oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 8 )

2018 ( 45 )

2017 ( 35 )

2016 ( 59 )

Custom range...

Search Results: 1 - 10 of 31897 matches for " FONSECA-GONZáLEZ "
All listed articles are free for downloading (OA Articles)
Page 1 /31897
Display every page Item
Mixed-function oxidases and esterases associated with cross-r esistance between DDT and lambda-cyhalothrin in Anopheles darlingi Root 1926 populations from Colombia
Fonseca-González, Idalyd;Qui?ones, Martha L;McAllister, Janet;Brogdon, William G;
Memórias do Instituto Oswaldo Cruz , 2009, DOI: 10.1590/S0074-02762009000100003
Abstract: in order to establish the insecticide susceptibility status for anopheles darlingi in colombia, and as part of the national network on insecticide resistance surveillance, five populations of insects from three colombian states were evaluated. standardised who and cdc bottle bioassays, in addition to microplate biochemical assays, were conducted. populations with mortality rates below 80% in the bioassays were considered resistant. all field populations were susceptible to deltamethrin, permethrin, malathion and fenitrothion. resistance to lambda-cyhalothrin and ddt was detected in the amé-beté population using both bioassay methods with mortality rates of 65-75%. enzyme levels related to insecticide resistance, including mixed function oxidases (mfo), non-specific esterases (nse), glutathione s-transferases and modified acetylcholinesterase were evaluated in all populations and compared with a susceptible natural strain. only mosquitoes from amé-beté presented significantly increased levels of both mfo and nse, consistent with the low mortalities found in this population. the continued use of lambda-cyhalothrin for an. darlingi control in this locality has resulted in a natural resistance to this insecticide. in addition, ddt resistance is still present in this population, although this insecticide has not been used in colombia since 1992. increased metabolism through mfo and nse may be involved in cross-resistance between lambda-cyhalothrin and ddt, although kdr-type nerve insensitivity cannot be discarded as a possible hypothesis. additional research, including development of a kdr specific assay for an. darlingi should be conducted in future studies. our data demonstrates the urgent need to develop local insecticide resistance management and surveillance programs throughout colombia.
Dosis diagnósticas para vigilar la resistencia a insecticidas de los vectores de malaria en Colombia Diagnostic doses for monitoring insecticide resistance of malaria vectors in Colombia
IDALYD FONSECA-GONZáLEZ,ROCíO CáRDENAS,WILBER GóMEZ,LILIANA SANTACOLOMA
Revista Colombiana de Entomología , 2010,
Abstract: El control de los mosquitos vectores de malaria se realiza principalmente con aplicaciones de insecticidas ya sea en las paredes internas de las viviendas o en toldillos. Por lo anterior, la vigilancia de la resistencia a insecticidas en estas especies es fundamental para la definición de planes y estrategias de control de malaria. El propósito de este estudio fue determinar las dosis diagnósticas de varios insecticidas de uso en salud pública para los principales vectores de malaria en Colombia: Anopheles darlingi, A. albimanus y A. nuneztovari, utilizando la metodología de las botellas impregnadas desarrollada por los Centros para la Prevención y Control de Enfermedades. Se seleccionaron poblaciones naturales de las tres especies sometidas a baja o nula presión con insecticidas con las cuales se realizaron bioensayos para determinar las líneas base de susceptibilidad. Se establecieron las dosis diagnósticas (concentración del insecticida y tiempo diagnóstico) o curvas de saturación, para los insecticidas lambdacialotrina, deltametrina, fenitrotión, malatión y DDT para los tres vectores; ciflutrina, permetrina y propoxur para A. albimanus y A. darlingi; y etofenprox y bendiocarb para A. darlingi. Las dosis diagnósticas determinadas en estas poblaciones permitirán evaluar el estado de la resistencia a insecticidas de los principales vectores de malaria a lo largo de su distribución en Colombia, fortaleciendo el sistema de vigilancia de la resistencia y facilitando la toma de decisiones para un uso más adecuado de los insecticidas en el control de malaria en el país. The control of mosquito vectors of malaria is largely based on insecticide applications, either on the inside walls of dwellings or on treated nets. For that reason, the surveillance of insecticide resistance in these species is essential for the definition of plans and strategies of malaria control. The purpose of this study was to determine the diagnostic doses of several insecticides used in public health for the main vectors of malaria in Colombia: Anopheles darlingi, A. albimanus and A. nuneztovari, using the methodology of impregnated bottles developed by the Centers for Disease Control and Prevention. Natural populations of the three species, submitted to low or no insecticide pressure, were selected with which bioassays were conducted to determine baseline susceptibility. Diagnostic doses (insecticide concentration and diagnostic time), or saturation curves, were established for the insecticides lambda-cyhalothrin, deltamethrin, fenitrothion, malathion and DDT for the three vectors;
Selección artificial de resistencia a lambda-cialotrina en Aedes aegypti y resistencia cruzada a otros insecticidas Artificial selection of insecticide resistance to lambda-cyhalothrin in Aedes aegypti and cross resistance to other insecticides
DUVERNEY CHAVERRA-RODRíGUEZ,NICOLáS JARAMILLO-OCAMPO,IDALYD FONSECA-GONZáLEZ
Revista Colombiana de Entomología , 2012,
Abstract: Aedes aegypti es el principal vector del dengue alrededor del mundo. El control químico de larvas y adultos se basa principalmente en insecticidas organofosforados y piretroides; para los cuales se ha registrado el desarrollo de resistencia en campo. El manejo de la resistencia requiere evaluar la rapidez con la que ésta se desarrolla y la posible generación de resistencia cruzada entre ambos grupos de insecticidas. Este estudio evaluó durante siete generaciones el efecto de la selección con lambda-cialotrina sobre Ae. aegypti en el desarrollo de la resistencia a este piretroide y sus consecuencias en la aparición de resistencia cruzada a los insecticidas temefós, malatión y permetrina en condiciones de laboratorio. Se obtuvieron adultos a partir de larvas colectadas en campo en Cúcuta (Colombia) y sus descendientes fueron expuestos a concentraciones del insecticida incrementadas gradualmente cada generación. El desarrollo de la resistencia fue confirmado usando bioensayos en larvas y adultos. La selección incrementó los grados de resistencia (GR) en cada generación (1,25X promedio). La población de la generación F7 fue altamente resistente a lambda-cialotrina en adultos (F1 = 100% mortalidad disminuyó a F7 = 35% de mortalidad) y larvas (GR 50 F1 = 24,22X hasta GR50 F7 = 61,52X) al compararla con la cepa de referencia en susceptibilidad Rockefeller. La cepa resistente a lambda-cialotrina no presentó resistencia cruzada con temefós y malatión (organofosforados), pero sí a permetrina (piretroide). La información obtenida sugiere que la rotación de piretroides con organofosforados continúa siendo una alternativa apropiada para manejar la aparición de la resistencia en las estrategias de control del dengue. Aedes aegypti is the main vector of dengue virus worldwide. The chemical control of larvae and adults is based principally on organophosphate and pyrethroid insecticides, for which resistance has developed in the field. The management of resistance requires evaluating how rapidly it can develop and the possible generation of cross-resistance between both groups of insecticides. This study evaluates the effects of selection on Ae. aegypti with lambda-cyhalo-thrin on the development of resistance to this pyrethroid over seven generations and its impact on the appearance of cross-resistance to temephos, malathion, and permethrin insecticides under laboratory conditions. Adults were obtained from larvae collected in the field in Cúcuta (Colombia) and the descendants were exposed to gradually increasing concentrations of insecticides each generation. The deve
Geometric Morphometrics of Nine Field Isolates of Aedes aegypti with Different Resistance Levels to Lambda-Cyhalothrin and Relative Fitness of One Artificially Selected for Resistance
Nicolás Jaramillo-O., Idalyd Fonseca-González, Duverney Chaverra-Rodríguez
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096379
Abstract: Aedes aegypti, a mosquito closely associated with humans, is the principal vector of dengue virus which currently infects about 400 million people worldwide. Because there is no way to prevent infection, public health policies focus on vector control; but insecticide-resistance threatens them. However, most insecticide-resistant mosquito populations exhibit fitness costs in absence of insecticides, although these costs vary. Research on components of fitness that vary with insecticide-resistance can help to develop policies for effective integrated management and control. We investigated the relationships in wing size, wing shape, and natural resistance levels to lambda-cyhalothrin of nine field isolates. Also we chose one of these isolates to select in lab for resistance to the insecticide. The main life-traits parameters were assessed to investigate the possible fitness cost and its association with wing size and shape. We found that wing shape, more than wing size, was strongly correlated with resistance levels to lambda-cyhalothrin in field isolates, but founder effects of culture in the laboratory seem to change wing shape (and also wing size) more easily than artificial selection for resistance to that insecticide. Moreover, significant fitness costs were observed in response to insecticide-resistance as proved by the diminished fecundity and survival of females in the selected line and the reversion to susceptibility in 20 generations of the non-selected line. As a practical consequence, we think, mosquito control programs could benefit from this knowledge in implementing efficient strategies to prevent the evolution of resistance. In particular, the knowledge of reversion to susceptibility is important because it can help in planning better strategies of insecticide use to keep useful the few insecticide-molecules currently available.
Dosis diagnósticas para vigilar la resistencia a insecticidas de los vectores de malaria en Colombia
FONSECA-GONZáLEZ,IDALYD; CáRDENAS,ROCíO; GóMEZ,WILBER; SANTACOLOMA,LILIANA; BROCHERO,HELENA; OCAMPO,CLARA; SALAZAR,MIRIAM; MCALLIS TER,JANET; BROGDON,WILLIAM; QUI?ONES,MARTHA;
Revista Colombiana de Entomología , 2010,
Abstract: the control of mosquito vectors of malaria is largely based on insecticide applications, either on the inside walls of dwellings or on treated nets. for that reason, the surveillance of insecticide resistance in these species is essential for the definition of plans and strategies of malaria control. the purpose of this study was to determine the diagnostic doses of several insecticides used in public health for the main vectors of malaria in colombia: anopheles darlingi, a. albimanus and a. nuneztovari, using the methodology of impregnated bottles developed by the centers for disease control and prevention. natural populations of the three species, submitted to low or no insecticide pressure, were selected with which bioassays were conducted to determine baseline susceptibility. diagnostic doses (insecticide concentration and diagnostic time), or saturation curves, were established for the insecticides lambda-cyhalothrin, deltamethrin, fenitrothion, malathion and ddt for the three vectors; cyfluthrin, permethrin and propoxur for a. albimanus and a. darlingi, and etofenprox and bendiocarb for a. darlingi. the diagnostic doses determined in these susceptible populations will allow an evaluation of the status of insecticide resistance of the main malaria vectors across their distribution in colombia, strengthening the resistance surveillance system and facilitating decision making for a more appropriate use of insecticides to control malaria in the country.
Integración conceptual Green-Lean en el dise?o, planificación y construcción de proyectos
Martinez,Patricia; González,Vicente; Fonseca,Eduardo;
Revista ingeniería de construcción , 2009, DOI: 10.4067/S0718-50732009000100001
Abstract: current competitiveness scenario in which engineering companies act, demands new production approaches, where the environmental variables play a key role. in such a way, the sustainability concept should begin to be managed by all the agents involved: engineers, architects, owners, among others. sustainability concept, being of general character, has remained in a conceptual context, becoming difficult the development of tools that facilitate its consideration through the entire project life cycle. this study had as purpose to integrate the philosophies of sustainable construction, or green building, and lean construction, the latter employee as the necessary complement to give an analysis baseline focused on the production management. the design, planning and construction stages were defined as the enclosed life cycle, being determined integration vectors by means of the morphological analysis and cross-impact matrix. the vectors with direct relationship for the implementation of the green-lean integration were determined. as implementation tool of the green-lean integration, constructability was used which allowed sequencing the construction processes. this conceptual exercise was only applied at design level. as a result, at conceptual level was stated that the tools applied in the project management (lean construction and constructability), give a sound support for the implementation, and future application, of sustainability criteria in the processes and stages involving the whole project life cycle.
Integración conceptual Green-Lean en el dise o, planificación y construcción de proyectos Green-Lean conceptual integration in the project design, planning and construction
Patricia Martinez,Vicente González,Eduardo Fonseca
Revista ingeniería de construcción , 2009,
Abstract: El actual escenario de competitividad en el que se mueven las empresas de ingeniería, demanda nuevos enfoques de producción, donde las variables medioambientales juegan un papel relevante. En este sentido el concepto de sustentabilidad debe empezar a ser manejado por todos los agentes involucrados: ingenieros, arquitectos, mandantes, entre otros. El concepto de sustentabilidad, por ser de carácter general, se ha mantenido en un ámbito más bien conceptual, haciéndose complejo el desarrollo de herramientas que faciliten su consideración a través del ciclo de vida completo de un proyecto. Este estudio tuvo por propósito integrar las filosofías de Construcción sustentable, o Green Building, y Lean Construction, esta última empleada como el complemento necesario para entregar una base de análisis centrada en la gestión de producción. Se definió como ciclo de vida acotado las etapas de dise o, planificación y construcción, determinándose vectores de integración por medio del análisis morfológico y matrices de impacto cruzado. Se determinaron los vectores con relación directa para la implementación de la integración Green-Lean. Para operacionalizar la integración Green-Lean se empleó como herramienta de implementación la Constructabilidad, la que permitió secuenciar los procesos de construcción, ejercicio conceptual aplicado sólo a la etapa de dise o. Como resultado, se estableció a nivel conceptual que las herramientas aplicadas en la gestión de proyectos de construcción (Lean Construction y Constructabilidad), entregan un soporte sólido para la operacionalización, y futura aplicación, de criterios de sustentabilidad en los procesos y etapas que involucra el ciclo de vida completo de los proyectos de construcción. Current competitiveness scenario in which engineering companies act, demands new production approaches, where the environmental variables play a key role. In such a way, the sustainability concept should begin to be managed by all the agents involved: engineers, architects, owners, among others. Sustainability concept, being of general character, has remained in a conceptual context, becoming difficult the development of tools that facilitate its consideration through the entire project life cycle. This study had as purpose to integrate the philosophies of Sustainable Construction, or Green Building, and Lean Construction, the latter employee as the necessary complement to give an analysis baseline focused on the production management. The design, planning and construction stages were defined as the enclosed life cycle, being determined integration
Rese a de "Lawlessness and Economics: Alternative Modes of Governance" de DIXIT, Avinash K.
Marisol FONSECA GONZáLEZ-ARAGóN
Boletín mexicano de derecho comparado , 2010,
Abstract:
Diagnóstico genético en disquinesia ciliar primaria: Revisión bibliográfica
Grau L,Carolina; González B,Sergio; Fonseca A,Ximena;
Revista de otorrinolaringología y cirugía de cabeza y cuello , 2011, DOI: 10.4067/S0718-48162011000100011
Abstract: primary cilliary dyskinesia (pcd) is an heterogeneous genetic disease caused by a structural and/or functional alteration of the ciliary skeleton. it is a diagnostic challenge due to its protean clinical presentation and to the complexity of screening and diagnostic methods. the method hitherto regarded as the gold standard is the analysis of ciliary structure by transmission electron microscopy (tem). this presents limitations because analyzes a limited number of ciliary axonemes, and may exclude cases with typical functional and clinical presentation. in recent years new diagnostic methods have been developed based on novel knowledge of the structural ciliary proteins, the genes encoding these proteins and mutations associated to dcp. these new methods include genetic analysis and the study of protein expression in cilia of the affected patients. this paper reviews dcp pathophysiology, the current diagnostic methods applied, and summarizes the international literature regarding the diagnosis of dcp based on genetic screening.
Respuesta terapéutica de pacientes con malaria por plasmodium falciparum a los antimaláricos y fenotipo y genotipo del citocromo p450
Valentina Guzmán,Jaime Carmona Fonseca,Fanny Cuesta González
Iatreia , 2004,
Abstract: En la evaluación de la eficacia a los antimaláricos, la falta de concordancia entre el fenotipo observado In vivo en el paciente (respuesta exitosa, falla) e In vitro en el parásito (sensible, resistente), sugiere que factores como el metabolismo del medicamento en el hospedero pueden cumplir un papel determinante. El metabolismo de varios antimaláricos es realizado por el complejo citocromo P-450 (CYP450) en el hígado (1) y su actividad es vulnerable a la inhibición y a la inducción por: el estado nutricional, el genotipo enzimático y la administración concomitante de otros medicamentos (2). La amodiaquina (AQ) es metabolizada al compuesto activo Ndesetilamodiaquina por el CYP2C8 y la mefloquina (MQ) es metabolizada a carboximefloquina (su forma de excreción), por el CYP3A4; la inhibición del CYP450 puede convertir un metabolismo rápido en lento llevando a concentraciones inefectivas del medicamento, mientras que la inducción puede acelerar la conversión a su metabolito y favorecer la excreción rápida del mismo.
Page 1 /31897
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.