various environmental toxins. Over time, this dynamic interplay eventuates in adverse
FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth
Gaifen Liu, Haidong Zhu, Vasiliki Lagou, Bernard Gutin, Inger S Stallmann-Jorgensen, Frank A Treiber, Yanbin Dong, Harold Snieder
BMC Medical Genetics , 2010, DOI: 10.1186/1471-2350-11-57
Abstract: We conducted a cross-sectional study in EA and AA youths. One thousand, nine hundred and seventy-eight youths (48.2% EAs, 47.1% male, mean age 16.5 years) had measures of anthropometry. Percent body fat (%BF) was measured by dual-energy X-ray absorptiometry, visceral adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAAT) by magnetic resonance imaging. Energy intake and physical activity were based on self report from up to 7 24-hour recalls. Physical activity was also measured by accelerometry.FTO rs9939609 was significantly associated with body mass index (BMI) (P = 0.01), weight (P = 0.03) and waist circumference (P = 0.04), with per-allele effects of 0.4 kg/m2, 1.3 kg and 0.8 cm, respectively. No significant association was found between rs9939609 and %BF, VAT, SAAT or insulin resistance (P > 0.05), or between rs9939609 and energy intake or vigorous physical activity (P > 0.05). No significant interactions of rs9939609 with ethnicity, gender, energy intake or physical activity were observed (P > 0.05).The FTO variant rs9939609 is modestly associated with BMI and waist circumference, but not with energy intake or physical activity. Moreover, these effects were similar for EAs and AAs. Improved understanding of the effect of the FTO variant will offer new insights into the etiology of excess adiposity.Obesity is becoming an increasingly important clinical and public health challenge worldwide and is associated with several comorbidities such as type 2 diabetes, cardiovascular diseases, metabolic syndrome and certain forms of cancer [1-3]. Obesity results from the combined effects of genes, environment and life style[4]. In this context, an understanding of the effects of life style and genes on obesity and also their interactions is important to provide a basis for determining the role they could have on the development and prevention of obesity.Lifestyle factors, including diet and physical inactivity, are important contributors to weight gain and o
Development and Validation of a Smartphone Heart Rate Acquisition Application for Health Promotion and Wellness Telehealth Applications
Mathew J. Gregoski,Martina Mueller,Alexey Vertegel,Aleksey Shaporev,Brenda B. Jackson,Ronja M. Frenzel,Sara M. Sprehn,Frank A. Treiber
International Journal of Telemedicine and Applications , 2012, DOI: 10.1155/2012/696324
Abstract: Objective. Current generation smartphones' video camera technologies enable photoplethysmographic (PPG) acquisition and heart rate (HR) measurement. The study objective was to develop an Android application and compare HRs derived from a Motorola Droid to electrocardiograph (ECG) and Nonin 9560BT pulse oximeter readings during various movement-free tasks. Materials and Methods. HRs were collected simultaneously from 14 subjects, ages 20 to 58, healthy or with clinical conditions, using the 3 devices during 5-minute periods while at rest, reading aloud under observation, and playing a video game. Correlation between the 3 devices was determined, and Bland-Altman plots for all possible pairs of devices across all conditions assessed agreement. Results. Across conditions, all device pairs showed high correlations. Bland-Altman plots further revealed the Droid as a valid measure for HR acquisition. Across all conditions, the Droid compared to ECG, 95% of the data points (differences between devices) fell within the limits of agreement. Conclusion. The Android application provides valid HRs at varying levels of movement free mental/perceptual motor exertion. Lack of electrode patches or wireless sensor telemetric straps make it advantageous for use in mobile-cell-phone-delivered health promotion and wellness programs. Further validation is needed to determine its applicability while engaging in physical movement-related activities. 1. Introduction Many cellular phones now possess high-speed data transmission capabilities (e.g., 3G, 4G) and have embedded microprocessors (e.g., Bluetooth, ANT) with the capability to wirelessly connect to external devices. As a result, cell phones offer several advantages over desktop or laptop computers in telemonitoring-related applications such as higher population penetration, increased privacy, lower cost to purchase, easier ability to transport, and overall increased personal convenience of use [1, 2]. Cell phones are widely used in telemonitoring serving as a conduit for receiving biohealth information from portable medical devices (e.g., blood pressure, glucose and pulse oximeter monitors, weight scales) and mobile sensors (e.g., physical activity; accelerometer counts, heart rate, respiration rate, pulse pressure via chest- or armbands, and wireless electrodes). Once cell phones have received the pertinent information, it is microprocessed, encrypted, and the data packets are transferred to some form of localized or web-based server for secondary processing. At the server level, the data packets are organized into a
BluetoothTM Enabled Acceleration Tracking (BEAT) mHealth System: Validation and Proof of Concept for Real-Time Monitoring of Physical Activity  [PDF]
Aleksey Shaporev, Mathew Gregoski, Vladimir Reukov, Teresa Kelechi, David Morgan Kwartowitz, Frank Treiber, Alexey Vertegel
E-Health Telecommunication Systems and Networks (ETSN) , 2013, DOI: 10.4236/etsn.2013.23007
Abstract: Physical activity is critical to improve the condition of patients with chronic leg and foot ulcers, especially those who are obese and experienced multiple co-morbid conditions. Unfortunately, these individuals are unable to engage in guideline based physical activity (PA) programs. A prototype of BluetoothTM enabled acceleration tracking (BEAT) mHealth system was developed and manufactured for remote monitoring and stimulation of adherence to PA in deconditioned patients. The system consists of a miniature accelerometer-based sensor, smartphone application, and a network service. Validation testing showed high reliability and reproducibility of the BEAT sensors. Pilot study with human subjects demonstrated high accuracy of the BEAT system in recognition of different exercises and calculating overall outcomes of PA. Taken together, these results indicate that BEAT system could become a valuable tool for realtime monitoring of PA in deconditioned patients.

 

Il 'convento per spiriti più liberi' di Nietzsche - Per una visione estremamente attuale di un inattuale
Hubert Treiber
Scienza & Politica : per una Storia delle Dottrine , 1998, DOI: 10.6092/issn.1825-9618/2941
Abstract: Il 'convento per spiriti più liberi' di Nietzsche - Per una visione estremamente attuale di un inattuale
Crowd Flow Modeling of Athletes in Mass Sports Events -- a Macroscopic Approach
Martin Treiber
Physics , 2014, DOI: 10.1007/978-3-319-10629-8_3
Abstract: We propose a macroscopic model in form of a dispersion-transport equation for non-congested flow of the athletes which is coupled to a kinematic-wave model for congested flow. The model takes into account the performance (i.e., free-flow speed distributions) of the athletes in the different starting groups. The model is calibrated and validated on data of the German $\textit{Rennsteig Half Marathon 2012}$ and the Swedish $\textit{Vasaloppet 2012}$ cross-country ski race. Simulations of the model allow the event managers to improve the organization by determining the optimum number of starting groups, the maximum size of each group, whether a wave start with a certain starting delay between the groups is necessary, or what will be the effects of changing the course. We apply the model to simulate a planned course change for the Rennsteig Half Marathon 2013, and determine whether critical congestions are likely to occur.
Obesity related methylation changes in DNA of peripheral blood leukocytes
Xiaoling Wang, Haidong Zhu, Harold Snieder, Shaoyong Su, David Munn, Gregory Harshfield, Bernard L Maria, Yanbin Dong, Frank Treiber, Bernard Gutin, Huidong Shi
BMC Medicine , 2010, DOI: 10.1186/1741-7015-8-87
Abstract: We conducted a genome wide methylation analysis on seven obese cases and seven lean controls aged 14 to 18 years from extreme ends of the obesity distribution and performed further validation of six CpG sites from six genes in 46 obese cases and 46 lean controls aged 14 to 30 years.In comparison with the lean controls, we observed one CpG site in the UBASH3A gene showing higher methylation levels and one CpG site in the TRIM3 gene showing lower methylation levels in the obese cases in both the genome wide step (P = 5 × 10-6 and P = 2 × 10-5 for the UBASH3A and the TRIM3 gene respectively) and the validation step (P = 0.008 and P = 0.001 for the UBASH3A and the TRIM3 gene respectively).Our results provide evidence that obesity is associated with methylation changes in blood leukocyte DNA. Further studies are warranted to determine the causal direction of this relationship as well as whether such methylation changes can lead to immune dysfunction.See commentary: http://www.biomedcentral.com/1741-7015/8/88/abstract webciteObesity is the epidemic of our time, with sharply and steadily rising rates [1,2]. The major adverse consequences of obesity including type 2 diabetes, atherosclerosis and essential hypertension, when added together, account for a large number of disease related deaths [3,4]. If the obesity-related cancer cases are added to this number, obesity-related mortality by far exceeds that of other common diseases [5]. The latter indicates the urgent need to develop novel efficient therapeutic modalities for this condition.The common denominator in the pathogenesis of the co-morbidities of obesity is the presence of an active, low-grade inflammatory process [6]. Despite evidence linking obesity to alterations in inflammatory response, little is known about the specific effects of obesity on the immune system. Recently, there has been a greater appreciation of the role of epigenetics, meiotically and mitotically heritable changes in gene expression that are no
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