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Search Results: 1 - 10 of 345032 matches for " Francisco J Juan "
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Use of botulinum toxin-A for musculoskeletal pain in patients with whiplash associated disorders [ISRCTN68653575]
Francisco J Juan
BMC Musculoskeletal Disorders , 2004, DOI: 10.1186/1471-2474-5-5
Abstract: This is a prospective, randomized, controlled clinical trial and botulinum toxin-A (Botox?) injections will be compared with placebo injections. The primary objective is to determine the efficacy of Botox? in the management of musculoskeletal pain in whiplash associated disorders.Botulinum toxin type-A toxin has been studied in small trials on whiplash associated disorder patients and has generally been found to relieve pain and improve range of motion. Specifically, we seek to assess the efficacy of Botox? in reducing pain and to improve the cervical spine range of movement, during the 6-month trial period.The term "whiplash" has been used to describe a mechanism of injury, and the various clinical manifestations as a consequence of the injury. Moreover, signs and symptoms have been designated the 'whiplash syndrome'. In 1995, the Quebec Task Force (QTF) on Whiplash Associated Disorders (WAD) adopted the following definition of whiplash: "whiplash is an acceleration-deceleration mechanism of energy transfer to the neck. It may result from rear-end or side-impact motor vehicle collisions, but can also occur during diving or other mishaps. The impact may result in bony or soft-tissue injuries (whiplash-injury), which in turn may lead to a variety of clinical manifestations called Whiplash Associated Disorders"[1]. Whiplash patients can be classified according to severity of signs and symptoms. The QTF-WAD classification system consists of five levels: WAD 0 indicates no complaints or physical signs; WAD I indicates neck complaints but no physical signs; WAD II indicates neck complaints and musculoskeletal signs (such as a decreased range of motion or muscle tenderness); WAD III and IV indicate neck complaints and neurological signs (WAD III) or fracture/dislocation (WAD IV), respectively. Research [2-5] has revealed that the most common presenting symptoms following an acute motor vehicle collision were neck pain (88–100 percent) and headache (54–66 percent). Other s
An Importance-Performance Analysis of Primary Health Care Services: Managers vs. Patients Perceptions  [PDF]
Francisco J. Miranda, Antonio Chamorro, Luis R. Murillo, Juan Vega
Journal of Service Science and Management (JSSM) , 2010, DOI: 10.4236/jssm.2010.32028
Abstract: Using importance-performance analysis (IPA), this paper examines the perceptions of patients and managers of health centres of several health care quality services attributes. IPA is an approach to the measurement of customer/user satisfaction which allows for a simple and functional identification of both the strong and the weak aspects, or improvement areas, of a given service. Taking both the importance assigned by users to all relevant aspects of a given service and the perceived performance of the establishment in providing the service, the result is an IPA grid with four quadrants. To the best of our knowledge, this is the first time this methodology has been used to compare the perceptions of health centre patients and managers. The results showed patients and managers to have very different perceptions of all the quality service attributes. Implications for researchers and health centre managers are discussed. The study illustrates the usefulness of the IPA model as a managerial tool in identifying areas to which marketing resources should be allocated in order to improve and enhance the quality of the health centre services provided.
El miedo a madurar en mujeres con obesidad mórbida postgastrectomía: predictores clínicos
Guisado,Juan A.; Vaz,Francisco J.;
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2002, DOI: 10.4321/S0211-57352002000100004
Abstract: introduction: to analyze the eating behaviour in morbidly obese patients undergoing bariatric surgery. methods: the eating disorder inventory (edi) was administered to 85 morbidly obese women-undergoing gastric surgery (vertical banded gastroplasty) for lossing weight. results: the age at surgery and the onset obesity age were correlated with maturity fears subescale. discussion: the findings agree with studies that describe dependence, inmaturity and maturity fears inmorbidly obese patients.
Aspectos clínicos del trastorno por atracón "binge eating disorder"
Guisado,Juan A.; Vaz,Francisco J.;
Revista de la Asociación Espa?ola de Neuropsiquiatría , 2001, DOI: 10.4321/S0211-57352001000100003
Abstract: the binge eating disorders (bed) is a new eating disorders that describes the eating disturbance of a large number of individuals who suffer from recurrent binge eating but who do not regularly engage in the compensatory behaviors to avoid weight gain seen inbulimia nervosa. we analyze the clinical features (eating behavior, psychopathology, body image), questionnaires, and treatment for the management of the bed.
Origin and SEM analysis of aerosols in the high mountain of Tenerife (Canary Islands)  [PDF]
Juan D. Delgado, Omaira E. García, Ana M. Díaz, Juan P. Díaz, Francisco J. Expósito, Emilio Cuevas, Xavier Querol, Andrés Alastuey, Sonia Castillo
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.210139
Abstract: Focusing on aerosolized matter of relevance to respiratory health, a major public health issue worldwide, we studied mineral and biological aerosol (bioaerosol) composition (TSP and PM2.5) and geographical origins during dust intrusions in the Canary Islands. Seven days’ back- ward trajectories were assessed daily during March 2004 with the ends of back trajectories being the sampling station of Iza?a (high moun- tain, 2360 m a.s.l. at the Ca?adas del Teide National Park, Tenerife island), a free troposphere site allowing characterization of dust with low influence of other pollutant sources. Scanning electron microscopy (SEM) was used to survey major types of airborne particles in the dust plumes. Control, non-intrusion conditions correspond to Atlantic oceanic middle troposphere (OMT) air masses. Of the 14 samples taken, 1 corresponded to a control (clear atmosphere conditions), and the remaining 13 to dust intrusions, with the following sources: African Dust; EAM: mixture of Europe, Africa and Oceanic; MaA: maritime aerosols. Of the air masses, 79% were directly transported to the islands from Africa, and an increase of African dust events was detected when comparing with a 52-year previous data sequence. Quartz microcristals and aggregates of quartz and platy clay were the dominant minerals identified, with marine salt and gypsum also present. Freshwater diatom tests (from two Aulacoseira species) represented the most important biogenic aerosols, although fungi and pollen were also detected. The diverse and complex mixture of respirable particles in large quantities in airborne dust, especially from nearby Sahara and from the Sahelian region, is of maximum interest for air- way pathology in the Canaries, including the highly visited highlands in Tenerife.
Old and New Identities for Bernoulli Polynomials via Fourier Series
Luis M. Navas,Francisco J. Ruiz,Juan L. Varona
International Journal of Mathematics and Mathematical Sciences , 2012, DOI: 10.1155/2012/129126
Abstract: The Bernoulli polynomials restricted to [0,1) and extended by periodicity have nth sine and cosine Fourier coefficients of the form /. In general, the Fourier coefficients of any polynomial restricted to [0,1) are linear combinations of terms of the form 1/. If we can make this linear combination explicit for a specific family of polynomials, then by uniqueness of Fourier series, we get a relation between the given family and the Bernoulli polynomials. Using this idea, we give new and simpler proofs of some known identities involving Bernoulli, Euler, and Legendre polynomials. The method can also be applied to certain families of Gegenbauer polynomials. As a result, we obtain new identities for Bernoulli polynomials and Bernoulli numbers.
Local Gene Regulation Details a Recognition Code within the LacI Transcriptional Factor Family
Francisco M. Camas ,Eric J. Alm,Juan F. Poyatos
PLOS Computational Biology , 2010, DOI: 10.1371/journal.pcbi.1000989
Abstract: The specific binding of regulatory proteins to DNA sequences exhibits no clear patterns of association between amino acids (AAs) and nucleotides (NTs). This complexity of protein-DNA interactions raises the question of whether a simple set of wide-coverage recognition rules can ever be identified. Here, we analyzed this issue using the extensive LacI family of transcriptional factors (TFs). We searched for recognition patterns by introducing a new approach to phylogenetic footprinting, based on the pervasive presence of local regulation in prokaryotic transcriptional networks. We identified a set of specificity correlations –determined by two AAs of the TFs and two NTs in the binding sites– that is conserved throughout a dominant subgroup within the family regardless of the evolutionary distance, and that act as a relatively consistent recognition code. The proposed rules are confirmed with data of previous experimental studies and by events of convergent evolution in the phylogenetic tree. The presence of a code emphasizes the stable structural context of the LacI family, while defining a precise blueprint to reprogram TF specificity with many practical applications.
Characterization of the iron-regulated desA promoter of Streptomyces pilosus as a system for controlled gene expression in actinomycetes
Francisco J Flores, Javier Rincón, Juan F Martín
Microbial Cell Factories , 2003, DOI: 10.1186/1475-2859-2-5
Abstract: The binding of the DmdR (acronym for divalent metal dependent repressor) to the desA promoter in presence of Fe2+ or other divalent ions has been characterized. A 51 bp DNA fragment of the desA promoter containing the 9 bp inverted repeat was sufficient for binding of the DmdR repressor, as observed by the electrophoretic mobility shift assay. The desA mobility shift was prevented by neutralizing DmdR with anti-DmdR antibodies or by chelating the divalent metal in the binding reaction with 2,2'-dipyridyl. Binding to the desA promoter was observed with purified DmdR repressors of Streptomyces coelicolor or Rhodococcus fascians suggesting that there is a common mechanism of iron-regulation in actinomycetes. The complete desA promoter region was coupled using transcriptional fusions to the amy reporter gene (encoding α-amylase) in low copy or multicopy Streptomyces vectors. The iron-regulated desA promoter was induced by addition of the iron chelating agent 2,2'-dipyridyl resulting in a strong expression of the reporter gene.The iron-regulated desA promoter can be used for inducible expression of genes in Streptomyces species, as shown by de-repression of the promoter when coupled to a reporter gene.Iron is an important nutrient for microorganisms since it plays an essential role for cell growth. Iron acts as a cofactor of a large number of enzymes, forms part of cytochromes and is required for nitrogen fixation and DNA synthesis [1-3]. Despite its abundance in soil, the bioavailability of iron is quite low since it is usually present as insoluble complexes [3,4]. To solve the bioavailability problem microorganisms have developed highly efficient iron-scavenging systems based on the synthesis of siderophores that have high iron affinity [5-7]. The systems of iron assimilation in microorganisms are strictly regulated to control the intracellular iron levels since at high concentrations iron is toxic for cells [8-15]. Siderophores form a six-coordinated octaedral complex
Abandonar el Tabaco: Meta-análisis y Modelo de Ecuaciones Estructurales desde la Teoría de la Conducta Planificada
Topa,Gabriela; Moriano,Juan Antonio; Morales,J. Francisco;
Clínica y Salud , 2012,
Abstract: meta-analyses of the theory of planned behavior have not been applied to smoking cessation despite that progressively increases the number of primary studies. we conducted a meta-analysis of 121 effect sizes (es) on theory of planned behavior and smoking cessation and examined the influences of four potential moderator variables. global es have been obtained, with medium (es = .28 for intention-behaviour, es = .33 for perceived control-intention, es = .29 for subjective norm-intention) or large (es = .40 for attitude-intention) values. results of moderator analyses showed that time interval between intention and behaviour; scale correspondence, and participants' age moderated the es. finally, the pooled correlation matrix has been used as an input for structural equation model analyses (sem), testing a wider model. the theory effectively explained smoking cessation intention and behaviour.
Arteritis de Takayasu y aneurisma gigante en escolar: Reporte de caso Takayasu arteritis and giant aneurysm in a school student: A case report
Ernesto Vallejo,Francisco J Montero,Juan P Rojas
Revista Colombiana de Cardiología , 2012,
Abstract: La arteritis de Takayasu es una vasculitis de grandes vasos que afecta a la aorta y sus ramas principales, llevando a estenosis y trombosis, así como a la formación de aneurismas. Se reporta una incidencia global de 2,6 casos por millón por a o, siendo baja en ni os. La terapia de elección son los corticoides, seguidos de inmunosupresores en casos de resistencia. Se reporta el caso clínico de un paciente con arteritis de Takayasu con formación de aneurisma gigante de la aorta. Takayasu's arteritis is a vasculitis of large vessels that affects the aorta and its major branches, leading to stenosis and thrombosis, as well as aneurysm formation. An overall incidence of 2.6 cases per million per year has been reported, being lower in children. Corticosteroids are the therapy of choice, followed by immunosuppressants in cases of resistance. We report the case of a patient with Takayasu's arteritis with formation of giant aneurysm of the aorta.
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