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Search Results: 1 - 10 of 474740 matches for " Fernanda A. Andrade "
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Parametros demográficos de Micoureus demerarae (Didelphidae, Marsupialia) em áreas contíguas de manguezal e terra firme, Bragan?a, Pará, Brasil
Andrade, Fernanda A. G.;Fernandes, Marcus E. B.;Brito, Stélio A. C.;
Revista Brasileira de Zoologia , 2007, DOI: 10.1590/S0101-81752007000200002
Abstract: this study investigated some aspects of the population dynamics of micoureus demerarae (thomas, 1905), such as: density, recruitment, and survivorship in two contiguous ecosystems, mangal and terra firme at the fazenda das salinas in the northeast of the state of pará. one transect in each system was used for fieldwork. data collection was carried out from november 2002 to september 2003. the following population parameters were estimated: density, recruitment, and survivorship. the results defined an open population with an even distribution for individuals from mangal and a clumped one for individuals from terra firme, and the evident seasonality with higher proportion of males in the terra firme. the reproductive period was the most important parameter to the population fluctuation in the beginning of the dry season. the environmental impacts over the population dynamics parameters of m. demerarae seem to be determinant for the maintenance of these populations.
Chitosan-Grafted Copolymers and Chitosan-Ligand Conjugates as Matrices for Pulmonary Drug Delivery
Fernanda Andrade,Francisco Goycoolea,Diego A. Chiappetta,José das Neves,Alejandro Sosnik,Bruno Sarmento
International Journal of Carbohydrate Chemistry , 2011, DOI: 10.1155/2011/865704
Abstract: Recently, much attention has been given to pulmonary drug delivery by means of nanosized systems to treat both local and systemic diseases. Among the different materials used for the production of nanocarriers, chitosan enjoys high popularity due to its inherent characteristics such as biocompatibility, biodegradability, and mucoadhesion, among others. Through the modification of chitosan chemical structure, either by the addition of new chemical groups or by the functionalization with ligands, it is possible to obtain derivatives with advantageous and specific characteristics for pulmonary administration. In this paper, we discuss the advantages of using chitosan for nanotechnology-based pulmonary delivery of drugs and summarize the most recent and promising modifications performed to the chitosan molecule in order to improve its characteristics. 1. Introduction Alongside the successful market launch of different products over the last decades, a continuous effort to formulate delivery systems for the pulmonary administration of a wide variety of drugs has been extensively described in the literature [1, 2]. The particular anatomical, physiological, and pathophysiological features of the respiratory tract pose enormous challenges that need to be overcome in order to obtain effective lung deposition, uniform distribution, in loco retention (main challenge is to circumvent mucocilliary clearance), and stability (particularly to enzymatic degradation) of therapeutic agents [1, 3]. Nevertheless, particular attention has been dedicated not only to drugs themselves but also to excipients required to improve the bioavailability of drugs administered pulmonarily. In this context, excipients that could transiently enhance the absorption of drugs are on the spot. Chitosan, a polysaccharide with structural characteristics similar to glucosamines and obtained by the alkaline deacetylation of chitin, derived from the exoskeleton of crustaceans, is one of such appealing excipients. The safety and tolerability of chitosan are synergistic characteristics towards its application in drug delivery by different administration routes. Despite the natural properties, some drawbacks are associated with the poor solubility at physiologic pH and the passive targeting effect. Thus, chemical modifications of chitosan by conjugating various functional groups allow the control of the hydrophilicity and the solubility at neutral and basic pH and open new opportunities to expand the application of this biopolymer. In this paper, we revise some of the most recent and promising
Persistent developmental stuttering as a cortical-subcortical dysfunction: evidence from muscle activation
Andrade, Claudia Regina Furquim de;Sassi, Fernanda Chiarion;Juste, Fabiola;Mendon?a, Lucia Iracema Zanotto de;
Arquivos de Neuro-Psiquiatria , 2008, DOI: 10.1590/S0004-282X2008000500010
Abstract: background: one contemporary view of stuttering posits that speech disfluencies arise from anomalous speech motor control. purpose: to verify the rest muscle tension and speech reaction time of fluent and stuttering adults. method: 22 adults, divided in two groups: g1 - 11 fluent individuals; g2 - 11 stutterers. electromyography recordings (inferior orbicularis oris) were collected in two different situations: during rest and in a reaction time activity. results: the groups were significantly different considering rest muscle tension (g2 higher recordings) and did not differ when considering speech reaction time and muscle activity during speech. there was a strong positive correlation between speech reaction time and speech muscle activity for g2 - the longer the speech reaction time, the higher the muscle activity during speech. conclusion: in addition to perceptible episodes of speech disfluency, stutterers exhibit anomalies in speech motor output during fluent speech. correlations with a possible cortical-subcortical disorder are discussed.
Dieta de Micoureus demerarae (Thomas) (Mammalia, Didelphidae) associada às florestas contíguas de mangue e terra firme em Bragan?a, Pará, Brasil
Fernandes, Marcus E. B.;Andrade, Fernanda A. G.;Silva Júnior, José de S. e;
Revista Brasileira de Zoologia , 2006, DOI: 10.1590/S0101-81752006000400015
Abstract: the diet of micoureus demerarae (thomas, 1905) was studied in mangrove and terra firme stands by using stomachal and faecal samples. the number of captured individuals was inversely proportional to availability of fruits and insects, being coleoptera and hemiptera the most consumed arthropod orders and passifloraceae and arecaceae the most ingested fruits. thus, either fruits variability or their high yield during the dry season seem to explain the increase of captured animals in the terra firme stands, where they originally come from. the food items suggest that this species has an omnivorous diet, independently of the seasonality or distribution of available resources.
El metabolismo ácido de las crasuláceas: diversidad, fisiología ambiental y productividad
José Luis Andrade,Erick de la Barrera,Casandra Reyes García,M. Fernanda Ricalde
Boletín de la Sociedad Botánica de México , 2007,
Abstract: México posee una gran diversidad de especies con el Metabolismo ácido de las Crasuláceas (CAM). Las especies c o n este metabolismo pueden crecer en sitios donde la disponibilidad de agua es infrecuente, como son las zonas áridas y semiáridas y las copas de los árboles, o como hidrofitas en sitios con poca disponibilidad de CO2. Esta revisión presenta aspectos metodológicos, evolutivos, ecológicos y fisiológicos de este tipo de fotosíntesis. Además, se presentan datos de estudios recientes relacionados con la influencia de las condiciones ambientales en el ciclo diario de la fotosíntesis CAM. Finalmente, se presenta una reflexión sobre la falta de estudios en la fisiología de plantas CAM en México a pesar de su enorme diversidad.
The Relation of Externalizing Behavior and Central Auditory Processing Deficits in 4-Year-Old Children  [PDF]
Cristina de Andrade Varanda, Eva Cristina de Carvalho Souza Mendes, Nilva Nunes Campina, Maria da Gra?a Giordano de Marcos Crescenti Aulicino, Rita de Cássia Gottardi van Opstal Nascimento, Cláudia Maria Fernandes Marczak, Karla Regina de Jesus Grilo, Elaine Cristina Diogo, Fernanda Mello, Renata Cristina Borges Corrêa, Fernanda Dreux Miranda Fernandes
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.613156
Abstract: The integrity of the central auditory system is a fundamental condition for language development. Good language development is related to good academic performance and adaptive behavior. Therefore, the evaluation of auditory processing along with behavior as well as the verification of a possible relationship between them can indicate possible ways on how to deal with both problem behavior and difficulties in language. 187 parents of preschoolers (mean age 3.8 years) were interviewed individually and asked to fill in the CBCL (Child Behavior Checklist), for ages 1(1/2) to 5, providing a behavioral profile concerning externalizing and internalizing behavior. Children were assessed regarding central auditory processing skills through the Simplified Assessment of the Auditory Processing—SAAP (Pereira & Schochat, 1997) including Sound Source Localization (SSL); Non-Verbal Sound Sequence Memory (NVSSM); Verbal Sounds Sequence Memory (VSSM). To investigate a possible association between central auditory processing skills and behavioral problems, all the scores in CBCL and the total scores of Simplified Auditory Processing Assessment were correlated with functional parameters using the Spearman rank correlation. The behaviors “acts too young for age”; “constantly seeks help”; “does not eat well”; “does not seem to feel guilty after misbehaving”; “easily frustrated”; “nervous movements or twitching”; “nervous, highstrung, or tense”; “poorly coordinated or clumsy”; “repeatedly rocks head or body”; “stares into space and seems preoccupied”, “sulks a lot” and “wanders away” were correlated with poor auditory processing skills. This indicates that the school staff along with health professionals should provide informational counseling regarding, not only the communicative difficulties associated with a poor performance on central auditory processing skills but also the psychosocial difficulties that these children may be facing.
Temas em avalia o psicológica
Fernanda Andrade de Freitas
Psico-USF , 2002, DOI: 10.1590/s1413-82712002000200015
Abstract:
Vascular Relaxation Induced by C-Type Natriuretic Peptide Involves the Ca2+/NO-Synthase/NO Pathway
Fernanda A. Andrade, Carolina B. A. Restini, Marcella D. Grando, Leandra N. Z. Ramalho, Lusiane M. Bendhack
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095446
Abstract: Aims C-type natriuretic peptide (CNP) and nitric oxide (NO) are endothelium-derived factors that play important roles in the regulation of vascular tone and arterial blood pressure. We hypothesized that NO produced by the endothelial NO-synthase (NOS-3) contributes to the relaxation induced by CNP in isolated rat aorta via activation of endothelial NPR-C receptor. Therefore, the aim of this study was to investigate the putative contribution of NO through NPR-C activation in the CNP induced relaxation in isolated conductance artery. Main Methods Concentration-effect curves for CNP were constructed in aortic rings isolated from rats. Confocal microscopy was used to analyze the cytosolic calcium mobilization induced by CNP. The phosphorylation of the residue Ser1177 of NOS was analyzed by Western blot and the expression and localization of NPR-C receptors was analyzed by immunohistochemistry. Key Findings CNP was less potent in inducing relaxation in denuded endothelium aortic rings than in intact ones. L-NAME attenuated the potency of CNP and similar results were obtained in the presence of hydroxocobalamin, an intracellular NO0 scavenger. CNP did not change the phosphorylation of Ser1177, the activation site of NOS-3, when compared with control. The addition of CNP produced an increase in [Ca2+]c in endothelial cells and a decrease in [Ca2+]c in vascular smooth muscle cells. The NPR-C-receptors are expressed in endothelial and adventitial rat aortas. Significance These results suggest that CNP-induced relaxation in intact aorta isolated from rats involves NO production due to [Ca2+]c increase in endothelial cells possibly through NPR-C activation expressed in these cells. The present study provides a breakthrough in the understanding of the close relationship between the vascular actions of nitric oxide and CNP.
Evaluation of antibiotic activity produced by Pseudomonas aeruginosa LV strain against Xanthomonas arboricola pv. pruni  [PDF]
Fernanda Corrêa da Silva Vasconcellos, Admilton Gon?alves de Oliveira, Lucilene Lopes-Santos, amile Priscila de Oliveira Beranger, Martha Viviana Torres Cely, Ane Stefano Simionato, Juliana Fonteque Pistori, Flavia Regina Spago, Jo?o Carlos Palazzo de Mello, Juca Abramo Barrera San Martin, Celia Guadalupe Tardeli de Jesus Andrade, Galdino Andrade
Agricultural Sciences (AS) , 2014, DOI: 10.4236/as.2014.51008
Abstract:

Bacterial spot caused by Xanthomonas arboricola pv. pruni (Xap) is considered as a major problem in peach orchards. Copper and antibiotics are used to control, and biocontrol should be a new alternative with low environment impact. The objective was evaluated by the antibiotic activity of the metabolite produced by Pseudomonas aeruginosa LV strain. The free cells supernatant was fractionated with a serial organic solvent with crescent polarity and a dichloromethane phase was concentrated and lyophilised, and after was fractionated using vacuum liquid chromatography. The antibiotic activity of the F3 fraction containing an organometallic compound was tested on Xap in vitro and in a greenhouse conditions. Plants were sprayed with F3 before or after Xap infection and the results showed changes in exopolysaccharides and cell morphology. The F3 concentration of 450 μg·mL-1 was more effective. The results showed that F3 fraction could be a new alternative to control bacterial spot.

PESCADOR, a web-based tool to assist text-mining of biointeractions extracted from PubMed queries
Adriano Barbosa-Silva, Jean-Fred Fontaine, Elisa R Donnard, Fernanda Stussi, J Ortega, Miguel A Andrade-Navarro
BMC Bioinformatics , 2011, DOI: 10.1186/1471-2105-12-435
Abstract: To help the concept-oriented exploration of such data we developed PESCADOR, a web tool that extracts a network of interactions from a set of PubMed abstracts given by a user, and allows filtering the interaction network according to user-defined concepts. We illustrate its use in exploring protein aggregation in neurodegenerative disease and in the expansion of pathways associated to colon cancer.PESCADOR is a platform independent web resource available at: http://cbdm.mdc-berlin.de/tools/pescador/ webciteThe repository of biomedical literature available from the NCBI's PubMed database [1] is used by researchers to find references related to particular topics or authors. This resource contains a wealth of biological data but it is vast (currently containing more than 20 million records) and therefore multiple tools have been generated to search it (recently reviewed in [2]). On the one hand, thematic analysis within biomedical text has been used to arrange bibliography according to topics in clusters [3,4] or categories [5], or to find literature relevant to genes [6,7]. On the other hand, PubMed is a formidable resource for information extraction tools, for example to obtain references to genes [8], relations between genes [9], functional gene annotations [10] or gene associated bibliographic profiles [11].A particularly valuable task in information extraction is the identification of biomolecular interactions from biomedical text data where the interactors and the type of interaction are identified [12,13], for example, a protein-protein interaction (PPI) between Neuroserpin and Abeta. Some web tools such as iHOP [14], STRING [15] or AliBaba [16], can generate networks that include biomolecular interactions extracted from the literature.However, current text mining tools for biomolecular interactions are not flexible enough to filter interactions extracted from a thematic PubMed query (centered on a novel research theme of interest) according to concepts consider
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