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Search Results: 1 - 10 of 3080 matches for " Felix Ellett "
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Real-Time Whole-Body Visualization of Chikungunya Virus Infection and Host Interferon Response in Zebrafish
Nuno Palha,Florence Guivel-Benhassine,Valérie Briolat,Georges Lutfalla,Marion Sourisseau,Felix Ellett,Chieh-Huei Wang,Graham J. Lieschke,Philippe Herbomel,Olivier Schwartz,Jean-Pierre Levraud
PLOS Pathogens , 2013, DOI: 10.1371/journal.ppat.1003619
Abstract: Chikungunya Virus (CHIKV), a re-emerging arbovirus that may cause severe disease, constitutes an important public health problem. Herein we describe a novel CHIKV infection model in zebrafish, where viral spread was live-imaged in the whole body up to cellular resolution. Infected cells emerged in various organs in one principal wave with a median appearance time of ~14 hours post infection. Timing of infected cell death was organ dependent, leading to a shift of CHIKV localization towards the brain. As in mammals, CHIKV infection triggered a strong type-I interferon (IFN) response, critical for survival. IFN was mainly expressed by neutrophils and hepatocytes. Cell type specific ablation experiments further demonstrated that neutrophils play a crucial, unexpected role in CHIKV containment. Altogether, our results show that the zebrafish represents a novel valuable model to dynamically visualize replication, pathogenesis and host responses to a human virus.
The Question of the Student In Educational Reform
David P. Ericson,Frederick S. Ellett
Education Policy Analysis Archives , 2002,
Abstract: In pursuing the goals of educational reform over the past several decades, educational policy makers have focused on teachers, administrators, and school structures as keys to higher educational achievement. As the would-be beneficiaries of reform, students, and their interaction with the educational system, have been almost entirely overlooked in the pursuit of educational excellence. Yet, as we argue, students are as causally central as educators in bringing about higher educational achievement. In what follows, we examine rational student interaction with the educational system and show why a large number of students have incentives to undercut the intent of the reforms. These are incentives created by our development of an educationally-based, meritocratic social and economic system. No one, apparently, is asking what exactly is in the reforms from the point of view of quite rational, if sometimes irresponsible, student self-interest. Indeed, the eduationally-based, meritocratic social and economic system may be actually forming student preferences guaranteed to result in educational mediocrity rather than excellence. Finally, we comment upon the meaning of "educational excellence" and show why the educational reformers' understanding of the purpose of public education—to compete in the global economic system—can only fail to capture it. In doing so, we point to the kinds of educational structures and policies that create multiple pathways to competent adulthood that do have a chance of bringing about the reformers' stated goal of excellence in the educational system. But these are structures and policies that challenge the entire conceptual framework of the current educational reform movement.
Do We Need Dark Energy to Explain the Cosmological Acceleration?  [PDF]
Felix M. Lev
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.329153
Abstract: The phenomenon of the cosmological acceleration discovered in 1998 is usually explained as a manifestation of a hypothetical field called dark energy which is believed to contain more than 70% of the energy of the Universe. This explanation is based on the assumption that empty space-time background should be flat and hence a nonzero curvature of the background is a manifestation of a hidden matter. We argue that quantum theory should proceed not from space-time background but from a symmetry algebra. Then the cosmological acceleration can be easily and naturally explained from first principles of quantum theory without involving empty space-time background, dark energy and other artificial notions. We do not assume that the reader is an expert in the given field and the content of the paper can be understood by a wide audience of physicists.
Great Expectations—Narratives and the Elicitation of Aesthetic Chills  [PDF]
Felix Schoeller, Leonid Perlovsky
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.616205
Abstract: We clarify the relation between the perception of narratives and aesthetic emotions by relating them to mechanisms of knowledge-acquisition. Stories elicit emotions by diverging from expectations one may formulate on the basis of their properties. The greater the divergence, the stronger the emotion. Models of emotions, expectations, and knowledge-acquisition are briefly presented. We relate them to research pertaining to narrative structures and provide a mathematical description for aesthetic emotions. We conclude by underlining the fundamental role played by aesthetic emotions in the workings of the human mind.
Enforcement of Fundamental Rights in National Constitutions: Resolving the Conflict of Jurisdiction between the Federal High Court and State High Court in Nigeria  [PDF]
Odike Felix, Alero Akujobi
Beijing Law Review (BLR) , 2018, DOI: 10.4236/blr.2018.91004
Abstract: Fundamental human rights are those natural or human rights that are guaranteed to individuals as a citizen of a free and civilized state. They are incorporated in the supreme or basic law of a country as fundamental human rights. This paper examines the conflict of jurisdictions between the federal high court and the state high courts in the enforcement of fundamental human rights with particular emphasis on how the Nigerian case law has contributed to the confusion. To resolve the issue, the paper surveyed the position of enforcement of fundamental human rights in few other common law jurisdictions such as India, Pakistan and Ghana, and concluded that in Nigeria, the federal high court only has jurisdiction to enforce fundamental human rights arising from a cause of action that falls within its limited exclusive jurisdiction.
Creativity and Culture: Nigerian Conceptions  [PDF]
Felix-Kingsley Obialo
Creative Education (CE) , 2018, DOI: 10.4236/ce.2018.916215
Abstract: Creativity is an inevitable phenomenon resulting in people’s need to solve their problems. This phenomenon is captured differently by each culture’s values and beliefs. Though Western conceptions of creativity dominate literature with an impressive contribution from Eastern cultural conceptions, African conceptions of creativity seem to be obscure. This article uses the three dominant Nigerian cultures namely Hausa, Igbo and Yoruba to underscore the relationship between culture and creativity. It contends that any concept of creativity is reflective of a people’s cultural viewpoint. While communal and religious interpretations of the association are traditionally Nigerian, there is, however, a contemporary dimension to the Nigerian concept of creativity which is also Western in outlook. The result is an amalgam of the traditional Nigerian and Western conceptions of creativity in one socio-cultural setting called Nigeria. However, the fusion of these two cultural concepts does not rob the traditional Nigerian notions of creativity the enduring traits of what other cultures understand to be creative. Consequently, if the various cultural understandings of creativity have all led to growth and development in their different cultural settings, it behooves multiple stakeholders of the Nigerian society the duty and responsibility of promoting the prevailing conceptions of creativity from their cultural backdrop for the growth and development of the Nigerian experience.
Pro-Inflammatory Cytokines (TNF-α and IL-1) in Nigerian Women with Breast Cancer  [PDF]
Chukwurah Ejike Felix, Iyare Festus Ehigiator, Chukwurah Felix Chinedum
Open Journal of Immunology (OJI) , 2018, DOI: 10.4236/oji.2018.82002
Abstract:

Background: Breast cancer remains an important medical challenge, despite sustained global efforts at its prevention and control. Various immunological factors are expressed in the serum during breast tumourigenesis, and can be of value in the surveillance of the disease. These serum bio-markers include pro-inflammatory cytokines since breast cancer is associated with chronic inflammation. In our locality with different racial/ethnic variations from Caucasian as well as environmental factors, there is scanty information on the value of these serum factors in screening and surveillance of breast cancer—hence the need for this study. Methodology: A total of 68 females (mean age = 48.7 ± 8.7 yrs) with clinically and pathologically confirmed breast cancer were recruited by self selection; representing breast cancer patients group. Due to small sample size they were further grouped into advanced stage breast cancer cases (N = 40) and early stage breast cancer cases (N = 28). Controls consisted of two groups: A—Patient control group (N = 21) comprised females with benign breast tumour (15 cases with fibroadenoma and 6 cases with fibrocystic disease) and group B—apparently healthy age/sex matched control group (N = 21). Pre-treatment samples

Serum Immunoglobulins (IgG, IgM and IgA) in Nigerian Women with Breast Cancer  [PDF]
Chukwurah Ejike Felix, Ogbodo Sylvester Ogbonna, Chukwurah Felix Chinedum
Open Journal of Immunology (OJI) , 2018, DOI: 10.4236/oji.2018.83005
Abstract: Background: Breast cancer remains intractable and the leading cause of cancer related death among women. The appearance of breast tumour and its progression poses great clinical unpredictability before and after diagnosis, therapy and appearance of recurrent secondary deposits. Various immunological changes occur during breast tumourigenesis, and can be of value in the surveillance of the diseases. In our environment, there is scanty information on the value of these immunological factors especially immunoglobulins in screening and surveillance of breast cancer—hence the need for this study. Methodology: A total of 59 females (mean age = 48.7 ± 8.7 yrs) with clinically and pathologically confirmed breast cancer were prospectively recruited alongside with 20 patients with benign breast tumour representing patients’ control group and 20 apparently healthy age and sex-matched control subjects (mean age = 47.5 ± 13.4 yrs). Breast cancer patients were further grouped into early stage breast cancer (N = 25) and advanced stage breast cancer (N = 34). Patients were subjected to standard treatment modalities and pre- and post-treatment samples collected at intervals. Samples were assayed for IgG & IgM by immunoenzymatic methods and IgA by immunoturbidimetric method. Questionnaires and measurements were used to obtain necessary demographic and anthropologic information from the subjects. Results: Results showed that in all stages of breast cancer and treatment groups, the mean serum IgG, IgM and IgA levels respectively were not significantly raised (P > 0.05) when compared. Results also showed that majority (59%) of the patients presented at advanced stage of the disease. Low level of education and low income were among the prevailing risk factors. Majority (63%) of the cases had body mass index suggesting obesity (>30 kg/m2). Conclusion: Results suggest that serum immunoglobulin (IgG, IgM and IgA) levels are of limited value in surveillance of breast cancer in our environment. Based on our findings, it could also be concluded that low levels of education and low income are among the risk factors. Advocacy and evidence based policies aimed at prevention and early detection of the disease should be prioritized.
Risk Assessment of Trace Metals in Soils in the Vicinity of NPA Expressway Open Dump in Warri Metropolis, Delta State, Nigeria  [PDF]
Helen Ataikiru, Felix E. Okieimen
Journal of Environmental Protection (JEP) , 2019, DOI: 10.4236/jep.2019.104032
Abstract: Heavy metals are non-biodegradable. They accumulate in the environment and subsequently contaminate the food chain. It is therefore essential to monitor heavy metals content in the soil, so as to prevent too much accumulation in human beings and animals through food chain. Test soil samples were collected from Nigeria Ports Authority (NPA) Expressway open dump, and background (control) soil samples were also collected at about 2 km from the open dump and spatial test samples were also collected. The physicochemical properties of the soil were determined. Tessier’s sequential extraction protocols were used to assess the geochemical forms of Cr, Pb, Zn, and Mn in the soil of the open dump. The concentrations of the heavy metals in the extracts were determined in a pre-calibrated atomic absorption spectrophotometer and they are above the background sample values. The metal assessment index (Igeo) evaluated, indicated that the soil in the vicinity of the open dump was highly polluted. The results obtained showed the mobile metal pools which are available to plants roots.
In-Medium Effects in the Holographic Quark-Gluon Plasma
Felix Rust
Advances in High Energy Physics , 2010, DOI: 10.1155/2010/564624
Abstract: We use the gauge/gravity duality to investigate various properties of strongly coupled gauge theories, which we interpret as models for the quark-gluon plasma (QGP). In particular, we use variants of the D3/D7 setup as an implementation of the top-down approach of connecting string theory with phenomenologically relevant gauge theories. We focus on the effects of finite temperature and finite density on fundamental matter in the holographic quark-gluon plasma, which we model as the =2 hypermultiplet in addition to the =4 gauge multiplet of supersymmetric Yang-Mills theory. We use a setup in which we can describe the holographic plasma at finite temperature and either baryon or isospin density and investigate the properties of the system from three different viewpoints. (i) We study meson spectra. Our observations at finite temperature and particle density are in qualitative agreement with phenomenological models and experimental observations. They agree with previous publications in the according limits. (ii) We study the temperature and density dependence of transport properties of fundamental matter in the QGP. In particular, we obtain diffusion coefficients. Furthermore, in a kinetic model we estimate the effects of the coupling strength on meson diffusion and therewith equilibration processes in the QGP. (iii) We observe the effects of finite temperature and density on the phase structure of fundamental matter in the holographic QGP. We trace out the phase transition lines of different phases in the phase diagram.
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