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Search Results: 1 - 10 of 47 matches for " Fell "
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Memory transition between communicating agents
Elena FELL
Essachess : Journal for Communication Studies , 2012,
Abstract: What happens to a memory when it has been externalised and embodied but has not reached its addressee yet? A letter that has been written but has not been read, a monument before it is unveiled or a Neolithic tool buried in the ground – all these objects harbour human memories engrained in their physicality; messages intended for those who will read the letter, admire the monument and hold the tool. According to Ilyenkov’s theory of objective idealism, the conscious and wilful input encoded in all manmade objects as the ‘ideal’ has an objective existence, independent from the author, but this existence lasts only while memories are shared between communicating parties. If all human minds were absent from the world for a period of time, the ‘ideal’, or memories, would cease to exist. They would spring back to existence, however, once humans re-entered the world. Ilyenkov’s analysis of memories existing outside an individual human consciousness is informative and thorough but, following his line of thought, we would have to accept an ontological gap in the process of memory acquisition, storage and transmission. If there is a period, following memory acquisition and preceding its transmission, when memories plainly do not exist, then each time a new reader, spectator or user perceives them, he or she must create the author’s memories ex nihilo. Bergson’s theory of duration and intuition can help us to resolve this paradox.This paper will explore the ontological characteristics of memory passage in communication taken at different stages of the process. There will be an indication of how the findings of this investigation could be applicable to concrete cases of memory transmission. In particular, this concerns intergenerational communication, technological memory, the use of digital devices and the Internet.
Learning from a Rapid Health Impact Assessment of a proposed maternity service reconfiguration in the English NHS
Greg Fell, Sophie Haroon
BMC Public Health , 2008, DOI: 10.1186/1471-2458-8-138
Abstract: This HIA used routine maternity data for 2004–2005 in Huddersfield, in addition to published evidence. Standard HIA techniques were used.We re-highlighted the socio economic differences in smoking status at booking and quitting during pregnancy. We focused on the key concerns of the public, that of adverse obstetric events on a Midwife Led Unit (MLU) with distant obstetric cover. We estimate that twenty percent of women giving birth in a MLU may require urgent transfer to obstetric care during labour. There were no significant socio economic differences. Much of the risk can be mitigated though robust risk management policies. Additional travelling distances and costs could affect lower socio-economic groups the greatest because of lower car ownership and geographical location in relation to the units. There is potential that with improved community antenatal and post natal care, population outcomes could improve significantly, the available evidence supports this view.Available evidence suggests that maternity reconfiguration towards enhanced community care could have many potential benefits but carries risk. Investment is needed to realise the former and mitigate the latter.The usefulness of this Health Impact Assessment may have been impeded by its timing, and the politically charged environment of the proposals. Nonetheless, the methods used are readily applicable to assess the impact of other service reconfigurations. The analysis was simple, not time intensive and used routinely available data. Careful consideration should be given to both the timing and the political context in which an analysis is undertaken.Within many parts of the country, the NHS is undertaking reconfiguration of services. The push for this is coming from a number of sources; the drive for greater efficiency, choice, practical issues such as workforce shortages and the Working Time Directive [1]. In many districts, commissioners and provider organisations are initiating significant consul
Taiwan’s Democracy: Towards a Liberal Democracy or Authoritarianism?
Dafydd J. Fell
Journal of Current Chinese Affairs , 2010,
Abstract: This paper examines how Taiwan moved from being viewed as a model Asian democracy to one allegedly suffering from democratic reversal. The reasons for the declining domestic and international reputation of Taiwan’s democracy are discussed. Lastly, some key political challenges facing Taiwan’s democracy are outlined.
Can Capital Income Tax Improve Welfare in an Incomplete Market Economy with a Labor-Leisure Decision?
Danijela Medak Fell
Financial Theory and Practice , 2006,
Abstract: This paper is a quantitative exercise in the economic analysis of optimal fiscal policy. We look at an incomplete market economy where agents face idiosyncratic labor productivity shocks and borrowing constraints. We find the steady state equilibrium of this economy and then analyze the effect of a government policy introducing a capital income tax and redistributing the proceeds of tax collection back to the agents in the form of a labor subsidy. We find that this type of policy can indeed improve the welfare of the economy, but its quantitative effect is small. We thus conclude that using capital income tax as fiscal policy instrument is not an effective way to cure the problem of market incompleteness.
Temporal trends in the frequency of twins and higher-order multiple births in Canada and the United States
Deshayne B Fell, KS Joseph
BMC Pregnancy and Childbirth , 2012, DOI: 10.1186/1471-2393-12-103
Abstract: Live birth data from Canada (excluding Ontario) and the United States from 1991-2009 were used to calculate rates of twins, and triplet and higher-order multiples (triplet+). Temporal trends were assessed using tests for linear trend and absolute and relative changes in rates.Twin live births in the United States increased from 23.1 in 1991 to 32.2 per 1,000 live births in 2004, remained stable between 2004 and 2007, and then increased slightly to an all-time high of 33.2 per 1,000 live births in 2009. In Canada, rates also increased from 20.0 in 1991 to 28.3 per 1,000 live births in 2004, continued to increase modestly between 2004 and 2007, and rose to a high of 31.4 per 1,000 in 2009. Rates of triplet+ live births in the United States increased dramatically from 81.4 in 1991 to 193.5 per 100,000 live births in 1998, remained stable between 1998 and 2003 and then decreased to 148.9 per 100,000 in 2007. The rate declined marginally in 2008, but then rose again in 2009 to 153.5 per 100,000. Rates of triplet+ live births were much lower in Canada, although the temporal pattern of change was similar.The rate of twin live births in the United States and Canada continues to increase, though more modestly than during the 1990s. Recent declines in rates of triplet+ live births in both countries have been followed by unstable trends.The dramatic increase in multiple gestation births (i.e., twin, triplet, quadruplet and higher) over the past several decades [1-4] has been of great concern to health care providers, policy makers and researchers. Notwithstanding advances in clinical care that have improved perinatal outcomes for multi-fetal gestations [5-7], rates of preterm birth [2,6,8,9], low birth weight [2,9], fetal and infant mortality [1,6,10] and long-term developmental disability such as cerebral palsy [11,12] remain substantially higher among multiple gestation births compared with their singleton counterparts. Since the risks for these adverse outcomes tend to rise
Effect of mixed film coating on pharmacokinetics of paracetamol tablets
K Ofori-Kwakye, JT Fell
Journal of Science and Technology (Ghana) , 2005,
Abstract: This study was carried out to evaluate the effect of mixed film coating on pharmacokinetics of paracetamol tablets. The tablet cores were prepared and film-coated with a mixture of pectin (0.98%w/w), chitosan (0.16%w/w), HPMC (0.06%w/w), glycerol (0.24%w/w) and 0.1M HCl (98.55%w/w). A single oral dose (1200 mg) of the coated tablets having a coat weight gain of 9%w/w was administered to 5 healthy male volunteers under fasting conditions. Saliva samples were collected at regular time intervals over a 16h period and analysed for paracetamol by reverse phase HPLC. The main pharmacokinetic parameters were determined using non-compartmental analysis. The parameters for the uncoated tablets were similar to published values while wide variations were observed for the coated tablets. The mean lag time (Tlag) was higher in the coated tablets (2.14 ± 1.21h) than the uncoated tablets (0.15 ± 0.05h). The mean AUC0- α (16.92 ± 9.84μg/ml-1h-1) and mean Cmax (3.15 ± 2.10μg/ml-1) of the coated tablets were 47% and 25%, respectively of the corresponding values of the uncoated tablets. There was a 9-fold increase in the mean Tmax (8.40 ± 2.88h) of the coated tablets as compared to the uncoated tablets. The rate and extent of drug absorption was low in the film-coated tablets compared to the uncoated tablets, demonstrating the ability of the mixed films to modulate drug release. The mixed pectin/chitosan/HPMC film coating has the potential for use in the design of controlled release dosage forms.
L’enseignement de la civilisation
Jacqueline Covo,ève-Marie Fell
Cahiers de Civilisation Espagnole Contemporaine , 2007, DOI: 10.4000/ccec.114
Abstract: L’enseignement de la civilisationLa commission a re u 18 réponses. Dans deux cas, deux collègues avaient répondu au sein du même Département. Ce sont donc 16 départements hispanistes qui ont répondu, soit moins de la moitié des départements concernés. Par ailleurs, les réponses sont très difficiles à traiter, dans la mesure où les filières ne sont pas toujours les mêmes (B et LEA) et où certaines réponses, à caractère individuel, comportent des lacunes. Enfin il faut noter que les grands dépa...
Sex Hormone Receptor Repertoire in Breast Cancer
Gerald M. Higa,Ryan G. Fell
International Journal of Breast Cancer , 2013, DOI: 10.1155/2013/284036
Abstract: Classification of breast cancer as endocrine sensitive, hormone dependent, or estrogen receptor (ER) positive refers singularly to ERα. One of the oldest recognized tumor targets, disruption of ERα-mediated signaling, is believed to be the mechanistic mode of action for all hormonal interventions used in treating this disease. Whereas ERα is widely accepted as the single most important predictive factor (for response to endocrine therapy), the presence of the receptor in tumor cells is also of prognostic value. Even though the clinical relevance of the two other sex hormone receptors, namely, ERβ and the androgen receptor remains unclear, two discordant phenomena observed in hormone-dependent breast cancers could be causally related to ERβ-mediated effects and androgenic actions. Nonetheless, our understanding of regulatory molecules and resistance mechanisms remains incomplete, further compromising our ability to develop novel therapeutic strategies that could improve disease outcomes. This review focuses on the receptor-mediated actions of the sex hormones in breast cancer. 1. Introduction Epidemiological, biological, and clinical data strongly implicate the role of sex hormones, primarily estrogens, in breast cancer; yet, their mere presence does not contribute to the malignant process. Inherent in this technically accurate paradox is that while the former supports the well-established link between estrogens, and possibly androgens, in this endocrine-related cancer, the latter infers that generation of the malignant phenotype requires other cellular components. Perhaps the most important “other” element is the hormone receptor. While the ligand/receptor construct is conceptually very simple, the molecular mechanisms by which sex hormones regulate a number of dynamic yet delicate processes in their target tissues are exceedingly more complex. The impetus for undertaking this endeavor was to merge our increased, though by no means complete, understanding of the estrogen and androgen receptors in breast cancer. As such, numerous published papers, some old but of enduring scientific value, were evaluated to support the conclusion that the nuclear steroid receptors are the essential link between hormone and disease. And to further enhance reader appreciation of this complex structure, the biology of the receptor is briefly reviewed in order to provide additional insight into the proposed mechanisms which promote tumor growth as well as facilitate tumor resistance. Here, the reader can learn a little about the treatment of hormone-dependent breast cancer,
Resolution of the wavefront set using general continuous wavelet transforms
Jonathan Fell,Hartmut Führ,Felix Voigtlaender
Mathematics , 2014,
Abstract: We consider the problem of characterizing the wavefront set of a tempered distribution $u\in\mathcal{S}'(\mathbb{R}^{d})$ in terms of its continuous wavelet transform, where the latter is defined with respect to a suitably chosen dilation group $H\subset{\rm GL}(\mathbb{R}^{d})$. In this paper we develop a comprehensive and unified approach that allows to establish characterizations of the wavefront set in terms of rapid coefficient decay, for a large variety of dilation groups. For this purpose, we introduce two technical conditions on the dual action of the group $H$, called microlocal admissibilty and (weak) cone approximation property. Essentially, microlocal admissibilty sets up a systematical relationship between the scales in a wavelet dilated by $h\in H$ on one side, and the matrix norm of $h$ on the other side. The (weak) cone approximation property describes the ability of the wavelet system to adapt its frequency-side localization to arbitrary frequency cones. Together, microlocal admissibility and the weak cone approximation property allow the characterization of points in the wavefront set using multiple wavelets. Replacing the weak cone approximation by its stronger counterpart gives access to single wavelet characterizations. We illustrate the scope of our results by discussing -- in any dimension $d\ge2$ -- the similitude, diagonal and shearlet dilation groups, for which we verify the pertinent conditions. As a result, similitude and diagonal groups can be employed for multiple wavelet characterizations, whereas for the shearlet groups a single wavelet suffices. In particular, the shearlet characterization (previously only established for $d=2$) holds in arbitrary dimensions.
Uma leitura crítica da técnica e da tecnologia: da raz o instrumental à tecnoética
Daniel Felipe Victor Martins,André Felipe de Albuquerque Fell,Nilke Pizziolo Fell
Navus : Revista de Gest？o e Tecnologia , 2013,
Abstract: O trabalho busca promover uma análise e crítica sobre modelos de conhecimentos entre a técnica e a tecnologia pautadas na sua aplicabilidade como ciência, por meio de dois caminhos temporais: pela via moderna e contemporanea. Partimos da argumenta o de como esses modelos de conhecimento instrumentais s o levados na condi o de finalidade para o homem. No nosso enfoque, tais modelos instrumentais representam a base de sustenta o da sociedade para atender às necessidades da evolu o humana. A reflex o se desenvolve em duas partes, a saber: a primeira analisa os elementos entre a técnica e a tecnologia quanto conceito, progresso e suas implica es; na segunda, justificamos como a categoria ética se coloca como eixo de equilíbrio entre a identidade da técnica e da tecnologia, pela via tecnoética. A argumenta o prop e um eficiente instrumento de compreens o para um novo olhar da compreens o da virtude e progresso das a es do homem.
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