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Search Results: 1 - 10 of 3733 matches for " Federico Gobbi "
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The Role of Rapid Diagnostic Tests in Managing Malaria
Zeno Bisoffi ,Federico Gobbi,Andrea Angheben,Jef Van den Ende
PLOS Medicine , 2009, DOI: 10.1371/journal.pmed.1000063
Abstract:
DIAGNOSIS OF MALARIA INFECTION WITH OR WITHOUT DISEASE
Zeno Bisoffi,Federico Gobbi,Dora Buonfrate,Jef Van den Ende
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: The revised W.H.O. guidelines for malaria management in endemic countries recommend that treatment should be reserved to laboratory confirmed cases, both for adults and children. Currently the most widely used tools are rapid diagnostic tests (RDTs), that are accurate and reliable in diagnosing malaria infection. However, an infection is not necessarily a clinical malaria, and RDTs may give positive results in febrile patients who have another cause of fever. Excessive reliance on RDTs may cause overlooking potentially severe non malarial febrile illnesses (NMFI) in these cases. In countries or areas where transmission intensity remains very high, fever management in children (especially in the rainy season) should probably remain presumptive, as a test-based management may not be safe, nor cost effective. In contrast, in countries with low transmission, including those targeted for malaria elimination, RDTs are a key resource to limit unnecessary antimalarial prescription and to identify pockets of infected individuals. Research should focus on very sensitive tools for infection on one side, and on improved tools for clinical management on the other, including biomarkers of clinical malaria and/or of alternative causes of fever.
UNIPOLLS, nuovo prodotto CILEA per la gestione delle elezioni delle rappresentanze studentesche di Ateneo
Federico Ferrario,Luca Fronterotta,Andrea Gobbi,Chiara Molinaro
Bollettino del CILEA , 2009, DOI: 10.1472/bc.v0i113.1454
Abstract: L'articolo presenta il sistema software UNIPOLLS realizzato dal CILEA per la gestione delle attività e dei prodotti inerenti le elezioni delle rappresentanze studentesche in seno agli organi universitari. The paper presents the UNIPOLLS software system carried out by CILEA for administering activities and products dealing with student elections within each university college.
Autochthonous Cases of Mycetoma in Europe: Report of Two Cases and Review of Literature
Dora Buonfrate, Federico Gobbi, Andrea Angheben, Stefania Marocco, Claudio Farina, Jef Van Den Ende, Zeno Bisoffi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100590
Abstract: Background Mycetoma is a chronic granulomatous infection involving cutaneous and subcutaneous tissues. It is endemic in tropical and subtropical areas, but sporadic cases have been reported also in countries of temperate climate. The purpose of this paper is to review the cases of mycetoma in European subjects (and presumably acquired in Europe), to give an insight in the main factors associated with this condition, and to describe two previously unpublished cases observed at our Centre. Methods and Findings PubMed was systematically searched for case reports and case series of mycetoma in Europeans reported between 1980 and 2014, using specific search strategies. Two further cases diagnosed by the authors are described. Forty-two cases were collected. Eleven cases were caused by Scedosporium apiospermium, mainly in immunosuppressed patients from Bulgaria, Germany, the Netherlands, Portugal, Slovenia, Spain and the United Kingdom. Excluding all patients with immunosuppression, 29 cases remain. Most of them were reported from Bulgaria and in Albanian patients (all diagnosed outside Albania). In the Bulgarian case series many different micro-organisms, both bacteria and fungi, were isolated, while all the 5 cases from Albania were caused by Actinomadura spp. Other countries reporting cases were Greece, Italy and Turkey. In general, Actinomadura spp is the most frequent causative agent isolated, followed by Nocardia spp and Madurella mycetomatis. The foot was the most reported site involved. Most patients were medically treated, but unfortunately a long-term follow up (at least one year) was available only in a few cases. Conclusions Our review and our own cases suggest that Europeans without travel history can be affected by Madura foot. The lack of a surveillance system is likely to cause an underreporting of cases. Moreover, the unfamiliarity of Western doctors with this peculiar infection may cause a mismanagement, including unnecessary amputations.
Public Policy Making in the Coastal Zone of the Venice Lagoon: Is There a Good Balance between Economic Development, the Social Dimension and Environmental Protection?  [PDF]
Maria Sabrina De Gobbi
Open Journal of Political Science (OJPS) , 2013, DOI: 10.4236/ojps.2013.34019
Abstract:

This paper shows how much citizens’ views are taken into account in local policy decision-making concerning the management of the coastal area of the Venice Lagoon. Through the application of a somewhat innovative version of the contingent valuation method (CVM), it is possible to understand how to set a good balance among economic development, the social dimension and environmental protection in a coastal zone. The methodology allows for a clear assessment of the economic value of non-use values. In 2010, an online survey was conducted in the Venice area to find out how local much citizens value two protected areas in the Venice Lagoon. Four hypotheses were tested to find out whether the age of respondents, the municipality where they live, their income level, and the visited and protected sites are factors determining a different willingness to pay for environmental protection. The economic, social and environmental situation of the coastal zone of the Venice Lagoon in 2010 was then compared to that of 2012 to try to draw conclusions on the level of sustainability of the management of the Venice coastal area. The comparison indicates that there have been some improvements in citizens’ participation in decision-making

Making Youth Entrepreneurship Work in Sub-Saharan Africa: Some Factors of Success  [PDF]
Maria Sabrina De Gobbi
Open Journal of Business and Management (OJBM) , 2014, DOI: 10.4236/ojbm.2014.24036
Abstract: The need to foster private sector development and to combat youth unemployment has made youth entrepreneurship a very attractive option. The present paper tries to identify key factors determining successful entrepreneurship especially in developing countries in Sub-Saharan Africa, starting from evidence from both poor and rich economies. Primary and secondary data from the International Labour Organization as well as secondary data from other institutions have been used. It appears that a young entrepreneur aged 25 - 34, well-educated, with a strong social capital and living in a country with a culture favourable to entrepreneurship and where there are positive perceptions of the attitude of the youth towards entrepreneurship is more likely to be successful than other young entrepreneurs.
Randomized Clinical Trial on Ivermectin versus Thiabendazole for the Treatment of Strongyloidiasis
Zeno Bisoffi ,Dora Buonfrate,Andrea Angheben,Marina Boscolo,Mariella Anselmi,Stefania Marocco,Geraldo Monteiro,Maria Gobbo,Giulia Bisoffi,Federico Gobbi
PLOS Neglected Tropical Diseases , 2011, DOI: 10.1371/journal.pntd.0001254
Abstract: Background Strongyloidiasis may cause a life-threatening disease in immunosuppressed patients. This can only be prevented by effective cure of chronic infections. Direct parasitologic exams are not sensitive enough to prove cure if negative. We used an indirect immune fluorescent antibody test (IFAT) along with direct methods for patient inclusion and efficacy assessment. Methodology/Principal Findings Prospective, randomized, open label, phase III trial conducted at the Centre for Tropical Diseases (Verona, Italy) to compare efficacy and safety of ivermectin (single dose, 200 μg/kg) and thiabendazole (two daily doses of 25 mg/Kg for two days) to cure strongyloidiasis. The first patient was recruited on 6th December, 2004. Follow-up visit of the last patient was on 11th January, 2007. Consenting patients responding to inclusion criteria were randomly assigned to one of the treatment arms. Primary outcome was: negative direct and indirect (IFAT) tests at follow-up (4 to 6 months after treatment) or subjects with negative direct test and drop of two or more IFAT titers. Considering 198 patients who concluded follow-up, efficacy was 56.6% for ivermectin and 52.2% for thiabendazole (p = 0.53). If the analysis is restricted to 92 patients with IFAT titer 80 or more before treatment (virtually 100% specific), efficacy would be 68.1% for ivermectin and 68.9% for thiabendazole (p = 0.93). Considering direct parasitological diagnosis only, efficacy would be 85.7% for ivermectin and 94.6% for thiabendazole (p = 0.21). In ivermectin arm, mild to moderate side effects were observed in 24/115 patients (20.9%), versus 79/108 (73.1%) in thiabendazole arm (p = 0.00). Conclusion No significant difference in efficacy was observed, while side effects were far more frequent in thiabendazole arm. Ivermectin is the drug of choice, but efficacy of single dose is suboptimal. Different dose schedules should be assessed by future, larger studies. Trial Registration Portal of Clinical Research with Medicines in Italy 2004–004693–87
Should Malaria Treatment Be Guided by a Point of Care Rapid Test? A Threshold Approach to Malaria Management in Rural Burkina Faso
Zeno Bisoffi, Halidou Tinto, Bienvenu Sodiomon Sirima, Federico Gobbi, Andrea Angheben, Dora Buonfrate, Jef Van den Ende
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058019
Abstract: Background In Burkina Faso, rapid diagnostic tests for malaria have been made recently available. Previously, malaria was managed clinically. This study aims at assessing which is the best management option of a febrile patient in a hyperendemic setting. Three alternatives are: treating presumptively, testing, or refraining from both test and treatment. The test threshold is the tradeoff between refraining and testing, the test-treatment threshold is the tradeoff between testing and treating. Only if the disease probability lies between the two should the test be used. Methods and Findings Data for this analysis was obtained from previous studies on malaria rapid tests, involving 5220 patients. The thresholds were calculated, based on disease risk, treatment risk and cost, test accuracy and cost. The thresholds were then matched against the disease probability. For a febrile child under 5 in the dry season, the pre-test probability of clinical malaria (3.2%), was just above the test/treatment threshold. In the rainy season, that probability was 63%, largely above the test/treatment threshold. For febrile children >5 years and adults in the dry season, the probability was 1.7%, below the test threshold, while in the rainy season it was higher (25.1%), and situated between the two thresholds (3% and 60.9%), only if costs were not considered. If they were, neither testing nor treating with artemisinin combination treatments (ACT) would be recommended. Conclusions A febrile child under 5 should be treated presumptively. In the dry season, the probability of clinical malaria in adults is so low, that neither testing nor treating with any regimen should be recommended. In the rainy season, if costs are considered, a febrile adult should not be tested, nor treated with ACT, but a possible alternative would be a presumptive treatment with amodiaquine plus sulfadoxine-pyrimethamine. If costs were not considered, testing would be recommended.
How reliable are Hanle measurements in metals in a three-terminal geometry?
Oihana Txoperena,Marco Gobbi,Amilcar Bedoya-Pinto,Federico Golmar,Xiangnan Sun,Luis E. Hueso,Fèlix Casanova
Physics , 2012, DOI: 10.1063/1.4806987
Abstract: We test the validity of Hanle measurements in three-terminal devices by using aluminum (Al) and gold (Au). The obtained Hanle and inverted Hanle-like curves show an anomalous behavior. First, we measure Hanle signals 8 orders of magnitude larger than those predicted by standard theory. Second, the temperature and voltage dependences of the signal do not match with the tunneling spin polarization of the ferromagnetic contact. Finally, the spin relaxation times obtained with this method are independent of the choice of the metallic channel. These results are not compatible with spin accumulation in the metal. Furthermore, a scaling of the Hanle signal with the interface resistance of the devices suggests that the measured signal is originated in the tunnel junction.
Schistosoma mansoni Eggs in Spleen and Lungs, Mimicking Other Diseases
Federico Gobbi,Giulia Martelli?,Luciano Attard?,Dora Buonfrate?,Andrea Angheben?,Valentina Marchese?,Laura Bortesi?,Maria Gobbo?,Elisa Vanino?,Pierluigi Viale
PLOS Neglected Tropical Diseases , 2015, DOI: 10.1371/journal.pntd.0003860
Abstract:
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