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Search Results: 1 - 10 of 144511 matches for " F. Shahraki "
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L-Fucose as a terminal sugar in cellular glycoconjugates of colonic carcinoma
Arab MR,Arab F,Karimi M,Shahraki MR
Tehran University Medical Journal , 2008,
Abstract: "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 st1":*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Glycoconjugates are a class of cell surface glycoproteins, the terminal sugars of which are important indicators of neoplasia and the aberrant biological behavior of cancer cells. Lectins are a class of plant or animal glycoproteins that specifically bind to the terminal sugars of glycoconjugates. The aim of the present study is to identify the presence of L-fucose in cell surface glycoconjugates and extracellular matrix glycoconjugates of cancer cells of different grades of colonic adenocarcinoma."n"n Methods: Paraffin blocks of colonic adenocarcinoma tissue from 30 patients were collected from the Pathology Department of Khatam Al Anbia Hospital in Zahedan, Iran. Sections, 5-7μm thick, were prepared and stained using hematoxylin and eosin. Sections were graded histopathologically and then stained using the lectin Ulex europaeus agglutinin (UEA, 10μm/mL), which binds specifically to L-fucose, and Alcian blue (pH=2.5). Sections were graded blindly according to lectin staining intensity on a scale of 0-3. Collected data were analyzed using Kruskall-Wallis and Mann Whitney nonparametric tests with SPSS."n"n Results: Our results show that there is a significant difference in the staining intensity for L-fucose between tumoral cells of different grades of colon carcinoma (p<0.001). Results show that the degree of UEA lectin binding to cancer cells is lower in the cytoplasm and nucleus and higher in the extracellular matrix in tumors, with the degree increasing with histopathological grade. Furthermore, staining intensity differs in different portions of cancer cells."n"n Conclusions: The increased staining intensity of L-fucose in the extracellular matrix of colon carcinoma is a reflection of the aberrant protein glycosylation pathway in neoplasia. "nKeywords: Colon, adenocarcinoma, lecti
Recurrent Abdominal Pain: an Etiological Study Among in a Referreal Childrens Medical Center in Iran
T Shahraki,F Farahmand,GhR Khatami,M Najafi
Iranian Journal of Pediatrics , 2007,
Abstract: Objective: Recurrent abdominal pain (RAP) affects a significant number of children each year. It can be defined as experience of at least three episodes of pain, severe enough to affect activities, over a period of three months. The purpose of this study was to determine the organic and non-organic causes of RAP. Also, evaluate different variables of RAP such as age, sex, location and duration of pain, accompanying symptoms and stressful life events in two groups.Material & Methods: During one year period from October 2003 to September 2004, 70 children (aged 4-12 years), were investigated in a referral Children's Center in Tehran. All patients underwent a thorough interview and complete physical examination and an initial sample of blood, urine, and stool evaluation. If any evidence of alarm symptoms (such as vomiting and night pain) were observed, additional studies were performed including abdominal ultrasonography, radiography, and/ or upper gastrointestinal Endoscopy.Findings: An organic cause was found in 21 (30%) patients and non-organic cause was identified in 49 (70%) cases. Main observations in non-organic groups were: more periumblical pain location, positive history for stressful life events in child and their family. Also, gastrointestinal problems were the most common organic causes in 60% of children. Other organic causes were urinary tract infections 10%, kidney stone 10%, cholelitiasis (5%), Giardiasis (15%), and abdominal migraine (5%). Endoscopy seems to be a safe and reliable method in diagnosis of a number of organic lesions otherwise not detected by ordinary investigations. Our data suggest that among the children with RAP, non-organic causes are more commons (70%) than organic causes (30%).Conclusion: This study showed that in spite of accessing to better instruments in medical sciences in recent decades , the percentage of nonorganic RAP in children is still high.
Analysis of Cryogenic Ammonia System for Energy Conservation
B. Raei,F. Shahraki,M. Khorrami,A. Ghadi
Iranica Journal of Energy and Environment (IJEE) , 2010,
Abstract: There are several alternatives to enhance the efficiency of energy usage and to decrease energy losses. Pinch technology is the best method of approach to enhance energy efficiency. Heat exchangers network (HEN) of refrigeration unit of ammonia production process was analyzed to use pinch technology to decrease energy usage. The obtained results showed that pinch technology was unsuccessful for the shaft work targeting capabilities. In contrast, it is posed that for optimization of such systems, one should use the combined pinch and exergy analysis (CPEA) method. In this analysis CPEA method was used in the system. It was observed that the refrigeration system use cold streams for cooling the hot streams. Therefore, retrofitting the refrigeration cycle without changing the main process is impossible. Some suggestions were made for improving the refrigeration system, such as the use of economizer after cooler, multistage cycle and removal of the 111-FFD3 stream. It was also observed that the exchanger 128-E act as an intercooler and the flashed 110-F, 111-F and 112-F act as an economizer. In addition, ammonia refrigerant was used at three different temperatures of -33,-7 and 13.5 C. Also, eliminated the 111-FFD3 stream bring about 2% reduction in exergy loss.
The Comparison of Eucalyptus Aqueous Extract and Insulin on Blood Sugar and Liver Enzymes in Diabetic Male Rats
Ahmadreza Shahraki,Mohammadreza Shahraki
Zahedan Journal of Research in Medical Sciences , 2013,
Abstract: Background: Since eucalyptus is a traditional plant which has been consumed as antidiabetic in herbal medicines, the aim of this survey was to compare the effect of eucalyptus aqueous extract and insulin on serum blood sugar and liver enzymes in streptozotocin (STZ) diabetic male rats. Material & Methods: The experiment was performed on four groups of rats: sham control (A), diabetic control (B), diabetic (C) which received insulin and diabetic group (D) which consumed Eucalyptus aqueous extract in drinking water for 4 weeks (n=8). Sham control and B group did not receive any agents. At the end, animals were deep anesthetized by diethyl ether, sacrificed and blood samples were collected. Blood sugar, serum lipids and liver enzymes were measured by ordinary methods. Obtained data were analyzed using ANOVA and Tukey tests. Results were expressed as mean±SD. Statistical difference of p<0.05 was recognized significant. Results: Results showed that blood sugar in group C significantly decreased compared with that of group B but ALT, AST and ALP activity value significantly increased compared with those of other groups. Conclusion: These results indicated that Eucalyptus aqueous extract caused decreased blood sugar but increased liver enzymes activity in STZ diabetic male rats
Metabotropic glutamate receptors and their ligands applications in neurological and psychiatric disorders
Ali Shahraki
Physiology and Pharmacology , 2011,
Abstract: Metabotropic glutamate receptors (mGluRs) consist of a large family of G-protein coupled receptors that are critical for regulating normal neuronal function in the central nervous system. The wide distribution and diverse physiological roles of various mGluR subtypes make them highly attractive targets for the treatment of a number of neurological and psychiatric disorders. The discovery of subtype selective ligands for these receptors has provided the tools to support a number of preclinical studies, suggesting the numerous therapeutic potential that lies in the ability selectively to modulate a specific mGluR subtype. mGluRs do not activate ion channels directly but instead through G-protiens activate second messenger mechanisms in the neurons. So far 8 subtypes of mGluRs have been identified which divided into three groups (Group I, II, and III) according to their sequence similarities, Signal transduction mechanisms and pharmacological properties. Depending on the receptor subtype, they might be localized at presynaptic or postsynaptic sites which regulate glutamate and other neurotransmitters release. As I applied many mGluR ligands on hippocampal slices and observed interesting results on synaptic transmission and modulation of certain neurotransmitters such as adenosine, I intended to study their application in neurological diseases. The method was based on my experiences from researches and different seminars to evaluate last decade development on mGluRs and their ligands application in certain neurological disorders. Therefore, aim of this review article is to describe mGluRs and their role in the excitotoxicity and neuroprotection. Then, application of different mGluR ligands for the treatment of a variety of neurological disorders including schizophrenia, Parkinson's disease, anxiety disorders, epilepsy, and drug abuse has been described.
Intellectual Property Valuation: Case Study in Iran
Alireza Shahraki
International Journal of Academic Research in Business and Social Sciences , 2012,
Abstract: Today most people are aware of the significance of competition in the international markets and establishing knowledge-based companies, which provide the infrastructure for such competition (development of global intellectual property infrastructure). Business executives become veteran and qualified with basic knowledge of intellectual property (IP) and careers and jobs based on IP to develop and increase their leadership influence in the IT era.Understanding that intellectual property valuation is effective in management resources, and that results of such valuation is used in the process of decision-making, signifies intellectual property valuation even more.Intellectual property will gradually become the criteria and milestone of a company’s prospective performance and efficiency. On an average, 40% of a company's value being considered as its intangible assets will never appear in its balance sheet. It seems necessary to mention here that the results of inquiry i can say there is no specific method for the valuation of intellectual assets and most existing methods or based on three common approaches to valuation (income approach, cost, market) Or are mostly empirical and subjective .Therefore not precisely stating that an appropriate valuation model and the dimensions and features are comprehensive. This article is presented in a way that must be at least the following terms: The base price, The strategic importance of product, Financial Assessment, Technical evaluation, Risk assessment, assessing the market, Public acceptance and Test procedures.
Efficient Power Loading in MIMO-OFDM Based Cognitive Radio Networks  [PDF]
Hamid Shahrokh Shahraki, Kamal Mohamed-Pour
Communications and Network (CN) , 2011, DOI: 10.4236/cn.2011.31002
Abstract: Due to their spectrum shaping capability and high adaptability, the multi-carrier systems are considered as prime candidates for use in the Cognitive Radio (CR) networks. In these structures, the deactivation of the primary users’ (PUs) bands makes the secondary users (SUs) use a limited number of sub-carriers, so the total capacity of CR networks is reduced. However, multiple transmit antennas can be applied to OFDM- based CR to compensate for such a low capacity. The present study investigates the problem of power allo-cation in MIMO-OFDM based CR Networks. The objective is maximizing the total capacity of CR systems in the downlink path under both interference on the PUs’ bands and maximum power of the CR transmitter constraints. It is shown that the optimal solution has high computational complexity, and therefore, an effi-cient sub-optimal algorithm is suggested for this application. As simulation results show, the suggested algo-rithm in the present paper is more enhanced and efficient than the previous algorithms.
The effect of constipation treatment on voiding dysfunction in children
Tooran Shahraki,Simin Sadeghi,Mansoor Shahraki
Zahedan Journal of Research in Medical Sciences , 2010,
Abstract: Background: Constipation and voiding dysfunction are common in children. The purpose of present study is to evaluate resolution of voiding dysfunction before and after treatment of constipation.Materials and Method: Forty-eight children (1.5-11years) with evidence of voiding dysfunction and chronic constipation were evaluated in year 1387- 1388. Patients treated for constipation for 3 months.Voiding dysfunctional score based on DVSS before and three months after treatment were compared. Girls with score > 6 and boys with score of 9 were included.Results: 35.4% and 65.4% of subjects were boys and girls, respectively. Median score of voiding dysfunction revealed significant differences before and after treatment (p=0.001). Comparison of scores in both sexes and ages were not significant, (p=0.4, 0.9, respectively). After treatment, enuresis and encoprosis as well as frequency in defecation showed significant improvement among girls and boys, (p=0.003 and 0.001 respectively).Conclusion: results of this study showed that treatment of constipation may be effective in improvement of voiding dysfunction in children. More studies recommend in this regard
Effects of Vitamin E, Calcium Carbonate and Milk of Magnesium on Muscular Cramps in Pregnant Women
Azar Danesh Shahraki
Journal of Medical Sciences , 2006,
Abstract: Muscular cramp is a painful, local and unusual contraction of one or a group of muscles; more than half of pregnant women suffer from leg muscular cramps. The present study investigates the effect of vitamin E treatment, milk of magnesium suspension and calcium carbonate treatment on pregnant women with leg cramps. This is a descriptive cross-sectional interventional study on 120 pregnant multiparous women aged between 25 to 35 years which suffered from muscular cramps and were in 25-28th week of gestational age provisionally referred to shahrekord gynecology clinic between September 2004 and July 2005. They were randomizely divided to three groups. The number, tensity and duration of cramps were registered for a term of 45 days the first group was given vitamin E, second group was given milk of magnesium suspension (oral) and third group was given calcium carbonate tablet. On 45th and 90th days of treatment, the number, tensity and duration of muscular cramps was repeatedly examined. Mean of cramp duration in each three groups was reduced in second visit but in third visit only that group which took vitamin E showed reduction in mean cramp duration. During the second visit of all three groups had reduction in the number of leg cramps in comparison with the first visit and means the tensity of cramp pains was reduced but in third visit (after 90 days of treatment) the severity and number of pains in first group remarkably was reduced in comparison with two other groups. It seems that vitamin E is more effective in reduction of number, severity and duration of leg cramps during the pregnancy in comparison with milk of magnesium suspension and calcium carbonate.
Vanadium induces liver toxicity through reductive activation by glutathione and mitochondrial dysfunction  [PDF]
Mir-Jamal Hosseini, Nina Seyedrazi, Jafar Shahraki, Jalal Pourahmad
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.38134
Abstract: Pentavalent vanadium (V5+) (metavanadate salt) tox- icity is a challenging problem to the health professionals and has been recognized as an industrial hazard that adversely affects human and animal health, but its cytotoxic mechanisms have not yet been completely understood. In this study, we investigated the cytotoxic mechanisms of V5+ in freshly isolated rat hepatocytes. V5+ cytotoxicity was associated with reactive oxygen species (ROS) formation, collapse of mitochondrial membrane potential, lysosomal membrane rupture and cytochrome c release into the hepatocyte cytosol. All of the above mentioned V5+ -induced cytotoxicity markers were significantly (p < 0.05) prevented by ROS scavengers, antioxidants and mitochondrial permeability transition (MPT) pore sealing agents. Hepatocyte glutathione (GSH) was also rapidly oxidized and GSH-depleted hepatocytes were more resistant to lithium-induced oxidative stress markers. This suggests that V5+ is activated by GSH. Our findings also showed that the lysosomotropic agents prevented V5+ induced mitochondrial membrane potential collapse. On the other hand, mitochondrial MPT pore sealing agents inhibited lysosomal membrane damage caused by V5+. It can therefore be suggested that there is probably a toxic interaction (cross-talk) between mitochondrial and lysosomal oxidative stress generating systems, which potentiates ROS formation and further damages both sub-organelles in V5+-induced induced hepatotoxicity. In conclusion, V5+-induced cytotoxicity can be attributed to oxidative stress started from glutathione mediated metal reductive activation and continued by mitochondrial/lysosomal toxic interaction.
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