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Search Results: 1 - 10 of 222934 matches for " FERRARI Maria de Lourdes de Abreu "
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Whipple's disease. Report of five cases with different clinical features
FERRARI Maria de Lourdes de Abreu,VILELA Eduardo Garcia,FARIA Luciana Costa,COUTO Claudia Alves
Revista do Instituto de Medicina Tropical de S?o Paulo , 2001,
Abstract: Whipple's disease (WD) is a rare systemic disease of infectious etiology which involves the small intestine but can virtually affect any organ. We present here five cases (four males and one female) ranging in age from 20 to 59 years. All patients had intestinal involvement associated or not with clinical manifestations linked to this organ. Vegetation in the tricuspid valve was observed in one patient, suggesting endocarditis caused by Tropheryma whippelii, with disappearance of the echocardiographic alterations after treatment. In one of the male patients the initial clinical manifestation was serologically negative spondylitis, with no diarrhea occurring at any time during follow-up. Ocular involvement associated with intestinal malabsorption and significant weight loss were observed in one case. In the other two cases, diarrhea was the major clinical manifestation. All patients were diagnosed by histological examination of the jejunal mucosa and, when indicated, of extraintestinal tissues by light and electron microscopy. After antibiotic treatment, full remission of symptoms occurred in all cases. A control examination of the intestinal mucosa performed after twelve months of treatment with sulfamethoxazole-trimethoprim revealed the disappearance of T. whippelii in four patients. The remaining patient was lost to follow-up.
Manifesta??es articulares em pacientes com doen?a de Crohn e retocolite ulcerativa
Lanna, Cristina Costa Duarte;Ferrari, Maria de Lourdes Abreu;Carvalho, Marco Ant?nio Parreiras de;Cunha, Aloísio Sales da;
Revista Brasileira de Reumatologia , 2006, DOI: 10.1590/S0482-50042006000700008
Abstract: joint involvement is the most commom extraintestinal manifestation in patients with crohn's disease and ulcerative colitis. the colitic arthritis, lately called enteropathic arthritis, is classified as one of the diseases of the spondyloarthropathies group. there are two patterns of joint involvement: 1) peripheral arthritis, usually coincides with exacerbations of the inflammatory bowel disease and is not associated with the hla b27 antigen; and 2) axial involvement, characterized by spondylitis and sacroiliitis, which the clinical course is independent of the intestinal disease, and has an association with hla b27.
Evaluation of inflammatory activity in Crohn’s disease and ulcerative colitis
Eduardo Garcia Vilela,Henrique Osvaldo da Gama Torres,Fabiana Paiva Martins,Maria de Lourdes de Abreu Ferrari
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i9.872
Abstract: Crohn’s disease and ulcerative colitis evolve with a relapsing and remitting course. Determination of inflammatory state is crucial for the assessment of disease activity and for tailoring therapy. However, no simple diagnostic test for monitoring intestinal inflammation is available. Noninvasive markers give only indirect assessments of disease activity. Histopathological or endoscopical examinations accurately assess inflammatory activity, but they are invasive, time consuming and expensive and therefore are unsuitable for routine use. Imaging procedures are not applicable for ulcerative colitis. The usefulness of ultrasound and Doppler imaging in assessing disease activity is still a matter of discussion for Crohn’s disease, and an increased interest in computed tomography enterograph (CTE) has been seen, mainly because it can delineate the extent and severity of bowel wall inflammation, besides detecting extraluminal findings. Until now, the available data concerning the accuracy of magnetic resonance enterography in detecting disease activity is less than CTE. Due to this, clinical activity indices are still commonly used for both diseases.
Whipple's disease. Report of five cases with different clinical features
FERRARI, Maria de Lourdes de Abreu;VILELA, Eduardo Garcia;FARIA, Luciana Costa;COUTO, Claudia Alves;SALGADO, Célio Jefferson;LEITE, Virgínia Rios;BRASILEIRO FILHO, Geraldo;BAMBIRRA, Eduardo Alves;MENDES, Claudia Maria de Castro;CARVALHO, Silas de Castro;OLIVEIRA, Celso Affonso de;CUNHA, Aloísio Sales da;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2001, DOI: 10.1590/S0036-46652001000100009
Abstract: whipple's disease (wd) is a rare systemic disease of infectious etiology which involves the small intestine but can virtually affect any organ. we present here five cases (four males and one female) ranging in age from 20 to 59 years. all patients had intestinal involvement associated or not with clinical manifestations linked to this organ. vegetation in the tricuspid valve was observed in one patient, suggesting endocarditis caused by tropheryma whippelii, with disappearance of the echocardiographic alterations after treatment. in one of the male patients the initial clinical manifestation was serologically negative spondylitis, with no diarrhea occurring at any time during follow-up. ocular involvement associated with intestinal malabsorption and significant weight loss were observed in one case. in the other two cases, diarrhea was the major clinical manifestation. all patients were diagnosed by histological examination of the jejunal mucosa and, when indicated, of extraintestinal tissues by light and electron microscopy. after antibiotic treatment, full remission of symptoms occurred in all cases. a control examination of the intestinal mucosa performed after twelve months of treatment with sulfamethoxazole-trimethoprim revealed the disappearance of t. whippelii in four patients. the remaining patient was lost to follow-up.
Time Elapsed from AML Diagnosis to Induction Chemotherapy Affects Overall Survival  [PDF]
Luís Arthur Flores Pelloso, Sandra Serson Rohr, Mihoko Yamamoto, Maria de Lourdes L. Ferrari Chauffaille
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.45108
Abstract:

We aimed to study the effect of elapsed time from AML diagnosis to treatment (TDT) on OS in a group of patients from public Hospital in Brazil. 41 AML (23 M, 18 F, 41 yrs, 18 - 84 yrs, from 2001 to 2004). There were 38 de novo AML and 3 secondary, median TDT was 6 days (range 1 - 82 d); the young ones were treated earlier than old ones (TDT 4 days vs 11, p = 0.07). Longer TDT (>10 d) was associated with worse CR rates (p = 0.02) and OS (p = 0.04). When patients were categorized into TDT from 1 - 4 d (I) vs >5 (II), those from I presented better OS than II (p = 0.004). When TDT was longer than 7 days OS decreased even more. Hb was higher in patients with TDT I vs II (8.3 vs 7.5 g/dL, p = 0.03) but WBC (p = 0.34) and platelet count (p = 0.75) were not different. Patients with TDT of 10 d were younger than TDT > 10 d (median age 41 vs 70 yrs, p = 0.001). The OS was 15.1% in 2 yrs and 8.6% in 7 yrs. Our data suggest longer TDT, when analyzed continuously, predicted for lower CR rates and OS rates.

Eosinofilia reacional, leucemia eosinofílica cr?nica e síndrome hipereosinofílica idiopática
Chauffaille, Maria de Lourdes Lopes Ferrari;
Revista Brasileira de Hematologia e Hemoterapia , 2010, DOI: 10.1590/S1516-84842010000500013
Abstract: mild eosinophilia with values of less than 1000 eosinophils/μl is commonly seen in the clinical practice and can be secondary to parasitic, inflammatory or allergic diseases or to drug reactions. additionally, eosinophilia may be due to connective tissue disorders, infections and occasionally to hematopoietic malignancies or solid tumors. the criteria established in the 1970s, for the definition of idiopathic hypereosinophilic syndrome is today unsatisfactory to characterize all conditions described as eosinophilia. now these conditions are better understood due to the evolution of cellular and molecular biology. this knowledge has helped to characterize distinct disorders involving myeloid and lymphoid lineages. hence, eosinophilia is categorized as reactive, clonal or idiopathic. with the introduction of anti-tyrosine kinase (imatinib mesylate) therapy, which is effective for the fip1l1/pdgfra rearrangement, there is a possibility to control or cure chronic eosinophilic leukemia. for this reason, precise and fast diagnosis is necessary for ideal therapeutic decisions before organic lesions that are irreversible, such as heart injury, become established. the aim of this manuscript is to review eosinophilia and offer an update on diagnostic and therapeutic investigations.
Increased Risk of Acute Myeloid Leukemia in Patients with CYP1A1 Polymorphisms  [PDF]
Luís Arthur Flores Pelloso, Ismael Dale Cotrim Guerreiro da Silva, Naiara C?rrea Nogueira de Souza, Mihoko Yamamoto, Maria de Lourdes L. Ferrari Chauffaille
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.45111
Abstract:

Acute Myeloid Leukemia (AML) is a group of genetically diverse hematopoietic malignancies arising from cell progenitors developing in the myeloid pathway or from primitive stem cells. Genetic susceptibility of AML may account for an increased risk of AML due to partial metabolism of or biocativation of carcinogens. Chemical compounds are metabolized by a two-tiered phase detoxifying system. Polymorphisms in these pathways may lead to DNA damage and development of AML. We determined the frequencies of carcinogen metabolism gene polymorphisms (CYP1A1, del{GSTM1} and del{GSTT1}) in a case control-study based on polymorphism analysis. Fifty-eight consecutively AML patients (median age 62 years) and 174 sex and age-matched control group were assessed by a PCR-RFLP assay. There were 51 de novo and 7 secondary AML. CYP1A1*2A and CYP1A1*2C polymorphisms were more frequent in CG than AML p < 0.001 and in contrast, CYP1A1*3 and CYP1A1*4 were more frequent in AML than CG p <

Initial Analysis of Lipid Metabolomic Profile Reveals Differential Expression Features in Myeloid Malignancies  [PDF]
Adriana Ramos de Oliveira, Ismael Dale Cotrim Guerreiro Da Silva, Edson G. Lo Turco, Helio Alves Martins Júnior, Maria de Lourdes L. Ferrari Chauffaille Chauffaille
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.615138
Abstract: The purpose of this preliminary study was to determine the comparative lipid profile of blood plasma samples of healthy individuals and patients with Myeloproliferative Neoplasms. Methods: Untargeted Shotgun MS/MS Analysis was performed to evaluate plasma samples from 153 participants, being 90 of the Control Group, 43 Myeloproliferative Neoplasms (MPN), 11 Myelodysplastic Syndromes (MDS) and 9 Acute Myeloid Leukemias (AML). Lipids were extracted from plasma using the Bligh-Dyer protocol. Data were acquired using the AB-Sciex Analyst TF, processed using the AB-Sciex LipidViewTM and the web-based analytical pipeline MetaboAnalyst 2.0 (www.metaboanalyst.ca). Results: Untargeted analysis identified in negative and positive-modes a total of 658 features at 2 ppm resolution. PCA and PLS-DA analysis revealed clear discrimination among groups, in particular for AML patients. Main lipid groups differentially expressed were: Monoacylglycerols (MAG), Glucosylceramide E (GlcdE), Ethyl Esters (EE), Lysophosphatidic acid (LPA), Sulfoquinovosil diacylglycerols (SQDG), Monoglycerols (MG), Methyl Ethanolamines (ME), Lysophosphatidylcholines (LPC), Dimethyl Phosfatidyletanolamines (DMPE), Monometylphosphatidiletanolamines (MMPE), Ceramide-1-phosphate (CerP), Glicerophosphoglycerols (GP), Lysomonomethyl-Phosphatidylethanolamines (LMMPE), Phosphatidic Acids (PA), Ergosterols (ERG), Glycerophosphoserine (PS), Diacylglycerols (DAG), Hexocylceramides (HexCer) and Lanosterol (Lan). ROC Curve Analysis revealed Total LMMPE as the strongest discriminating marker between Controls from Patients. In addition, these lipids were also able to differentiate MDS and AML from NPM. Conclusions: The Myeloproliferative Neoplasms from the point of view
Varia??o temporal e vertical de atributos químicos de um gleissolo do Rio Guamá cultivado com Canaranas
Abreu, Eliana Maria Acioli de;Fernandes, Antonio Rodrigues;Ruivo, Maria de Lourdes Pinheiro;
Revista Brasileira de Ciência do Solo , 2007, DOI: 10.1590/S0100-06832007000200010
Abstract: sediments carried away by the muddy waters of the guamá river and the heterogeneity of these substances are responsible for the soil formation and diversity of chemical characteristics in the periodically flooded areas. this study aimed at determining the physical and chemical attributes of a low floodplain (varzea) soil of the guamá river, in different periods, cultivated with paramaribo canarana (echinochloa polystachya h.b.k) or canarana erecta lisa (echinochloa pyramidales lam). the experimental design was entirely randomized, in a 4 x 4 factorial scheme (4 depths and 4 sampling periods) with 6 replications. composite soil samples were collected at six equidistant points from a transection, at depths of 0-10, 10-20, 20-30, and 30-40 cm in may, august and november/2002 and february/2003. soil texture, organic matter, ph in h2o, ph in kcl, extractable p, exchangeable k, al, ca, and mg and the micronutrients cu, mn, zn, and fe were determined. the soil of the area under study is classified as gleysol, i.e., little developement, poorly drained, normally acid, with a silt- clay-loam horizon. the soil chemistry composition was affected by seasonality. during the rainy season and when the most intense flooding occurred in the floodplain, in february, the ph, cu and soluble iron concentrations increased and mg and exchangeable aluminum decreased. during lower soil humidity periods base saturation and ctc were higher. iron was the nutrient that showed the greatest variation in the flooded soil; the increases exceeded 1000 % during the period of more pronounced flooding (february).
Septic arthritis as the first sign of Candida tropicalis fungaemia in an acute lymphoid leukemia patient
Vicari, Perla;Pinheiro, Ronald Feitosa;Chauffaille, Maria de Lourdes Lopes Ferrari;Yamamoto, Mihoko;Figueiredo, Maria Stella;
Brazilian Journal of Infectious Diseases , 2003, DOI: 10.1590/S1413-86702003000600012
Abstract: fungal infections caused by candida species have increased in incidence during the past two decades in england, north america and europe. candidal arthritis is rare in patients who are not intravenous drug users or are who not using a prostheses. we report the case of a 24-year-old man with acute lymphoid leukemia, who developed candida tropicalis arthritis during an aplastic period after chemotherapy. this is the eighth case described in the literature of c. tropicalis causing arthritis without intra-articular inoculation. we call attention to an unusual first sign of fungal infection: septic arthritis without intra-articular inoculation. however, this case differs from the other seven, since despite therapy a fast and lethal evolution was observed. we reviewed reported cases, incidence, risk factors, mortality and treatment of neutropenic patients with fungal infections.
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