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Search Results: 1 - 10 of 2295 matches for " Fabian Deutskens "
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Vaccine-induced antibodies linked to bovine neonatal pancytopenia (BNP) recognize cattle major histocompatibility complex class I (MHC I)
Fabian Deutskens, Benjamin Lamp, Christiane M Riedel, Eveline Wentz, Günter Lochnit, Klaus Doll, Heinz-Jürgen Thiel, Till Rümenapf
Veterinary Research , 2011, DOI: 10.1186/1297-9716-42-97
Abstract: A mysterious hemorrhagic disease of cattle emerged in 2007 affecting solely newborn calves [1]. First named "blood sweating", "hemorrhagic diathesis" and "bleeding calf syndrome" it was finally designated "bovine neonatal pancytopenia" (BNP) at the Satellite Symposium of the European Buiatric Congress in 2009 [2]. During the last years an increasing number of calves were affected by this syndrome. BNP cases were reported for several breeds and both genders are affected equally. Reports of BNP affected calves are known from several European countries including France, Germany, United Kingdom, Ireland, Netherlands, Belgium, Luxembourg, Italy, and Spain [2,3]. The disease is unknown in countries which do not vaccinate against bovine virus diarrhea virus (BVDV) like Denmark, Austria, and Switzerland [4].BNP is characterized by severe external and internal hemorrhages. Clinical studies have shown that the bleedings are caused by a massive thrombocytopenia, usually connected with a severe leukopenia and depletion of bone marrow cells, the latter may result in complete aplasia [1,5-7]. Mortality is up to 90% in affected calves; mild to subclinical manifestations are rarely observed [8].In the past, bleeding disorders in cattle due to thrombocytopenia have been described primarily as a consequence of intoxications and viral infections, but sporadic cases were also linked to bacterial septicemia, hereditary diseases or immune mediated processes [9]. Several hypotheses have been put forward with regard to the etiology of BNP, such as bacterial and virus infections (BVDV, bluetongue virus, porcine circovirus 2 [9]) or intoxications but could not be confirmed [1,8,10]. A genetic etiology of BNP was discussed, but BNP appearance showed no link to certain genotypes. Epidemiological studies showed that mutations in coagulation factor XI [11] or certain MHC class II haplotypes [12] were not associated with BNP outbreaks. In BNP affected calves, the often dramatic decline of thrombo
The Asymptotic Eigenvalues of First-Order Spectral Differentiation Matrices  [PDF]
Jue Wang, Fabian Waleffe
Journal of Applied Mathematics and Physics (JAMP) , 2014, DOI: 10.4236/jamp.2014.25022
Abstract: We complete and extend the asymptotic analysis of the spectrum of Jacobi Tau approximations that were first considered by Dubiner. The asymptotic formulas for Jacobi polynomials PN(α ,β ) ,α ,β > -1 are derived and confirmed by numerical approximations. More accurate results for the slowest decaying mode are obtained. We explain where the large negative eigenvalues come from. Furthermore, we show that a large negative eigenvalue of order N2 appears for -1 <α < 0 ; there are no large negative eigenvalues for collocations at Gauss-Lobatto points. The asymptotic results indicate unstable eigenvalues for α > 1 . The eigenvalues for Legendre polynomials are directly related to the roots of the spherical Bessel and Hankel functions that are involved in solving Helmholtz equation inspherical coordinates.
Surrogates are just surrogates, but helpful just the same
Carol Fabian
Breast Cancer Research , 2007, DOI: 10.1186/bcr1816
Abstract: To be credible, an SEB must have biological plausibility and a strong association with ultimate outcome. To be used for prevention, an SEB should be identified as being causally related to the development of precancer and cancer. Modulation of the SEB through an intervention should predict outcome. The SEB should be reproducible and reliable. Reproducibility is generally maximized with a quantitative biomarker. Optimally, both risk and response SEBs should be prospectively validated in a clinical trial in which the nonsurrogate outcome is also being evaluated [1,2].SEBs are used in clinical trials to identify effective new strategies faster and more economically with fewer patients. They may also offer insight into why or why not a particular therapy does not work. In the patient care setting, SEBs are used to determine whether and when to change the therapeutic plan.In the metastatic setting, typically the same surrogate markers are measured repeatedly to assess response or progression often by imaging and/or physical examination. Two surrogate markers can independently predict the same outcome, but results at any single point in time may be discordant. Consequently, it is important to understand the biology that underlies the surrogate in order to avoid making inappropriate clinical decisions.In the neoadjuvant setting, a low Ki-67 a few weeks after initiation of treatment and pathological response after several months of treatment both predict long-term disease-free survival [3-5]. Both biomarkers are currently used in the research setting, and pathological stage after neoadjuvant treatment is used clinically to estimate distant disease-free survival. It is probable that, in the near future, early reduction in breast proliferation will be used along with clinical indices to determine whether to switch antihormonal or chemotherapeutic treatment during the neoadjuvant period. Pathological response after neoadjuvant chemotherapy will also probably be used to determi
Colecionando pensamentos: sobre os atos de colecionar
Fabian, Johannes;
Mana , 2010, DOI: 10.1590/S0104-93132010000100003
Abstract: ever since anthropology became a discipline, fieldwork and in situ research, combined with the study of material objects stored/displayed in museums, both formed an integral part of the way anthropological knowledge is produced. scientific/academic collectionism became stocked with theoretical premises and methodological procedures conceived under the paradigm of ‘natural history.' dealing with this heritage is as important as it is difficult to respond to the post-colonial challenges faced by ethnographic museums wherever they are located. the rebirth of material culture studies played a crucial role in these reorientations and developments and was just as significant as anthropology's ‘literary turn' towards reading culture as a text. the creation of virtual archives of texts can be (and probably already is) a significant element in any documentation of collections.
La recogida de basura en Mega-ciudades: En el marco de la sostenibilidad
Revista INVI , 2010, DOI: 10.4067/S0718-83582010000300006
Abstract: understanding complex urban societies is only possible when their formal and informal aspects are studied. one of the strongest tools for this task is the study of waste, as it enables a distinction between these two aspects, even when the demands of society exceed the legislative framework. by defining waste as a resource, it normalizes vastly dissimilar realities. then, waste management in cities such as tokyo, mexico city, madrid and paris can be thoroughly studied, coming into light their operational differences as well as their vulnerabilities. this article shows the relation between the interaction of cities and normative gaps. through this comparison, the innate capacity of societies to adapt to these imperfections is highlighted, being useful to understand the informal sector and its contribution to the efficiency of the urban system, especially in developing countries.
Chronic kidney disease in HIV infec tion: early detec tion and preventive strategies
J Fabian
Continuing Medical Education , 2007,
Extreme cities and isotropic territories: Scenarios and projects arising from the environmental emergency of the central Veneto città diffusa
Lorenzo Fabian
International Journal of Disaster Risk Science , 2012, DOI: 10.1007/s13753-012-0003-5
Abstract: In Italy extreme cities and territories occur at the extremities of lagoons, coastlines, and river deltas, in hydraulically reclaimed and hydrogeologically instable areas, and those where the water supply network has been placed underground, channeled into piping, or removed altogether. These areas are now increasingly subject to natural calamities and extreme weather conditions, and the consequences of climate change and the fragility of the more and more impermeable and urbanized land surface are clearly evident. Isotropic territories are characterized by weak hierarchization of infrastructure and settlement. The metropolitan area of Venice, aptly described as a diffuse city (città diffusa), and other diffusely organized territories characterized by settlement dispersion are good examples of this phenomenon. This article reviews recent research at the University IUAV of Venice in a study on climate change and water forms, a project in which the profound relations between water networks, the geological nature of the terrain, forms of urbanization, and energy saving are tested out. The study of the territories of the Venetian metropolitan area provides a series of initial working hypotheses as to how the ongoing environmental emergency can become an opportunity for a development project of the city and the territory, capable of structuring its various parts differently.
The chemistry of gold-fluoro compounds: A continuing challenge for gold chemists
Fabian Mohr
Gold Bulletin , 2004, DOI: 10.1007/BF03215208
Abstract: This article gives a brief overview of the chemistry of gold-fluoro compounds known to date. The synthesis, structures, reactivity and computational results of gold fluorides are reviewed, discussed according to the gold oxidation state. The literature up to (and including) 2003 has been covered.
QCD Radiation Effects on the H->WW->l nu l nu Signal at Hadron Colliders
Stoeckli, Fabian
High Energy Physics - Phenomenology , 2008,
Abstract: The discovery of a Standard Model Higgs boson is possible when experimental cuts are applied which increase the ratio of signal and background cross-sections. We present a study of the pp->H->WW signal cross-section at hadron colliders which requires a selection of Higgs bosons with small transverse momentum. We compare predictions for the efficiency of the experimental cuts from a NNLO QCD calculation and the event generator MC@NLO and are able to predict a reliable number for the cross-section after the aplpication of such experimental cuts.
Library Architecture: Some Observations
Bernhard Fabian
Liber Quarterly : The Journal of European Research Libraries , 2002,
Abstract: There are plenty of libraries (among them many university and research libraries) which do not provide adequate work-places. Chairs may have been selected for their stylish look rather than for their physical comfort. Desk lamps may have been deemed unnecessary (they might have distorted the overall impression which the reading room was expected to make) And so on. I keep wondering how many librarians have spent some time in their libraries as readers, and have assessed their reading rooms from the user’s point of view. Have they been in a cubicle? Or have they read a book under glaring neon lights? Do they know how well their air-conditioning works? I know a library in which the only window that can be opened is in the librarian’s office.
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