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Celiac disease: Alternatives to a gluten free diet
Fabiana Zingone,Pietro Capone,Carolina Ciacci
World Journal of Gastrointestinal Pharmacology and Therapeutics , 2010,
Abstract: Celiac disease is a chronic inflammatory disorder of the small intestine caused by the ingestion of gluten or related rye and barley proteins. At present, the only available treatment is a strict gluten-exclusion diet. However, recent understanding of the molecular basis for this disorder has improved and enabled the identification of targets for new therapies. This article aims to critically summarize these recent studies.
Human leukocyte antigen DQ2/8 prevalence in non-celiac patients with gastrointestinal diseases
Daniel DiGiacomo,Antonella Santonicola,Fabiana Zingone,Edoardo Troncone
World Journal of Gastroenterology , 2013, DOI: 10.3748/wjg.v19.i16.2507
Abstract: AIM: To investigate the prevalence of human leukocyte antigen (HLA) DQ2/8 alleles in Southern Italians with liver and gastrointestinal (GI) diseases outside of celiac disease. METHODS: HLA DQ2/8 status was assessed in 443 patients from three ambulatory gastroenterology clinics in Southern Italy (University of Federico II, Naples, Loreto Crispi Hospital, Ruggi D’Aragona Hospital, Salerno). Patients were grouped based on disease status [pre-post transplant liver disease, esophageal/gastric organic and functional diseases, irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD)] and DQ2/8 alleles, which correspond to a celiac disease genetic risk gradient. Subject allele frequencies were compared to healthy Italian controls. RESULTS: One hundred and ninety-six out of four hundred and forty-three (44.2%) subjects, median age 56 years and 42.6% female, were DQ2/8 positive. When stratifying by disease we found that 86/188 (45.7%) patients with liver disease were HLA DQ2/8 positive, 39/73 (53.4%) with functional upper GI diseases and 19/41 (46.3%) with organic upper GI diseases were positive. Furthermore, 38/105 (36.2%) patients with IBS and 14/36 (38.9%) with IBD were HLA DQ2/8 positive (P = 0.21). Compared to healthy controls those with functional upper GI diseases disorders had a 1.8 times higher odds of DQ2/8 positivity. Those with liver disease had 1.3 times the odds, albeit not statistically significant, of DQ2/8 positivity. Both those with IBS and IBD had a lower odds of DQ2/8 positivity compared to healthy controls. CONCLUSION: The proportion of individuals HLA DQ2/8 positive is higher in those with liver/upper functional GI disease and lower in IBS/IBD as compared to general population estimates.
Life Events and the Onset of Celiac Disease from a Patient’s Perspective
Carolina Ciacci,Monica Siniscalchi,Cristina Bucci,Fabiana Zingone,Ivonne Morra,Paola Iovino
Nutrients , 2013, DOI: 10.3390/nu5093388
Abstract: Stressful events have been investigated in various immune-mediated diseases but not in celiac disease. Our aim was to examine the relationship of stressful events assessed by the standardized interview of Paykel with the diagnosis of celiac disease in comparison to patients, with a diagnosis of gastroesophageal reflux disease used as the control group. Adults with celiac disease ( n = 186) reported more frequent and more severe life events in the years prior to the diagnosis than control patients ( n = 96) (67.2% vs. 37.5%, p < 0.001, mean Paykel score 11.5 vs. 13.4, p = 0.001, respectively). Findings were not significantly different between celiac disease and control patients for the time lapse between the event and the diagnosis (mean 5.5 vs. 5.7 months). Pregnancy was defined as a negative event by 20.3% of celiac women, but never by control women. Findings were confirmed when analyses were repeated in the subgroup of patients of both groups with diagnosis made within one year of onset of symptoms. Data indicate that, before diagnosis, the number of stressful events in celiac disease was more frequent although less severe than in the control group suggesting that life events may favor the clinical appearance of celiac disease or accelerate its diagnosis.
PROgnosticating COeliac patieNts SUrvivaL: The PROCONSUL Score
Federico Biagi, Annalisa Schiepatti, Georgia Malamut, Alessandra Marchese, Christophe Cellier, Sjoerd F. Bakker, Chris J. J. Mulder, Umberto Volta, Fabiana Zingone, Carolina Ciacci, Anna D’Odorico, Alida Andrealli, Marco Astegiano, Catherine Klersy, Gino R. Corazza
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0084163
Abstract: Introduction It has been shown that mortality rates of coeliac patients correlate with age at diagnosis of coeliac disease, diagnostic delay for coeliac disease, pattern of clinical presentation and HLA typing. Our aim was to create a tool that identifies coeliac patients at higher risk of developing complications. Methods To identify predictors of complications in patients with coeliac disease, we organised an observational multicenter case-control study based on a retrospective collection of clinical data. Clinical data from 116 cases (patients with complicated coeliac disease) and 181 controls (coeliac patients without any complications) were collected from seven European centres. For each case, one or two controls, matched to cases according to the year of assessment, gender and age, were selected. Diagnostic delay, pattern of clinical presentation, HLA typing and age at diagnosis were used as predictors. Results Differences between cases and controls were detected for diagnostic delay and classical presentation. Conditional logistic models based on these statistically different predictors allowed the development of a score system. Tertiles analysis showed a relationship between score and risk of developing complications. Discussion A score that shows the risk of a newly diagnosed coeliac patient developing complications was devised for the first time. This will make it possible to set up the follow-up of coeliac patients with great benefits not only for their health but also for management of economic resources. Conclusions We think that our results are very encouraging and represent the first attempt to build a prognostic score for coeliac patients.
National Observatory on Special Education: Network Study about Inclusive Education in Brazil  [PDF]
Mendes Eniceia, Cia Fabiana
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.39009

Considering the importance of collaborative networks of research, a group of Brazilian researchers has created the National Observatory on Special Education (in Portuguese Oneesp), whose focus is on the production of integrated studies about policies and practices directed to the issue of school inclusion in Brazilian reality. The present project has focused on a nationwide study about a government policy to stimulate the creation of support services to students with special educational needs in regular schools, called “Multifunctional Resource Rooms (MRR)”. According to official data, between 2005 and 2011 the Brazilian Ministry of Education had financed 30.000 MRR spread in all Brazilian states. To what extent this type of service has supported the education of children and young with educational special needs? To answer these questions 203 researchers from 16 Brazilian states, representing 22 universities are leading a network study to analyze the municipalities’ implementation of this policy. Studies were conducted involving 58 municipalities for concurrently produce, knowledge and professional development through collaborative research, and were conducted through interviews with focus groups composed of approximately 450 MRR teachers, and then a national study survey in progress, directed to about 500 MRR teachers. The analysis of the results, still preliminary, indicated that the policies of the municipalities, despite following some guidelines from the Ministry of Education, were translated to their reality and assumed quite different local expressions depending in part on local history of the development of services of special education in determined reality.

Prevalence of Eating Disorders in Adults with Celiac Disease
V. Passananti,M. Siniscalchi,F. Zingone,C. Bucci,R. Tortora,P. Iovino,C. Ciacci
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/491657
Abstract: Background. Symptoms of celiac disease negatively impact social activities and emotional state. Aim was to investigate the prevalence of altered eating behaviour in celiac patients. Methods. Celiac patients and controls completed a dietary interview and the Binge Eating Staircases, Eating Disorder Inventory (EDI-2), Eating Attitudes Test, Zung Self-Rating Depression Scale, State Trait Anxiety Inventory Forma Y (STAI-Y1 and STAI-Y2), and Symptom Check List (SCL-90). Results. One hundred celiac adults and 100 controls were not statistically different for gender, age, and physical activity. STAI-Y1 and STAI-Y2, Somatization, Interpersonal, Sensitivity, and Anxiety scores of the SLC-90 were higher in CD patients than controls. EDI-2 was different in pulse thinness, social insecurity, perfectionism, inadequacy, ascetisms, and interpersonal diffidence between CD and HC women, whilst only in interceptive awareness between CD and HC men. A higher EAT-26 score was associated with the CD group dependently with gastrointestinal symptoms. The EAT26 demonstrated association between indices of diet-related disorders in both CD and the feminine gender after controlling for anxiety and depression. Conclusion. CD itself and not gastrointestinal related symptoms or psychological factors may contribute pathological eating behavior in celiac adults. Eating disorders appear to be more frequent in young celiac women than in CD men and in HC. 1. Introduction Celiac disease (CD) is a chronic inflammatory immune-mediated disease. It is a common condition with a prevalence in the western world of about 1?:?100 [1, 2]. Characterized by a clinical heterogeneity, CD presents with a large spectrum of gastrointestinal and extra-intestinal symptoms and it may be diagnosed at any age [3–9]. CD patients also frequently experience somatisation, depression, and anxiety before diagnosis [10–12]. These psychological conditions are in general, associated with changes in appetite, and weight [13, 14]. A respectable body of data has demonstrated that an association exists between emotional dysfunction and eating disorders [13]. Only few studies, which utilized small sample sizes, though have explored emotional dysfunction and eating disorders in celiac disease [15, 16]. The present case-control study was designed to evaluate the prevalence of behavior suggestive of eating disturbances in untreated CD adult patients and to investigate a possible relationship between emotional-psychological factors and the presence of eating disorders. 2. Methods 2.1. Study Population Newly diagnosed CD adults
Are error correction models the best alternative to assess capital mobility in developing countries?
Rocha, Fabiana;
Economia Aplicada , 2006, DOI: 10.1590/S1413-80502006000200007
Abstract: jansen (1996) and jansen and schulze (1996), based on a sample of developed countries argue that an error correction model would be the correct specification to estimate saving-investment correlations. the purpose of this paper is to verify if the same claim can be made using a sample of developing countries. regarding developing countries is an error correction model indeed superior, as suggested by jansen and jansen and schulze? how serious is the potential bias from using regressions in levels and in first differences instead of an error correction model? although the theory implies that there is a long-run relationship between saving and investment, this does not seem to be the case for the majority of the developing economies individually. therefore, the equation in differences is not poorly specified. based on this equation it seems to be an intermediate degree of capital mobility in developing countries according to the criterion of feldstein and horioka.
Capital mobility in developing countries: evidence from panel data
Rocha, Fabiana;
Estudos Econ?micos (S?o Paulo) , 2007, DOI: 10.1590/S0101-41612007000300004
Abstract: the purpose of this paper is to show that the use of panel data can shed some light on the feldstein-horioka puzzle. the use of panel data would bring in two advantages. first, it would avoid the bias towards low capital mobility brought by the use of time-averaged data. second, it would make possible to take into account specific effects (heterogeneity) like a country's size. pooling annual data for the period 1960-1996 for 29 developing countries, the estimated impact of saving on investment is considerably smaller and it is possible to conclude that there is some degree of capital mobility in developing countries. therefore, the high estimated saving-investment correlation seems to be due more to the existence of specific individual country effects than to capital immobility. the coefficient stability through time remains a puzzle though.
Los murales de Portinari en la Sala Hispánica de la Biblioteca del Congreso de los EE.UU.: construcción plástica de una identidad panamericana
Cuadernos del CILHA , 2011,
Abstract: on the edge of its engagement in world war ii, united states' government implemented a program of cultural and commercial interchanges with latin america in order to protect its interests in the hemisphere and to counterattack the influence exerted by the axis. the agency responsible for this mission was the office of the coordinator of inter american affairs, leaded by nelson rockefeller. to meet this goal, ociia engaged, as advisers or members of staff, representative and influential citizens from a variety of spheres. a strong pan-american net expanded towards latin america and established ties with artists, intellectuals and politicians that shared the same common enemy: nazism and fascism, their values of ethnic superiority and of a political system based on dictatorship. in the visual arts section, ociia dedicated mostly to organize and circulate exhibitions in the states and in latin america. occasionally, ociia also founded artistic projects, as was the case with the four murals painted by brazilian artist candido portinari at the hispanic room of the library of congress. portinari' s art poetic and ideology, as well as his previous work in the states, eased pan-americanism' s objectives. the murals built a multicultural hemispheric identity through the arts, an identity based on respect for racial and cultural diversity. at the same time, the murals reflected the artist's social concerns, and affirmed the creative possibilities of american people to produce an alternative modern process.
Is there any rationale to the Brazilian fiscal policy?
Rocha, Fabiana;
Revista Brasileira de Economia , 2001, DOI: 10.1590/S0034-71402001000300001
Abstract: barro's tax smoothing hypothesis (tsh) implies that, when faced by a temporary increase in expenditure, the government should issue debt in order to spread the increase in taxes over time and minimize the welfare costs of high tax rates. changes in the tax rate should then be unpredictable. this paper performs a test of the tsh that goes beyond the random walk tests usually done in literature. it examines the implied restrictions of the tsh on a vector autoregression (var) model using brazilian data for the period 1970-94. the tests reject the hypothesis for the full sample period. for the period 1987-92, however, disregarding the volatility of the actual budget surplus, the tsh seems to provide a better approximation to the historical movements of brazilian fiscal data series.
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