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Search Results: 1 - 10 of 42 matches for " FZ Azzaoui "
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Attempt at the determination of aluminum nitrate LD50 and the study of its neurotoxicological effect in Wistar rat
FZ Azzaoui
Biology and Medicine , 2012,
Abstract: Values of oral lethal dose of aluminum (Al) nitrate are extremely different and rare in the literature. The study is an attempt to determine the oral LD50 of aluminum nitrate in the Wistar rats and to measure the effect of the high doses of this aluminum compound on rats’ different organs, on acetylcholinesterase (AChE) activity, and on acetylcholine (ACh) levels in the hippocampus. Four groups of male Wistar rats are used (n = 28). The treated groups receive three doses of aluminum nitrate (Al1 = 2,500 mg/kg, Al2 = 3,500 mg/kg, and Al3 = 4,500 mg/kg) once by gavage, while control rats receive tap water. All rats are examined twice daily for mortality and impairment during the 2-week experiment. The bodyweight (BW) is measured at the beginning and at the end of the experiment. Dissection is realized for each dyed rat and the dosage of AChE activity and ACh levels isrealized at the end of the experiment by colorimetric method. The obtained results show that the higher dose (Al3) kills 30% of the rats under study and causes spleens’ dark discoloration in the dyed rats. Both Al2 and Al3decrease significantly the spleen weight (p < 0.01) and AChE activity (p < 0.01), but increase significantly the ACh levels (p < 0.01 and p < 0.001, respectively), in hippocampus of rats. Even if the lethal dose of aluminum nitrate is not reached, the effect of the high acute doses on viscera and cholinergic system is demonstrated.
Spectral representation of some non stationary alpha-stable processes
Nourddine Azzaoui
Mathematics , 2008,
Abstract: In this paper, we give a new covariation spectral representation of some non stationary symmetric $\alpha$-stable processes (S$\alpha$S). This representation is based on a weaker covariation pseudo additivity condition which is more general than the condition of independence. This work can be seen as a generalization of the covariation spectral representation of processes expressed as stochastic integrals with respect to independent increments S$\alpha$S processes (see Cambanis (1983)) or with respect to the general concept of independently scattered S$\alpha$S measures (Samorodnitsky and Taqqu 1994). Relying on this result we investigate the non stationarity structure of some harmonisable S$\alpha$S processes especially those having periodic or almost-periodic covariation functions.
FZ Zainal
Malaysian Family Physician , 2007,
Malaysian Family Physician , 2008,
Non Linear Magnetic Hysteresis Modelling by Finite Volume Method for Jiles-Atherton Model Optimizing by a Genetic Algorithm  [PDF]
Seddik Azzaoui, Kamel Srairi, Mohamed El Hachemi Benbouzid
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2011, DOI: 10.4236/jemaa.2011.36032
Abstract: This paper describes a generalization methodology for nonlinear magnetic field calculation applied on two-dimensional (2-D) finite Volume geometry by incorporating a Jiles-Atherton scalar hysteresis model. The scheme is based upon the definition of modified governing equation derived from Maxwell’s equations considered the magnetization M. This paper shows how to extract optimal parameters for the Jiles-Atherton model of hysteresis by a real coded genetic algorithm approach. The parameters identification is performed by minimizing the mean squared error between experimental and simulated magnetic field curves. The calculated results are validated by experiences performed in an SST’s frame.
The Effects of Isosorbide Dinitrate on in Vitro Proliferation of WEHI-164 Cells and Peripheral Blood Mononuclear Cells
Hajighasemi F,Resvan Madani FZ
Tehran University Medical Journal , 2012,
Abstract: Background: Isosorbide dinitrate has been broadly used in the treatment of various ischemic heart diseases. Isosorbide is a nitric oxide donor which increases blood flow to tumors through vasodilatation and consequently accelerates the access of chemo-drugs to them. Furthermore, this drug has inhibitory effects on angiogenesis, tumor growth and metastasis in vivo. Moreover, its ant-inflammatory effects have also been reported. In the present study we evaluated the effects of isosorbide on the proliferative activity of fibrosarcoma WEHI-164 cell line and peripheral blood mononuclear cells (PBMCs). Methods: WEHI-164 fibrosarcoma cells and human PBMCs were cultured in complete Roswell Park Memorial Institute (RPMI) 1640 medium with 10% fetal bovine serum and 2×104 cells/mL for WEHI-164 and 2×105 cells/mL for PBMCs. The cells were then incubated at the exponential growth phase with different concentrations of isosorbide (4×10-6-1.6×10-3 M) for 24, 48 and 72 hours. Subsequently, isosorbide effects on proliferation of the cells were evaluated by trypan blue dye exclusion (TB) test and MTT assay. Statistical comparisons between groups were made by analysis of variance. Results: The proliferative activity of WEHI-164 fibrosarcoma cells and human PBMCs treated with different concentrations of isosorbide, did not show any significant difference with untreated control cells. Conclusion: The results of this study showed that isosorbide neither had any significant effects on the proliferative activity of fibrosarcoma WEHI-164 cells nor on human PBMCs. Our findings suggest that anti-tumoral effects of isosorbide reported by other investigators may be mediated through non-cytotoxic mechanisms.
Nutritional Status and School Achievements in a Rural Area of Anti-Atlas, Morocco  [PDF]
Mohamed El Hioui, Fatima-Zahra Azzaoui, Ahmed Omar Touhami Ahami, Youssef Aboussaleh
Food and Nutrition Sciences (FNS) , 2011, DOI: 10.4236/fns.2011.28119
Abstract: Nutritional status is the best indicator of the global well-being of children. However, malnutrition affects physical growth, cognitive development, physical work capacity, and it consequently influences human performance and health. The present study was designed to identify factors that may influence the nutritional status and educational achievements of the children in a rural area of ANTI Atlas of Morocco. The nutritional status of 162 children (12 to 15 years of age) was assessed by nutritional anthropometry and compared with tables of weight-for-age and height-for-age z-scores (WAZ and HAZ) identifying wasting and stunting, respectively. A questionnaire was developed to collect information about socio-economic and demographic status of the children’s families. Also, educational achievements were assessed by their score in mathematics. A total of 162 children (64 boys and 98 girls), aged 12 –15 years. Results revealed 22.8% of stunting and 35.2% of wasting. Child age (p = 0.027), illiteracy of the mother (p = 0.004) was determinant factors with wasting. Stunting was significantly associated with gender (p = 0.03) and parents’ employment (p = 0.009). However, using logistic regression analysis, the results showed that stunting (p = 0.04) and mother level of education (p = 0.032) were significantly correlated with school achievements.In this area of study, malnutrition remains a major problem among adolescents’ school performances, which can affect their future. The main causes of malnutrition seem to be the bad weaning practices among school children and cultural attitudes of food. The educational achievements of school children are influenced by maternal education and stunting.
Biochemical and Neurobiological Study of Moroccan Autists  [PDF]
Hakim Harchaoui, Fatima-Zahra Azzaoui, Ahmed Ahami, Samira Boulbaroud, Mohamed El Hioui
Neuroscience & Medicine (NM) , 2013, DOI: 10.4236/nm.2013.44039

Autism spectrum disorder (ASD) is a range of complex neurodevelopment disorders, characterized by social impairments, communication difficulties, and restricted, repetitive, and stereotyped patterns of behavior. Its diagnosis is very difficult and consists of only clinical criteria. The aim of this study is to confirm autism disorder, among three children (2 girls and 1 boy), recruited in a social association of children in a precarious situation, located in Rabat, Morocco, and to evaluate some biological and neurobiological parameters among these children. The confirmation of autistic status is realized using Questionnaire (E2) and the evaluation of biological parameters (organic acids, urinary peptides, toxic metals and essential elements) is done in urine and hair of these children. Obtained children’s scores of E2 Questionnaire, is found in the favor of autism. Moreover, abnormal levels of urinary organic acids, urinary peptides, toxic and essential metals are observed.

Early Maladaptive Schemas, Working Memory and Academic Performances of Moroccan Students  [PDF]
A. Ahami, K. Mammad, F.-Z. Azzaoui, S. Boulbaroud, F.-Z. Rouim, S. Rusinek
Open Journal of Medical Psychology (OJMP) , 2017, DOI: 10.4236/ojmp.2017.62004
Abstract: Our aim is to study the early maladaptive schemas and the memory span abilities and to evaluate the relationship between these schemas and the memory in one side and academic performance in the other side among Moroccan students. A cross-sectional study is conducted among 212 students, randomly selected from different institutions of the IBN TOFAIL University, located in the city of Kenitra (NW of Morocco). Three neurocognitive tests are used: the short version of the Early Maladaptive Schemas Questionnaire to evaluate the early maladaptive schemas (EMS), the sub-test of the Wechsler to evaluate the working memory among these subjects, and a general questionnaire about socio-economic data, nutritional and mental health status and also, academic performances of each student. The obtained results showed some significant negative correlations between forward memory span and activated schema, and significant negative correlations are registered between backward memory span and activated schema. More, thirty-three percent of students passed the exams of the autumn term against 67% who failed it. Moreover, significant negative correlations are registered between the schemas and the number of Units validated in the autumn term. In addition, fifty-three percent of students had a normal forward memory, 47% had an excellent forward memory and no one had pathological one. However, 63% had a pathological backward memory span, 28% had normal memory and 9% had an excellent backward memory. The EMS appeared in connection with the student’s working memory and the academic performance. Deeper investigations are needed to understand this relationship and also to study other possible factors that could affect this important neurocognitive function.
Diagnosis of Anxiety Disorders in University Students through the Early Maladaptive Schemas and Beck’s Inventory  [PDF]
K. Mammad, A. Ahami, F.-Z. Azzaoui, S. Boulbaroud, W. Idrissi, K. Karjouh, L. Fofana
Psychology (PSYCH) , 2017, DOI: 10.4236/psych.2017.813134
Abstract: Aim is to diagnose the prevalence of anxiety disorders using early maladaptive schemas and Beck’s anxiety inventory among students. The present study is a cross-sectional study conducted among 212 students, aged 17 to 25 years, randomly selected from different institutions of the IBN TOFAIL University, located in the city of Kenitra (NW of Morocco). Two neurocognitive tests were used: The Beck Anxiety Inventory to evaluate anxiety & the short version of the early maladaptive schema questionnaire of Schmidt, Joiner, Young and Telch (1995) which was translated in French by Rusinek & Hautekéete (2000) to evaluate schemas. The obtained results of measure of anxiety show that the inadequate early maladaptive schemas positively correlated with the Beck Anxiety Inventory: Emotional deprivation (r = 0.1635, p < 0.05) Isolation (r = 0.2305, p = 0.001) and Insufficient self-control (r = 0.1819, p < 0.01), Abandon (r = 0.2514, p = 0.001) Vulnerability (r = 0.1505, p < 0.05), Fear of losing control (r = 0.1510, p < 0.05). A band appears between early maladaptive schemas and Beck anxiety inventory revealing the existence of anxiety in university students, which has appeared in some maladaptive schemas, especially: Emotional deprivation, Isolation, Insufficient self-control, Abandon, Vulnerability, Fear of losing control. Deeper investigations needed to understand this relationship and to study other possible factors that could affect this important neurocognitive function.
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