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Search Results: 1 - 10 of 26526 matches for " Felipe; Bernardez Pereira "
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Aplica??o de escore de marcadores de baixo custo no prognóstico de pacientes com insuficiência cardíaca cr?nica
Montes Pena,Felipe; Bernardez Pereira,Sabrina; Giro,Camila; Seixas,Karina; Ferreira Barcelos,Amanda; Tinoco Mesquita,Evandro;
Insuficiencia card?-aca , 2011,
Abstract: purpose. to demonstrate that score based on low cost laboratory markers can determine prognosis of ambulatory patients with heart failure (hf). introduction. hf is a disease known for her evolving with high mortality. biomarkers are emerging as an important aid in the standard clinical evaluation of a variety of cardiovascular disorders, including hf. methods. this study consists on a prospective cohort of outpatients with hf, the markers selected were: sodium, high density lipoprotein (hdl), creatinine, creatinine clearance, uric acid and hemoglobin. one point for changes in each marker was given and defined as low risk: 0-2 points, moderate risk: 3-4 points, and high risk: 5-6 points. the primary outcome was death from cardiovascular causes and secondary deaths from cardiovascular causes associated with hospitalizations for cardiovascular causes. the statistical methods used were chi-square, student t test, cox regression and it was used the kaplan meier curve analysis of events. results. we studied 146 patients with mean age 58±13.04, 44 male patients (30.2%) and 102 female ones (69.8%). the primary outcomes were: 15 (10.2%) deaths and secondary: 54 (37%) compound events. the number of individuals according to the stage of risk: low: 68, intermediate: 63 and higher: 15. the rate of events in low, intermediate and high risk were eight (11.7%), 34 (54%) and 12 (80%), respectively. according to the risk stratification, the hazard ratio for low risk (hr=0.14, p=0.0001), moderate (hr=1.69, p=0.01) and high (hr=2.46, p=0.001). conclusion. the multi-markers score based on markers of low cost admits prognostic stratification of patients, allowing predicting deaths and hospital admissions, and also creating a therapeutic strategy for follow-up of patients according to risk stratification.
Sintomas depressivos e hospitaliza??es por insuficiência cardíaca: prevalência, preditores e mortalidade
Pena,Felipe Montes; Carreira,Maria Angela Magalh?es de Queiroz; Faria,Carlos Augusto Cardozo de; Modenesi,Renata de Faria; Barcelos,Amanda Ferreira; Piraciaba,Maria Clara Teixeira; Pereira,Sabrina Bernardez; Soares,Jamil da Silva;
Insuficiencia card?-aca , 2010,
Abstract: background. studies of depressive symptoms (ds) has been made in patients hospitalized for heart failure (hf) and the influence of various characteristics has been ignored. objectives. to assess prevalence, predictors and correlated to the severity of ds and mortality in hf hospitalizations. methods. this prospective study examined consecutive hospitalizations for hf. we analyzed sociodemographic data and clinical outcome was death. in analysis of ds was used beck depression inventory ii. comparative analysis were made between groups with and without ds and subjected to logistic regression variables with p between 0.05 and 0.1. we evaluated the relationship between the severity of sd and mortality. it was considered statistically significant p <0.05. results: we evaluated 103 patients, 63.1% women, 50.5% were married and 73.8% literate. a total of 75.2% were in new york heart association (nyha) functional class ii and iii. hypertension was the most common comorbidity (92.2%). the ds was present in 69 (67%) patients. the predictors of ds were: marital status (p=0.03) and logistic regression: sex (p<0.0001), lifestyle (0.002) and etiology of hf (p<0.0001). mortality was related to the ds in moderate symptoms (p=0.04) and severe (0.01). conclusion. the ds are common in hf hospitalizations. the prevalence varies according to clinical characteristics of patients. the predictors were gender, marital status, lifestyle and etiology of hf. mortality was related to moderate and severe ds.
Polimorfismos beta1-adrenérgico associados com Fibrila??o Atrial na Insuficiência Cardíaca Sistólica
Nascimento, Bruno Costa do;Pereira, Sabrina Bernardez;Ribeiro, Georgina Severo;Mesquita, Evandro Tinoco;
Arquivos Brasileiros de Cardiologia , 2012, DOI: 10.1590/S0066-782X2012005000037
Abstract: background: the sympathetic nervous system is of great importance in the pathogenesis of atrial fibrillation in systolic heart failure. the identification of polymorphisms in the beta1-adrenergic receptor gene (adbr1) represents an important step in understanding this pathogenesis. objective: this study assessed the association between the two functional polymorphisms of the beta1-adrenergic receptor gene (adbr1), ser49gly and arg389gly, and the presence of atrial fibrillation in patients with systolic heart failure. methods: case-control study with 144 patients with systolic heart failure, including 24 with atrial fibrillation (cases) and 120 without atrial fibrillation (controls). genomic dna was extracted from peripheral blood leukocytes and the genotypes of ser49gly and arg389gly polymorphisms were identified in all individuals by pcr/rflp (polymerase chain reaction / restriction fragment length polymorphism). results: mean age was 59 ± 13 years, 70% of patients were males, 42% had ischemic causes and 74% had hypertension. genotypes ser49ser and arg389arg were significantly associated with atrial fibrillation (p = 0.005 and p = 0.01, respectively). after logistic regression, both adjusted for left atrial size and age, the significant association persisted (arg389arg - odds ratios: 2.78, 95% confidence interval = 1.02 to 7.56 and ser49ser - odds ratios: 8.02, 95% confidence interval = 1.02 to 63.82). conclusion: both genotypes were associated with atrial fibrillation in patients; however, only ser49gly polymorphism was is in hardy-weinberg equilibrium.
Os polimorfismos dos receptores adrenérgicos na insuficiência cardíaca: o que a genética explica?
Pereira, Sabrina Bernardez;Gava, Isabela Ambrósio;Giro, Camila;Mesquita, Evandro Tinoco;
Arquivos Brasileiros de Cardiologia , 2010, DOI: 10.1590/S0066-782X2010000600019
Abstract: a insuficiência cardíaca (ic) é uma doen?a complexa, onde diversos mecanismos fisiopatológicos atuam e diferentes polimorfismos genéticos est?o envolvidos. o sistema adrenérgico está diretamente relacionado a esta patologia participando da auto-regula??o cardiovascular, tendo papel crucial na deterioriza??o da fun??o cardíaca. os beta-bloqueadores surgiram como um grande avan?o da cardiologia no tratamento da ic, no entanto a resposta medicamentosa varia para cada paciente podendo estar relacionado a diversos fatores, entre eles o genético. a determina??o pela genética do desenvolvimento da ic, da resposta medicamentosa e prognóstico s?o quest?es que ser?o abrangidas nesta revis?o.
Perfil clínico-demográfico e indicadores de qualidade da insuficiência cardíaca em uma área rural
Balieiro, Henrique Miller;Osugue, Raphael Kasuo;Rangel, Samuel Pereira;Brand?o, Raphael;Balieiro, Tatiana Leal;Bernardez, Sabrina;Mesquita, Evandro Tinoco;
Arquivos Brasileiros de Cardiologia , 2009, DOI: 10.1590/S0066-782X2009001200020
Abstract: background: data on heart failure (hf) in brazil are ensued from tertiary centers. this information can not be extended to the rural population, for it reflects distinct social, economic and cultural characteristics. objective: to establish the clinical and demographic profile and quality indicators for hf in rural areas. methods: transversal cohort study that included 166 patients from the rural area of valen?a, rio de janeiro, brazil. after the evaluation of clinical, laboratorial and echocardiograph data, chi-square and fisher's exact tests were used for analysis of proportion, as well as the student's t-test for numeric variables, in order to establish the population's characteristics. results: mean age was 61±14 years old, as 85 of them (51%) were men, 88 (53%) were afro-brazilian and 85 (51%) had heart failure with reduced ejection fraction (hfref). systemic arterial hypertension (151 patients, 91%) and metabolic syndrome (103 patients, 62%) were prevalent comorbidities. the most common etiologies were: hypertensive (77 patients, 46%) and ischemic (62 patients, 37%). quality indicators in hf were: 43 patients (26%) with previous echocardiogram, 102 patients (62%) were in use of beta-blockers, 147 patients (88%) received angiotensin converter enzyme inhibitor (acei) or angiotensin receptor blockers (arb), and 22% of the patients with atrial fibrillation (af) were under treatment with oral anticoagulation. for heart failure with normal ejection fraction (hfnef), females (p=0.001; od: 0.32; ci=0.17-0.60), metabolic syndrome (p=0.004; od: 0.28; ci=1.31-4.78) and hypertensive etiology (p<0.0001; od: 6.83; ci=3.45-13.5) were predominant. for ciref, males (p=0.001; od: 0.32; ci=0.170-0.605) and ischemic etiology (p<0.0001; od: 0.16; ci=0.079-0.330) were predominant. conclusion: in rural areas, hf shows similarity with regard to sex, ethnicity and classification. hypertensive etiology was the most commonly present. hfnef was prevalent among women and in the presence o
Relativizando o Leviat?: empresários e política econ?mica no governo Janio Quadros
Loureiro, Felipe Pereira;
Estudos Econ?micos (S?o Paulo) , 2010, DOI: 10.1590/S0101-41612010000300003
Abstract: this article examines the brazilian entrepreneurs' attitudes towards the economic policy of janio quadros' government. the analysis concentrates on the s?o paulo's associations of industrial, commercial and agricultural employers. it is argued that these groups played an important role in shaping economic policies, in particular those related to the exchange rate, credit and antitrust legislation. the evidences gathered in this article bring new light on the management of economic policy during a critical period of brazilian history.
Varrendo a democracia: considera??es sobre as rela??es políticas entre Janio Quadros e o Congresso Nacional
Loureiro, Felipe Pereira;
Revista Brasileira de História , 2009, DOI: 10.1590/S0102-01882009000100008
Abstract: this article examines the relation between president janio quadros and the national congress during the early 1960’s. based on the analysis of the discourse of these figures, it proposes that quadros maneuvered to diminish the legitimacy of the congress in the public opinion, thus disrespecting its constitutional competencies. consequently, it shows that not only did the congress structure political mechanisms in an attempt to recover its credibility with society, but also that this dispute and its results had important effects on president jo?o goulart’s administration and even on the 1964 military coup.
Los primeros grupos humanos depredadores en el sur de la Peninsula (Andalucía, Murcia, Albacete).
Ricardo Montes Bernardez
Munibe Antropologia-Arkeologia , 1992,
Abstract: En este trabajo se traza una revisión y una síntesis general sobre el estado de la investigación acerca del Paleolítico Inferior en el Sur de la Península Ibérica : Andalucía, Murcia y Sur de Albacete.
Reliability Estimators for the Components of Series and Parallel Systems: The Weibull Model  [PDF]
Felipe L. Bhering, Carlos A. de B. Pereira, Adriano Polpo
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.511157

This paper presents a hierarchical Bayesian approach to the estimation of components’ reliability (survival) using a Weibull model for each of them. The proposed method can be used to estimation with general survival censored data, because the estimation of a component’s reliability in a series (parallel) system is equivalent to the estimation of its survival function with right- (left-) censored data. Besides the Weibull parametric model for reliability data, independent gamma distributions are considered at the first hierarchical level for the Weibull parameters and independent uniform distributions over the real line as priors for the parameters of the gammas. In order to evaluate the model, an example and a simulation study are discussed.

Treatment of Materials Contaminated with Polychlorinated Biphenyls (Pcbs): Comparison of Traditional Method and Supercritical Fluid Extraction  [PDF]
Dannielle Jannaine Silva, Felipe V. Pietri, José Ermirio F. Moraes, Reinaldo Camino Bazito, Camila Gambini Pereira
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.312A118

The objective of this study was to develop an experimental methodology for the extraction of polychlorinated biphenyls (PCBs) from contaminated soil and wood material using the Soxhlet extraction method and supercritical fluid technology. The sample PCB contents were quantified using Gas Chromatography-Mass Spectrometry (GC/MS). Conventional extractions of PCBs from soil samples showed higher extraction yields for samples with the highest initial PCB levels and longest extraction times. Specific PCBs yielded 74.0% - 78.3% removal using ethanol as the solvent. 91.0% - 94.3% removal of the total PCB content was achieved using hexane as the solvent. Supercritical fluid extraction of soil samples resulted in 50.0% - 70.5% removal for specific PCBs and 57.3% removal of the total PCB content. For wood, the use of Soxhlet extraction resulted in 87.0% - 94.0% removal for specific PCBs and 95.0% - 96.3% removal of the total PCB content. Supercritical fluid extraction of wood samples resulted in 91.1% - 95.0% removal of specific PCBs and 95.1 % of the total PCB content.

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