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Search Results: 1 - 10 of 208882 matches for " FRIDA L; ZANELLA "
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Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
MORIEL,PATRICIA; PLAVNIK,FRIDA L; ZANELLA,MARIA T; BERTOLAMI,MARCELO C; ABDALLA,DULCINEIA SP;
Biological Research , 2000, DOI: 10.4067/S0716-97602000000200010
Abstract: lipid peroxidation and lipid-derived oxidized products have been implicated in the pathogenesis of a variety of human diseases. to clarify the role of oxidative stress in essential hypertension and hypercholesterolemia the in vitro oxidative susceptibility of ldl, the antioxidant status and the lipid peroxide content of blood plasma were examined in hypercholesterolemic (hc), hypertensive (h), hypercholesterolemic/hypertensive (hh) and normolipidemic/normotensive subjects (n). plasma ascorbate and lipid-soluble antioxidants were lower, while ldl oxidizability, ce-ooh and tl-ooh were higher in h, hc, and hh groups than in the n group. no difference was observed among groups for pl-ooh and isoprostanes. in summary, the results show that: 1) lipid- and water-soluble antioxidants are lower in hypercholesterolemic and hypertensive patients as compared to normal subjects, whereas the lipid peroxide content and the ldl susceptibility to oxidation were higher; 2) total cholesterol, ldl-cholesterol, apob and ce-ooh were negatively correlated with the content of a-tocopherol; 3) there was a positive correlation between the content of lipid-soluble antioxidants and the resistance of ldl to oxidation; and 4) ce-ooh and tl-ooh were positively correlated with total cholesterol and ldl-cholesterol.
Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
PATRICIA MORIEL,FRIDA L PLAVNIK,MARIA T ZANELLA,MARCELO C BERTOLAMI
Biological Research , 2000,
Abstract: Lipid peroxidation and lipid-derived oxidized products have been implicated in the pathogenesis of a variety of human diseases. To clarify the role of oxidative stress in essential hypertension and hypercholesterolemia the in vitro oxidative susceptibility of LDL, the antioxidant status and the lipid peroxide content of blood plasma were examined in hypercholesterolemic (HC), hypertensive (H), hypercholesterolemic/hypertensive (HH) and normolipidemic/normotensive subjects (N). Plasma ascorbate and lipid-soluble antioxidants were lower, while LDL oxidizability, CE-OOH and TL-OOH were higher in H, HC, and HH groups than in the N group. No difference was observed among groups for PL-OOH and isoprostanes. In summary, the results show that: 1) lipid- and water-soluble antioxidants are lower in hypercholesterolemic and hypertensive patients as compared to normal subjects, whereas the lipid peroxide content and the LDL susceptibility to oxidation were higher; 2) total cholesterol, LDL-cholesterol, apoB and CE-OOH were negatively correlated with the content of a-tocopherol; 3) there was a positive correlation between the content of lipid-soluble antioxidants and the resistance of LDL to oxidation; and 4) CE-OOH and TL-OOH were positively correlated with total cholesterol and LDL-cholesterol.
Validation study of an automated wrist monitor, omron model HEM-608, compared with the standard methods for blood pressure measurement
Plavnik, Frida Liane;Zanella, Maria Teresa;
Arquivos Brasileiros de Cardiologia , 2001, DOI: 10.1590/S0066-782X2001001200004
Abstract: objective - the aim of our study was to assess the profile of a wrist monitor, the omron model hem-608, compared with the indirect method for blood pressure measurement. methods - our study population consisted of 100 subjects, 29 being normotensive and 71 being hypertensive. participants had their blood pressure checked 8 times with alternate techniques, 4 by the indirect method and 4 with the omron wrist monitor. the validation criteria used to test this device were based on the internationally recognized protocols. results - our data showed that the omron hem-608 reached a classification b for systolic and a for diastolic blood pressure, according to the one protocol. the mean differences between blood pressure values obtained with each of the methods were -2.3 +7.9mmhg for systolic and 0.97+5.5mmhg for diastolic blood pressure. therefore, we considered this type of device approved according to the criteria selected. conclusion - our study leads us to conclude that this wrist monitor is not only easy to use, but also produces results very similar to those obtained by the standard indirect method.
Validation study of an automated wrist monitor, omron model HEM-608, compared with the standard methods for blood pressure measurement
Plavnik Frida Liane,Zanella Maria Teresa
Arquivos Brasileiros de Cardiologia , 2001,
Abstract: OBJECTIVE - The aim of our study was to assess the profile of a wrist monitor, the Omron Model HEM-608, compared with the indirect method for blood pressure measurement. METHODS - Our study population consisted of 100 subjects, 29 being normotensive and 71 being hypertensive. Participants had their blood pressure checked 8 times with alternate techniques, 4 by the indirect method and 4 with the Omron wrist monitor. The validation criteria used to test this device were based on the internationally recognized protocols. RESULTS - Our data showed that the Omron HEM-608 reached a classification B for systolic and A for diastolic blood pressure, according to the one protocol. The mean differences between blood pressure values obtained with each of the methods were -2.3 +7.9mmHg for systolic and 0.97+5.5mmHg for diastolic blood pressure. Therefore, we considered this type of device approved according to the criteria selected. CONCLUSION - Our study leads us to conclude that this wrist monitor is not only easy to use, but also produces results very similar to those obtained by the standard indirect method.
Fine Mapping of Loci on BTA2 and BTA26 Associated with Bovine Viral Diarrhea Persistent Infection and Linked with Bovine Respiratory Disease in Cattle
Ricardo Zanella,Holly L. Neibergs
Frontiers in Genetics , 2011, DOI: 10.3389/fgene.2011.00082
Abstract: Bovine respiratory disease (BRD) is considered to be the most costly infectious disease in the cattle industry. Bovine viral diarrhea virus (BVDV) is one of the pathogens involved with the BRD complex of disease. BVDV infection also negatively impacts cow reproduction and calf performance. Loci associated with persistently infected animals (BVD-PI) and linked with BRD have previously been identified near 14 Mb on bovine chromosome 2 (BTA2) and 15.3 Mb on bovine chromosome 26 (BTA26). The objective of this study was to refine the loci associated with BVD-PI and linked with BRD. Association testing for BVD-PI was performed on a population of 65 BVD-PI calves, 51 of their dams, and 60 unaffected calves (controls) with 142 single nucleotide polymorphisms (SNPs) on BTA2 and 173 SNPs on BTA26. Comparisons were made between BVD-PI calves and controls calves and the dams of BVD-PI calves and controls calves. For the linkage analysis of BRD, the same markers were used to genotype two half-sib families consisting of the sires and 72 BRD positive and 148 BRD negative offspring. Using an allelic chi-square test, 11 loci on BTA2 and 8 loci on BTA26 were associated with the dams of the BVD-PI calves (P < 0.05) and 4 loci on BTA2 and 11 loci on BTA26 were associated with BVD-PI calves. This demonstrates that although some of the loci on BTA2 and BTA26 are jointly involved in the fetal and dam response to BVD-PI infection, there are loci that are solely associated with the maternal or fetal susceptibility to disease. One locus on BTA2 and two loci on BTA26 were found to be linked (P < 0.05) with BRD. The regions linked with BRD were also associated with BVD-PI demonstrating that both the broad (BRD) and narrow (BVD-PI) definition of disease identified shared genomic regions as important in disease susceptibility. These results further refined the loci associated with BVD-PI and linked with BRD.
Eficácia de uma interven??o psicológica no estilo de vida para redu??o do risco coronariano
Pugliese, Rita;Zanella, Maria Tereza;Blay, Sérgio Luís;Plavinik, Frida;Andrade, Marco Antonio;Galv?o, Roberto;
Arquivos Brasileiros de Cardiologia , 2007, DOI: 10.1590/S0066-782X2007001600003
Abstract: objective: to evaluate the efficacy of a program of lifestyle change through psychological intervention, combined with pharmacological therapy, for coronary risk reduction in uncontrolled hypertensive patients with overweight and dyslipidemia over 11 months of follow-up. methods: a randomized controlled trial with 74 patients assigned to three different treatment programs. one group (ct) only received conventional pharmacological treatment. another group (og) received pharmacological treatment and participated in a guidance program to control cardiovascular risk factors. a third group (lspi) received pharmacological treatment and participated in a brief psychological intervention program for reduction of estresse levels and changing of eating behavior. the main measure was the framingham risk index. results: ct patients presented an average reduction of 18% (p = 0.001) in coronary risk; og patients elevated the risk by 0.8% (ns) and the lspi group showed an average reduction of 27% on the framingham risk index (p = 0.001). conclusion: pharmacological treatment combined with psychological intervention for reduction of estresse level and changing of eating behavior resulted in additional benefits in coronary risk reduction.
Hyperglycemia and nocturnal systolic blood pressure are associatedwith left ventricular hypertrophy and diastolic dysfunction in hypertensive diabetic patients
Jo?o S Felício, Juliana T Pacheco, Sandra R Ferreira, Frida Plavnik, Valdir A Moisés, Oswaldo Kohlmann, Artur B Ribeiro, Maria T Zanella
Cardiovascular Diabetology , 2006, DOI: 10.1186/1475-2840-5-19
Abstract: Ninety-one hypertensive patients with type 2 diabetes mellitus (DM) (group-1 [G1]), 59 essential hypertensive patients (group-2 [G2]) and 26 healthy controls (group-3 [G3]) were submitted to 24-h Ambulatory Blood Pressure Monitoring (ABPM) and echocardiography (ECHO) with Doppler. We calculated an average of fasting blood glucose (AFBG) values of G1 from the previous 4.2 years and a glycemic control index (GCI) (percentual of FBG above 200 mg/dl).G1 and G2 did not differ on average of diurnal systolic and diastolic BP. However, G1 presented worse diastolic function and a higher average of nocturnal systolic BP (NSBP) and LVMI (NSBP = 132 ± 18 vs 124 ± 14 mmHg; P < 0.05 and LVMI = 103 ± 27 vs 89 ± 17 g/m2; P < 0.05, respectively). In G1, LVMI correlated with NSBP (r = 0.37; P < 0.001) and GCI (r = 0.29; P < 0.05) while NSBP correlated with GCI (r = 0.27; P < 0.05) and AFBG (r = 0.30; P < 0.01). When G1 was divided in tertiles according to NSBP, the subgroup with NSBP≥140 mmHg showed a higher risk of LVH. Diabetics with NSBP≥140 mmHg and AFBG>165 mg/dl showed an additional risk of LVH (P < 0.05; odds ratio = 11). In multivariate regression, both GCI and NSBP were independent predictors of LVMI in G1.This study suggests that hyperglycemia and higher NSBP levels should be responsible for an increased prevalence of LVH in hypertensive patients with Type 2 DM.Clinical, epidemiologic and pathological data support the occurrence of a specific cardiomyopathy related to diabetes mellitus (DM) [1-3]. However, the exact cause of this complication is still being discussed. Proposed causes include metabolic abnormalities (hyperglycemia and changes in myocardial lipid metabolism), hypertension and autonomic neuropathy [3-6]. As DM is usually associated to hypertension and coronary arteriosclerosis [2] and they all can reduce myocardial performance, it's hard to dissociate cardiac abnormalities (LVH and diastolic dysfunction) originated from those conditions to that straightly rela
Reprodutibilidade da medida ambulatorial da press?o arterial em pacientes hipertensos com diabete melito tipo 2
Felício, Jo?o Soares;Pacheco, Juliana Torres;Ferreira, Sandra Roberta;Plavnik, Frida;Kohlmann, Oswaldo;Ribeiro, Artur Beltrame;Zanella, Maria Tereza;
Arquivos Brasileiros de Cardiologia , 2007, DOI: 10.1590/S0066-782X2007000200012
Abstract: objective: to evaluate the reproducibility of ambulatory blood pressure monitoring (abpm) (spacelabs-90207) and placebo effect on abpm. methods: blood pressure was measured in the office and over two abpm periods with an interval from one to ten months (mean 4.9 months), in 26 patients with type 2 diabetes mellitus and hypertension. eleven patients (g1) had two abpms without taking antihypertensive drugs for 15 days, whereas g2 (n=15) had the second abpm after administration of a placebo for 15 days. results: in the evaluation of the coefficient of variation (cv) of diurnal (awake) systolic bp (dsbp), of diurnal (awake) diastolic bp (ddbp), of 24-hour systolic bp (24hsbp) and of 24-hour diastolic bp (24hdbp), the values found were 4.6%, 3.9%, 5.0%, 4.0% for g1 and 4.3%, 5.1%, 3.7%, 5.1% for g2 respectively. we also determined the cv of nocturnal (sleep) systolic and diastolic bp (nsbp and ndbp) for g1 (7.7%; 8.2%) and g2 (5.6%; 6.3%). heart rate cv during alertness and sleep were: g1=5.9% and 9.0%; g2=6.9% and 5.8% respectively. when the total number of 'patients was analyzed, all variables showed a strong correlation between the first and second abpm measurements (dsbp, r = 0.76; p < 0.001; ddbp, r = 0.65; p < 0.001; 24hsbp, r = 0.77; p < 0.001; 24hdbp, r = 0.70; p < 0.001; nsbp, r = 0.62; p < 0.001; ndbp, r = 0.52; p < 0.01). office systolic and diastolic bp and 24hsbp and 24hdbp also showed correlation (r = 0.65; p < 0.001; r = 0.57; p < 0.01). conclusion: mean of pressure levels measured by abpm presented good reproducibility and were not affected by placebo.
Blood pressure and cardiorenal responses to antihypertensive therapy in obese women
Rosa, Eduardo Cantoni;Zanella, Maria Tereza;Kohlmann, Nárcia Elisa Bellucci;Ferreira, Sandra Roberta Gouveia;Plavnik, Frida Liane;Ribeiro, Artur Beltrame;Kohlmann Jr., Osvaldo;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2008, DOI: 10.1590/S0004-27302008000100010
Abstract: objective: blood pressure(bp) and target organ responses to antihypertensive drugs are not well established in hypertensive obese patients. this study is aimed at evaluating the effects of obesity and adiposity distribution patterns on these responses. methods: 49 hypertensive obese women were designated to different groups according to waist to hip ratio measurements - 37 with troncular and 12 with peripheral obesity. patients were treated for 24-weeks on a stepwise regimen with cilazapril alone or a cilazapril/hydrochlorothiazide/amlodipine combination therapy to achieve a bp lower than 140/90mmhg. ambulatory blood pressure monitoring (abpm), echocardiography, and albuminuria were assessed before and after the intervention. results: after 24 weeks, weight loss was less than 2% in both groups. abpm targets were achieved in 81.5% of patients upon a combination of 2(26.5%) or 3(55.1%) drugs. similar reductions in daytime-sbp/dbp: -22.5/-14.1(troncular obesity) / -23.6/-14.9mmhg (peripheral obesity) were obtained. decrease in nocturnal-sbp was greater in troncular obesity patients. upon bp control, microalbuminuria was markedly decreased, while only slight decrease in left ventricular mass was observed for both groups. conclusions: in the absence of weight loss, most patients required combined antihypertensive therapy to control their bp, regardless of their body fat distribution pattern. optimal target bp and normal albuminuria were achieved in the group as a whole and in both obese patient groups, while benefits to cardiac structure were of a smaller magnitude.
Jornadas de trabalho na enfermagem: entre necessidades individuais e condi??es de trabalho
Silva,Amanda Aparecida; Rotenberg,Lúcia; Fischer,Frida Marina;
Revista de Saúde Pública , 2011, DOI: 10.1590/S0034-89102011000600014
Abstract: objective: to assess factors associated with professional and total hours of work (work + home) among nursing staff. methods: cross-sectional study conducted in a university hospital in the city of s?o paulo, southeastern brazil, between 2004 and 2005. a total of 696 workers (nurses, nurse technicians and aids), mostly women (87.8%) working day and/or night shifts, participated in the study. a self-administered questionnaire was used to collected information on demographic characteristics, and working and life conditions. translated and adapted into portuguese versions of the job stress scale, effort-reward imbalance, short-form-health-related quality of life and the work ability index were also administered. logistic regression models were used for data analysis. results: sole breadwinner, working night shifts and effort-reward imbalance were the variables associated with both professional (or = 3.38, or = 10.43, or = 2.07, respectively) and total hours of work (or = 1.57, or = 3.37, or = 2.75, respectively). there was no significant association between the variables related to hours of work and low work ability index. inadequate rest at home was statistically associated with professional (or = 2.47) and total hours of work (or = 1.48). inadequate leisure time was significantly associated with professional hours of work (or = 1.58) and barely associated with total hours of work (or = 1.43). conclusions: the sole breadwinner, working night shifts and effort-reward imbalance are variables that need to be further investigated in studies on work hours among nursing staff. these studies should explore workers' income and the relationship between effort and reward, taking into consideration gender issues.
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