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Search Results: 1 - 10 of 474 matches for " Fereidoun Azizi "
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CLINICAL EVALUATION OF LIOTHYRONINE (IRAN HORMONE): COMPARISON WITH CYTOMEL
Fereidoun Azizi
Iranian Journal of Nuclear Medicine , 1996,
Abstract: In order to evaluate the effect of liothyronine formulated by Iran Hormone Co.(LT3,IH), 20 patients with primary hypothyroidism received 25mg LT3-IH daily. Another 40 hypothyroids were randomly divided into 4 groups and entered a double blind clinical trail. Two groups received 37.5 and 50mg LTrIH and other two groups took 37.5 and 50mg Cytomel (LTr SKF). Serum T4, T3 and TSH concentrations and resin T3 uptake were measured by commercial kits before and one month after intervention. After one month therapy with 25g LT3-IH, T3 increased from 80±33 to 142±36 ng/dl and TSH decreased from 58±24 to 0.5±0.7 /AJ/m". Both LT3-IH and Cytomel increased T3 and decreased T4 and TSH concentration; TSH 62±28 & 81±39 before and 0.8±0.7 & 4.0±4.5 after one month of 37.5/;g T, daily; TSH 78±31 & 82±38 before and 0.5±0.4 & 0.4±0.6 ,mU/ml, respectively one months after daily ingestion of 50 mg LT3-IH and Cytomel, respectively. This study demonstrates similar effectiveness of LT3-IH and Cytomel in reduction of serum TSH and elevation of serum T3 in patients with hypothyroidism.
A New Diterpene Extracted from Daphne Mucronata, Effects on Human K562 and CCRF-CEM Cell Lines  [PDF]
Mehdi Hedayati, Razieh Yazdanparast, Marjan Zarif Yeganeh, Laleh Hoghooghi Rad, Fereidoun Azizi
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.21008
Abstract: Background: Daphne Mucronata extract has a decreasing effect on the size of breast adenocarcinoma in rats. So in this study, the effect of Daphne Mucronata purified diterpene were investigated on co culture of human monocytes and two human leukemia cell lines (K562, CCRF-CEM). Materials and Methods: Each cell line mono-layer culture, in log phase growth, was treated with 10 to 160 μL of the extract (1 g/ml leave powder) and purified compound (0.94 nM). For a comparative study, Taxol (5 to 40 μM) was used in the presence and absence of LPS. Human monocytes were isolated by adhesion method. TNF-α in cultured media were measured by sensitive biotin-streptoavidin ELISA method. Results: Fifty percent of growth inhibition was shown by 160 μL (1:100 dilution, 0.5 g of the powdered leaves/ml) of the extract and 0.94 nM of the purified component, and there was more inhibition in K562 cells (P < 0.05). Four fold increases in growth inhibition was shown in co culture of isolated human monocytes and leukemia cell lines. There was a direct relationship between monocytes TNF-α secretion and growth inhibition degree. Conclusion: Daphne Mucronata extract and its purified diterpene through increasing monocytes TNF-α releasing, potentially inhibit Leukemia cell line.
Population attributable risk for diabetes associated with excess weight in Tehranian adults: a population-based cohort study
Farhad Hosseinpanah, Mehdi Rambod, Fereidoun Azizi
BMC Public Health , 2007, DOI: 10.1186/1471-2458-7-328
Abstract: Using data of a population-based short-term cohort study in Iran, which began in 1997 with 3.6-year follow-up, we calculated the adjusted odds ratios (OR) and population attributable risks (PAR) of developing T2DM, i.e. the proportion of diabetes that could have been avoided had overweight and/or obesity not been present in the population.Of the 4728 subjects studied, aged ≥ 20 years, during the 3.6-year follow-up period, 3.8% (n = 182) developed T2DM. This proportion was 1.4%, 3.6%, and 7.8% for the normal, overweight, and obese subjects, respectively. When compared to normal BMI, the adjusted ORs for incident diabetes were 1.76 [95% confidence interval (CI) 1.07 to 2.89] for overweight and 3.54 (95% CI 2.16 to 5.79) for obesity. The PARs adjusted for family history of diabetes, age, triglycerides, systolic blood pressure was 23.3% for overweight and 37.1% for obesity. These figures were 7.8% and 26.6% for men and 35.3% and 48.3% for women, respectively.Incident T2DM is mainly attributable to excess weight, significantly more so in Tehranian women than men. Nonetheless, the contribution of excess weight in developing T2DM was lower in our short-term study than that reported in long-term periods. This probably reflects the significant role of other risk factors of T2DM in a short-term follow-up. Hence, prevention of excess weight probably should be considered as a major strategy for reducing incidence of T2DM; the contribution of other risk factors in developing T2DM in short-term period deserve to be studied and be taken into account.Progressive increment of body weight of the population is a major problem faced by the public health systems in a number of countries. Today, more than 1.1 billion adults worldwide are overweight, of which 312 million are obese [1]. In the past 20 years, the rates of obesity have tripled in developing countries adopting Western lifestyles. In Iran, as well as other developing countries, the prevalence of overweight and obesity shows a
The prevalence of idiopathic hirsutism and polycystic ovary syndrome in the Tehran Lipid and Glucose Study
Fahimeh Tehrani, Homeira Rashidi, Fereidoun Azizi
Reproductive Biology and Endocrinology , 2011, DOI: 10.1186/1477-7827-9-144
Abstract: One thousand and two women, aged 18-45 years, were randomly selected from among reproductive aged women who participated in the TLGS. Those women with either hirsutism or menstrual dysfunction were assessed for biochemical hyperandrogenemia; whereas those participants with hirsutism per se were further assessed for subclinical menstrual dysfunction. PCOS were diagnosed using the National Institute of Health (NIH) criteria. IH was defined as hirsutism without clinical or sub clinical menstrual dysfunction or biochemical hyperandrogenemia (BH).The mean ± SD of age of study population was 29.2 ± 8.7 years. Estimated prevalences of idiopathic hirsutism and pure menstrual dysfunction were 13.0% (95% CI: 10.9%-15.1%) and 1.5%(95% CI: 1.1%-1.9%), respectively. The prevalence of PCOS was 8.5% (95% CI: 6.8% - 10.2%); more than one third of these cases would possibly have remained undiagnosed or misdiagnosed, had we not assessed them for subclinical menstrual dysfunction or biochemical hyperandrogenemia.These data from a large representative and non selected population of women confirm the concept that IH and PCOS are the two most common gynecological endocrinopathies among reproductive aged women. The estimated prevalence of these conditions is highly influenced by their screening methods at the community level.Hirsutism, the presence of terminal hairs in females in a male-like pattern, affects between 5% and 10% of women and is considered as idiopathic hirsutism (IH) with the presence of hirsutism and the absence of anovulation and/or hyperandrogenemia [1]. The definition of IH has varied significantly over the past three decades, along with changes in the definition of polycystic ovary syndrome (PCOS), however as IH is a diagnosis of exclusion, it is often difficult to fully differentiate these two disorders [2]. There are only a few community based studies documented that have estimated the prevalence of these two conditions [3-5].The reported prevalence range of PCOS is
Predictive performance of the visceral adiposity index for a visceral adiposity-related risk: Type 2 Diabetes
Mohammadreza Bozorgmanesh, Farzad Hadaegh, Fereidoun Azizi
Lipids in Health and Disease , 2011, DOI: 10.1186/1476-511x-10-88
Abstract: Participants free of diabetes at baseline with at least one follow-up examination (5,964) were included for the current study. Weibull regression models were developed for interval-censored survival data. Absolute and relative integrated discriminatory improvement index (IDI) and cut-point-based and cut-point-free net reclassification improvement index (NRI) were used as measures of predictive ability for incident diabetes added by VAI, as compared to the MetS and WHtR.The annual incidence rate of diabetes was 0.85 per 1000 person. Mean VAI was 3.06 (95%CIs 2.99-3.13). Diabetes risk factors levels increased in stepwise fashion across VAI quintiles. Risk gradient between the highest and lowest quintile of VAI was 4.5 (95%CIs 3.0-6.9). VAI significantly improved predictive ability of the MetS. The relative IDI and cut-point free NRI for predictive ability added to MetS by VAI were 30.3% (95%CIs 18.8-41.8%) and 30.7% (95%CIs 20.8-40.7%), respectively. WHtR, outperformed VAI with cut-point-free NRI of 24.6% (95%CIs 14.1-35.2%).In conclusion, although VAI could be a prognostic tool for incident diabetes events, gathering information on its components (WC, BMI, TGs, and HDL-C) is unlikely to improve the prediction ability beyond what could be achieved by the simply assessable and commonly available information on WHtR.The prevalence of Type 2 diabetes (hereafter diabetes) is undergoing a rapid progression [1], largely as a consequence of the epidemic proportions reached by obesity in various populations of the world [2]. "However, physicians have been puzzled by the heterogeneity of obesity as not every obese patient develops chronic complications [3]." In this regard, visceral adiposity, has been found to be associated with an increased risk of a cluster of diabetogenic, atherogenic, prothrombotic and inflammatory metabolic abnormalities increasing the risk of diabetes [3]. Visceral obesity [4] is associated with deterioration of insulin sensitivity [5], increased risk o
Predictive performances of lipid accumulation product vs. adiposity measures for cardiovascular diseases and all-cause mortality, 8.6-year follow-up: Tehran lipid and glucose study
Mohammadreza Bozorgmanesh, Farzad Hadaegh, Fereidoun Azizi
Lipids in Health and Disease , 2010, DOI: 10.1186/1476-511x-9-100
Abstract: Among participants of Tehran Lipid and Glucose Study, 6,751 participants (2,964 men), aged ≥ 30 years, were followed for a median of 8.6 years. We observed 274 deaths (men: 168) and 447 CVD events (men: 257). Levels of common CVD risk factors significantly increased across LAP quartiles. Mortality rates did not differ by LAP quartiles. Among participants free of CVD at baseline [6331 (2,741 men)], CVD incident rates per 1000 person increased in a stepwise fashion with increasing LAP quartile values in both men (from 6.9 to 17.0) and women (from 1.3 to 13.0), (Ps < 0.001).Among women, a 1-SD increment in log-LAP conferred a 41% increased risk for CVD (HR 1.41, 95% CIs 1.02-1.96). Among men, however, LAP was not observed to be independently associated with increased risk of CVD; except in a sub-group of men assigned to the lifestyle modification interventions, where, LAP predicted CVD risk.After adjustment with CVD risk factors LAP turned to be inversely associated with risk of all-cause mortality (HR, men 0.74, 95% CIs 0.61-0.90; women, 0.94 95% CIs 0.74-1.20).Among women, magnitude of increased risk of CVD due to LAP was not different from those of anthropometric measures. Among men, however, WHpR was observed to be more strongly associated with increased risk of CVD than was LAP.Among neither men nor women were the predictive performances (discrimination, calibration, goodness-of-fit) of the LAP better than those of different anthropometric measures were.If LAP is to be used for predicting CVD, it might not be superior to WHtR or WHpR.In his seminal 1988 Banting award lecture, Reaven introduced insulin resistance as a fundamental "disorder" associated with a set of metabolic abnormalities contributed to the development of cardiovascular disease (CVD) [1]. Large prospective studies [2-7] have shown that insulin resistance is a predictor of coronary artery disease (CAD). It is also relevant to mention that as Reaven found insulin resistant individuals who were not ob
Diabetes prediction, lipid accumulation product, and adiposity measures; 6-year follow-up: Tehran lipid and glucose study
Mohammadreza Bozorgmanesh, Farzad Hadaegh, Fereidoun Azizi
Lipids in Health and Disease , 2010, DOI: 10.1186/1476-511x-9-45
Abstract: The cross-sectional analyses were performed on a sample included 3,682 men and 4,989 women who were not pregnant, aged ≥ 20 years. According to the age (≥ 50 and <50 years) - and sex-specific analyses, odds ratios (ORs) of LAP for prevalent diabetes were higher than those of BMI, WHpR, or WHtR among women, after adjustment for mean arterial pressure and family history of diabetes. The OR of LAP in old men was lower than those of other adiposity measures; in young men, however, LAP was superior to BMI but identical to WHpR and WHtR in identifying prevalent diabetes. Except in young men, LAP showed highest area under the receiver operating characteristic curves (AROC) for prevalent diabetes (P for trend ≤ 0.005).For longitudinal analyses, a total of 5,018 non-diabetic subjects were followed for ~6 years. The ORs of BMI, WHpR, and WHtR were the same as those of LAP in both sexes and across age groups; except in young men where LAP was superior to the BMI. AROCs of LAP were relatively the same as anthropometric adiposity measures.LAP was a strong predictor of diabetes and in young individuals had better predictability than did BMI; it was, however, similar to WHpR and WHtR in prediction of incident diabetes.There is an emerging view that type 2 diabetes (hereafter diabetes) may reflect not so much as an isolated impairment of glucose regulation, rather the complex metabolic consequences of accumulating ectopic lipids or hepatic fat [1-4]. Obesity is commonly used to imply excess fat, but it is ordinarily classified according to excess weight. This semantic inconsistency may help to explain why the body mass index (BMI) performs only modestly as a predictor of medical risk [5].Lipid accumulation should be defined and measured specifically in those contexts where accumulation may represent a physiologic danger [6,7]. These contexts might be described as lipid over accumulation [8]. Attributing culpability to components of adipose or lean tissue should also be avoided; sin
TaqI B1/B2 and -629A/C cholesteryl ester transfer protein (CETP) gene polymorphisms and their association with CETP activity and high-density lipoprotein cholesterol levels in a Tehranian population. Part of the Tehran Lipid and Glucose Study (TLGS)
Daneshpour, Maryam S;Hedayati, Mehdi;Azizi, Fereidoun;
Genetics and Molecular Biology , 2007, DOI: 10.1590/S1415-47572007000600001
Abstract: we examined the cholesteryl ester transfer protein (cetp) gene taqi intron 1 b1/b2 polymorphism and the -629a/c cetp promoter polymorphism in respect to high-density lipoprotein cholesterol (hdl-c) in a healthy iranian population taken from the tehran lipid and glucose study (tlgs). the relationship between cetp activity and hdl-c level was also determined along with body mass index, blood pressure and tobacco smoking status. pcr-rflp used to amplify a segment of the cetp intron 1 taqi (b2/b1) polymorphism from 1021 individuals and we selected 345 individuals from the lowest, middle and highest hdl-c deciles and investigated the -629a/c polymorphism. we also evaluated the cetp activity of 103 of these individuals, each with at least one homozygous allele. the presence of the taqi b2 and -629a/c a alleles were significantly associated with increased hdl-c levels (b2b2 = 1.19 ± 0.31 mmoll-1 vs. b1b1 = 1.01 ± 0.2 mmol l-1 for p < 0.001; aa = 1.15 ± 0.41 mmol l-1 vs. cc = 0.95 ± 0.28 mmol l-1 for p < 0.001) and decreased the cetp activity (b1b1 = 67.8 ± 8.9 pmol l-1 vs. b2b2 = 62.6 ± 9.6 pmol l-1 for p < 0.01; cc = 68.6 ± 8.4 pmol l-1 vs. aa = 62.7 ± 9.7 pmol l-1 for p < 0.002). the frequencies were 0.382 for the taqi b2 allele and 0.462 for the -629a/c a allele, with linkage disequilibrium analysis giving d = 0.0965 and d' = 0.4695. we demonstrated that the taqi b1 and b2 alleles and the -629a/c a and c alleles were in linkage disequilibrium in our population and that there was a significant association between the b2 and a alleles and high hdl-c levels and low cetp activity. linkage disequilibrium between the taqi a and b2 alleles also detected.
Appropriate Iodine Nutrition in Iran: 20 Years of Success
Hossein Delshad,Ladan Mehran,Fereidoun Azizi
Acta Medica Iranica , 2010,
Abstract: Iodine is a trace element in the human body, its only known function is the synthesis of thyroid hormones. Effects of iodine deficiency, termed iodine deficiency disorders (IDD), include endemic goiter, hypothyroidism, cretinism, decreased fertility rate, increased infant mortality and mental retardation. 2.2 billion people worldwide are at risk for IDD. Of these, 30-70% have goiter and 1-10% have cretinism. Two decades ago the I.R. Iran was among the countries most severely affected by iodine deficiency, but during the last two decades has made much progress in the development of universal salt iodization strategies and IDD prevention, and since 1996 meets all WHO/UNICEF/ICCIDD criteria for the sustainable elimination of iodine deficiency.
Anthropometric predictors of incident type 2 diabetes mellitus in Iranian women
Hadaegh Farzad,Shafiee Gita,Azizi Fereidoun
Annals of Saudi Medicine , 2009,
Abstract: Background and Objectives: Studies have shown a strong association between excess weight and risk of incident diabetes in Iranian women. Therefore, we investigated anthropometric indices in the prediction of diabetes in Iranian women. Subjects and Methods: We examined 2801 females aged 220 years (mean [SD] age, 45.2 [12.9] years) in an Iranian urban population who were non-diabetic or had abnormal glucose tolerance at baseline. We estimated the predictive value of central obesity parameters (waist circumference [WC], waist-to-hip ratio [ WHR ], waist-to-height ratio [WHtR], body mass index [BMI]) in the prediction of diabetes. We classified each parameter in quartiles and compared the lowest with the highest quartile after adjusting for confounding variables, includ--ing age, hypertension, triglyceride levels, HDL-cholesterol, family history of diabetes, and abnormal glucose tolerance in a multivariate model. Receiver operator characteristic (ROC) curves were used to determine the predictive power of each variable. Results: Over a median follow up of 3.5 years (11 months-6.3 years), 114 individuals developed diabetes (4.1%). The risk for developing diabetes was significantly higher for the highest quartile of BMI, WC, WHR and WHtR, respectively, compared to the lowest quartile, and the risk decreased but remained statistically significant when abnormal glucose tolerance was included in the multivariate model. WHtR had the highest area under the ROC curve. Conclusions: In Iranian women, BMI, WC, WHR, WHtR were predictive of development of type 2 diabetes, but WHtR was a better predictor than BMI.
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