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Search Results: 1 - 10 of 3011 matches for " Francesca Malvestiti "
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Recombinant Chromosome 4 from a Familial Pericentric Inversion: Prenatal and Adulthood Wolf-Hirschhorn Phenotypes
Francesca Malvestiti,Francesco Benedicenti,Simona De Toffol,Sara Chinetti,Adelheid H?ller,Beatrice Grimi,Gertrud Fichtel,Monica Braghetto,Cristina Agrati,Eleonora Bonaparte,Federico Maggi,Giuseppe Simoni,Francesca Romana Grati
Case Reports in Genetics , 2013, DOI: 10.1155/2013/306098
Abstract: Pericentric inversion of chromosome 4 can give rise to recombinant chromosomes by duplication or deletion of 4p. We report on a familial case of Wolf-Hirschhorn Syndrome characterized by GTG-banding karyotypes, FISH, and array CGH analysis, caused by a recombinant chromosome 4 with terminal 4p16.3 deletion and terminal 4q35.2 duplication. This is an aneusomy due to a recombination which occurred during the meiosis of heterozygote carrier of cryptic pericentric inversion. We also describe the adulthood and prenatal phenotypes associated with the recombinant chromosome 4. 1. Introduction Wolf-Hirschhorn Syndrome (WHS) results from partial deletion of the distal short arm of chromosome 4 (4p16.3). The clinical features are variable, with increasing severity depending on the extent of the deletion, although the minimal diagnostic criteria should include the association of typical facial appearance, growth delay, mental retardation, and seizures [1]. Considering that small and large 4p16.3 deletions are associated with mild and severe WHS phenotype, respectively, Zollino et al. [1] have suggested a WHS classification in three categories based on the clinical presentation, all sharing the minimal diagnostic criteria: “mild” form (deletions < 3.5?Mb) refers to patients with a mild mental retardation (MR), possible fluent language, and usually independent walking by the age of 2-3 years; “classical” form (deletions 5–18?Mb) is characterized by major malformations, severe psychomotor delay (PMD), delay or absence of speech, and late walking; “severe” one (deletions > 22–25?Mb) has severe PMD and MR, facial anomalies, severe scoliosis, and psychotic behaviour. At a molecular level, two WHS critical regions (WHSCRs) have been identified: the WHSCR region, which is 165?Kb in size and it is located at about 2?Mb from the telomere between the markers D4S166 and D4S3327 [2], and the WHSCR-2 region which embraces a 300–600?Kb interval between the loci D4S3327 and D4S168 and it is mapped distal to WHSCR at about 1,9?Mb from the telomere [1]. Most of the 4p16 deletions involved in WHS occur de novo, but in 10%–15% of cases the derivative chromosome 4 originate from chromosomal rearrangements in one of the parents. Four different rearrangements are reported [1]: (1) isolated 4p deletion (70% of patients); (2) unbalanced translocation (22%); (3) inverted duplication associated with terminal 4p deletion (6%); (4) recombinant chromosome 4, rec(4), consisting of unbalanced pericentric inversion with a large 4q segment duplicated on the deleted 4p (2%). Herein we describe a
Longitudinal Tracking of Human Fetal Cells Labeled with Super Paramagnetic Iron Oxide Nanoparticles in the Brain of Mice with Motor Neuron Disease
Paolo Bigini, Valentina Diana, Sara Barbera, Elena Fumagalli, Edoardo Micotti, Leopoldo Sitia, Alessandra Paladini, Cinzia Bisighini, Laura De Grada, Laura Coloca, Laura Colombo, Pina Manca, Patrizia Bossolasco, Francesca Malvestiti, Fabio Fiordaliso, Gianluigi Forloni, Massimo Morbidelli, Mario Salmona, Daniela Giardino, Tiziana Mennini, Davide Moscatelli, Vincenzo Silani, Lidia Cova
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0032326
Abstract: Stem Cell (SC) therapy is one of the most promising approaches for the treatment of Amyotrophic Lateral Sclerosis (ALS). Here we employed Super Paramagnetic Iron Oxide nanoparticles (SPIOn) and Hoechst 33258 to track human Amniotic Fluid Cells (hAFCs) after transplantation in the lateral ventricles of wobbler (a murine model of ALS) and healthy mice. By in vitro, in vivo and ex vivo approaches we found that: 1) the main physical parameters of SPIOn were maintained over time; 2) hAFCs efficiently internalized SPIOn into the cytoplasm while Hoechst 33258 labeled nuclei; 3) SPIOn internalization did not alter survival, cell cycle, proliferation, metabolism and phenotype of hAFCs; 4) after transplantation hAFCs rapidly spread to the whole ventricular system, but did not migrate into the brain parenchyma; 5) hAFCs survived for a long time in the ventricles of both wobbler and healthy mice; 6) the transplantation of double-labeled hAFCs did not influence mice survival.
The Use of Materials from Biomass as Construction Materials  [PDF]
Francesca Giglio
Open Journal of Civil Engineering (OJCE) , 2013, DOI: 10.4236/ojce.2013.32A009

The paper describes some studies conducted by the author, about low impact materials and, particularly, on alternative uses of biomass materials for building materials. Italy needs to develop renewable energy sources and agriculture offers many opportunities: biomass, vegetable residues for livestock breeding, food industry waste, organic waste, solid biofuels, biogas, and biofuels, will be the new renewable energy sources. Researches for promoting sustainable development, including chemistry field are increasing interest in the exploitation of vegetal biomass, in particular waste as a raw material for production of bio-products and biofuels. Not always, however, the use of waste materials such as biomass is the most appropriate, or in any case, the one with less energy expenditure. As ever more evident, in fact, the construction sector is approaching the possibility of using these materials for other purposes, combining the demands of saving natural resources, the need for energy efficiency in buildings and production processes.

Public Private Partnerships for Transportation Infrastructure Delivery  [PDF]
Francesca Leccis
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.35004

The term Public Private Partnerships includes different forms of collaboration between the public and the private sector. These formulas are adopted in a constantly increasing number of countries all over the world in order to overcome the chronic lack of funding and ensure the delivery of infrastructure projects. The paper illustrates the vital role of cooperation between public bodies and private entities in the delivery of public transportation infrastructure. In particular, it focuses on toll roads and highways. Key factors of success and risk are identified and illustrated through five case studies from Chile, Hungary, South Africa-Mozambique, United Kingdom and California.

Synthesis of 1-phenyl-3-pyrroline in water Síntese de 1-fenil-3-pirrolina em água
Thiago Muniz de Souza,Ivani Malvestiti,Lothar W. Bieber
Orbital : the Electronic Journal of Chemistry , 2012,
Abstract: Pyrrolines are bioactive compounds and can be used as starting materials or as intermediates in the synthesis of natural products [1,2]. N-phenyl-pyrrolines have been prepared by reaction of N-propargylanilines catalyzed by Cu(I) [3] or the ring-closing metathesis of allylamines [4]. We present a simple, efficient and low cost new methodology to prepare 1-phenyl-3-pyrolines through nucleophilic displacement reaction SN2. Three parameters were studied, namely, solvent (acetonitrile, dioxane, DMSO, THF and water), bases (DBU, CsCO3, K2CO3, NaHCO3) and reaction time. The reaction conditions were tested with 1,4-dibromobutene and aniline. The best results were obtained with two experimental conditions: (i) in organic medium (acetonitrile) and sodium borohydride (with or without base) and (ii) in water (scheme 1) the reaction presented a conversion of 96% (GC), without the need for purification because the product precipitates. In both conditions only trace amounts of N-phenylpyrrole were observed. The aqueous condition is more interesting due to the use of green solvent, good yield and easy purification. To ascertain the scope of this new methodology we are testing it with other aromatic amines and aliphatic amines in order to obtain pyrroline derivates. Pirrolinas s o compostos bioativos e podem ser usados como material de partida ou como intermediários na síntese de produtos naturais [1,1]. N-fenil-pirrolinas têm sido sintetizadas por meio de rea es de N-propargilanilinas catalisada por Cu(I) [3] e por rea es de cicliza o de dialilanilinas via metátese [4]. Apresentamos uma nova rota sintética baseada numa metodologia simples, eficiente e de baixo custo para obten o de 1-fenil-3-pirrolina através de uma rea o de substitui o nucleofílica SN2. Estudou-se o efeito de três fatores, a saber, solvente (água, acetonitrila, dioxano, DMSO, THF e água), base (DBU, CsCO3, K2CO3, NaHCO3) e tempo reacional. Testamos as condi es com 1,4-dibromobuteno e anilina. Duas condi es experimentais levaram aos melhores resultados: (i) em meio organico (acetonitrila) e borohidreto de sódio (com e sem base) e (ii) em água, conforme o esquema 1, a rea o apresentou uma convers o de 96% (CG), sem necessidade de purifica o uma vez que o produto precipita. Ambas as condi es se mostraram seletivas uma vez que n o se observou a forma o do N-fenilpirrol. A metodologia em água é mais interessante por utilizar um solvente verde, ter bons rendimentos e facilidade de isolamento. O escopo da rea o está sendo avaliado utilizando outras aminas
Identity in Sport Teams  [PDF]
Cristina Zucchermaglio, Francesca Alby
Psychology (PSYCH) , 2011, DOI: 10.4236/psych.2011.23031
Abstract: In this paper we analyze identity in a soccer team using a discursive perspective, in which individual psycho-logical functioning is considered to be built in and through social interactions within groups. Analysis is based on naturally-occurring interactions that were audio recorded during technical meetings before and after the match. The data were collected within an ethnographic investigation of an Italian soccer tam carried out over a two-month period. The results show that the team’s members made rhetorical use of a complex repertoire of their own and others’ social identities, and that two main variables influenced the use of social identity markers: a) the role of the speakers (in particular the “power” role of the coach); b) the result of the match around which the interactive discourse revolved. Against this background, we discuss how narratives and identity positionings were used to achieve specific goals and to perform specific actions, such as the planning of future matches and the interpretation of victories and defeats.
Students’ Metaphors for Defining Their Learning Experience with Audio-Visible versus Invisible Authors. Results from a Case Study in a Social Science Discipline  [PDF]
Terry Inglese, Francesca Rigotti
Creative Education (CE) , 2011, DOI: 10.4236/ce.2011.23025
Abstract: This article summarizes an instructional experience designed and conducted at the University of Lugano – Communication Sciences – (Switzerland) within a Political Theory’s freshmen course, which involved disciplines like: philosophy, political science and epistemology. We offered students two types of authors to be learned: one through a multimedia video interview in combination with written texts of these authors, defined as the audio-visible authors, and one type of author offered only through a text-based format (the invisible author). We gathered quantitative data (students’ performance on their written exam compositions, their grades; the number of written words they wrote; and the number of times students mentioned the two types of authors in their written compositions). We also collected qualitative data (through semi-structured interviews and thinking aloud protocols), analyzing the metaphors students used to define the reading and learning experience with the audio-visible and the invisible authors. Results show that students perform better when the author to be studied is offered with more media instructional supports, they tend to establish a social relationship with the author, and the quality of their critical thinking and the level of interest in a new subject both increase. The article is divided in three parts: we will first give some definitions of what a metaphor is; second, we will describe our case study and the results of the data analysis; third, we will discuss the results.
An Induced Demand Model for High Speed 1 in UK  [PDF]
Francesca Pagliara, John Preston
Journal of Transportation Technologies (JTTs) , 2013, DOI: 10.4236/jtts.2013.31005

Induced travel is an important component of travel demand and increasing attention has been paid to building analytical model to get more precise travel demand forecasting. In general, induced demand can be defined in terms of additional trips that would be made if travel conditions improved (less congested, lower vehicle costs or tolls). In this paper the induced demand resulting from higher design speeds and, therefore by less travel time, for the High Speed 1 in UK will be modelled on the basis of the relationship between existing High Speed Rail demand (dependent variable) to existing High Speed Rail travel times and costs. The covariates include socioeconomic variables related to population and employment in the zones connected by the High Speed Rail services. This model has been calibrated by mean of a before and after study carried on the corridor, when the new High Speed Rail services was introduced. Elasticities of induced travel (trips and VMT) have been computed with respect to fares, travel time and service frequency.

Wild food plants of popular use in Sicily
Francesca Lentini, Francesca Venza
Journal of Ethnobiology and Ethnomedicine , 2007, DOI: 10.1186/1746-4269-3-15
Abstract: Numerous scientific researches conducted in the last few years have revealed that a diet rich in fibre, complex carbohydrates, vitamins and mineral salts, is the diet considered most ideal in order to maintain good health and prevent various illnesses. Fruit and vegetables are the food that contains a large quantity of vitamins and it is mainly because of this that many researchers have focused their attention on the studies of nutritional plants.Many species have already been examined concerning this aspect but there are nevertheless many more which merit examination. Ethnobotany is a preliminary method of research, suitable for gathering information on the nutritional use of plants. It has been proven, time and time again, that the 'quack' medical knowledge handed down by the common people constitutes sources of information useful for scientific research and that many plants utilised exclusively in popular tradition, when exposed under scientific examination, have been found to be useful for different sectors in the industry [1]. Therefore, science and tradition have a strong connection between them; science, in fact, has often traditional origins.Considering the fact that ethnobotany mainly concentrates on the individuation of plants with an applicative purpose, the authors, that have shown an interest in the argument for a long time, have completed a research conducted on the plants used as food and/or for aromatic purposes in popular, Sicilian tradition and have referred to, in this contribution, the results obtained.One of the main objectives of this research is to individuate, amongst the plants of the Sicilian flora, those more or less known for their nutritional use and to provide suggestions on how to embark upon researches in the medical-nutritional field. In fact, many nutritional plants are also utilised for medical purposes and are often advised as a remedy in order to stabilise alternative functions of the human organism or simply to purify or cure so
Multiplicity results for asymmetric boundary value problems with indefinite weights
Francesca Dalbono
Abstract and Applied Analysis , 2004, DOI: 10.1155/s108533750440102x
Abstract: We prove existence and multiplicity of solutions, with prescribed nodal properties, to a boundary value problem of the form u″
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