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Dise o y desarrollo curricular para la ense anza de las matemáticas.
Eugenio Filloy
Perfiles educativos , 1995,
Abstract: Ante las diferentes concepciones de los fundamentos de las matemáticas, el autor propone un dise o curricular para la ense anza de esta disciplina en el nivel básico con un marco general amplio, tomando en cuenta algunas consideraciones para normar los criterios en relación con: los conceptos, el sistema de signos, la cognición, la relación con lo real, los conocimientos prácticos, y la función analítica e instrumental para otros saberes.
Los pu ales con empu adura globular de frontón en la necrópolis de la IIa Edad del Hierro de La Hoya (Laguardia, Alava)
Filloy Nieva, Idoia
Gladius , 2002, DOI: 10.3989/gladius.2002.56
Abstract: Four examples of frontón-hilt daggers are presented here. They were found at the Necropolis of La Hoya (Laguardia, Alava), dated in the Second Iron Age. A typologic study of them, as well of their archeological context is the subject of this paper. They are contemporary, within very narrow limits, to other types of daggers, like the Miraveche-Monte Bernorio or tang-hilt ones and, furthermore, they appear at the same stratigraphical contexts. These examples represent a very important percentage of this type of weapons found at the Iberian Peninsula, and this drives us to question about the ethnical origin of the human group who made them. Presentamos cuatro ejemplares de pu ales con empu adura globular-de frontón localizados en la Necrópolis de la IIa Edad del Hierro de La Hoya (Laguardia, Alava). Se lleva a cabo un estudio tipométrico de los mismos, así como una presentación de su contexto. Registrados en el mismo contexto estratigráfico que pu ales de otras tipologías como los de Monte Bernorio-Miraveche o los de enmangue en espiga, todos ellos inhumados en un breve lapso temporal. Estos ejemplares constituyen un importante porcentaje dentro de la totalidad de este tipo de armas localizadas en territorio peninsular, lo cual lleva al planteamiento sobre el origen étnico del tipo
Respuesta de las aves rapaces al uso de la tierra: un enfoque regional
Filloy,Julieta; Bellocq,M. Isabel;
El hornero , 2007,
Abstract: the pampean region of argentina has been gradually and completely transformed by agriculture (croplands and pastoral farming) and urbanization. currently, there is a n-s gradient from a pure cropland through mix-farming to a pure pastoral landscape. we examine the response of raptorial birds to agricultural intensity by surveying birds and land use along 17 transects covering the gradient. to examine the relationship between species presence or abundance and agricultural intensity we used logistic and simple regressions and correlograms. we used mantel test and redundancy analysis to explore relationships between bird abundance and landscape elements. we recorded a total of 11 raptor species. abundance of the raptor assemblage responded to the spatial structure of land use in the region, being more abundant in pastoral farming landscapes. nonetheless, most species were found in both croplands and pastoral landscapes. from a regional perspective, the use of the land for crops seems to be more detrimental to raptors than pastoral farming, even though most raptor species showed to be tolerant to land use. however, within each particular landscape (cropland or pastoral land), the studied raptor species showed differences in the type of habitat they exploit.
Tabaco y salud oral en estudiantes de la Universidad de Santiago de Compostela
Fernández-Riveiro,Paula; Gonzálvez Becerra,Patricia; Leis Filloy,Catherine; Smyth Chamosa,Ernesto;
RCOE , 2007, DOI: 10.4321/S1138-123X2007000100002
Abstract: objective. the aim of this study was to describe the habits related to oral health and to determine the patterns of tobacco smoking among students at the university of santiago de compostela. material and methods. advanced students in dentistry carried out a survey on habits and an examination of the oral cavity of their peers. they also determined co concentration in exhaled air. results. the questionnaires were answered by 1279 students, 27.5% of which were male and 72.5% female. the mean age of the sample was 21.4 years. among respondents, 90% washed their teeth after eating, above 80% spent more than 1 minute in their oral hygiene and used an average of more than 3 toothbrushes per year. nearly 100% of the sample visited the dentist. we performed 342 examinations which resulted in a dmf rate of 3.71 and a restoration rate of 70.8%; 32.4% of the population smoked an average of 11.5 cigarettes per day. the most frequent starting age of the habit was 16 years-old. no significant differences were found between smokers and non smokers for most of the studied variables with the exceptions of the presence of discolored teeth, the amount of toothpaste used for brushing teeth and the subjective perception of oral health. the average value of expired co in smokers was 12.6. conclusions. among students of our university there is a high degree of awareness concerning oral health. tobacco smoking habit is less frequent than in the general population in the same age range. there were no differences between smokers and non smokers for oral health and oral health habits.
Role of carotid ultrasonography in the evaluation of cardiovascular risk in patients with rheumatoid arthritis
Miguel A Gonzalez-Gay, Carlos Gonzalez-Juanatey, Jose A Miranda-Filloy, Javier Martin, Javier Llorca
Arthritis Research & Therapy , 2010, DOI: 10.1186/ar3186
Abstract: With respect to these interesting observations, we would like to further emphasize the importance of carotid ultrasonography in the evaluation of the cardiovascular risk of patients with RA and the importance of the duration of the disease as a predictor of severity, so it can influence the development of cardiovascular events in these patients. We previously reported that, in long-standing RA patients with no classic cardiovascular risk factors at the time of the carotid assessment, the duration of the disease was the best predictor of carotid plaques [2]. On the other hand, RA is a chronic inflammatory disease, and even in the apparently quiescent phases of the disease, the cumulative effect of the chronic inflammatory burden may account for the progression of the atherosclerosis disease. In this regard, we observed that the mean values of C-reactive protein (CRP) over an extended follow-up rather than a single determination of CRP at the time of the carotid ultrasonography evaluation were associated with the carotid IMT [3]. Moreover, we found that carotid artery IMT had a high predictive power for the development of cardiovascular events over a 5-year follow-up period in 47 patients with RA without clinically evident cardiovascular disease at the time of the carotid ultrasonography evaluation [4]. In our study, carotid IMT categorized in quartiles was strongly associated with the development of cardiovascular events [4]. When logistic regression models were performed, carotid IMT at the time of the ultrasonographic study yielded a high predictive power for the development of cardiovascular events over the 5-year follow-up period. On the other hand, the duration of the disease is also considered an important risk factor of future cardiovascular events [5].Taking all of these considerations together, we propose that ultrasonographic assessment of the carotid artery be performed on all patients with RA in order to establish a subgroup of patients with a high risk o
Response to 'Infliximab therapy increases body fat mass in early rheumatoid arthritis independently of changes in disease activity and levels of leptin and adiponectin: a randomized study over 21 months'
Miguel A Gonzalez-Gay, Carlos Gonzalez-Juanatey, Jose A Miranda-Filloy, Javier Martin, Maria T Garcia-Unzueta, Javier Llorca
Arthritis Research & Therapy , 2011, DOI: 10.1186/ar3301
Abstract: With respect to this, we have prospectively followed a cohort of patients who had RA refractory to conventional disease-modifying ant rheumatic drugs, including methotrexate, and who, owing to disease severity, underwent anti-TNF-α-infliximab therapy. Among them, a subgroup of 33 consecutive RA patients who were on periodical treatment with infliximab and who agreed to participate in the study was assessed to determine the short- term effect of this drug on insulin resistance, ghrelin, and adipokine profile. Besides noting a dramatic improvement of insulin resistance following infliximab administration [2], we observed that, upon administration of this drug, serum ghrelin concentrations (in picograms per milliliter) increased significantly (896.1 ± 314.8, median 861.2, interquartile range (IQR) 700.5 to 879.9 before infliximab at time 0 (baseline) and 976.3 ± 373.0, median 905.8, IQR 752.6 to 1,152.8 after infliximab infusion at 120 minutes; P < 0.001) and that increases in ghrelin concentrations were associated with reductions in P-selectin concentrations (r = -0.513; P = 0.002) [3]. However, ghrelin concentrations were not related to the DAS28 (disease activity score using 28 joint counts), the mean erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) from disease diagnosis or the ESR, platelet count, CRP, or cumulative prednisone dose at the time of the study [3]. Moreover, we observed a significant correlation between leptin levels and body mass index [4].Apart from stimulating growth hormone production, ghrelin regulates energy homeostasis through increasing food intake and decreasing fat utilization, leading to increased adiposity through growth hormone-independent mechanisms [5]. Ghrelin is further associated with metabolic syndrome features, and ghrelin administration has beneficial effects not only on cachexia in patients with heart failure and chronic obstructive pulmonary disease but also on insulin sensitivity in overweight patients and end
Anti-TNF-Alpha-Adalimumab Therapy Is Associated with Persistent Improvement of Endothelial Function without Progression of Carotid Intima-Media Wall Thickness in Patients with Rheumatoid Arthritis Refractory to Conventional Therapy
Carlos Gonzalez-Juanatey,Tomas R. Vazquez-Rodriguez,Jose A. Miranda-Filloy,Ines Gomez-Acebo,Ana Testa,Carlos Garcia-Porrua,Amalia Sanchez-Andrade,Javier Llorca,Miguel A. González-Gay
Mediators of Inflammation , 2012, DOI: 10.1155/2012/674265
Abstract: To determine whether treatment with the anti-TNF-alpha blocker adalimumab yields persistent improvement of endothelial function and prevents from morphological progression of subclinical atherosclerosis in patients with rheumatoid arthritis (RA) refractory to conventional therapy, a series of 34 consecutive RA patients, attending hospital outpatient clinics and who were switched from disease modifying antirheumatic drug therapy to anti-TNF-alpha-adalimumab treatment because of severe disease, were assessed by ultrasonography techniques before the onset of adalimumab therapy (at day 0) and then at day 14 and at month 12. Values of flow-mediated endothelium-dependent vasodilatation at day 14 and at month 12 were significantly higher (mean ± standard deviation (SD): %; median: 5.7% at day 14, and mean ± SD: %; median: 6.9% at month 12) than those obtained at day 0 (mean: %; median: 3.6%; and , resp.). Endothelium-independent vasodilatation results did not significantly change compared with those obtained at day 0. No significant differences were observed when carotid artery intima-media wall thickness values obtained at month 12 (mean ± SD: ?mm) were compared with those found at day 0 ( ?mm) ( ). In conclusion, anti-TNF-alpha-adalimumab therapy has beneficial effects on the development of the subclinical atherosclerosis disease in RA. 1. Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with accelerated atherosclerosis and increased incidence of cardiovascular (CV) events [1]. Besides a genetic component [2] and classic (traditional) CV risk factors [3], chronic inflammation plays a pivotal role in the development of atherogenesis in patients with RA [4]. Different validated techniques are currently available to determine subclinical atherosclerosis in patients with rheumatic diseases. Macrovascular endothelial dysfunction, an early stage in atherosclerosis, can be detected by brachial ultrasonography as the result of impaired flow-mediated endothelium-dependent vasodilatation (FMD). Carotid ultrasound studies are also useful to disclose the presence of subclinical atherosclerosis [5]. By this technique, morphological changes such as abnormally increased carotid artery intima-media wall thickness (IMT) and carotid plaques can be observed [5]. A number of studies have shown short-term improvement of endothelial function in RA refractory to disease modifying antirheumatic drugs (DMARDs) following anti-TNF-alpha therapy [6, 7]. However, carotid ultrasound studies in patients with RA undergoing anti-TNF-alpha therapy have
The lp13.3 genomic region -rs599839- is associated with endothelial dysfunction in patients with rheumatoid arthritis
Raquel López-Mejías, Carlos González-Juanatey, Mercedes García-Bermúdez, Santos Casta?eda, José A Miranda-Filloy, Ricardo Blanco, Javier Llorca, Javier Martín, Miguel A González-Gay
Arthritis Research & Therapy , 2012, DOI: 10.1186/ar3755
Abstract: A total of 128 RA patients without history of CV events were genotyped for rs599839 A/G polymorphism. The presence of endothelial dysfunction was assessed by brachial ultrasonography (brachial flow-mediated endothelium-dependent (FMD)).Patients carrying the allele G exhibited more severe endothelial dysfunction (FMD%: 4.61 ± 3.94%) than those carrying the wild allele A (FMD%: 6.01 ± 5.15%) (P = 0.08). Adjustment for gender, age at the time of study, follow-up time and classic CV risk factors disclosed a significant association between the rs599839 polymorphism and FMD (G vs. A: P = 0.0062).Our results confirm an association of the rs599839 polymorphism with endothelial dysfunction in RA.Rheumatoid arthritis (RA) is a complex polygenic autoimmune inflammatory disease with high risk of cardiovascular (CV) complications [1]. This is a consequence of accelerated atherosclerosis [1]. Besides classic CV risk factors and chronic systemic inflammation, recent studies have emphasized the relevance of several genetic polymorphisms, such as HLA-DRB1 and TNF, in the susceptibility to CV disease in RA [2,3].A major issue in the process of accelerated atherosclerosis in RA is the development of endothelial dysfunction, an early step in the development of atherosclerosis. An important step forward might be to identify high-risk RA patients who would benefit from active therapy to prevent clinical disease. Several noninvasive imaging techniques provide the opportunity to study the relationship of surrogate markers to the development of atherosclerosis. Among them, ultrasound techniques based on flow velocity are considered efficient ways to measure subclinical atherosclerosis. Using brachial artery ultrasonography assessment, we and others have disclosed the presence of endothelial dysfunction expressed by abnormal levels of flow-mediated endothelium-dependent vasodilatation (FMD) in patients without clinically evident CV disease who had either long-standing RA [4] or early-onset R
A1298C polymorphism in the MTHFR gene predisposes to cardiovascular risk in rheumatoid arthritis
Rogelio Palomino-Morales, Carlos Gonzalez-Juanatey, Tomas R Vazquez-Rodriguez, Luis Rodriguez, Jose A Miranda-Filloy, Benjamin Fernandez-Gutierrez, Javier Llorca, Javier Martin, Miguel A Gonzalez-Gay
Arthritis Research & Therapy , 2010, DOI: 10.1186/ar2989
Abstract: Six hundred and twelve patients fulfilling the 1987 American College of Rheumatology classification criteria for RA, seen at the rheumatology outpatient clinics of Hospital Xeral-Calde, Lugo and Hospital San Carlos, Madrid, were studied. Patients and controls (n = 865) were genotyped using predesigned TaqMan SNP genotyping assays.No significant differences in allele or genotype frequencies for the MTHFR gene polymorphisms between RA patients and controls were found. Also, no association between the MTHFR 677 C>T polymorphism and CV events or endothelial dysfunction was observed. However, the MTHFR 1298 allele C frequency was increased in patients with CV events after 5 years (38.7% versus 30.3%; odds ratio = 1.45; 95% confidence interval = 1.00 to 2.10; P = 0.04) and 10 years (42.2% versus 31.0%; odds ratio = 1.62; 95% confidence interval = 1.08 to 2.43; P = 0.01) follow up. Moreover, patients carrying the MTHFR 1298 AC and CC genotypes had a significantly decreased flow-mediated endothelium-dependent vasodilatation (4.3 ± 3.9%) compared with those carrying the MTHFR 1298 AA genotype (6.5 ± 4.4%) (P = 0.005).Our results show that the MTHFR 1298 A>C gene polymorphism confers an increased risk for subclinical atherosclerosis and CV events in patients with RA.Patients with rheumatoid arthritis (RA) have increased risk of cardiovascular (CV) disease due to accelerated atherosclerosis [1]. Besides classic CV risk factors, a number of nontraditional CV risk factors have also been implicated in the elevated CV mortality observed in these patients [2].In this regard, chronic inflammation and the genetic background increase the risk of CV events in RA regardless of the presence of traditional CV risk factors [3]. Hyperhomocysteinemia has been found to be an independent nontraditional risk factor for CV disease, including coronary disease, in the general population [4]. Homocysteine is an intermediary amino acid formed during the conversion of methionine to cysteine. High ele
Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis
Rogelio J Palomino-Morales, Tomas R Vazquez-Rodriguez, Orlando Torres, Inmaculada C Morado, Santos Casta?eda, Jose A Miranda-Filloy, Jose L Callejas-Rubio, Benjamin Fernandez-Gutierrez, Miguel A Gonzalez-Gay, Javier Martin
Arthritis Research & Therapy , 2010, DOI: 10.1186/ar2962
Abstract: In total, 212 patients diagnosed with biopsy-proven GCA were included in this study. DNA from patients and matched controls was obtained from peripheral blood. Samples were genotyped for the IL18-137 G>C (rs187238), the IL18-607 C>A (rs1946518), and the IL18-1297 T>C (rs360719) gene polymorphisms with polymerase chain reaction, by using a predesigned TaqMan allele discrimination assay.No significant association between the IL18-137 G>C polymorphism and GCA was found. However, the IL18 -607 allele A was significantly increased in GCA patients compared with controls (47.8% versus 40.9% in patients and controls respectively; P = 0.02; OR, 1.32; 95% CI, 1.04 to 1.69). It was due to an increased frequency of homozygosity for the IL18 -607 A/A genotype in patients with GCA (20.4%) compared with controls (13.4%) (IL18 -607 A/A versus IL18 -607 A/C plus IL18 -607 C/C genotypes: P = 0.04; OR, 1.59; 95% CI, 1.02 to 2.46). Also, the IL18-1297 allele C was significantly increased in GCA patients (30.7%) compared with controls (23.0%) (P = 0.003; OR, 1.48; 95% CI, 1.13 to 1.95). In this regard, an increased susceptibility to GCA was observed in individuals carrying the IL18-1297 C/C or the IL18-1297 C/T genotypes compared with those carrying the IL18-1297 T/T genotype (IL18-1297 C/C plus IL18-1297 T/C versus IL18-1297 T/T genotype in GCA patients compared with controls: P = 0.005; OR, 1.61; 95% CI, 1.15 to 2.25). We also found an additive effect of the IL18 -1297 and -607 polymorphisms with TLR4 Asp299Gly polymorphism. The OR for GCA was 1.95 for combinations of genotypes with one or two risk alleles, whereas carriers of three or more risk alleles have an OR of 3.7.Our results show for the first time an implication of IL18 gene-promoter polymorphisms in the susceptibility to biopsy-proven GCA. In addition, an additive effect between the associated IL18 and TLR4 genetic variants was observed.Giant cell, arteritis (GCA) is a large- and medium-sized blood vessel systemic vasculitis
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