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Search Results: 1 - 10 of 25722 matches for " Fernanda X. Cunha "
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Membranous nephropathy in three paediatric patients
Nobre,Susana; Santos,Raquel; Gomes,Clara; Cunha,Fernanda X.; Correia,António J.;
Portuguese Journal of Nephrology & Hypertension , 2012,
Abstract: membranous nephropathy in childhood is usually secondary to an underlying cause. idiopathic membranous nephropathy is a rare cause of paediatric asymptomatic proteinuria/nephrotic syndrome. we reviewed the only three cases of membranous nephropathy followed in a paediatric hospital over the last ten years. all patients were female with mean age at diagnosis of 11.3 years (10-13 years). patients 1 and 2 presented with steroid-resistant nephrotic syndrome. patient 3 had a history of episodes of gross haematuria, and subnephrotic-range proteinuria refractory to enalapril and losartan. all patients had normal renal function. patient 2 had hypertension and microscopic haematuria. patients 1 and 2 underwent renal biopsy at an average of 51.5 days after initial symptoms; in patient 3, renal biopsy was performed seven years after initial presentation with episodes of gross haematuria, and five years after discovery of proteinuria. histopathological features indicated membranous nephropathy; in patients 2 and 3, some findings suggested the coexistence of a systemic clinical condition. secondary causes were sought in all patients. six months after diagnosis, patient 1 developed facial skin lesions suggestive of discoid lupus erythematosus and later had positive autoantibodies (ana, ena, anti-ssa). corticosteroids and angiotensin ii receptor antagonists or angiotensin converting enzyme inhibitors were given to all patients. those with nephritic syndrome required the addition of ciclosporin to achieve remission. at the latest evaluation (mean follow-up 31.3 months), patients 1 and 3 were in remission, and patient 2 had sub-nephrotic range proteinuria as the result of poor adherence to medication. all had normal renal function and blood pressure. all were receiving treatment with prednisolone and enalapril, and patients 1 and 2 were also receiving ciclosporin. diagnosing idiopathic membranous nephropathy in children can be challenging. at least one of our patients had atypical f
Preventive but Not Curative Efficacy of Celecoxib on Bladder Carcinogenesis in a Rat Model
José Sereno,Belmiro Parada,Flávio Reis,Fernanda X. Cunha,Edite Teixeira-Lemos,Patrícia Garrido,Rui Pinto,Petronila Rocha-Pereira,Paula Neto,José Ruivo,Paulo Rodrigues-Santos,Sara Nunes,Alfredo Mota,Arnaldo Figueiredo,Frederico Teixeira
Mediators of Inflammation , 2010, DOI: 10.1155/2010/380937
Abstract: To evaluate the effect of a cyclooxygenase 2 inhibitor, celecoxib (CEL), on bladder cancer inhibition in a rat model, when used as preventive versus as curative treatment. The study comprised 52 male Wistar rats, divided in 5 groups, during a 20-week protocol: control: vehicle, carcinogen: 0.05% of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), CEL: 10?mg/kg/day of the selective COX-2 inhibitor Celebrex, preventive CEL (CEL+BBN-P), and curative CEL (BBN+CEL-C) groups. Although tumor growth was markedly inhibited by the preventive application of CEL, it was even aggravated by the curative treatment. The incidence of gross bladder carcinoma was: control 0/8(0%), BBN 13/20(65%), CEL 0/8(0%), CEL+BBN-P 1/8(12.5%), and BBN+CEL-C 6/8(75%). The number and volume of carcinomas were significantly lower in the CEL+BBN-P versus BBN, accompanied by an ample reduction in hyperplasia, dysplasia, and papillary tumors as well as COX-2 immunostaining. In spite of the reduction of tumor volumes in the curative BBN+CEL-C group, tumor malignancy was augmented. An anti-inflammatory and antioxidant profile was encountered only in the group under preventive treatment. In conclusion, preventive, but not curative, celecoxib treatment promoted a striking inhibitory effect on bladder cancer development, reinforcing the potential role of chemopreventive strategies based on cyclooxygenase 2 inhibition. 1. Introduction Bladder cancer is a prevalent tumor, accounting for 5%–10% of all malignancies in Western countries [1, 2]. It has a high recurrence and progression rate and the prognosis, except for superficial forms, is poor [3]. Furthermore, it has high mortality rates and socioeconomic costs [4, 5]. The conventional surgical techniques and therapeutic options might cause discomfort to patients, especially in invasive and aggressive forms of cancer [6, 7]. Therefore, the improvement of bladder cancer management and treatment could rely on better preventive strategies. The identification of promising drugs remains dependent on a better elucidation of the molecular/cellular mechanisms underlying cancer appearance and progression [8, 9]. Apart from the genetic features and markers already characterized [10, 11], the cellular and molecular mechanisms for development and/or progression might involve inflammatory, proliferative, and oxidative stress phenomena that should be better elucidated. Inflammation through the cyclooxygenase (COX) pathway has been involved in cancer development [12]. While COX-1 is constitutively expressed in a huge range of tissues, playing a role in
Método científico e prática docente: as representa??es sociais de professores de ciências do ensino fundamental
Silva, Fernanda;Cunha, Ana Maria;
Ciência & Educa??o (Bauru) , 2012, DOI: 10.1590/S1516-73132012000100003
Abstract: this research investigated social representations of science teachers working at the 5th-8th grades in the scientific method and the effects of those representations on their educational practices. the methodological theoretical reference used was that of the social representations, in the moscovician perspective. the instruments used for the research were questionnaires and interviews. the analysis, although with some incoherence, points to a prevalence of constructivist representations. in relation to the effects that those representations have on the subjects' practices, we concluded that this happens in part. in general the teachers evaluate as advantageous the use of that methodology in the teaching of sciences, justifying the fact that they don't use it as due to some operational difficulties and even due to educational pressures.
Luz, camara, ac o: orienta es para a filmagem da actividade real de trabalho
Liliana Cunha,Rita Gil Mata,Fernanda Correia
Laboreal , 2006,
Abstract: During a seminar that took place at FPCEUP[1], Christian Lascaux, a director that develops his activity in ergonomic and work psychology teams at CNAM[2], CNRS[3] and Paris 8 University[4], we acquired a different view of video utilisation in activity analysis: resorting to film helps not only to assist the observation of the work situation, but also supports the development of other work analysis methods, offering an opportunity for the workers being confronted with their work practices, as shown by the self-confrontation method (Clot et al. 2000).Multiple questions arise at the moment of filming: how and when to use de video? What is the necessary material? How long should it be?The answer to these questions integrates the recognition that it is not possible to present a unique answer, which will depend on the specific context, the request presented, the subjacent objectives and the methodological options assumed.
Nutritional Screening in a University Hospital: Comparison between Oncologic and Non-Oncologic Patients  [PDF]
Selma F. C. Cunha, Lidiane S. Tanaka, Roberta G. Salom?o, Danielle M. Macedo, Thatiane D. Santos, Fernanda M. Peria
Food and Nutrition Sciences (FNS) , 2015, DOI: 10.4236/fns.2015.61009
Abstract: Background & Aims: We compared the screening nutritional data of patients with malignant and non-malignant disease, and classified their nutritional risk according to the primary tumor’s site. Methods: Subjective Global Assessment was applied to 3008 patients within 48 h of admission to a public university. Subjects were divided into Oncologic Group (n = 576) or Non-Oncologic Group (n = 2432) according to the presence of neoplasms or other diseases respectively. These data were compared by the t-student test and classic chi-square test, with statistical significance set at p < 0.05. Results: The Oncologic Group presented a higher prevalence of weight loss (60.3% vs. 49.3%), quantitative (40.7% vs. 28.5%) and qualitative (16.4% vs. 7.6%) alterations in the food intake pattern, gastrointestinal symptoms and muscle waste (23.2% vs. 13.2%) as compared to the Non-Oncologic Group. Also, there was a higher prevalence of nutritional disturbances in the Oncologic Group, with 49.5% of the subjects moderately (or suspected to be malnourished) and 12.7% severely mal-nourished. Severe malnourishment was mainly observed in patients with head and neck (25%), upper digestive tract (21.9%) and soft tissue and bones (17.9%) tumors. Conclusion: When compared to other hospitalized patients, patients with neoplastic disease were in higher nutritional risk.
Avalia??o do uso do Servi?o Brasileiro de Respostas Técnicas: um servi?o de informa??o destinada à microempresa brasileira
Ramos, Hélia Chaves;Carvalho, Fernanda;Cunha, Murilo Bastos da;
Ciência da Informa??o , 2006, DOI: 10.1590/S0100-19652006000300025
Abstract: the article addresses the information needs of the productive sector from the perspective of a technological information service destined to small business, the brazilian service for technical answers (servi?o brasileiro de respostas técnicas sbrt), which is an effort shared by government, research institutions, universities and private sector. a descriptive exploratory survey was conducted by means of the application of a questionnaire to the users of one of sbrt members, the technological development support center of the university of brasilia (cdt/unb). the results have revealed that service is being mainly used by individuals (92%), entrepreneurs "searching for new business". this was the answer of 35% of the individuals, concerning their motivations to use the service. the technological solutions provided by sbrt have actually been applied for the improvement of processes and production (54%).
Avalia??o do desempenho de catalisadores híbridos Ziegler-Natta/metaloceno na homo- e copolimeriza??o de etileno
Cunha, Fernanda O. V.;Forte, Madalena C.;Zacca, Jorge J.;
Polímeros , 2000, DOI: 10.1590/S0104-14282000000300008
Abstract: hybrid catalysts formed by a heterogeneous ziegler-natta catalyst (mgcl2.ticl4) and a metallocene (cpticl3) were prepared in this work. the formation of a new catalytic species cpti(ibu)cl2 on the (100) mgcl2 face has been proposed. these catalyst systems were applied to synthesize high density polyethylene (hdpe) and linear low density polyethylene (lldpe), using only triethyl aluminium (tea) as a cocatalyst. the influence of al/ti molar ratio, temperature and time of polymerization on the catalyst activity and on the polymer properties were evaluated. the catalyst activities were about 5.0 kgpol/gcat.h for ethylene polymerization and 7.0 kgpol/gcat.h for ethylene-1-butene coplymerization.
Suportes poliméricos para catalisadores sulf?nicos: síntese e caracteriza??o
Coutinho, Fernanda M. B.;Cunha, Luciana da;Gomes, Ailton S.;
Polímeros , 2004, DOI: 10.1590/S0104-14282004000100011
Abstract: polymer supports were synthesized by aqueous suspension copolymerization of styrene and divinylbenzene in the presence of diluent mixtures formed by toluene (good solvent) and heptane (bad solvent) in different compositions. two relative concentrations of dvb (60 and 80%) and two dilution degrees relative to the monomers volume (100 and 200%) were used in the copolymerizations. the supports were characterized in dry and swollen states and their properties were related to the synthesis parameters. in the dry state, the bulk density, surface area, pore volume and morphology of the copolymers were determined. in the swollen state, a study was made of the copolymers behavior in toluene and heptane respectively. in this work the advantages of using polymer supports in the preparation of sulfonic catalysts were discussed including a comparison between homogeneous and heterogeneous catalysts often used in organic synthesis.
Doen?a do refluxo gastroesofágico e retardo de linguagem: estudo de caso clínico
Machado, Fernanda Prada;Cunha, Maria Claudia;Palladino, Ruth Ramalho Ruivo;
Pró-Fono Revista de Atualiza??o Científica , 2009, DOI: 10.1590/S0104-56872009000100014
Abstract: background: co-occurrence of feeding and language disorders. aim: to investigate possible connections between feeding and language disorders, based on a bio-psychic perspective. method: a clinical-qualitative methodology, developed through a longitudinal study of a clinical case of a three year old boy with the complaint "does not speak or eat" and with a medical diagnosis of gastroesophageal reflux disease. results: the analyzed case was considered emblematic of connections between feeding and language disorders. conclusions: results indicate that there is a relationship between oral language and feeding problems. it is suggested for speech-language therapists who work with language problems to investigate feeding habits, as well as for those who for with the stomatognathic system to investigate the oral language of their patients.
Feeding and eating behaviors in children with autism and typically developing children
Fernanda Prada Machado,Maria Claudia Cunha,Ruth Ramalho Ruivo Palladino
Revista da Sociedade Brasileira de Fonoaudiologia , 2009, DOI: 10.1590/s1516-80342009000300023
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