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Search Results: 1 - 10 of 869 matches for " Federica Migliardo "
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Self-distribution-function procedure in elastic incoherent neutron scattering for biosystems molecular motion characterization
Salvatore Magazù,Federica Migliardo,Antonio Benedetto,Miguel Gonzalez,Claudia Mondelli
Spectroscopy: An International Journal , 2010, DOI: 10.3233/spe-2010-0454
Abstract: In the present contribution we present a new procedure for the Mean Square Displacement (MSD) determination from Elastic Incoherent Neutron Scattering (EINS) where the connection between the Self-Distribution Function (SDF) and the measured EINS intensity profile is highlighted. We show how the SDF procedure allows both the total and the partial MSD evaluation, through the total and the partial SDFs. The procedure is applied on EINS data collected, by the IN13 backscattering spectrometer (ILL, Grenoble), on aqueous mixtures of sucrose and trehalose.
Molecular Mechanisms of Survival Strategies in Extreme Conditions
Salvatore Magazù,Federica Migliardo,Miguel A. Gonzalez,Claudia Mondelli,Stewart F. Parker,Beata G. Vertessy
Life , 2012, DOI: 10.3390/life2040364
Abstract: Today, one of the major challenges in biophysics is to disclose the molecular mechanisms underlying biological processes. In such a frame, the understanding of the survival strategies in extreme conditions received a lot of attention both from the scientific and applicative points of view. Since nature provides precious suggestions to be applied for improving the quality of life, extremophiles are considered as useful model-systems. The main goal of this review is to present an overview of some systems, with a particular emphasis on trehalose playing a key role in several extremophile organisms. The attention is focused on the relation among the structural and dynamic properties of biomolecules and bioprotective mechanisms, as investigated by complementary spectroscopic techniques at low- and high-temperature values.
Monetary Policy Transmission in Italy: A BVAR Analysis with Sign Restriction
Carlo Migliardo
AUCO Czech Economic Review , 2010,
Abstract: In this paper, we propose a Bayesian VAR model to examine the short term effects of monetary policy shocks on the Italian economy. Firstly, our BVAR model uses the Cholesky decomposition to identify four kinds of macroeconomic shocks, namely, supply, demand, interest rate and monetary shocks. Then, from the theoretical model, we derive and impose a minimum set of robust sign restrictions to identify the transmission mechanism of monetary tightening. The outcomes from the sign identification confirm the micro evidence on inflation persistence. Moreover, our results show a greater persistence of inflation to monetary restriction than Cholesky identification presents. Overall, we find that a monetary innovation brings a decline of 30 basis point of GDP, this result is almost invariant across both prior and identification technique.
Fragility of Bioprotectant Glass-Forming Systems in Extremophiles
S. Magazù,F. Migliardo
Journal of Atomic, Molecular, and Optical Physics , 2009, DOI: 10.1155/2009/638063
Abstract: A central issue in the adaptation of proteins and enzymes to extreme conditions is the conservation of their functional state, which is characterized by a well-balanced compromise of stability and flexibility. In this review work an overview of elastic neutron scattering (ENS) findings on a class of bioprotectant glass-forming systems, such as trehalose and its homologous (maltose and sucrose) water mixtures, is presented as a function of temperature and concentration. ENS, in fact, allows to determine some remarkable quantities in order to characterize the correlation among dynamical properties, the flexibility and fragility of biomolecules. The experimental results have pointed out a dynamical transition, which shows a crossover in molecular fluctuations between harmonic and anharmonic dynamical regimes. The ENS findings allow to characterize both the trehalose rigidity and flexibility, which are strictly connected to its superior bioprotective effectiveness. In this frame the lowest flexibility and fragility character of trehalose/H2O mixture with respect to maltose and sucrose/H2O mixtures indicate a better attitude to encapsulate biostructures in more rigid and temperature insensitive structures in approaching the glass transition.
Effectiveness and Efficiency of Educational Measures: Evaluation Practices, Indicators and Rhetoric  [PDF]
Federica Cornali
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.23034
Abstract: In recent years, evaluating the performance of educational organizations has sparked increasing interest and debate. Many expectations ride on the smooth operation of school systems. It is widely believed that countries’ social and economic well-being will depend to an ever greater extent on the quality of their citizens’ education: the emergence of the so-called “knowledge society”, the transformation of information and the media, and increasing specialization on the part of organizations all call for high skill profiles and levels of knowledge. Today’s education systems are required to be both effective and efficient, or in other words, to reach the goals set for them while making the best use of available resources. This paper, by presenting and discussing a case study, will analyze several dimensions of schools’ effectiveness and efficiency, highlighting the importance of selecting evaluation procedures that can provide representations that reflect the actual situation to the greatest possible extent.
UMIS: A Service for User Model Interoperability  [PDF]
Federica Cena, Roberto Furnari
Advances in Internet of Things (AIT) , 2012, DOI: 10.4236/ait.2012.24012
Abstract: In this paper we describe UMIS, a service architecture that enables user adaptive applications to exchange User Model data on the Web. UMIS provides a set of facilities that allow applications to interoperate with minimum changes in their internal logics and knowledge representation. The goal is to support the process of interoperability in three ways: providing an efficient centralized discovery service; offering a service for simple interaction for the exchange of UM value in a p2p way; and offering a negotiation mechanism to be used in case of communication hurdles (i.e. semantic ambiguities and missing response). We developed a proof-of-concept prototype of UMIS and we tested it with an existing user-adaptive application. According to our test results, our approach improves the communication with respect to standard solutions for interoperability regarding the quality of exchange, with a negligible impact on the communication costs and traffic generation.
The Impact of Acoustics and Energy Efficiency Protocols on Comfort in the Building Industry  [PDF]
Marco Caniato, Federica Bettarello
Open Journal of Civil Engineering (OJCE) , 2013, DOI: 10.4236/ojce.2013.32A005

Comfort in buildings is one of the most requested value to reach. Today, designers have to deal with so many technical features including outer appearance, air-conditioning, structural layouts, acoustic insulation and inner treatments, materials bio-compatibility, material recycling and reuse, water wasting and so on. In the same time, costumers want to buy buildings which won’t cost a lot in terms of heating and cooling as in the past. Besides, every single apartment, loft, office etc., even if there are many of them in a single building, has to be very quiet. Voluntary or compulsory standards, protocols and state laws lead the designers throughout the project and in some cases to the final in field tests too. Nevertheless, different sort of calculations, leading philosophy, expected results, parameters and tags are included in order to achieve the final aims. In this paper, energy efficiency and acoustic performances of buildings are discussed, proposing and comparing designing solutions for a specific case study.

Paul de Saint Robert: Sciences and Interdisciplinary Culture in the 19th Century  [PDF]
Federica Maffioli, Gianfranco Medici
Advances in Historical Studies (AHS) , 2014, DOI: 10.4236/ahs.2014.34019
Abstract: The Count Paul Ballada de Saint Robert (1815-1888) was an Italian scientist and important promoter of scientific culture, he succeeded in combining pure and applied science, art and social interests into one of the most elevated synthesis. Based on previous works published at the SISFA 2012 (Maffioli & Medici, 2013: pp. 313-319; Medici & Maffioli, 2013: pp. 329-336) in this paper we propose two of his many writings as demonstration of interdisciplinary of his studies: the first part is about the conclusions of Saint Robert concerning the retreat of glaciers, while the second part is about the Saint Robert scientific approach and explanation of the true meaning of the verses 22.24 of the I chant of Dante’s Purgatory.
How homogeneous are the trehalose, maltose and sucrose water solutions ? An Insight from Molecular Dynamics simulations
A. Lerbret,P. Bordat,F. Affouard,M. Descamps,F. Migliardo
Physics , 2005,
Abstract: The structural properties resulting from the reciprocal influence between water and three well-known homologous disaccharides, namely trehalose, maltose and sucrose, in aqueous solutions have been investigated in the 4-66 wt % concentration range by means of molecular dynamics computer simulations. Hydration numbers clearly show that trehalose binds to a larger number of water molecules than do maltose or sucrose, thus affecting the water structure to a deeper extent. Two-dimensional radial distribution functions of trehalose definitely reveal that water is preferentially localized at the hydration sites found in the dihydrate crystal, this tendency being enhanced when increasing trehalose concentration. In a rather wide concentration range (4-49 wt %), the fluctuations of the radius of gyration and of the glycosidic dihedral angles of trehalose indicate a higher flexibility with respect to maltose and sucrose. At sugar concentrations between 33 wt % and 66 wt %, the mean sugar cluster size and the number of sugar-sugar hydrogen bonds (HBs) formed within sugar clusters reveal that trehalose is able to form larger clusters than sucrose but smaller than maltose. These features suggest that trehalose-water mixtures would be more homogeneous than the two others, thus reducing both desiccation stresses and ice formation.
La subjetividad antropofágica: aportes para una concepción devorativa de la vida
Estudios de filosof?-a pr??ctica e historia de las ideas , 2010,
Abstract: this paper arises from the research of the anthropofagic movement, originated in brazil in the twenties. the "anthropofagic subjectivity" is analyzed, since it is considered to have a significant potentiality, because it implies not only an analysis and a criticism of the prevailing subjectivity, but also a rebuilding and a proposal of another kind of subjectivity, which considers the current complexity and specially the challenge of the otherness. the answer here does not strengthen the individual identities, which are entrenched in the tolerance of multiculturalism, but this subjectivity opens to the interpellation of the other, and only from there the sense could be built.
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