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Search Results: 1 - 10 of 33868 matches for " Fernández Valladares "
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Antibody-Conjugated Nanoparticles for Biomedical Applications
Manuel Arruebo,Mónica Valladares,áfrica González-Fernández
Journal of Nanomaterials , 2009, DOI: 10.1155/2009/439389
Abstract: Nanoscience and Nanotechnology have found their way into the fields of Biotechnology and Medicine. Nanoparticles by themselves offer specific physicochemical properties that they do not exhibit in bulk form, where materials show constant physical properties regardless of size. Antibodies are nanosize biological products that are part of the specific immune system. In addition to their own properties as pathogens or toxin neutralizers, as well as in the recruitment of immune elements (complement, improving phagocytosis, cytotoxicity antibody dependent by natural killer cells, etc.), they could carry several elements (toxins, drugs, fluorochroms, or even nanoparticles, etc.) and be used in several diagnostic procedures, or even in therapy to destroy a specific target. The conjugation of antibodies to nanoparticles can generate a product that combines the properties of both. For example, they can combine the small size of nanoparticles and their special thermal, imaging, drug carrier, or magnetic characteristics with the abilities of antibodies, such as specific and selective recognition. The hybrid product will show versatility and specificity. In this review, we analyse both antibodies and nanoparticles, focusing especially on the recent developments for antibody-conjugated nanoparticles, offering the researcher an overview of the different applications and possibilities of these hybrid carriers.
Comportamiento de las reintervenciones en cirugía general. Hospital General Docente ?Abel Santamaría?. Pinar del Río
Sánchez Portela,Carlos A; Delgado Fernández,Juan Carlos; García Valladares,Adonis;
Revista de Ciencias M??dicas de Pinar del R?-o , 2012,
Abstract: introducction: re-operations constitute a serious object of concerns to surgeons and have encouraged multiple studies. objective: to describe the behavior of the re-operations in the surgical service. method: a descriptive, retrospective, cross-sectional study choosing the re-operated patients in the service of surgery at "abel santamaria cuadrado" university hospital during 2006-2007. pinar del rio. age, sex, and indication to perform the re-operation, period of time between the initial operation and the re-operation, number of re-operations and cause of death were the variables taken. the target group included the patients who underwent major surgeries (3128) and the sample comprised 108 patients requiring re-operations. percentage terms were used as a statistical method and the results showed in tables. results: 69, 38% belonged to male sex, 59, 2 % of the patients were in the seventies. mechanical intestinal occlusion and lithiasis prevailed as emergencies 67, 34%. the 57, 41% of the re-operations were performed seven days after the initial surgery. the main causes of re-operations were: residual peritonitis (34, 87%), intra-abdominal collections (18,07%) and dehiscence of suture (14,71%). as the numbers of re-operations increased the mortality rate of the re-operated patients also increased (43,52%). conclusion: as early the diagnosis of an intra-abdominal complication is performed and as rapid the decision of re-operations is made, complications will diminish and survival rates possibilities will augment.
Una nueva biblioteca digital UCM:DIALOGYCA BDDH (“Biblioteca Digital de Diálogo Hispánico
Arrigoni,Eleonora,Baranda, Consolación,Fernández Valladares, Mercedes,Vian, Ana
Pecia Complutense : Boletín de la Biblioteca Histórica de la Universidad Complutense de Madrid , 2009,
Abstract: Descripción del proyecto de una base de datos documental,DIALOGYCA BDDH (“Biblioteca Digital de Diálogo Hispánico")destinada a establecer el corpus de diálogos hispánicos, desde su nacimiento hasta la actualidad, textos aún en proceso de localización, recopilación, edición y estudio filológico, histórico-lingüístico e histórico-literario.
Comportamiento de las reintervenciones en cirugía general. Hospital General Docente Abel Santamaría . Pinar del Río Behavior of the re-operations in general surgery at "Abel Santamaria Cuadrado" University Hospital. Pinar del Rio
Carlos A Sánchez Portela,Juan Carlos Delgado Fernández,Adonis García Valladares
Revista de Ciencias M??dicas de Pinar del R?-o , 2012,
Abstract: Introducción: Las reintervenciones constituyen un grave problema que inquietan a los cirujanos y han inspirado múltiples estudios. Objetivo: Describir el comportamiento de las reintervenciones en el servicio de cirugía, se propuso realizar este trabajo. Método: Se realizó un estudio descriptivo, retrospectivo, de corte transversal de los pacientes reintervenidos en el servicio de cirugía general en el Hospital General Docente "Abel Santamaría Cuadrado" de Pinar del Río en los a os 2006 y 2007. Se analizaron la edad, el sexo, indicación de la reintervención, tiempo entre la operación inicial y la reintervención, número de reintervenciones y la causa de muerte. El universo de estudio fueron los pacientes sometidos a cirugía mayor (3128) y la muestra quedó constituida por 108 pacientes que fue preciso reintervenir. Se realizó cálculo porcentual como método estadístico y se plasmaron los resultados en tablas. Resultados: El 69,38% correspondió al sexo masculino, y el 59,2% se hallaba en la séptima década de vida. El 67,34 % fueron operados de urgencia, predominando la oclusión intestinal mecánica y la litiasis vesicular. El 57,41% de las reintervenciones se realizó antes del séptimo día de la intervención inicial. Las causas principales de reintervención fueron: peritonitis residual (34,87%), colecciones intraabdominales (18,07%) y dehiscencias de sutura (14,71%). A medida que se incrementó el número de reintervenciones aumento la mortalidad y esta fue del 43,52% en los pacientes reintervenidos. Conclusiones: Mientras más precozmente se realice el diagnóstico de una complicación intrabdominal y más rápido se decida la reintervención menores serán las complicaciones y mayor la posibilidad de sobrevida del enfermo. Introducction: Re-operations constitute a serious object of concerns to surgeons and have encouraged multiple studies. Objective: To describe the behavior of the re-operations in the surgical service. Method: A descriptive, retrospective, cross-sectional study choosing the re-operated patients in the service of surgery at "Abel Santamaria Cuadrado" University Hospital during 2006-2007. Pinar del Rio. Age, sex, and indication to perform the re-operation, period of time between the initial operation and the re-operation, number of re-operations and cause of death were the variables taken. The target group included the patients who underwent major surgeries (3128) and the sample comprised 108 patients requiring re-operations. Percentage terms were used as a statistical method and the results showed in tables. Results: 69, 38% belonged to male sex, 59,
Consideraciones acerca de la evaluación de los objetivos educativos en la disciplina Morfofisiología
ndez Martínez,María Josefina; Hidalgo García,Carmen Rosa; Fernández Franch,Neyda; Betancourt Valladares,Miriela;
Humanidades M??dicas , 2012,
Abstract: the assessment of educational objectives in the human morphophisiology discipline is difficult due to the fact that stomatology curriculum does not contain the methodology to be followed by teaching staffs of the subjects included. this paper presents the theoretical and pedagogical basis for didactic work of teaching staffs related to the referred evaluation.
Afecciones hipofisarias durante la gestación: un seguimiento de cinco a?os
Valdés Carrillo,Ramón; Fernández Alech,Rogelio; Valladares Hernández,Martha; Rodríguez Vásquez,Belkis;
Revista de Ciencias M??dicas de Pinar del R?-o , 2004,
Abstract: endocrinopathics during pregnancy are entities with proper characteristics. hypophyseal dysfunction is not frequent but not less important. thirty pregnant suffering from hypophyseal disorders were studied, all them attended to provincial endocrinology and pregnancy consultations. the average age was 19.3 ± 6.1 years, prevailing the caucasian race. tsh, 1h, fsh and prl as well as fo and campimetry were determined quarterly. results obtained showed that microadenoma of the hypophysis prevailed in 16 cases followed by empty primary or secondary sella (turcica) syndrome (6 cases), being less frequent craniopharingeoma, macroadenoma (operated on) and diabetes insipidus, in hormones there was a marked increase of prolactine in all quarterlies of pregnancy, fsh and 1h had normal standards but low, ths showed no variations. only 3 patients suffering from microadenoma needed the administration of parlodel during pregnancy. concluding that no tumour growth was found in patients suffering from microadenoma, malformation was not reported in women taking bromocriptine during pregnancy. some women presented hypogalactia after pregnancy.
Consideraciones acerca de la evaluación de los objetivos educativos en la disciplina Morfofisiología Considerations about the evaluation of the teaching objectives in Morphophisioloy
María Josefina Méndez Martínez,Carmen Rosa Hidalgo García,Neyda Fernández Franch,Miriela Betancourt Valladares
Humanidades M??dicas , 2012,
Abstract: La evaluación de los objetivos educativos en la disciplina Morfofisiología de la carrera de Estomatología resulta difícil porque los programas de estudio no brindan a los colectivos de las asignaturas una metodología que lo facilite. Este trabajo ofrece los fundamentos teóricos para el trabajo didáctico de dichos colectivos en relación a la evaluación. The assessment of educational objectives in the Human Morphophisiology discipline is difficult due to the fact that Stomatology curriculum does not contain the methodology to be followed by teaching staffs of the subjects included. This paper presents the theoretical and pedagogical basis for didactic work of teaching staffs related to the referred evaluation.
Defensas antioxidantes en la insuficiencia renal crónica experimental Antioxidant defenses in the experimental chronic renal failure
Miriela Betancourt Valladares,Ygber Luis González de la Cruz,Neyda Fernández Franch,Norma Gutiérrez Méndez
Revista Cubana de Investigaciones Biom??dicas , 2011,
Abstract: OBJETIVO: Evaluar el comportamiento de las defensas antioxidantes en relación con las modificaciones funcionales progresivas en la insuficiencia renal crónica experimental. MéTODOS: Estudio experimental controlado en 40 ratas Wistar provocando insuficiencia renal por ablación de 5/6 de la masa renal. La muestra se dividió en 4 grupos de 10 animales, 1 grupo control y 3 experimentales (E) sometidos a extirpación del ri ón derecho y ligadura de dos ramas de la arteria renal izquierda. El grupo experimental E-I evolucionó 2 sem después de la nefrectomía, el grupo E-II 4 sem y el grupo E-III durante 6 sem. Se realizó aclaramiento plasmático de ácido paraminohipúrico (PAH) e inulina (I) para medir flujo plasmático renal efectivo (FPR) e intensidad de filtración glomerular (IFG) respectivamente. Los cambios de IFG y FPR permitieron constatar las modificaciones funcionales a medida que progresaba la insuficiencia renal. Los indicadores de defensa antioxidante incluyeron la actividad de la enzima superóxido dismutasa (SOD) y los niveles de glutatión reducido (GSH), medidos en homogenado de ri ón. Se realizó análisis de regresión lineal para relacionar cambios funcionales y defensas antioxidantes. RESULTADOS: La función renal decreció progresivamente después de la nefrectomía. Se produjo disminución de la actividad de la SOD seguida de una superinducción a las 6 semanas y los niveles de GSH comenzaron a disminuir en la 4ta. sem posnefrectomía. CONCLUSIONES: Los cambios en los indicadores de defensa antioxidante a nivel renal sugieren que el estrés oxidativo aumenta en el órgano correlacionándose con la pérdida progresiva de la función renal. OBJECTIVE: to evaluate the changes on antioxidant defenses in kidneys while function changes on remaining tissue during progression of renal failure after performing subtotal nephrectomy. METHODS: an experimental trial in 40 Wistar rats was done. The renal failure was induced by surgical ablation of 5/6 of the renal mass, removing the right kidney and tying two branches of the left renal artery to 30 rats; 3 study groups were formed and followed over a period of 2, 4, and 6 weeks. The remaining group of rats was used as control. Functional remainder state was evaluated by measurement of the Glomerular Filtration Rate (GFR) and effective Renal Plasmatic Flow (RPF), through renal plasmatic clearance methods. Measurement of reduced glutathione (GSH) and superoxide dismutase activity (SOD) in renal mass were used as markers of antioxidant defense. Lineal correlation was used to analyze correlations between progressive functional
Afecciones hipofisarias durante la gestación: un seguimiento de cinco a os Pituitary conditions during pregnancy: A five-year follow up
Ramón Valdés Carrillo,Rogelio Fernández Alech,Martha Valladares Hernández,Belkis Rodríguez Vásquez
Revista de Ciencias M??dicas de Pinar del R?-o , 2004,
Abstract: Las endocrinopatías durante la gestación son entidades con características propias. La disfunción hipofisaria es infrecuente pero no menos importante. Estudiamos 30 mujeres embarazadas con afecciones hipofisarias que asistían a consulta provincial de Endocrinología y Gestación creada al efecto. El promedio de edad fue de 19,3 ± 6,1 a os, predominando la raza blanca. Se determinó por trimestres TSH, LH, FSH y Prl, así como FO y campimetría. Como resultado obtuvimos que predominó el microadenoma de hipófisis en 16 casos; seguido de la silla turca vacía primaria o secundaria, con 6 casos; el craneofaringeoma, macroadenoma operado y diabetes insípida fueron los menos frecuentes. Hormonalmente se apreció un marcado aumento de la prolactina en todos los trimestres de la gestación, no así de la FSH y LH, que se mantuvieron normales, pero bajos. La TSH no sufrió variación alguna. En cuanto al tratamiento sólo 3 pacientes con microadenoma necesitaron la toma de Parlodel durante la gestación. Concluimos que no encontramos crecimiento tumoral en las portadoras de microadenoma; tampoco se reportó malformación alguna en las que tomaron Bromocriptina durante la gestación. Algunas pacientes presentaron hipogalactia después del cese del embarazo. Endocrinopathics during pregnancy are entities with proper characteristics. Hypophyseal dysfunction is not frequent but not less important. Thirty pregnant suffering from hypophyseal disorders were studied, all them attended to Provincial Endocrinology and Pregnancy Consultations. The average age was 19.3 ± 6.1 years, prevailing the Caucasian race. TSH, 1H, FSH and Prl as well as FO and campimetry were determined quarterly. Results obtained showed that microadenoma of the hypophysis prevailed in 16 cases followed by empty primary or secondary sella (turcica) syndrome (6 cases), being less frequent craniopharingeoma, macroadenoma (operated on) and diabetes insipidus, in hormones there was a marked increase of prolactine in all quarterlies of pregnancy, FSH and 1H had normal standards but low, THS showed no variations. Only 3 patients suffering from microadenoma needed the administration of Parlodel during pregnancy. Concluding that no tumour growth was found in patients suffering from microadenoma, malformation was not reported in women taking Bromocriptine during pregnancy. Some women presented hypogalactia after pregnancy.
Results of thrombolytic treatment with recombinant streptokinase in elderly and non elderly patients. Resultados del tratamiento trombolítico con estreptoquinasa recombinante en pacientes ancianos y no ancianos.
René Tomás Manso Fernández,Francisco Valladares Carvajal,Claudio González Rodríguez.,Marcos D. Iraola Ferrer
MediSur , 2012,
Abstract: Fundament: The great advances of modern medicine in the last 30 years, have deepened on the treatment of acute myocardial infarct dynamically and efficiently, allowing at present to show good results not only in the decrease of the mortality rate but also in the improvement of the patienta?Ts quality of life. Objective: To offer the precise results with recombinant sterptokinase in elder and non-elder patients with an acute myocardial infarct. Method: prospective observational study of 325 patients admitted with a diagnosis of an acute myocardial infarct at the ¨Dr. Gustavo Aldereguia Lima¨ Hospital. These patients received thrombolitic treatment with recombinant strptokinase (Heberkinase) i a dose of 1 500 000 units, and treatment with 325 mg of acetil salicilic acid too. Results: The presence of the infarct was more frequent in males (68,31%) mainly associated to the smoking habit, Hypertension, and cholesterolemia in patients less than 74 years of age and in those patients aged 75 or more, the infarct was associated to Hypertension and Diabetes. The most affected side of the heart was the anterior part(44,6%), and the thrombolitic treatment was developd in an average of 211, 76 minutes. Deaths increased with age. The most significant variables associated to mortality in the infarcted patients were the fact of being hemodinamically classified into a Killip-Kimball (K-K) Grade III-IV and having had arrhythmia and cardiac rupture. Fundamento: Los grandes avances acaecidos en la medicina moderna en los últimos 30 a os , han impregnado al tratamiento del infarto agudo del miocadio un gran dinamismo y eficiencia, lo que permite hoy mostrar resultados alentadores, tanto en la disminución de la mortalidad como también en la mejoría de la calidad de vida del paciente. Objetivo: Precisar los resultados del tratamiento con estreptoquinasa recombinante, en ancianos y no ancianos con infarto agudo del miocadio. Métodos: Estudio prospectivo observacional de 325 pacientes ingresados con infarto agudo del miocardio en el Hospital Provincial Universitario ¨Dr. Gustavo Aldereguìa Lima¨, de Cienfuegos, que recibieron terapéutica trombolítica con estreptoquinasa recombinante ( Heberquinasa) a la dosis de 1 500 000 unidades, y tratamiento conjunto con 325 mg de ácido acetilsalicìlico. Resultados: La presencia de infarto fue más frecuente en el sexo masculino (68,31 %); asociado en mayor porcentaje al tabaquismo, la hipertensión arterial, la hipercolesteronemia en los pacientes menores de 74 a os ; la hipertensión arterial y la diabetes en los mayores de 75 a os; la cara
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