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Search Results: 1 - 10 of 80764 matches for " FENG Yan-Fang "
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Synthesis, Crystal Structure, and Kinetics of the Thermal Decomposition of the Nickel(II) Complex of the Schiff Base 2-[(4 Methylphenylimino)methyl]-6-methoxyphenol
Yan-Fang Wang,Jian-Feng Liu,Hui-Duo Xian,Guo-Liang Zhao
Molecules , 2009, DOI: 10.3390/molecules14072582
Abstract: A new dinuclear complex, [Ni2(H2O)L4]·5H2O, consisting of chelating bidentate and bridging tridentate coordinated 2-[(4-methylphenylimino)methyl]-6-methoxyphenol (HL) Schiff base ligands and water molecules has been synthesized using a traditional method. The structure of this complex was characterized by FTIR and UV/Vis spectroscopy and thermogravimetric analyses (TG-DTG) and further confirmed by single-crystal X-ray diffraction. Its crystal structure is of monoclinic system, space group P21/c with a = 13.2837(5) ?, b = 27.3886(10) ?, c = 17.5415(6) ?, α = 90 o, β = 108.429(2) o, γ = 90 o, V = 6054.7(4) ?3, Z = 4. The crystal structure reveals that there is a Ni·Ni core, with a separation of 3.183 ?. Its thermal decomposition kinetics were also studied.
Inhibition of the ecto-beta subunit of F1F0-ATPase inhibits proliferation and induces apoptosis in acute myeloid leukemia cell lines
Wen-Li Zhao,Jian Wang,Yan-Fang Tao,Xing Feng
Journal of Experimental & Clinical Cancer Research , 2012, DOI: 10.1186/1756-9966-31-92
Abstract: Background Leukemia, a heterogeneous clonal disorder of hematopoietic progenitor cells, presents a world-wide health problem, especially in childhood. F1F0 ATPase, an inner mitochondrial enzyme, is expressed on the plasma membrane of tumor cells, and its inhibition induces both anti-angiogenic and anti-tumorigenic activity. Methods Monoclonal Antibody (McAb) against ATPase was produced by polyethylene glycol-mediated fusions and screened by ELISA. Proliferation, cell cycle and apoptosis of cells were analyzed when the surface ATPase of cells was blockaded with McAb. Results We detected cell-membrane expression of the F1F0 ATPase β subunit on 0.1% to 56% of the 11 cell lines derived from leukemia, including acute myeloid leukemia (AML). We produced a monoclonal antibody, McAb7E10, which recognizes both the native and recombinant ATPase β subunit, with a dissociation constant (KD) of 3.26E–10. We demonstrate that McAb7E10 binds to ATPase at the cell surface, where it is able to inhibit ATP synthesis. McAb7E10 significantly inhibited proliferation of AML cell lines in vitro: the relative inhibitory rates of 50 μg/mL McAb7E10 treated MV4-11and HL-60 cells were 69.6% and 81.9% respectively. Cell cycle analysis indicated that McAb7E10 significantly induced apoptosis in MV4-11 and HL-60 cells: the relative rates of apoptosis in 5, 10 and 50ug/mL McAb7E10 treated MV4-11 cells was 3.6 ± 0.83%, 8.4 ± 1.69% and 17.3 ± 2.56% compared to 1.5% ± 0.85% in mouse IgG treated cells (p < 0.01). The relative rate of apoptosis in 5, 10 and 50ug/mL McAb7E10 treated HL-60 cells was 5.5 ± 2.37%, 11.3 ± 3.62% and 19.9 ± 3.31% compared to 1.56% ± 0.97% in mouse IgG treated cells (p < 0.01). Annexin V staining demonstrated that the relative apoptotic rates in 50 μg/mL McAb7E10 treated MV4-11 and HL-60 cells were 50.5% ± 7.04% and 32.9% ± 4.52%, respectively, significantly higher than IgG control antibody treated cells were 21.9% ± 3.11% and 15.3% ± 3.95%, p < 0.01. Conclusions These findings indicate that ectopic expression of ATPase β subunit may be a tumor-associated antigen in hematological malignancies. The F1F0 ATPase β subunit provides a potential target for immunotherapy in AML and hematological malignancies.
Inversion mechanism of uncertain orders and parameters for the non-commensurate and hyper fractional order chaotic systems via differential evolution
Fei Gao,Feng-xia Fei,Qian Xu,Yan-fang Deng,Yi-bo Qi
Physics , 2012,
Abstract: In this paper, a novel uncertain fractional-orders and parameters' inversion mechanism via the differential evolution algorithms (DE) with a general mathematical model is proposed for non-commensurate and hyper fractional chaotic systems. The problems of fractional-order chaos' inversion estimation are converted into multiple modal non-negative objective functions' minimization, which takes fractional-orders and parameters as its particular independent variables. And the objective is to find optimal combinations of fractional-orders and systematic parameters by DE in the predefined intervals for fractional order chaotic systems such that the objective function is minimized. Simulations are done to estimate a series of non-commensurate and hyper fractional chaotic systems. The experiments' results show that the proposed inversion mechanism for fractional-order chaotic systems is a successful methods with the advantages of high precision and robustness.
Identification of unknown parameters and orders via cuckoo search oriented statistically by differential evolution for non-commensurate fractional order chaotic systems
Fei Gao,Feng-xia Fei,Qian Xu,Yan-fang Deng,Yi-bo Qi
Physics , 2012,
Abstract: Identification of the unknown parameters and orders of fractional chaotic systems is of vital significance in controlling and synchronization of fractional-order chaotic systems. In this paper, a non-Lyapunov novel approach is proposed to estimate the unknown parameters and orders together for non-commensurate and hyper fractional chaotic systems based on cuckoo search oriented statistically the differential evolution (CSODE). Firstly, a novel Gao's mathematical model is put and analysed in three sub-models, not only for the unknown orders and parameters' identification but also for systems' reconstruction of fractional chaos systems with time-delays or not. Then the problems of fractional-order chaos' identification are converted into a multiple modal non-negative functions' minimization through a proper translation, which takes fractional-orders and parameters as its particular independent variables. And the objective is to find best combinations of fractional-orders and systematic parameters of fractional order chaotic systems as special independent variables such that the objective function is minimized. Simulations are done to estimate a series of non-commensurate and hyper fractional chaotic systems with the new approaches based on CSODE, the cuckoo search and differential evolution respectively. The experiments' results show that the proposed identification mechanism based on CSODE for fractional-orders and parameters is a successful methods for fractional-order chaotic systems, with the advantages of high precision and robustness.
Self-growing differential equations for hyperchaotic systems reconstruction by modified genetic programming in a novel non-Lyapunov approach
Fei Gao,Feng-Xia Fei,Qian Xu,Yan-Fang Deng,Yi-Bo Qi
Physics , 2012,
Abstract: This paper has been withdrawn by the author due to a crucial sign error in equation 1.
Reconstruction mechanism with self-growing equations for hyper, improper and proper fractional chaotic systems through a novel non-Lyapunov approach
Fei Gao,Feng-Xia Fei,Qian Xu,Yan-Fang Deng,Yi-Bo Qi,Ilangko Balasingham
Physics , 2012,
Abstract: Identification of the unknown parameters and orders of fractional chaotic systems is of vital significance in controlling and synchronization of fractional-order chaotic systems. However there exist basic hypotheses in traditional estimation methods, that is, the parameters and fractional orders are partially known or the known data series coincide with definite forms of fractional chaotic differential equations except some uncertain parameters and fractional orders. What should I do when these hypotheses do not exist? In this paper, a non-Lyapunov novel approach with a novel united mathematical model is proposed to reconstruct fractional chaotic systems, through the fractional-order differential equations self-growing mechanism by some genetic operations ideas independent of these hypotheses. And the cases of identifying the unknown parameters and fractional orders of fractional chaotic systems can be thought as special cases of the proposed united mathematical reconstruction method in non-Lyapunov way. The problems of fractional-order chaos reconstruction are converted into a multiple modal non-negative special functions' minimization through a proper translation, which takes fractional-order differential equations as its particular independent variables instead of the unknown parameters and fractional orders. And the objective is to find best form of fractional-order differential equations such that the objective function is minimized. Simulations are done to reconstruct a series of hyper and normal fractional chaotic systems. The experiments' results show that the proposed self-growing mechanism of fractional-order differential equations with genetic operations is a successful methods for fractional-order chaotic systems' reconstruction, with the advantages of high precision and robustness.
Analyzing the gene expression profile of pediatric acute myeloid leukemia with real-time PCR arrays
Tao Yan-Fang, Wu Dong, Pang Li, Zhao Wen-Li, Lu Jun, Wang Na, Wang Jian, Feng Xing, Li Yan-Hong, Ni Jian, Pan Jian
Cancer Cell International , 2012, DOI: 10.1186/1475-2867-12-40
Abstract: Real-time PCR array was designed and tested firstly. Then gene expression profile of 11 pediatric AML and 10 normal controls was analyzed with real-time PCR arrays. We analyzed the expression data with MEV (Multi Experiment View) cluster software. Datasets representing genes with altered expression profile derived from cluster analyses were imported into the Ingenuity Pathway Analysis Tool.We designed and tested 88 real-time PCR primer pairs for a quantitative gene expression analysis of key genes involved in pediatric AML. The gene expression profile of pediatric AML is significantly different from normal control; there are 19 genes up-regulated and 25 genes down-regulated in pediatric AML. To investigate possible biological interactions of differently regulated genes, datasets representing genes with altered expression profile were imported into the Ingenuity Pathway Analysis Tool. The results revealed 12 significant networks. Of these networks, Cellular Development, Cellular Growth and Proliferation, Tumor Morphology was the highest rated network with 36 focus molecules and the significance score of 41. The IPA analysis also groups the differentially expressed genes into biological mechanisms that are related to hematological disease, cell death, cell growth and hematological system development. In the top canonical pathways, p53 and Huntington’s disease signaling came out to be the top two most significant pathways with a p value of 1.5E-8 and2.95E-7, respectively.The present study demonstrates the gene expression profile of pediatric AML is significantly different from normal control; there are 19 genes up-regulated and 25 genes down-regulated in pediatric AML. We found some genes dyes-regulated in pediatric AML for the first time as FASLG, HDAC4, HDAC7 and some HOX family genes. IPA analysis showed the top important pathways for pediatric AML are p53 and Huntington’s disease signaling. This work may provide new clues of molecular mechanism in pediatric AML.Ped
A Transaction Framework under Web Services Environment
一种Web服务环境下的事务保障框架

GONG Yan-Fang,HAN Yan-Bo,ZHAO Zhuo-Feng,
龚艳芳
,韩燕波,赵卓峰

计算机科学 , 2005,
Abstract: The business processes under Web services environment require transactional support in order to guarantee consistent and reliable execution.This paper analyzes the Web services transaction features and the challenge to satisfy these features,also reviews current research work and presents a possible way to integrate these work into effect.
Immunologic Characterization of Posthepatitis Cirrhosis Caused by HBV and HCV Infection
Wan-Yu Li,Yan-Fang Jiang,Qing-Long Jin,Hong Zhang,Xiang-Wei Feng,Jun-Qi Niu
Journal of Biomedicine and Biotechnology , 2010, DOI: 10.1155/2010/138237
Abstract: No specific treatment can reverse the liver injury in cirrhosis. This study aims to characterize immune status and correlations between cirrhosis induced by HBV and HCV. Phenotypes of peripheral blood lymphocyte subsets (T, NK, regulatory T cells) and Th cytokine secretion were analyzed using flow cytometry in 42 HBV-cirrhotic and 40 HCV-cirrhotic patients. Cirrhotic patients had a lower proportion of CD3
Experimental measurement of radiation dose in a dedicated breast CT system
Shen Shan-Wei,Wang Yan-Fang,Shu Hang,Tang Xiao,Wei Cun-Feng,Song Yu-Shou,Shi Rong-Jian,Wei Long
Physics , 2013,
Abstract: Radiation dose is an important performance indicator of a dedicated breast CT (DBCT). In this paper, the method of putting thermoluminescent dosimeters (TLD) into a breast shaped PMMA phantom to study the dose distribution in breasts was improved by using smaller TLDs and a new half-ellipsoid PMMA phantom. Then the weighted CT dose index (CTDIw) was introduced to average glandular assessment in DBCT for the first time and two measurement modes were proposed for different sizes of breasts. The dose deviations caused by using cylindrical phantoms were simulated using the Monte Carlo method and a set of correction factors were calculated. The results of the confirmatory measurement with a cylindrical phantom (11cm/8cm) show that CTDIw gives a relatively conservative overestimate of the average glandular dose comparing to the results of Monte Carlo simulation and TLDs measurement. But with better practicability and stability, the CTDIw is suitable for dose evaluations in daily clinical practice. Both of the TLDs and CTDIw measurements demonstrate that the radiation dose of our DBCT system is lower than conventional two-view mammography.
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