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Search Results: 1 - 10 of 25665 matches for " FRANCISCO; BLANCO "
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El diente paciente
Francisco M. Aguado Blanco
Panace@ : Revista de Medicina, Lenguaje y Traducción , 2007,
Rese a de "Hacia la integración laboral de las personas con discapacidad. Un estudio longitudinal" de R. De la Fuente
Francisco Javier Blanco Encomienda
The Splicing Factor SRSF1 as a Marker for Endothelial Senescence
Francisco Javier Blanco
Frontiers in Physiology , 2012, DOI: 10.3389/fphys.2012.00054
Abstract: Aging is the major risk factor per se for the development of cardiovascular diseases. The senescence of the endothelial cells (ECs) that line the lumen of blood vessels is the cellular basis for these age-dependent vascular pathologies, including atherosclerosis and hypertension. During their lifespan, ECs may reach a stage of senescence by two different pathways; a replicative one derived from their preprogrammed finite number of cell divisions; and one induced by stress stimuli. Also, certain physiological stimuli, such as transforming growth factor-β, are able to modulate cellular senescence. Currently, the cellular aging process is being widely studied to identify novel molecular markers whose changes correlate with senescence. This review focuses on the regulation of alternative splicing mediated by the serine–arginine splicing factor 1 (SRSF1, or ASF/SF2) during endothelial senescence, a process that is associated with a differential subcellular localization of SRSF1, which typically exhibits a scattered distribution throughout the cytoplasm. Based on its senescence-dependent involvement in alternative splicing, we postulate that SRSF1 is a key marker of EC senescence, regulating the expression of alternative isoforms of target genes such as endoglin (ENG), vascular endothelial growth factor A (VEGFA), tissue factor (T3), or lamin A (LMNA) that integrate in a common molecular senescence program.
Perceived Self-Efficacy in Problem Solving and Scientific Communication in University Students. A Gender Study  [PDF]
Francisco Javier Flores, Daniel Mayorga-Vega, José René Blanco, Humberto Blanco
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.55046

The purpose of the present study was to compare the profiles of perceived self-efficacy in problem solving and scientific communication between men and women university students. A total sample of 2089 participants, 902 women and 1187 men, aged 17 - 20 years participated in this study. The sample was constituted by all the freshmen university students from each degree offered by the Autonomous University of Chihuahua (Mexico). A quantitative approach with a descriptive and transversal survey design was used. All the participants completed the Self-Efficacy Problem Solving and Communication Scale. The results of the one-way multivariate analysis of variance, followed by the one-way univariate analyses of variance, showed that the men reported statistically significant better perceived self-efficacy in problem solving than the women (p < .05), but they had lower scores in the possibility for improving self-efficacy perceived than the women (p < .05). Regarding the scientific communication, the females reported statistically significant greater desired and reachable self-efficacy than the men (p < .05). However, for all the other variables statistically significant differences were not found (p > .05). Because of the differences between men and women in their perception of self-efficacy found, these findings suggest that in order to design any intervention for improving the perceived self-efficacy of the students, the variable gender should be taken into account.

Lattice 3-polytopes with six lattice points
Mónica Blanco,Francisco Santos
Mathematics , 2015,
Abstract: We classify lattice $3$-polytopes of width larger than one and with exactly $6$ lattice points. We show that there are $74$ polytopes of width $2$, two polytopes of width $3$, and none of larger width. We give explicit coordinates for representatives of each class, together with other invariants such as their oriented matroid (or order type) and volume vector. For example, according to the number of interior points these $76$ polytopes divide into $23$ tetrahedra with two interior points (clean tetrahedra), $49$ polytopes with one interior point (the $49$ canonical three-polytopes with five boundary points previously classified by Kasprzyk) and only $4$ hollow polytopes. We also give a complete classification of three-polytopes of width one with $6$ lattice points. In terms of the oriented matroid of these six points, they lie in eight infinite classes and twelve individual polytopes. Our motivation comes partly from the concept of distinct pair sum (or dps) polytopes, which, in dimension $3$, can have at most $8$ lattice points. Among the $74+2$ classes mentioned above, exactly $44 + 1$ are dps.
Lattice 3-polytopes with few lattice points
Mónica Blanco,Francisco Santos
Mathematics , 2014,
Abstract: This paper is intended as a first step in a program for a full algorithmic enumeration of lattice $3$-polytopes. The program is based in the following two facts, that we prove: 1. For each $n$ there is only a finite number of (equivalence classes of) $3$-polytopes of lattice width larger than one, where $n$ is the number of lattice points. Polytopes of width one are infinitely many, but easy to classify. 2. There is only a finite number of $3$-polytopes of lattice width larger than one that cannot be obtained by either glueing two smaller ones or by lifting in a very specific manner one of a list of five lattice $2$-polytopes. The $3$-polytopes in this finite list have at most $11$ lattice points. For $n=4$, all empty tetrahedra have width one (White). For $n=5$ we here show that there are exactly 9 different $3$-polytopes of width $2$, and none of larger width. Eight of them are the \emph{clean tetrahedra} previously classified by Kasprzyk and (independently) Reznick. In a subsequent paper, we show that for $n=6$ there are 74 polytopes of width $2$, two of width $3$, and none of larger width.
Effect of the Monocyte Locomotion Inhibitory Factor (MLIF) a Natural Anti-Inflammatory Produced by E. Histolytica on Apoptosis in Human CD4 + T Lymphocytes  [PDF]
Sara Rojas-Dotor, Liliana Vargas-Neri, Francisco Blanco-Favela
Pharmacology & Pharmacy (PP) , 2011, DOI: 10.4236/pp.2011.24032
Abstract: Apoptosis prevents the extravasation of intracellular material and the subsequent inflammatory response. Currently, it is not known whether Monocyte Locomotion Inhibitor Factor (MLIF), an anti-inflammatory pentapeptide, induces programmed cell death. We evaluated the effect of MLIF on extrinsic and intrinsic apoptosis pathways human CD4 + T lymphocytes. Cells were cultured for 24 h in RPMI-1640 medium alone (control) or in RPMI medium containing MLIF alone, PMA alone, PMA + MLIF or actinomycin D. Annexin V/propidium iodide-stained cells in early apoptosis showed that cells treated with MLIF or PMA + MLIF were not significantly different from control cells in medium; in contrast, cells treated with PMA or PMA + MLIF demonstrated significant differences from the control in delayed apoptosis. Cytochrome c and caspase 3 levels in cells treated with MLIF showed no significant differences from control cells, however, compared to the control, cells treated with PMA and PMA + MLIF exhibited a significant increase in cytochrome c and caspase 3 levels, which demonstrates that this weak induction of cell death is regulated by the intrinsic pathway of apoptosis. The Fas receptor was not detected in cell culture with any of the treatments employed, suggesting that the extrinsic pathway of apoptosis is not involved. The MLIF per se does not induce apoptosis in human CD4 + T lymphocytes; there may be an additional effect of PMA + MLIF producing the low levels of cell death recorded in the late apoptosis phase. MLIF acts as a natural, biological anti-inflammatory compound produced in axenic cultures of E. histolytica that does not cause apoptosis or elicit an immune response due to its small size, which could make it a strong candidate for future clinical applications.
Inhibidores de la integrasa y raltegravir en el manejo de la infección por virus de la inmunodeficiencia humana en la era de la resistencia a múltiples medicamentos
Guevara,Fredy; Blanco,Francisco; Arredondo,Miguel;
Infectio , 2010,
Abstract: immunodeficiency virus infection in humans (hiv) has generated a worldwide impact exceeding initial estimates for this disease. at present, it is necessary to search for new antiretroviral drugs within the families of known medication, but the search for new therapeutic objectives under the effect of medication which has not been exposed to the virus and, therefore without natural resistance to it, is even more important integrase inhibitors are the family of antiretroviral medication most recently approved for clinical use; raltegravir is a new drug with important attributes that make it a tool to be considered in rescue regimens, change therapies, and na?ve patient particular cases
Incremento de la Eficiencia en Centrales Termoeléctricas por Aprovechamiento de los Gases de la Combustión
Blanco,Jesús M; Pe?a,Francisco;
Información tecnológica , 2011, DOI: 10.4067/S0718-07642011000400003
Abstract: this paper presents a proposal for using the latent heat of the steam condensed in an economizer used to preheat the feeding water to the steam generator, with the aim of increasing the efficiency of thermal power plants. a novel methodology applied to power plants producing over 350 mw power plants and that use natural gas is developed. also, a detailed study of the different alternatives proposed is presented and their direct effects on the economic feasibility have been evaluated. increases up to 0.6 % in the global efficiency are obtained, besides short return investment periods, depending on the annual effective working hours of the power plant.
Obtención del Valor Real de las Pérdidas de Difícil Evaluación, Aplicables al Cálculo del Rendimiento de Calderas
Blanco,Jesús M; Pe?a,Francisco;
Información tecnológica , 2006, DOI: 10.4067/S0718-07642006000300018
Abstract: a study to obtain the real value of difficult-evaluation heat losses applied to the calculation of boiler efficiency is presented. a conventional value of 1 % over the gross caloric value of the fuel was assigned to each fuel. the proposed method allows to accurately determining these losses and is suitable for any type of fuel. for the study, both natural gas and fuel-oils (number 2 and low sulphur content fuel respectively) were selected. the conventional value of 1% over the gross caloric value has been useful to compare boiler efficiency as demonstrated in this work.
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