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Search Results: 1 - 10 of 483369 matches for " Fernando; Gil García "
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Papel del calcio en la modulación de la supervivencia intracelular de Mycobacterium tuberculosis
Diana Gil,Mauricio Rojas,Luis Fernando García
Iatreia , 2001,
Abstract: Mycobacterium tuberculosis ( Mtb) induce alteraciones en la se alización que podrían favorecer el crecimiento intracelular de la bacteria. Hay alteraciones en respuestas al IFNγ, activación de fosfatasas, inhibición del fagolisosoma y cambios en los flujos de iones como el Ca2+. Estos eventos dependen de los receptores por los cuales sea reconocida la micobacteria, por ejemplo, en macrófagos murinos la interacción con el receptor de manosa (MMR), pero no con CD14, ni receptores tipo “scavenger” induce flujos de Ca2+, que alteran la mitocondria y se asocian con apoptosis. En macrófagos humanos, la fagocitosis a través de receptores Fc, pero no de receptores de complemento, aumenta el Ca2+ que favorece la translocación al fagosoma de la calmodulina (CaM) que activa la kinasa II dependiente de CaM (CaMKII), permitiendo la fusión del fagolisosoma y disminuyendo el crecimiento de Mtb. El bloqueo de esta vía favorece el crecimiento de la micobacteria. Esto indica que el Ca2+ puede modular la apoptosis y las se ales que controlan la micobacteria, sugiriendo que la modulación de esta vía puede ser un blanco putativo para la intervención farmacológica. Por lo tanto proponemos como objetivo general establecer si la terapia anti-micobacteriana modula las vías de se alización dependientes de Ca2+ y la actividad de la CaMKII en macrófagos infectados con Mtb.
Cálculo de la vecindad mediante grafos en minería de textos
Artigas Fuentes,Fernando; Gil García,Reynaldo; Badía Contelles,José Manuel; Pons Porrata,Aurora;
Universidad, Ciencia y Tecnología , 2008,
Abstract: searching the most similar documents to a given one is crucial in text mining because it is the basic process of many techniques like classification or information retrieval. the documents are usually represented in high-dimensional feature space, where each term appeared in documents is treated as features and the weight of each term reflects its importance in the document. there are many approaches to find the vicinity of an object, but their performance drastically decreases as the number of dimensions grows. this problem prevents its application for documents. in this paper, we present an access method based on a graph structure that determines in an approximate way the vicinity of a novel document. the obtained method has a high selectivity and an acceptable error rate when it is embedded in a classifier and compared with the exhaustive method that evaluates all documents. our experimental analysis shows that it is feasible the use of the proposed method in problems of very high dimensionality, such as text mining.
La acreditación del programa de Ingeniería de Alimentos de la Corporación Universitaria Lasallista: una muestra del compromiso con la formación de profesionales idóneos y un aporte al desarrollo del País
Gil Garzón,Maritza Andrea; Garcés Giraldo,Luis Fernando; Restrepo Duque,Ana María;
Revista Lasallista de Investigación , 2010,
Abstract: introduction. in the educative sector, auto evaluation should be a permanent practice to make possible a critical look at the way institutions and programs assume the development o all of their processes, in such a way that the quality of their services is assured. if the auto evaluation is made in order to get an accreditation, the steps given by the colombian consejo nacional de acreditación -can must be followed. objective. to show the process and the results of the auto evaluation with accreditation purposes made at the food engineering program from corporación universitaria lasallista. methodology. the work lines, processes and instruments for the auto evaluation of the program were created, based on the procedures given by cna. analysis of the results. according to the auto evaluation, the program had a favorable grade for every factor evaluated. one of the most relevant was the position and the performance of the alumni, and so were the institutional infrastructure and the administrative organization that makes the work possible in our region. conclusions. the food engineering program received a 6 years high quality accreditation, according to the 9086 resolution produced on november 23rd, 2009, by the colombian education ministry.
La acreditación del programa de Ingeniería de Alimentos de la Corporación Universitaria Lasallista: una muestra del compromiso con la formación de profesionales idóneos y un aporte al desarrollo del país
Maritza Andrea Gil Garzón,Luis Fernando Garcés Giraldo,Ana María Restrepo Duque
Revista Lasallista de Investigación , 2010,
Abstract: Introducción. En el ámbito educativo, la autoevaluación debe ser una práctica permanente, que posibilite una mirada crítica a la forma como las instituciones y los programas asumen el desarrollo de todos los procesos, de forma que aseguren la calidad de los servicios que ofrecen. Si el proceso de autoevaluación se realiza con fines de acreditación, se deben seguir los lineamientos definidos para tal fin por el Consejo Nacional de Acreditación -CNA. Objetivo. Mostrar el proceso y los resultados de la autoevaluación con fines de acreditación del programa de Ingeniería de Alimentos de la Corporación Universitaria Lasallista. Materiales y métodos. Se crearon los lineamientos, procesos e instrumentos para la autoevaluación del Programa con base en los lineamientos de acreditación de programas del CNA. Resultados. De acuerdo con la autoevaluación del Programa y el informe del CNA, se obtuvo una calificación favorable de todos los factores evaluados; uno de los factores de mayor relevancia en la evaluación fue el posicionamiento y desempe o de los egresados; además de la infraestructura física de la Institución y su organización administrativa que hacen viable la labor Lasallista en nuestra región. Conclusiones. El programa de Ingeniería de Alimentos obtuvo la acreditación de alta calidad por 6 a os de acuerdo con la resolución 9086 del 23 de noviembre de 2009 expedida por el Ministerio de Educación Nacional.
e-Salud en México: antecedentes, objetivos, logros y retos
Judith Mariscal Avilés,J. Ramón Gil-García,Fernando Ramirez-Hernández
Espacios Públicos , 2012,
Abstract: En México, los esfuerzos para desarrollar una política pública de e-Salud han evolucionado de proyectos individuales y relativamente aislados a la creación de programas nacionales. Sin embargo, la fragmentación del Sistema Nacional de Salud, la concentración de las tecnologías en algunas zonas del país, los elevados costos de las tic y el desconocimiento de las mismas por los médicos y el personal administrativo de los hospitales, representan algunos de los principales retos que la estrategia e-Salud debe enfrentar en un futuro para ser exitosa.
Effectiveness of a Video-Feedback and Questioning Programme to Develop Cognitive Expertise in Sport
Luis García-González, M. Perla Moreno, Alberto Moreno, Alexander Gil, Fernando del Villar
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082270
Abstract: The importance within sport expertise of cognitive factors has been emphasised in many research studies. Adaptations that take place in athletes’ long-term memories are going to condition their decision-making and performance, and training programmes must be developed that improve these adaptations. In our study, we provide a tactical-cognitive training programme based on video-feedback and questioning in order to improve tactical knowledge in tennis players and verify its effect when transferred to athletes’ decision-making. 11 intermediate tennis players participated in this study (12.9±0.7 years old), distributed into two groups (experimental, n = 5; control, n = 6). Tactical knowledge was measured by problem representation and strategy planning with a verbal protocol. Decision-making was measured by a systematic observation instrument. Results confirm the effectiveness of a combination of video-feedback and questioning on cognitive expertise, developing adaptations in long-term memory that produce an improvement in the quality of tactical knowledge (content, sophistication and structure). This, in turn, is transferred to the athletes’ decision-making capacity, leading to a higher percentage of successful decisions made during game play. Finally, we emphasise the need to develop effective programmes to develop cognitive expertise and improve athletes' performance, and include it in athletes’ formative stages.
First Functional and Mutational Analysis of Group 3 N-Acetylneuraminate Lyases from Lactobacillus antri and Lactobacillus sakei 23K
María Inmaculada García-García, Fernando Gil-Ortiz, Francisco García-Carmona, álvaro Sánchez-Ferrer
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096976
Abstract: N-acetyl neuraminate lyases (NALs) catalyze the reversible aldol cleavage of N-acetyl neuraminic acid (Neu5Ac) to pyruvate and N-acetyl-D-mannosamine (ManNAc). Previous phylogenetic studies divided NALs into four different groups. Groups 1 and 2 have been well characterized at both kinetic and molecular levels, but no NAL from group 3 has been studied to date. In this work, a functional characterization of two group 3 members was performed using the recombinant NALs from Lactobacillus antri and Lactobacillus sakei 23K, revealing an optimal pH of between 6.0 and 7.0, low stability at basic pHs (>8.0), low optimal temperatures and, especially, low catalytic efficiency compared with their counterparts in group 1 and 2. The mutational analysis carried out showed that a plausible molecular reason for the low activity shown by Lactobacillus antri and Lactobacillus sakei 23k NALs compared with group 1 and 2 NALs could be the relatively small sugar-binding pocket they contain. A functional divergence analysis concluding that group 3 is more closely related to group 2 than to group 1.
El cedro rojo (Cedrela odorata L.) como alternativa de reconversión de terrenos agrícolas en el sur de Tamaulipas
Ramírez-García, Celene;Vera-Castillo, Gil;Carrillo-Anzures, Fernando;Maga?a-Torres, Octavio Salvador;
Agricultura técnica en México , 2008,
Abstract: the productive reconversion implies to modify the pattern of traditional production, through the establishment of alternative crops with higher agronomic viability, economic profitability and social viability. a reconversion option is the establishment of forest plantations. the objective of this work was to determine the feasibility of converting abandoned agricultural lands in commercial forest plantations, the study was conduced from 2000-2003. this feasibility was determined through the assessment of the survival, growth, health and vigour of a plantation of red cedar (cedrela odorata l.) located in the ejido doroteo arango, tamaulipas. at three years of established the plantation, a survival of 93%, a growth diameter average of 1.72 cm and 1.46 m in height was found. although attack of hypsipyla grandella, 90.3% were healthy trees and the proportion of vigorous trees was 84.36%. the obtained values of survival, growth, sanity and vigour of the assessed plantation show that the red cedar has a good adaptation and growth; this allow to affirm that the establishment of commercial forest plantations of cedar in the south of tamaulipas is a good option for abandoned agricultural lands.
Ambulatory Blood Pressure Monitoring in the Elderly
Juan Diego Mediavilla García,Fernando Jaén águila,Celia Fernández Torres,Blas Gil Extremera,Juan Jiménez Alonso
International Journal of Hypertension , 2012, DOI: 10.1155/2012/548286
Abstract: The incidence of hypertension is high in the elderly and is present in 2/3 of the patients older than 65 years. Prevalence can reach 90% in patients older than 80 years. The presence of isolated systolic hypertension (ISH) is characteristic of this population. However, the prevalence of hypertension by ambulatory blood pressure monitoring (ABPM) is not well known. In this study, we analyzed the special characteristics of hypertension in this population, giving special emphasis on ABPM readings.
Comparación de las lesiones por accidente de trabajo en trabajadores extranjeros y espa?oles por actividad económica y comunidad autónoma (Espa?a, 2005)
López-Jacob,Ma José; Ahonen,Emily; García,Ana M.; Gil,ángel; Benavides,Fernando G.;
Revista Espa?ola de Salud Pública , 2008, DOI: 10.1590/S1135-57272008000200004
Abstract: background: while the immigrant collective in spain has grown considerably in recent years, little is known about working conditions and their corresponding effects on occupational injury in this group. the objective of this study was to compare the incidences for both fatal and non-fatal injuries in foreign workers to that of spanish workers in 2005, by autonomous community and economic activity. methods: injury data came from the accident registry of the ministry of labor and social issues, and denominators were taken from available social security affiliation statistics from general and coal mining social security system. incidence indices for fatal and non-fatal occupational injuries for foreign and spanish workers were calculated. in addition, relative risks and their 95% confidence intervals (95%ci) were calculated by autonomous community and economic activity, using spanish workers as the reference group. results: overall, relative risk for occupational injury in foreign workers in 2005 was superior to base risk for both fatal (1.34; 95%ci: 1.11-1.62) and non-fatal injury (1.13; 95%ci: 1.13-1.14), though there were important differences by autonomous community and activity sectors. compared with spanish workers, risk for occupational injury was higher for foreign workers in industrial activities, while it was lower in construction, commerce and restaurants and hotels. by autonomous community, aragón and catalonia showed the highest risks for foreign workers. conclusions: a higher risk for occupational injury among foreign workers is confirmed, and may be higher than that observed. the differences in risk among economic activities and autonomous communities require more detailed analysis.
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