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Search Results: 1 - 10 of 144792 matches for " F. Marks "
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Disabling hip osteoarthritis: gender, body mass, health and functional status correlates  [PDF]
Ray Marks
Health (Health) , 2010, DOI: 10.4236/health.2010.27106
Abstract: Objective: To examine gender differences in self-reported pain and function before and after hip replacement surgery and the extent to which overweight, comorbidities and muscular status impact pain and function in adults with disabling end-stage hip joint osteoarthritis. Setting: Orthopedic Hospital Setting on the East Coast of the United States. Study Design: Cross-sectional retrospective chart review. Methods: The desired demographic, physical and psychological attributes of 1040 adults with end-stage hip osteoarthritis hospitalized for hip surgery were recorded and subjected to comparison and correlational analyses. These data included gender, self-reported weight, height, numbers and nature of physical and psychological comorbidities, pain intensity, ambulatory capacity and discharge destination. Sub-group analyses of 808 candidates hospitalized for primary unilateral surgery were also conducted using SPSS 16. Results: There were significant (p < 0.05) associations between gender, pain scores, comorbidity numbers and ambulatory capacity. Specifically, women who exhibited higher comorbid disease rates than men, exhibited higher pre-surgery pain levels and greater functional limitations in walking ability before and after surgery than men with the same condition. In sub-group analyses of men and women with the same mean age, comorbid prevalence rates, and body mass indices, women were found to have significantly higher ideal weights on average than men, and those with higher ideal weights recovered more slowly after surgery (p < 0.05). Conclusion: The presentation of hip joint osteoarthritis is not uniform, and may be impacted differentially by gender. Women with high ideal body weights, may be specifically impacted. Whether genetic or other factors account for gender differences in pain and function among adults with disabling hip osteoarthritis observation needs to be examined.
Information Systems Development Methodolgies in Developing Higher Education  [PDF]
Adam Marks
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.31019
Abstract: Studies concerned with the status of Information Systems Development Methodologies usage in many developing countries including the factors that influence and motivate their use, current trends, difficulties, and barriers to adoption are lacking, especially within the higher education sector. This paper examines these identified gaps in a developing country, namely the United Arab Emirates. The initial findings reveal that there is limited knowledge and understanding of the concept of ISDM in federal higher education institutions in the UAE. This is reflected in the quality of the software products being developed and released. However, the analysed data also reveals a trend whereby federal higher education institutions in the UAE are gradually moving towards increased ISDM adoption and deployment.
Osteoarthritis and Articular Cartilage: Biomechanics and Novel Treatment Paradigms  [PDF]
Ray Marks
Advances in Aging Research (AAR) , 2014, DOI: 10.4236/aar.2014.34039
Abstract:

Background: Osteoarthritis is a widespread highly painful disabling age-related disease with no known cure. Although novel strategies for ameliorating osteoarthritic damage abound, it is likely that none will be successful over time if the entire spectrum of the disease and the effects of joint biomechanics on joint tissues are not carefully considered. Objectives: 1) To detail the structure of healthy articular cartilage, the key tissue affected by osteoarthritis. 2) To detail what aspects of cartilage damage best characterize osteoarthritis. 3) To consider the role of biomechanical factors in developing solutions to treat osteoarthritic joint damage. Methods: Literature sources from 1980 onwards that have contributed to our knowledge of the topics relevant to this paper were accessed and retrieved. The data were categorized into four predominant themes and conclusions about the state of our knowledge and future directives were formulated. Conclusions: Osteoarthritis prevalence remains high, and a cure appears elusive. A rich body of data has helped us to better understand the key tissue involved, and suggests a repair process might be feasible, if the basic collective information on the role of biomechanics in mediating or moderating articular cartilage integrity and function is forthcoming.

Non-Operative Management of Hip Osteoarthritis  [PDF]
Ray Marks
Pain Studies and Treatment (PST) , 2015, DOI: 10.4236/pst.2015.32002
Abstract: This paper reviews several non-operative and non-pharmacologic management strategies advocated for alleviating the pain and disability experienced by people with hip osteoarthritis. It analyzes whether painful debilitating hip osteoarthritis, which has no effective cure and is often progressive, may be affected positively by non-operative interventions designed to control osteoarthritis pain. Finally, it provides an integrated plan of management for ameliorating hip osteoarthritis pain and disability in light of this knowledge.
The Marginal Propensity to Import in China and the Composition of Australia’s Exports: Some Interesting Revelations  [PDF]
Andrew Marks
Modern Economy (ME) , 2017, DOI: 10.4236/me.2017.87063
Abstract: The marginal propensity to import manufacturing products is rising more rapidly than the marginal propensity to import primary products in China, yet Australia’s exports to this country are concentrated in primary products thereby leading to large export revenue and hence output and employment losses. The over-reliance on primary product exports to China has also led to fluctuations export revenue and hence output and employment growth. These problems have been compounded due to these products dominating the export base. Adopting industry policy to stimulate manufacturing exports and thus broaden the export base has the potential to alleviate the losses and fluctuations in export revenue and hence output and employment growth when Australia trades with China and the rest of the world.
Tolerance of Ambiguity: A Review of the Recent Literature  [PDF]
Adrian Furnham, Joseph Marks
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.49102
Abstract:

This review paper attempts to update the literature on tolerance of ambiguity (TA) and related concepts since a previous review (Furnham & Ribchester, 1995). Various related concepts like Uncertainly Avoidance and In/Tolerance of Uncertainly are reviewed. Both correlational and experimental studies of TA are reviewed and tabulated. Further, an attempt was made to identify and critique various different questionnaires design to measure TA. Recommendations for the use of these tests in research are made. The reasons for progress and lack of progress in this field are highlighted.

Airport Information Systems—Airside Management Information Systems  [PDF]
Adam Marks, Kees Rietsema
Intelligent Information Management (IIM) , 2014, DOI: 10.4236/iim.2014.63016
Abstract:

Research on the intersection of the areas of aviation and management of information systems is scarce. Airports, more than ever before need to align their information systems to gain a competitive advantage and become more efficient in their operations. A proper classification is a prerequisite to systems alignment. The purpose of this paper is to provide descriptions of some of the airport management information systems, connections to or interoperability with other systems, and the key uses and users of each system. There are many types of management information systems and they can be organized or classified in a number of different ways. Furthermore, each system may or may not be necessary for a particular airport depending on the business goals and objectives and the certificate which the airport is operating under. Consequently, the system classification schema presented in this paper is neither all-inclusive nor exclusive; however, a number of leading aviation practitioners, business professionals, and educators in the industry were instrumental in both proposing and validating the schema. The study used interviews, documentation, and observation as the primary sources of data.

Evidence Implicating the Ras Pathway in Multiple CD28 Costimulatory Functions in CD4+ T Cells
Sujit V. Janardhan, Kesavannair Praveen, Reinhard Marks, Thomas F. Gajewski
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0024931
Abstract: CD28 costimulation is a critical event in the full activation of CD4+ T cells that augments cytokine gene transcription, promotes cytokine mRNA stability, prevents induction of anergy, increases cellular metabolism, and increases cell survival. However, despite extensive biochemical analysis of the signaling events downstream of CD28, molecular pathways sufficient to functionally replace the diverse aspects of CD28-mediated costimulation in normal T cells have not been identified. Ras/MAPK signaling is a critical pathway downstream of T cell receptor stimulation, but its role in CD28-mediated costimulation has been controversial. We observed that physiologic CD28 costimulation caused a relocalization of the RasGEF RasGRP to the T cell-APC interface by confocal microscopy. In whole cell biochemical analysis, CD28 cross-linking with either anti-CD28 antibody or B7.1-Ig augmented TCR-induced Ras activation. To determine whether Ras signaling was sufficient to functionally mimic CD28 costimulation, we utilized an adenoviral vector encoding constitutively active H-Ras (61L) to transduce normal, Coxsackie-Adenovirus Receptor (CAR) transgenic CD4+ T cells. Like costimulation via CD28, active Ras induced AKT, JNK and ERK phosphorylation. In addition, constitutive Ras signaling mimicked the ability of CD28 to costimulate IL-2 protein secretion, prevent anergy induction, increase glucose uptake, and promote cell survival. Importantly, we also found that active Ras mimicked the mechanism by which CD28 costimulates IL-2 production: by increasing IL-2 gene transcription, and promoting IL-2 mRNA stability. Finally, active Ras was able to induce IL-2 production when combined with ionomycin stimulation in a MEK-1-dependent fashion. Our results are consistent with a central role for Ras signaling in CD28-mediated costimulation.
Design and Characterization of a 5.2 GHz/2.4 GHz Fractional- Frequency Synthesizer for Low-Phase Noise Performance
Rogers John WM,Dai Foster F,Plett Calvin,Cavin MarkS
EURASIP Journal on Wireless Communications and Networking , 2006,
Abstract: This paper presents a complete noise analysis of a -based fractional- phase-locked loop (PLL) based frequency synthesizer. Rigorous analytical and empirical formulas have been given to model various phase noise sources and spurious components and to predict their impact on the overall synthesizer noise performance. These formulas have been applied to an integrated multiband WLAN frequency synthesizer RFIC to demonstrate noise minimization through judicious choice of loop parameters. Finally, predicted and measured phase jitter showed good agreement. For an LO frequency of 4.3 GHz, predicted and measured phase noise was rms and rms, respectively.
Physical Activity and Hip Fracture Disability: A Review
Ray Marks
Journal of Aging Research , 2011, DOI: 10.4061/2011/741918
Abstract: Objective. The present paper examines pertinent literature sources published in the peer-reviewed English language between 1980 and November 1, 2010 concerning hip fractures. The aim was to highlight potential intervention points to offset the risk of incurring a hip fracture and its attendant disability. Methods. An in-depth search of the literature using the key terms: disability, epidemiology, hip fracture, prevention, and risk factors was conducted, along with data from the author's research base detailing the disability associated with selected hip fracture cases. All articles that dealt with these key topics were reviewed, and relevant data were tabulated and analyzed. Results. Hip fractures remain an important but potentially preventable public health problem. Among the many related remediable risk factors, low physical activity levels are especially important. Related determinants of suboptimal neuromuscular function also contribute significantly to hip fracture disability. Conclusion. Physical activity participation can help to reduce the prevalence and excess disability of hip fractures and should be encouraged. 1. Background to the Problem In spite of much research, hip fractures continue to pose a serious health care problem as far as health policy makers and public health care organizations are concerned. Indeed, despite some evidence of declining hip fracture prevalence rates (e.g., [1, 2]), hip fractures remain a persistent cause of excessive morbidity, reduced life quality, and premature mortality among older adults [3, 4]. In addition, because the observed reversal of the hip fracture secular trend may not apply universally [5], it is likely the annual incidence of hip fractures will increase, rather than decrease over the next few decades [6]. Moreover, since hip fracture prevalence increases exponentially with age [7], as populations age and longevity increases worldwide [8], these injuries are likely to occur at accelerated rates [9]. This is important, because among those who sustain a hip fracture injury and survive, an increasing number continue to experience various degrees of subsequent disability, including the onset of painful disabling hip joint osteoarthritis, a high risk for falls, and further hip fracture injury. As a result, escalating and excessive monetary costs of care for this debilitating injury [8], which includes disability costs, nursing care, rehabilitation care, and surgical costs are predicted as well. The aforementioned likelihood of an increase, rather than a universal decrease in hip fracture prevalence
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