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Search Results: 1 - 10 of 60374 matches for " FRANCHI-TEIXEIRA Antonio Roberto "
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Estudo da libera??o renal de glicose em coelhos submetidos a hepatectomia total funcional e infus?o de noradrenalina
FRANCHI-TEIXEIRA, Antonio Roberto;JORGE, Gracinda L.;LEONARDI, Luís Sérgio;SAAD, Mário José Abdalla;
Arquivos de Gastroenterologia , 2001, DOI: 10.1590/S0004-28032001000300008
Abstract: aim ? to study the possible endogenous sources of glucose in the absence of the liver (equivalent to the anhepatic period of liver transplantation). material and methods - a experimental model of total functional hepatectomy in anesthetised rabbits was developed. the aorta and the right renal vein were catheterised in order to collect blood samples to measure glucose contents. the animals were divided into two groups: group 1, 5 animals underwent only norepinephrine infusion; group 2, 15 animals underwent norepinephrine infusion and submitted to total functional hepatectomy. results - in group 2, before the hepatectomy, arterial glucose levels were higher than venous ones and after the liver removal, the venous levels became higher than the arterial ones. this pattern showed an inversion in the glicemic curves. in group 1 this pattern was not observed. conclusion - the glicemic curves behavior observed in group 2 is not due to norepinephrine infusion, but represents renal glucose release after total functional hepatectomy.
Estudo da libera o renal de glicose em coelhos submetidos a hepatectomia total funcional e infus o de noradrenalina
FRANCHI-TEIXEIRA Antonio Roberto,JORGE Gracinda L.,LEONARDI Luís Sérgio,SAAD Mário José Abdalla
Arquivos de Gastroenterologia , 2001,
Abstract: Objetivo - Estudar as prováveis fontes endógenas de glicose na ausência do fígado (equivalente à fase anepática do transplante de fígado). Material e Métodos - Criou-se um modelo experimental de hepatectomia total funcional em coelhos anestesiados. A aorta e a veia renal direita foram cateterizadas para colheita de glicemias seriadas. Os animais foram divididos em dois grupos: grupo 1, com 5 animais submetidos apenas a infus o de noradrenalina e grupo 2, constando de 15 animais também submetidos a infus o de noradrenalina e tiveram seus fígados retirados. Resultados - Demonstram que, no grupo 2, antes da hepatectomia, as dosagens de glicemias arteriais foram maiores que as venosas, e após a retirada do órg o, estes valores se tornaram menores. Isto configurou invers o das curvas das glicemias. No grupo 1 n o foi observada essa invers o. Conclus o - Conclui-se que esse comportamento das curvas de glicemia observadas nos animais do grupo 2 n o se deve à a o da noradrenalina e significa libera o renal de glicose após a hepatectomia.
A new experimental model for acute hepatic failure in rats
Teixeira, Antonio Roberto Franchi;Machado, Marcel Cerqueira Cesar;Kubrusly, Márcia Saldanha;Molan, Nilza Trindade;Bellodi-Privato, Marta;Leite, Kátia Regina;D'Albuquerque, Luiz Augusto Carneiro;
Acta Cirurgica Brasileira , 2010, DOI: 10.1590/S0102-86502010000300009
Abstract: purpose: to develop a reliable surgical model of acute hepatic failure and hyperammonemia in rats that avoids porto-systemic shunt and bile duct ligation, applicable to hepatic encephalopathy research. methods: the pedicles of right lateral and caudate lobes were exposed and clamped. one hour later, the animal was reopened, clamps were released and anterior subtotal hepatectomy (resection of median and left lateral lobes) was performed, comprising 75% of liver removal. four hours after hepatectomy, blood samples and liver tissues were collected from alf and control groups. results: differences between alf and control groups were significant for alt, ast, total and direct bilirubin, sodium, potassium, alkaline phosphatasis, gamma-glutamyltransferase and most important, ammonia. histologically, significant differences were noticed between groups. conclusion: the model is useful for the study of specific aspects of alf and the development of new therapeutic approaches.
Rosiglitazone-enriched diet did not protect liver ischemia-reperfusion injury in a rat model
Teixeira, Antonio Roberto Franchi;Molan, Nilza Trindade;Bellodi-Privato, Marta;Coelho, Ana Maria;Leite, Kátia Ramos;Seguro, Ant?nio Carlos;Bacchella, Telésforo;Machado, Marcel Cerqueira César;
Acta Cirurgica Brasileira , 2008, DOI: 10.1590/S0102-86502008000400013
Abstract: purpose: to determine whether rosiglitazone-enriched diet offer protection in a classical model of liver ischemia-reperfusion injury in rats. methods: two days before the experiment, rats were divided into 2 groups: control group (n=13) rats fed with standard diet; rosi group (n=13): rats fed with a powdered standard diet supplemented with rosiglitazone. the animals were submitted to liver ischemia-reperfusion by clamping the pedicle of median and left anterolateral lobes. after 1 hour of partial hepatic ischemia, the clamp was removed for reperfusion. after 2 or 24 hours (control and rosi groups), blood was collected for enzymes and cytokines analysis. ischemic and non-ischemic liver were collected for malondialdehyde analysis and histological assessment. lungs were removed for tissue myeloperoxidase quantification. results: there were no statistical differences between groups for all analysed parameters. conclusion: in this model, rosiglitazone-enriched diet did not protect liver against ischemia-reperfusion injury.
Postconditioning ameliorates lipid peroxidation in liver ischemia-reperfusion injury in rats
Teixeira, Antonio Roberto Franchi;Molan, Nilza T.;Kubrusly, Márcia Saldanha;Bellodi-Privato, Marta;Coelho, Ana Maria;Leite, Kátia R.;Machado, Marcel Autran Cesar;Bacchella, Telésforo;Machado, Marcel Cerqueira César;
Acta Cirurgica Brasileira , 2009, DOI: 10.1590/S0102-86502009000100011
Abstract: purpose: liver ischemia-reperfusion injury is a phenomenon presents in events like liver resections and transplantation. the restoration of blood flow may leads to local and systemic injury. several techniques have been developed in order to avoid or ameliorate ischemia-reperfusion injury in clinical situations. the application of a sttuter reperfusion after the ischemic event (postconditioning) could alters the hydrodynamics and stimulates endogenous mechanisms that attenuate the reperfusion injury. the present study was designed to evaluate the potential protective effect of postconditioning in a model of ischemia-reperfusion in rats. methods: hepatic anterior pedicle of median and left anterolateral segments were exposed and clamped for 1 hour. two hours later, clamp was released in two different ways: control group (n=7): clamp was release straightforward; postconditioning group (n=7): clamp was released intermittently. lipid peroxidation (malondialdehyde) and expression of the glutathione-s-transferase-α-3 gene were studied. results: lipid peroxidation was significantly decreased in ischemic and non-ischemic liver by postconditioning. gst- α3 gene was overexpressed in postconditioned group, but not significantly. conclusion: postconditioning induced hepatoprotection by reducing lipid peroxidation in the ischemic and non-ischemic liver.
Halitose: proposta de um protocolo de avalia??o
Dal Rio, Ana Cristina Coelho;Nicola, Ester Maria Danielli;Teixeira, Ant?nio Roberto Franchi;
Revista Brasileira de Otorrinolaringologia , 2007, DOI: 10.1590/S0034-72992007000600015
Abstract: halitosis is an embarrassing symptom with a significant social impact. halitosis affects millions of people worldwide and many resources are spent annually in products to improve halitus, unsuccessfully. the study of halitosis in a scientific basis is justified once halitosis causes social restriction, decreases life quality and may be an indication of serious diseases. aim: to elaborate a protocol for halitosis assessment in order to minimize costs, avoid unnecessary tests and provide a guideline for diagnosis. methods: the protocol was created based on the literature and on the authors? personal experiences, adopting an evidence-based anamnesis. results: there are many causes of halitosis and most of them are related to the oral cavity; others are related to otolaryngologic and respiratory diseases. gastrointestinal diseases, liver/renal impairment and other metabolic syndromes are less frequent, but also important causes of halitosis. conclusion: there are important costs involved in halitosis assessment and treatment, including medical appointments, specialist assessment, and complementary tests. such costs would be minimized by adopting a protocol of evidence-based anamnesis and a flowchart for a rational clinical investigation.
Incidentaloma gigante de adrenal em paciente jovem
Andrade, Cristiano Feijó;Espírito Santo, Paulo Rogério Quieregatto do;Teixeira, Ant?nio Roberto Franchi;
Revista do Colégio Brasileiro de Cirurgi?es , 2000, DOI: 10.1590/S0100-69912000000500014
Abstract: incidental adrenal tumors are lesions occasionally observed during abdominal us or ct scans. these tumors have been observed in patients without clinical or laboratorial signs of adrenal disease. the authors report a case of a 18 - years - old young man who was admitted to the franco da rocha hospital, s?o paulo, with abdominal pain and a palpated mass in the epigastrium which began one month ago. these findings were preceeded by a blunt trauma at the epigastrium three months earlier. first clinical hypothesis was of a traumatic pancreatic pseudocyst. however, investigation and laparotomy showed a large left adrenal solid mass, weighting 700 g. the mass was removed and histology was performed. there was no evidence of malignant neoplasm, then the diagnostic of incidental adenoma of adrenal was confirmed. the authors hope to stimulate surgeons for early detection of these lesions in order to prevent the complications and improve the prognosis.
Endoscopic treatment of choledochal cyst type III
Rodrigues, Matheus Alessi;Sousa, Alexandre Venancio de;Falcone, Ciro;Coelho, Gabriel;Veiga, Durval Knox da;Zaidan, Mário;Callejas-Neto, Francisco;Teixeira, Roberto Franchi;
ABCD. Arquivos Brasileiros de Cirurgia Digestiva (S?o Paulo) , 2008, DOI: 10.1590/S0102-67202008000300010
Abstract: background: todani type iii cysts are not very common disease. endoscopically the choledochocele is not a challenging diagnosis. sometimes biliary stone disease is associated and events of cholangitis and pancreatitis may occur. normally these patients are referred for surgical treatment, mainly because there is a widespread concept that choledocal cysts are very prone to develop neoplasia and must be resected. nevertheless surgical resection is not free of morbidity. the chance for neoplasia in such cases seems to be related to the presence of pancreaticobiliary reflux towards the common bile duct. aim: to report a case of endoscopic treatment of choledochal cyst type iii with literature review. case report: young man with recurrent abdominal pain, fever and hyperamylasemia. an ercp showed pancreaticobiliary maljunction and calculus impaction. papillotomy was performed and complete biliary clearance was achieved. amylase contents in the common bile duct was measured and normal. due to absence of pancreatiobiliary reflux, a second endoscopic approach was performed and a wide communication between choledochocele and duodenum was done with diathermy (using the papillotome). the patient recovering was uneventful and in 30 months follow-up he remains asymptomatic. conclusion: since pancreatobiliary reflux is not present, surgical approach of the diverticulum seemed to be not necessary. endoscopic drainage of choledococele was a good option for conservative treatment.
Thermal Hydraulic Analysis Improvement for the IEA-R1 Research Reactor and Fuel Assembly Design Modification  [PDF]
Pedro Ernesto Umbehaun, Walmir Maximo Torres, José Antonio Batista Souza, Mitsuo Yamaguchi, Antonio Teixeira e Silva, Roberto Navarro de Mesquita, Nikolas Lymberis Scuro, Delvonei Alves de Andrade
World Journal of Nuclear Science and Technology (WJNST) , 2018, DOI: 10.4236/wjnst.2018.82006
Abstract: This paper presents the sequence of activities to improve the thermal hydraulic analysis of the IEA-R1 research reactor to operate in safe conditions after power upgrade from 2 to 5 MW and core size reduction from 30 to 24 fuel assemblies. A realistic analysis needs the knowledge of the actual operation conditions (heat flow, flow rates) beyond the geometric data and the uncertainties associated with manufacturing and measures. A dummy fuel assembly was designed and constructed to measure the actual flow rate through the core fuel assemblies and its pressure drop. First results showed that the flow distribution over the core is nearly uniform. Nevertheless, the values are below than the calculated ones and the core bypass flow rate is greater than those estimated previously. Based on this, several activities were performed to identify and reduce the bypass flow, such as reduction of the flow rate through the sample irradiators, closing some unnecessary secondary holes on the matrix plate, improvement in the primary flow rate system and better fit of the core components on the matrix plate. A sub-aquatic visual system was used as an important tool to detect some bypass flow path. After these modifications, the fuel assemblies flow rate increased about 13%. Additional tests using the dummy fuel assembly were carried out to measure the internal flow distribution among the rectangular channels. The results showed that the flow rate through the outer channels is 10% - 15% lower than the internal ones. The flow rate in the channel formed between two adjacent fuel assemblies is an estimated parameter and it is difficult to measure because this is an open channel. A new thermal hydraulic analysis of the outermost plates of the fuel assemblies takes into account all this information. Then, a fuel design modification was proposed with the reduction of 50% in the uranium quantity in the outermost fuel plates. In order to avoid the oxidation of the outermost plates by high temperature, low flow rate, a reduction of 50% in the uranium density in the same ones was shown to be adequate to solve the problem.
Branching of periodic orbits in reversible hamiltonian systems
Claudio Buzzi,Luci Any Roberto,Marco Antonio Teixeira
Mathematics , 2010,
Abstract: This paper deals with the dynamics of time-reversible Hamiltonian vector fields with 2 and 3 degrees of freedom around an elliptic equilibrium point in presence of symplectic involutions. The main results discuss the existence of one-parameter families of reversible periodic solutions terminating at the equilibrium. The main techniques used are Birkhoff and Belitskii normal forms combined with the Liapunov-Schmidt reduction.
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