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Search Results: 1 - 10 of 194217 matches for " Florimar Gil G "
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Brote por Klebsiella pneumoniae multiresistente y productora de β-lactamasa de espectro extendido en una unidad de alto riesgo neonatal Outbreak of multiresistant and extended spectrum β-lactamase producing Klebsiella pneumoniae in a high risk neonatal unit
A. Carolina González R,Florimar Gil G,Marisé Solórzano R,Jhon Cruz G
Revista chilena de infectología , 2011,
Abstract: Klebsiella pneumoniae productora de β-lactamasa de espectro expandido (BLEE) ha jugado un papel importante como causa de infecciones en la unidad de alto riesgo neonatal (UARN) del Instituto Autónomo Hospital Universitario de Los Andes (IAHULA). En el presente trabajo se describe un brote ocasionado por esta bacteria en los neonatos hospitalizados en dicha unidad durante el mes de febrero 2007, así como también, cepas aisladas en los meses siguientes al brote y además, se estudia el ambiente y el personal, como posible fuente de esta bacteria. Las cepas de K. pneumoniae aisladas del brote eran del mismo fenotipo de resistencia, productoras de (3LEE tipo TEM y SHV y pertenecían al mismo genotipo que las cepas aisladas de las manos y de las soluciones jabonosas, posible fuente de infección, lo cual indica que se trataba del mismo clon. El brote se resolvió usando dos importantes medidas: reforzando el lavado de manos y con la indicación oportuna de imipenem a los neonatos afectados. Klebsiella pneumoniae as a producer of extended spectrum beta-lactamase (ESBL) has played an important role as a cause of infection in the neonatal high risk unit (NHRU) of the Autonomous Hospital Institute of the Universidad de Los Andes (AHIULA). In this paper an outbreak caused by this bacterial specie that affected neonates hospitalized in this unit during February 2007 is described. Besides, the environment and the personnel were studied as possible sources of this organism. The strains of K. pneumonia isolated from the outbreak had the same resistance phenotype, produced ESBL type TEM and SHV and belonged to the same genotype as the isolated strains from the hands and the soapy solutions, possible sources of infection. This indicates that it was the same clone. The outbreak was resolved using two important measurements: reinforcing hand washing and with the opportune treatment of neonates with imipenem.
Brote por Klebsiella pneumoniae multiresistente y productora de β-lactamasa de espectro extendido en una unidad de alto riesgo neonatal
González R,A. Carolina; Gil G,Florimar; Solórzano R,Marisé; Cruz G,Jhon; Puig P,Juan; Suárez S,Marlene; Nieves B,Beatríz;
Revista chilena de infectología , 2011, DOI: 10.4067/S0716-10182011000100005
Abstract: klebsiella pneumoniae as a producer of extended spectrum beta-lactamase (esbl) has played an important role as a cause of infection in the neonatal high risk unit (nhru) of the autonomous hospital institute of the universidad de los andes (ahiula). in this paper an outbreak caused by this bacterial specie that affected neonates hospitalized in this unit during february 2007 is described. besides, the environment and the personnel were studied as possible sources of this organism. the strains of k. pneumonia isolated from the outbreak had the same resistance phenotype, produced esbl type tem and shv and belonged to the same genotype as the isolated strains from the hands and the soapy solutions, possible sources of infection. this indicates that it was the same clone. the outbreak was resolved using two important measurements: reinforcing hand washing and with the opportune treatment of neonates with imipenem.
Evaluación de actividad antibacteriana de mieles de Apis mellifera, contra Escherichia coli y Staphylococcus aureus Evaluation of the antibacterial activity of Apis mellifera honey against strains of Escherichia coli and Staphylococcus aureus
Greana Aguilera,Florimar Gil,Ana C González,Beatriz Nieves
Revista del Instituto Nacional de Higiene Rafael Rangel , 2009,
Abstract: La miel de abeja es un fluido dulce y viscoso producido por las abejas a partir del néctar y de la mielada. Se trata de una medicina antigua utilizada principalmente en el tratamiento de heridas, úlceras y quemaduras. En el presente trabajo se evaluó la actividad antimicrobiana de nueve mieles venezolanas, para lo cual se utilizaron cepas ATCC de Escherichia coli y Staphylococcus aureus. Las mieles analizadas se utilizaron concentradas y diluidas (1:2, 1:4, 1:8). Se observó la inhibición del crecimiento de S. aureus en la miel procedente del estado Trujillo sin diluir y en su dilución 1:2, mientras que no se observó inhibición del crecimiento de las cepas de E. coli, por lo que deberían probarse otras bacterias para futuras aplicaciones. Honey is a sweet and viscous fluid produced by bees from nectar and honeydew. It is an ancient natural medicine mainly used to treat wounds, ulcers and burns. In this study we have assessed the antibacterial activity against E. coli and S. aureus of nine Venezuelan honeys participating in the national honey contest year 2005, compared with a control artificial honey. The honeys were tested at three dilutions (1:2, 1:4, 1:8) and undiluted. Only S. aureus was inhibited by one undiluted honey sample and at the 1:2 dilution. The honeys from the contest, were of low therapeutical value against E. coli and S. aureus, but other bacterias should be tested for further applications.
Evaluación de actividad antibacteriana de mieles de Apis mellifera, contra Escherichia coli y Staphylococcus aureus
Aguilera,Greana; Gil,Florimar; González,Ana C; Nieves,Beatriz; Rojas,Yenny; Rodríguez M,Antonio; Vit,Patricia;
Revista del Instituto Nacional de Higiene Rafael Rangel , 2009,
Abstract: honey is a sweet and viscous fluid produced by bees from nectar and honeydew. it is an ancient natural medicine mainly used to treat wounds, ulcers and burns. in this study we have assessed the antibacterial activity against e. coli and s. aureus of nine venezuelan honeys participating in the national honey contest year 2005, compared with a control artificial honey. the honeys were tested at three dilutions (1:2, 1:4, 1:8) and undiluted. only s. aureus was inhibited by one undiluted honey sample and at the 1:2 dilution. the honeys from the contest, were of low therapeutical value against e. coli and s. aureus, but other bacterias should be tested for further applications.
Strategies to stabilize compact folding and minimize aggregation of antibody-based fragments  [PDF]
Diana Gil, Adam G. Schrum
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.44A011
Abstract:

Monoclonal antibodies (mAbs) have proven to be useful for development of new therapeutic drugs and diagnostic techniques. To overcome the difficulties posed by their complex structure and folding, reduce undesired immunogenicity, and improve pharmacoki- netic properties, a plethora of different Ab fragments have been developed. These include recombinant Fab and Fv segments that can display improved properties over those of the original mAbs upon which they are based. Antibody (Ab) fragments such as Fabs, scFvs, diabodies, and nanobodies, all contain the variable Ig domains responsible for binding to specific antigenic epitopes, allowing for specific targeting of pathological cells and/or molecules. These fragments can be easier to produce, purify and refold than a full Ab, and due to their smaller size they can be well absorbed and distributed into target tissues. However, the physicochemical and structural properties of the immunoglobulin (Ig) domain, upon which the folding and conformation of all these Ab fragments is based, can limit the stability of Ab-based drugs. The Ig domain is fairly sensitive to unfolding and aggregation when produced out of the structural context of an intact Ab molecule. When unfolded, Ab fragments may lose their specificity as well as establish non-native interactions leading to protein aggregation. Aggregated antibody fragments display altered pharmacokinetic and immunogenic properties that can augment their toxicity. Therefore, much effort has been placed in understanding the factors impacting the stability of Ig folding at two different levels: 1) intrinsically, by studying the effects of the amino acid sequence on Ig folding; 2) extrinsically, by determining the environmental conditions that may influence the stability of Ig folding. In this review we will describe the structure of the Ig domain, and the factors that impact its stability, to set the context for the different approaches currently used to achieve stable recombinant Ig domains when pursuing the development of Ab fragment-based biotechnologies.

Redes de solidaridad internacional. Para derribar el muro Norte-Sur
Carlos Gómez Gil
Política y Sociedad , 1996, DOI: -
Abstract: Sin resumen
Regularized perturbative series for the ionization potential of atomic ions
G. Gil,A. Gonzalez
Physics , 2013,
Abstract: We study $N$-electron atoms with nuclear charge $Z$. It is well known that, in the cationic ($Z > N$) high-$Z$ region, the atom behaves as a weakly interacting system. The anionic ($Z < N$) regime, on the other hand, is characterized by an instability threshold at $Z_c \lesssim N-1$, below which the atom spontaneously emits an electron. We construct a regularized perturbative series (RPS) for the ionization potential of ions in an isoelectronic sequence that exactly reproduces both, the large $Z$ and the $Z$ near $Z_c$ limits. The large-$Z$ expansion coefficients are analytically computed from perturbation theory, whereas the slope of the energy curve at $Z=N-1$ is computed from a kind of zero-range forces theory that uses as input the electron affinity and the covalent radius of the neutral atom with $N-1$ electrons. Relativistic effects, at the level of first-order perturbation theory, are considered. Our RPS formula is to be used in order to check the consistency of the ionization potential values for atomic ions contained in the NIST database.
Stability of atoms in the anionic domain (Z
G. Gil,A. Gonzalez
Physics , 2013,
Abstract: We study the stability and universal behaviour of the ionization energy of N-electron atoms with nuclear charge Z in the anionic domain (Z
Phase Instability as a Source of Modal Dynamics in Semiconductor Lasers
L. Gil,G. L. Lippi
Physics , 2014, DOI: 10.1103/PhysRevLett.113.213902
Abstract: Thanks to a new derivation of the fundamental equations governing multimode dynamics for a semiconductor laser near its threshold, we identify regimes of existence of a pure phase instability (and of a mixed phase-amplitude turbulence regime) which give an alternative satisfactory interpre- tation of the deterministic multimode dynamics observed in some devices. The existence of intrinsic noise generated by the phase instability reconciles in the same description the deterministic and random features of the semiconductor dynamics.
Beyond the standard approximations: an analysis leading to a correct description of phase instabilities in semiconductor lasers
L. Gil,G. L. Lippi
Physics , 2014, DOI: 10.1117/12.2052258
Abstract: Following an overview of modeling of (longitudinal) multimode semiconductor laser dynamics, we analyze in detail a model proposed in 2006 to explain deterministic, phase-locked modal alternation, experimentally observed a decade ago. Through a stability analysis, we prove that the numerically obtained electromagnetic field evolution, interpreted as an explanation of the experiments, is nothing more than an extremely long transient, so long as to be hardly identifiable in an entirely numerical approach. Comparison with a model we have recently derived, which predicts a phase instability (Benjamin-Feir-like) compatible with the experimental observations, highlights the crucial ingredient for the dynamics. The wide spectrum of unstable eigenvalues accompanying the phase instability plays the role of an equivalent noise in a fully deterministic description, thus reconciling the heuristic models which could qualitatively reproduce the experimental observation either with deterministic equations in the presence of mode-coupling, or through stochastically driven modal decompositions.
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