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Search Results: 1 - 10 of 40395 matches for " Fang He "
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Melatonin in Pain Modulation: Analgesic or Proalgesic?  [PDF]
Yongliang Liu, Hongwen He, Fang Huang
Pain Studies and Treatment (PST) , 2014, DOI: 10.4236/pst.2014.22009

Melatonin, as an endogenous hormone produced mainly in the pineal gland in a clear circadian fashion, has diverse physiological functions, such as the control of circadian rhythms, sleep regulation, antioxidant, etc. Recently, accumulating researches about melatonin and pain have been reported. In this review, comparison and summary about analgesic/proalgesic effect of melatonin in inflammatory and neuropathic pain will be made. Some possible pathways of melatonin involved in dual pain modulation might help to explain all these conflicting results in various situations.

Research on Heating Clay by Low Carbon Catalytic Combustion Furnace of Natural Gas  [PDF]
Kai Fang, Fan He, Shihong Zhang
Journal of Power and Energy Engineering (JPEE) , 2014, DOI: 10.4236/jpee.2014.212002

This article did a research about exhaust gas constituent inside the catalytic combustion furnace with Pd-based honeycomb monoliths of lean natural gas-air mixtures and discussed the feature of the exhaust gas. In addition, the near-zero pollutant emissions of catalytic combustion burner was proved by a test report provided by NIM. From a low-carbon prospective, the application prospect of catalytic combustion furnace was discussed

Caspase-2 Mediated Apoptotic and Necrotic Murine Macrophage Cell Death Induced by Rough Brucella abortus
Fang Chen, Yongqun He
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0006830
Abstract: Brucella species are Gram-negative, facultative intracellular bacteria that cause zoonotic brucellosis. Survival and replication inside macrophages is critical for establishment of chronic Brucella infection. Virulent smooth B. abortus strain 2308 inhibits programmed macrophage cell death and replicates inside macrophages. Cattle B. abortus vaccine strain RB51 is an attenuated rough, lipopolysaccharide O antigen-deficient mutant derived from smooth strain 2308. B. abortus rough mutant RA1 contains a single wboA gene mutation in strain 2308. Our studies demonstrated that live RB51 and RA1, but not strain 2308 or heat-killed Brucella, induced both apoptotic and necrotic cell death in murine RAW264.7 macrophages and bone marrow derived macrophages. The same phenomenon was also observed in primary mouse peritoneal macrophages from mice immunized intraperitoneally with vaccine strain RB51 using the same dose as regularly performed in protection studies. Programmed macrophage cell death induced by RB51 and RA1 was inhibited by a caspase-2 inhibitor (Z-VDVAD-FMK). Caspase-2 enzyme activation and cleavage were observed at the early infection stage in macrophages infected with RB51 and RA1 but not strain 2308. The inhibition of macrophage cell death promoted the survival of rough Brucella cells inside macrophages. The critical role of caspase-2 in mediating rough B. abortus induced macrophage cell death was confirmed using caspase-2 specific shRNA. The mitochondrial apoptosis pathway was activated in macrophages infected with rough B. abortus as demonstrated by increase in mitochondrial membrane permeability and the release of cytochrome c to cytoplasm in macrophages infected with rough Brucella. These results demonstrate that rough B. abortus strains RB51 and RA1 induce apoptotic and necrotic murine macrophage cell death that is mediated by caspase-2. The biological relevance of Brucella O antigen and caspase-2-mediated macrophage cell death in Brucella pathogenesis and protective Brucella immunity is discussed.
Identification and characterization of a new E3 ubiquitin ligase in white spot syndrome virus involved in virus latency
Fang He, Jimmy Kwang
Virology Journal , 2008, DOI: 10.1186/1743-422x-5-151
Abstract: White spot syndrome virus (WSSV) is a virulent shrimp pathogen responsible for high mortality in cultured shrimp, raising major concerns in the aquaculture industry. Disease outbreaks can reach a cumulative mortality of up to 100% within 3 to 7 days of infection [1]. Its circular dsDNA genome consists of 300 kbp that contains approximately 185 open reading frames (ORFs) [2,3], which is one of the largest viral genomes. Database searches reveal that more than 95% of these ORFs do not have any counterparts in other species and WSSV has thus been placed in a new virus family, the Nimaviridiae, genus Whispovirus [3].In the past several years, studies of WSSV mainly focused on the viral structural proteins and more than 30 proteins matching WSSV ORFs have been identified as envelop proteins and collagen-like protein [4-6]. Only a few non-structural genes have been characterized. Three latency-associated genes (LAG) were identified from specific-pathogen-free shrimp by microarray [7]. Among them, ORF89 was found to be a transcription repressor [8] and WSSV427 can interact with a shrimp phosphatase [9]. Microarray has also been employed in WSSV studies to find out three immediate early (IE) genes [10]. At the molecular level, there is little understanding of how WSSV establishes latent infections or of the genes responsible for the transition between latent and lytic infection, which eventually leads to mortality.Besides, four proteins of WSSV, namely WSSV199, WSSV222, WSSV249 and WSSV403 contain RING-H2 domains [2,11]. A previous study has revealed the involvement of the RING finger domain in specific ubiquitination events by acting as the E3 ubiquitin protein ligase. RING finger domains are subdivided into two subgroups, the C3HC4 (RING-HC) subgroup and the C3H2C3 (RING-H2) subgroup. Among these RING proteins from WSSV, WSSV222 mediates the degradation on a shrimp tumor suppressor as a viral E3 ligase [12] and WSSV249, also acting as an E3 ligase, sequesters the shrimp E
Partial melting of the dry mafic continental crust: Implications for petrogenesis of C-type adakites
Fang Huang,YongSheng He
Chinese Science Bulletin , 2010, DOI: 10.1007/s11434-010-3224-2
Abstract: C-type adakites have been commonly considered as a result of partial melting of the mafic lower continental crust (LCC) at high pressure, as supported by high P-T experiments on hydrous basalts. However, because the mafic eclogitic LCC is generally dry, experiments on water-bearing materials cannot be used to constrain the melting processes of the dry mafic LCC. Due to the lack of systematic melting experimental studies on dry mafic rocks at crustal pressures, MELTs software was applied to simulating melting of the dry mafic LCC at 1–2 GPa. Comparison of model results with experimental data indicates that, when melting degree is greater than 20%, melts from the dry mafic LCC at 1–3 GPa cannot produce the C-type adakitic melt with high SiO2 content (~70%). Although the limited experimental results about dry mafic rock melting at 1–2 GPa in the literature suggest that low degree melting (<10%) cannot produce silicic melt either, MELTs software simulation shows that, at pressure >1.8 GPa, low-degree melting can produce dacitic melt with high K2O/Na2O (~1) if SiO2 content of the melt is controlled by residual garnet. Furthermore, the simulation also suggests that, if pressure is <1.8 GPa, abundant plagioclase (plg) in the residual phase may decrease SiO2 content in the melt to below 62%, much lower than that of the C-type adakites observed in eastern China. Given the high P-T conditions required to produce melts with high SiO2 and extremely low HREE contents, such melts could easily be contaminated by other crustal-derived melts, implying that the C-type adakites from eclogite melting could be less commonly observed in the outcrops than previously believed. Besides the interpretation that garnet fractionates Sr, Y, and REE, high Sr/Y and La/Yb could be also produced by multiple ways such as inheriting the source features and fractional crystallizing clinopyroxene (cpx). Therefore, it may be problematic using high Sr/Y and La/Yb as criteria to identify adakites. Instead, REE patterns with strong depletion of HREE relative to MREE (e.g. high Gd/Yb) could be a better parameter to identify the role of garnet and thus adakites. Finally, geochemical models based on MELTs simulation indicate that Eu anomaly cannot be simply used to constrain the role of plg in magmatism because Eu anomaly in the melt is a function of source characteristics, oxygen fugacity (fO2) of magmatic systems, and plg/mafic minerals mode ratio.
Monoclonal Antibody Targeting Neutralizing Epitope on H5N1 Influenza Virus of Clade 1 and 0 for Specific H5 Quantification
Fang He,Jimmy Kwang
Influenza Research and Treatment , 2013, DOI: 10.1155/2013/360675
A Constraint-directed Local Search Approach to Nurse Rostering Problems
Fang He,Rong Qu
Electronic Proceedings in Theoretical Computer Science , 2009, DOI: 10.4204/eptcs.5.6
Abstract: In this paper, we investigate the hybridization of constraint programming and local search techniques within a large neighbourhood search scheme for solving highly constrained nurse rostering problems. As identified by the research, a crucial part of the large neighbourhood search is the selection of the fragment (neighbourhood, i.e. the set of variables), to be relaxed and re-optimized iteratively. The success of the large neighbourhood search depends on the adequacy of this identified neighbourhood with regard to the problematic part of the solution assignment and the choice of the neighbourhood size. We investigate three strategies to choose the fragment of different sizes within the large neighbourhood search scheme. The first two strategies are tailored concerning the problem properties. The third strategy is more general, using the information of the cost from the soft constraint violations and their propagation as the indicator to choose the variables added into the fragment. The three strategies are analyzed and compared upon a benchmark nurse rostering problem. Promising results demonstrate the possibility of future work in the hybrid approach.
A New Projection Algorithm for Generalized Variational Inequality
Changjie Fang,Yiran He
Journal of Inequalities and Applications , 2010, DOI: 10.1155/2010/182576
Abstract: We propose a new projection algorithm for generalized variational inequality with multivalued mapping. Our method is proven to be globally convergent to a solution of the variational inequality problem, provided that the multivalued mapping is continuous and pseudomonotone with nonempty compact convex values. Preliminary computational experience is also reported.
A New Projection Algorithm for Generalized Variational Inequality
Fang Changjie,He Yiran
Journal of Inequalities and Applications , 2010,
Abstract: We propose a new projection algorithm for generalized variational inequality with multivalued mapping. Our method is proven to be globally convergent to a solution of the variational inequality problem, provided that the multivalued mapping is continuous and pseudomonotone with nonempty compact convex values. Preliminary computational experience is also reported.
Evaluating Status Change of Soil Potassium from Path Model
Wenming He, Fang Chen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0076712
Abstract: The purpose of this study is to determine critical environmental parameters of soil K availability and to quantify those contributors by using a proposed path model. In this study, plot experiments were designed into different treatments, and soil samples were collected and further analyzed in laboratory to investigate soil properties influence on soil potassium forms (water soluble K, exchangeable K, non-exchangeable K). Furthermore, path analysis based on proposed path model was carried out to evaluate the relationship between potassium forms and soil properties. Research findings were achieved as followings. Firstly, key direct factors were soil S, ratio of sodium-potassium (Na/K), the chemical index of alteration (CIA), Soil Organic Matter in soil solution (SOM), Na and total nitrogen in soil solution (TN), and key indirect factors were Carbonate (CO3), Mg, pH, Na, S, and SOM. Secondly, path model can effectively determine direction and quantities of potassium status changes between Exchangeable potassium (eK), Non-exchangeable potassium (neK) and water-soluble potassium (wsK) under influences of specific environmental parameters. In reversible equilibrium state of , K balance state was inclined to be moved into β and χ directions in treatments of potassium shortage. However in reversible equilibrium of , K balance state was inclined to be moved into θ and λ directions in treatments of water shortage. Results showed that the proposed path model was able to quantitatively disclose moving direction of K status and quantify its equilibrium threshold. It provided a theoretical and practical basis for scientific and effective fertilization in agricultural plants growth.
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