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Search Results: 1 - 10 of 4199 matches for " Fanguo Kong "
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The Numerical Simulation of Aerodynamic Noise Generated by CRH3 Train’s Head Surface  [PDF]
Fanguo Kong, Jian Wang
Open Journal of Applied Sciences (OJAppS) , 2015, DOI: 10.4236/ojapps.2015.58049
Abstract: In order to solve the increasingly serious problem of railway noise which caused by the train’s speed-up, especially the problem of the dominant aerodynamic noise of the high-speed train, it’s necessary to have a numerical simulation analysis for the CRH3 train’s three dimensional flow model. Setting monitoring points in the positions that the surface curvature changes significantly, using the Large Eddy Simulation Method (LES) to have a transient simulation for the CRH3 train which is in the speed of 300 km/h and 350 km/h, applying the acoustics theory of Lighthill-Curle to predict the aerodynamic noise caused by the head of the CRH3 train. The generation and distribution of the train’s aerodynamic noise are analyzed, so as to provide some reasonable suggestions for the design of the train body.
Generation of novel high quality HMW-GS genes in two introgression lines of Triticum aestivum/Agropyron elongatum
Shuwei Liu, Shuangyi Zhao, Fanguo Chen, Guangmin Xia
BMC Evolutionary Biology , 2007, DOI: 10.1186/1471-2148-7-76
Abstract: To exploit how these new subunits were generated, we isolated HMW-GS genes from two sib hybrid lines (II-12 and 11-4-6) and compared them with those from their parents. The result shows that two genes of hybrid (H11-3-3 and H11-4-3) are directly introgressed from the donor parent Agropyron elongatum; one hybrid gene (H1Dx5) comes from point mutation of a parental wheat gene (1Dx2.1); two other hybrid genes (H1By8 and H1By16) are likely resulting from unequal crossover or slippage of a parental wheat gene (1By9.1); and the sixth novel hybrid gene (H1Dy12) may come from recombination between two parental genes.Therefore, we demonstrate that novel HMW-GS genes can be rapidly created through asymmetric somatic hybridization in a manner similar with the evolution mechanism of these genes supposed before. We also described gene shuffling as a new mechanism of novel HMW-GS gene formation in hybrids. The results suggest that asymmetric somatic hybridization is an important approach for widening HMW-GS genebank of wheat quality improvement.High molecular weight glutenin subunits are important component of wheat gluten proteins which are mainly responsible for dough viscosity and elasticity in wheat processing [1]. The HMW-GS accounts for up to about 12% of the total protein in the endosperm of common wheat (Triticum aestivum L.), while their allelic variation explains about 45% to 70% of the variation in bread making performance within European wheat cultivars [2-4]. Thus, their coding sequences are the prime candidates for molecular modification to enhance grain-processing quality [5].The genes encoding the wheat HMW-GS are located on the long arms of the homoeologous group 1 chromosomes [6-9]. Each locus consists of two tightly linked genes, termed x- and y-type genes according to their different molecular weights. So far, the structural characteristics of more than ten HMW-GS alleles have been revealed by DNA sequencing [10-18]. All of these HMW-GS contain a central repet
Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation
Yisheng Jiao, Wenbin Ou, Fanguo Meng, Haimeng Zhou, Aiyuan Wang
Molecular Cancer , 2011, DOI: 10.1186/1476-4598-10-125
Abstract: Herein, we demonstrate co-activation of multiple RTKs (EGFR, ERBB2, ERBB4, MET and/or AXL) in individual ovarian cancer cell lines and primary tumors. We also show that coordinate inhibition of this multi-kinase signaling has substantially greater effect on ovarian cancer proliferation and survival, compared to inhibition of individual activated kinases. The inhibition of this multi-RTK signaling by HSP90 suppression results in profound pro-apoptotic and anti-proliferative effects, and is associated with the inactivation of RTK downstream PI3-K/AKT/mTOR and RAF/MAPK signaling.These studies suggest that anti-multiple RTK strategy could be useful in the treatment of ovarian cancer.Ovarian cancer is a leading cause of cancer death among women in Western Europe and the United States, which has the highest mortality rate of all gynecologic malignancy [1,2]. Ovarian cancer histologic subtypes include epithelioid (serous, endometrioid, mucinous, clear cell and undifferentiated) and non-epitheliod [3], of which the epithelioid subtype accounts for 90% of ovarian malignancies [4]. Although more than 70% patients have increased 5-year survival rates after surgery followed by chemotherapy and second-line therapies [5], the low overall cure rates and the intolerable side effects of systemic chemotherapy asks for the development of novel and more effective pharmacological interventions. An improved understanding of ovarian cancer biology - including crucial growth factor signaling pathways - is needed for the identification of biologically rational targets for novel therapies.The increasing evidences suggest that receptor tyrosine kinase (RTK) activation participates in the oncogenic progression from nonneoplastic mesothelial lining of the ovaries or the fallopian tube epithelium to epithelial ovarian cancer. Epidermal growth factor receptor (EGFR) is amplified in approximately 4%-22% of ovarian cancer and activating EGFR mutations is rare with a frequency of 4% or less [6-8]. E
Construct the Community of IT Education and Break the Bottleneck of Rural School Educational Informationization  [PDF]
Dehua Kong
Intelligent Information Management (IIM) , 2012, DOI: 10.4236/iim.2012.44025
Abstract: Based on the current situation of rural educational informationization, my study found that the boost of rural elementary and secondary school’s educational informationization needed the cooperation of higher normal universities and local education administrative department. The construction of “IT education community” is the key to step off the predicament. The practice application and effect in Gaoping City further proved that the cooperation project broke the bottleneck of rural elementary and secondary school’s educational informationization.
The Atomic Regular Polyhedron Electronic Shell  [PDF]
Zilong Kong
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.410A1001

The periodic table of elements is arranged based on a series of regular polyhedron. The stability of inert gas atoms can be explained by the distribution of electrons, as well as their motion and magnetic force structure. A magnetic force regular octahedron is proposed. It is a unique configuration that best satisfies the convergence of electrons moving in the same direction within regular polyhedra. In the case of an electrostatic force crust, the formal electron spin accounts for the crusts intrinsic magnetic moment exceeding the speed of light. If one is to consider that the electron has a magnetic outer layer and an electrostatic inner layer, then the question can be solved and abovementioned inference can provide the basis for magnetic force and momentum for the regular octahedron model. The electron periphery has twenty-petal adsorptive substances; the existence of adsorptive substance causes the magnetic force greater than the electrostatic force. Each electronic shell in the regular polyhedron is in accordance with the electron configuration of periodic table of elements; the kinetic track of each electron is a surface of regular polyhedron. The magnetic properties of iron, cobalt, and nickel can be explained by the regular dodecahedron electronic shell of an atom. The electron orbit converged from reverse direction can explain diamond. The adsorptive substances found in atomic nuclei and electrons are defined as magnetic particles called magnetons. The thermodynamic magneton theory can be better explained when it is analyzed using principles of thermodynamics, superconductivity, viscosity, and even in the creation of glass. The structure of the light is a helical line.

Ferromagnetic Calculation of Terbium Dysprosium and Holmium with Polyhedron Electron Shell  [PDF]
Zilong Kong
Journal of Modern Physics (JMP) , 2015, DOI: 10.4236/jmp.2015.613179
Abstract: Based on the regular polyhedron model of multi-electronic atom combined with the Bohr hypothesis, the following supposition is put forward: the electron momentum multiplied by the inscribed sphere radius of edges of each regular polyhedron is equal to the Planck constant. The relationship between saturation magnetization rates and Planck constants is determined, and the ferromagnetism of atoms is obtained from regular dodecahedron and regular hexahedron. Then, terbium, dysprosium, and holmium saturation magnetization rate are obtained from electronic regular polyhedron configuration. Derivation of matter wave formula is from thermodynamics, avoiding over speed of light.
The Pricing of IPO by Investment Banks and Venture Capital: A Theoretical Model  [PDF]
Huanran Kong
Open Journal of Social Sciences (JSS) , 2018, DOI: 10.4236/jss.2018.610017
Abstract: The venture capitalists provide supervision and certification service for shareholding enterprises, which reduce the information asymmetry and attract more high quality investment banks. Thus, the price is close to the market price when the enterprise enters the market and under-pricing is avoided thereby. Based on the supervision and certification hypothesis, this paper builds a pricing model of investment banks and venture capital to explain the pricing mechanism of investment bank, investment risk pricing mechanism and the causes of underpricing.
Inactivation and Unfolding of the Hyperthermophilic Inorganic Pyrophosphatase from Thermus thermophilus by Sodium Dodecyl Sulfate
Hang Mu,Sheng-Mei Zhou,Yong Xia,Hechang Zou,Fanguo Meng,Yong-Bin Yan
International Journal of Molecular Sciences , 2009, DOI: 10.3390/ijms10062849
Abstract: Inorganic pyrophosphatase (PPase, EC is an essential constitutive enzyme for energy metabolism and clearance of excess pyrophosphate. In this research, we investigated the sodium dodecyl sulfate (SDS)-induced inactivation and unfolding of PPase from Thermus thermophilus (T-PPase), a hyperthermophilic enzyme. The results indicated that like many other mesophilic enzymes, T-PPase could be fully inactivated at a low SDS concentration of 2 mM. Using an enzyme activity assay, SDS was shown to act as a mixed type reversible inhibitor, suggesting T-PPase contained specific SDS binding sites. At high SDS concentrations, T-PPase was denatured via a two-state process without the accumulation of any intermediate, as revealed by far-UV CD and intrinsic fluorescence. A comparison of the inactivation and unfolding data suggested that the inhibition might be caused by the specific binding of the SDS molecules to the enzyme, while the unfolding might be caused by the cooperative non-specific binding of SDS to T-PPase. The possible molecular mechanisms underlying the mixed type inhibition by SDS was proposed to be caused by the local conformational changes or altered charge distributions.
Research and application of sidewall stability predic-tion method based on analytic hierarchy process and fuzzy integrative evaluation method  [PDF]
Bin Liu, Fanjun Kong
Natural Science (NS) , 2012, DOI: 10.4236/ns.2012.42021
Abstract: As a difficult problem, sidewall instability has been beset drilling workers all the time. Not only does it cause huge economic losses, but also it determines the success or failure of drilling engineering. Due to complex relationship between various factors which influence sidewall stability, it hasn’t been found a widely applied method to predicate sidewall stability so far. Therefore, in order to formulate corresponding measures to ensure successful drilling, searching for a kind of better method to forecast sidewall stability before drilling becomes an imperative and significant topic for drilling engineering. On the basis of traditional sidewall stability analytical method, we have put forward the Fuzzy Comprehensive Evaluation Method to forecast sidewall stability regulation using physico-chemical performance parameters of the clay mineral. This method has been improved by introducing the Analytic Hierarchy Process (AHP) and the Maximum Subjection Principle in the application process. After introducing Analytic Hierarchy Process to identify weight, and Maximum Subjection Principle to obtain evaluation results, it has reduced the influence of human factors and enhanced the accuracy of the fuzzy evaluation results. The application in Hailaer Area indicates that this method can predict sidewall stability of gas-oil well with high credibility and strong practicability.
Electromagnetic Wave and Gaseous Communication between Individuals  [PDF]
Kong Derick Njikeh
Neuroscience & Medicine (NM) , 2014, DOI: 10.4236/nm.2014.51004

The brain produces an electromagnetic wave throughout the day and the strength of this wave depends on the activity of the brain. It is said that this wave is a weak wave which does not cover a greater distance. But I do believe that it is like the radio wave in the distance it covers and frequency it possesses. I do believe that there is a communication between individuals through electromagnetic wave (brain wave) and a gas (Nitric Oxide) produced by the brain. This can be observed in our daily experiences. This can also help us understand that as a computer can receive and record the brain waves, so an individual can also receive and integrate these waves and it is being decoded to release the message it contains. In this respect, it can be said that the state of consciousness in an individual can be understood by another through concentration.

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