Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 30 )

2018 ( 19 )

2017 ( 27 )

2016 ( 31 )

Custom range...

Search Results: 1 - 10 of 3364 matches for " Francis Carbonaro "
All listed articles are free for downloading (OA Articles)
Page 1 /3364
Display every page Item
Identification and Replication of Three Novel Myopia Common Susceptibility Gene Loci on Chromosome 3q26 using Linkage and Linkage Disequilibrium Mapping
Toby Andrew equal contributor ,Nikolas Maniatis equal contributor,Francis Carbonaro,S. H. Melissa Liew,Winston Lau,Tim D. Spector,Christopher J. Hammond
PLOS Genetics , 2008, DOI: 10.1371/journal.pgen.1000220
Abstract: Refractive error is a highly heritable quantitative trait responsible for considerable morbidity. Following an initial genome-wide linkage study using microsatellite markers, we confirmed evidence for linkage to chromosome 3q26 and then conducted fine-scale association mapping using high-resolution linkage disequilibrium unit (LDU) maps. We used a preliminary discovery marker set across the 30-Mb region with an average SNP density of 1 SNP/15 kb (Map 1). Map 1 was divided into 51 LDU windows and additional SNPs were genotyped for six regions (Map 2) that showed preliminary evidence of multi-marker association using composite likelihood. A total of 575 cases and controls selected from the tails of the trait distribution were genotyped for the discovery sample. Malecot model estimates indicate three loci with putative common functional variants centred on MFN1 (180,566 kb; 95% confidence interval 180,505–180, 655 kb), approximately 156 kb upstream from alternate-splicing SOX2OT (182,595 kb; 95% CI 182,533–182,688 kb) and PSARL (184,386 kb; 95% CI 184,356–184,411 kb), with the loci showing modest to strong evidence of association for the Map 2 discovery samples (p<10?7, p<10?10, and p = 0.01, respectively). Using an unselected independent sample of 1,430 individuals, results replicated for the MFN1 (p = 0.006), SOX2OT (p = 0.0002), and PSARL (p = 0.0005) gene regions. MFN1 and PSARL both interact with OPA1 to regulate mitochondrial fusion and the inhibition of mitochondrial-led apoptosis, respectively. That two mitochondrial regulatory processes in the retina are implicated in the aetiology of myopia is surprising and is likely to provide novel insight into the molecular genetic basis of common myopia.
On the modelling of complex sociopsychological systems with some reasoning about Kate, Jules, and Jim
Nicola Bellomo,Bruno Carbonaro
International Journal of Differential Equations , 2006, DOI: 10.1155/denm/2006/86816
Abstract: This paper deals with the modelling of complex sociopsychological games and reciprocal feelings involving interacting individuals. The modelling is based on suitable developments of the methods of mathematical kinetic theory of active particles with special attention to modelling multiple interactions. A first approach to complexity analysis is proposed referring to both computational and modelling aspects.
Comment on "Structure and Hyperfine Parameters of E' Centers in alpha-quartz and Vitreous SiO2"
Vincenzo Fiorentini,C. M. Carbonaro
Physics , 1997,
Abstract: We point out that contrary to a recent suggestion by Boero et al. (PRL 78, 887 (1997)) the +1 charge state of the oxygen vacancy in alpha-quartz cannot be invoked as a candidate E' center in alpha-quartz and silica.
Functional calculus for generators of symmetric contraction semigroups
Andrea Carbonaro,Oliver Dragi?evi?
Mathematics , 2013,
Abstract: We prove that every generator of a symmetric contraction semigroup on a $\sigma$-finite measure space admits, for $1
Bellman function and linear dimension-free estimates in a theorem of Bakry
Andrea Carbonaro,Oliver Dragi?evi?
Mathematics , 2011,
Abstract: By using an explicit Bellman function, we prove a bilinear embedding theorem for the Laplacian associated with a weighted Riemannian manifold $(M,\mu_\phi)$ having the Bakry-Emery curvature bounded from below. The embedding, acting on the cartesian product of $L^p(M,\mu_\phi)$ and $L^q(T^*M,\mu_\phi)$, $1/p+1/q=1$, involves estimates which are independent of the dimension of the manifold and linear in $p$. As a consequence we obtain linear dimension-free estimates of the $L^p$ norms of the corresponding shifted Riesz transform. All our proofs are analytic.
Efficacy evaluation of a test CINtec® p16INK4a in screening for cervical HPV infection  [PDF]
Pafumi Carlo, Leanza Vito, Carbonaro Antonio, Leanza Gianluca, Stracquadanio Maria Grazia, D'Agati Alfio
Open Journal of Preventive Medicine (OJPM) , 2011, DOI: 10.4236/ojpm.2011.13020
Abstract: We submitted 437 patients with cytological alterations that suggest viral infections to HPV test. 154 patients (35.24%) resulted positive for HPV; among these, 128 (83.11%) with a low degree of infectivity, 19 (12.33%), with an average degree of infectivity and 7 (4.54%) with a high degree of infectivity).
Topical estrogenic therapy and urgency/frequency syndrome
Urogynaecologia International Journal , 2010, DOI: 10.4081/uij.2000.11
Abstract: In this study we elected postmenopausal patients suffering from urgency/frequency syndrome. Estriol in the form of vaginal cream was applied for a total of fifteen weeks. The outcome was positive (cured or rimproved) in 89.3 of cases.
Ab-initio study of oxygen vacancies in alpha-quartz
C. M. Carbonaro,V. Fiorentini,S. Massidda
Physics , 1996, DOI: 10.1016/S0022-3093(97)00286-X
Abstract: Extrinsic levels, formation energies, and relaxation geometries are calculated ab initio for oxygen vacancies in alpha-quartz SiO2. The vacancy is found to be thermodynamically stable in the charge states Q=+3, Q=0, Q=--2, and Q=-3. The charged states are stabilized by large and asymmetric distortions near the vacancy site. Concurrently, Franck-Condon shifts for absorption and recombination related to these states are found to be strongly asymmetric. In undoped quartz, the ground state of the vacancy is the neutral charge state, while for moderate p-type and n-type doping, the +3 and -3 states are favored, respectively, over a wide Fermi level window. Optical transitions related to the vacancy are predicted at around 3 eV and 6.5 eV (absorption) and 2.5 to 3.0 eV (emission), depending on the charge state of the ground state.
Proof of the thermodynamical stability of the E' center in SiO2
Carlo M. Carbonaro,Vincenzo Fiorentini,Fabio Bernardini
Physics , 2000, DOI: 10.1103/PhysRevLett.86.3064
Abstract: The E' center is a paradigmatic radiation-induced defect in SiO2 whose peculiar EPR and hyperfine activity has been known since over 40 years. This center has been traditionally identified with a distorted, positively-charged oxygen vacancy V_O+. However, no direct proof of the stability of this defect has ever been provided, so that its identification is still strongly incomplete. Here we prove directly that distorted V_O+ is metastable and that it satisfies the key requirements for its identification as E', such as thermal and optical response, and activation-deactivation mechanisms.
Stability of Ge-related point defects and complexes in Ge-doped SiO_2
C. M. Carbonaro,V. Fiorentini,F. Bernardini
Physics , 2002, DOI: 10.1103/PhysRevB.66.233201
Abstract: We analyze Ge-related defects in Ge-doped SiO_2 using first-principles density functional techniques. Ge is incorporated at the level of ~ 1 mol % and above. The growth conditions of Ge:SiO_2 naturally set up oxygen deficiency, with vacancy concentration increasing by a factor 10^5 over undoped SiO_2, and O vacancies binding strongly to Ge impurities. All the centers considered exhibit potentially EPR-active states, candidates for the identification of the Ge(n) centers. Substitutional Ge produces an apparent gap shrinking via its extrinsic levels.
Page 1 /3364
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.